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We prove discrete-to-continuum convergence for dynamical optimal transport on $\mathbb{Z}^d$-periodic graphs with cost functional having linear growth at infinity. This result provides an answer to a problem left open by Gladbach, Kopfer, Maas, and Portinale (Calc Var Partial Differential Equations 62(5), 2023), where the convergence behaviour of discrete boundary-value dynamical transport problems is proved under the stronger assumption of superlinear growth. Our result extends the known literature to some important classes of examples, such as scaling limits of $1$-Wasserstein transport problems. Similarly to what happens in the quadratic case, the geometry of the graph plays a crucial role in the structure of the limit cost function, as we discuss in the final part of this work, which includes some visual representations.
In 2020, COVID-19 modeling studies predicted rapid epidemic growth and quickly overwhelmed health systems in humanitarian and fragile settings due to preexisting vulnerabilities and limited resources. Despite the growing evidence from Bangladesh, no study has examined the epidemiology of COVID-19 in out-of-camp settings in Cox’s Bazar during the first year of the pandemic (March 2020-March 2021). This paper aims to fill this gap.
Methods
Secondary data analyses were conducted on case and testing data from the World Health Organization and the national health information system via the District Health Information Software 2.
Results
COVID-19 in Cox’s Bazar was characterized by a large peak in June 2020, followed by a smaller wave in August/September and a new wave from March 2021. Males were more likely to be tested than females (68% vs. 32%, P < 0.001) and had higher incidence rates (305.29/100 000 males vs. 114.90/100 000 female, P < 0.001). Mortality was significantly associated with age (OR: 87.3; 95% CI: 21.03-350.16, P < 0.001) but not sex. Disparities existed in testing and incidence rates among upazilas.
Conclusions
Incidence was lower than expected, with indicators comparable to national-level data. These findings are likely influenced by the younger population age, high isolation rates, and low testing capacity. With testing extremely limited, true incidence and mortality rates are likely higher, highlighting the importance of improving disease surveillance in fragile settings. Data incompleteness and fragmentation were the main study limitations.
COVID-19 vaccine effectiveness (VE) studies are limited in low- and middle-income countries. A case-control study was conducted among COVID-19 and other pneumonia patients admitted to a hospital in the Philippines during the pre-Omicron and Omicron periods. To elucidate factors associated with in-hospital death, 1782 COVID-19 patients were assessed. To estimate absolute VE for various severe outcomes, 1059 patients were assessed (869 [82.1%] COVID-19 cases; 190 [17.9%] controls). Factors associated with in-hospital death included older age, tuberculosis (adjusted odds ratio [aOR] 2.45 [95% confidence interval {95% CI} 1.69–3.57]), HIV (aOR 3.30 [95% CI 2.03–5.37]), and current smokers (aOR 2.65 [95% CI 1.72–4.10]). Pre-Omicron, the primary series provided high protection within a median of 2 months (hospitalization: 85.4% [95% CI 35.9–96.7%]; oxygen requirement: 91.0% [95% CI 49.4–98.4%]; invasive mechanical ventilation (IMV): 97.0% [95% CI 65.7–99.7%]; death: 96.5% [95% CI 67.1–99.6%]). During Omicron, the primary series provided moderate-high protection within a median of 6–9 months (hospitalization: 70.2% [95% CI 27.0–87.8%]; oxygen requirement: 71.4% [95% CI 29.3–88.4%]; IMV: 72.7% [95% CI −11.6–93.3%]; death: 58.9% [95% CI −82.8–90.8%]). Primary series VE against severe COVID-19 outcomes was consistently high for both pre-Omicron and Omicron in a setting where approximately half of the vaccinees received inactivated vaccines.
We show that for $\mathrm {C}^*$-algebras with the global Glimm property, the rank of every operator can be realized as the rank of a soft operator, that is, an element whose hereditary sub-$\mathrm {C}^*$-algebra has no nonzero, unital quotients. This implies that the radius of comparison of such a $\mathrm {C}^*$-algebra is determined by the soft part of its Cuntz semigroup.
Under a mild additional assumption, we show that every Cuntz class dominates a (unique) largest soft Cuntz class. This defines a retract from the Cuntz semigroup onto its soft part, and it follows that the covering dimensions of these semigroups differ by at most $1$.
Weed-suppression benefits of cover crops (CCs) have long been recognized; however, the specific ability of CCs to suppress highly epidemic Amaranthus spp. (Palmer amaranth (Amaranthus palmeri S. Watson), redroot pigweed (Amaranthus retroflexus L.), smooth pigweed (Amaranthus hybridus L.), and waterhemp [Amaranthus tuberculatus (Moq.) Sauer]) has not been widely discussed. The objective of this meta-analysis was to evaluate the implications of CC management decisions (CC type, planting and termination methods, residue fate after termination, and in-season weed management plan) on Amaranthus spp. weed density (ASWD) and Amaranthus spp. weed biomass (ASWB) compared with no CC (NCC) in temperate regions, including the United States and Canada. We found 41 studies conducted across the United States and Canada and extracted 595 paired observations. The results indicate that CCs reduced the ASWD by 58% in the early season (0 to 4 wk after crop planting [WAP]), by 48% in the midseason (5 to 8 WAP), and by 44% in the late season (>8 WAP). Similarly, CCs reduced ASWB by 59%, 55%, and 37% in the early, mid-, and late season, respectively. Meta-regression analysis showed CCs terminated within 2.5 wk of crop planting reduced ASWD by ≥50%. CC biomass required to reduce ASWD and ASWB by 50% was 4,079 kg ha−1 for ASWD and 5,352 kg ha−1 for ASWB. Among CC types, grasses and mixtures reduced ASWD by 60% and 77% in early season, 53% and 59% in midseason, and 44% and 47% in late season. Legume CCs were effective only during the early season (47% ASWD reduction), while brassicas did not affect ASWD. CC residues remaining on the soil surface were more effective for reducing ASWD than incorporation. CCs did not affect ASWD or ASWB compared with NCC when herbicides were used for in-season weed management. In general, CCs were found to reduce ASWD and ASWB and therefore can be used as an effective tool for integrated management of Amaranthus spp.
Animal agriculture employs approximately one-eighth of world’s human population and results in the slaughter of over 160 billion animals annually, representing perhaps the most extensive intertwining of human and animal lives on the planet. In principle, close, intersubjective relationships (involving shared attention and mental states) between humans and the animals in agriculture are possible, though these are infrequently studied and are unlikely to be achieved in farming, given systemic constraints (e.g. housing and management). Much scientific research on human-animal relationships within agriculture has focused upon a fairly restricted range of states (e.g. reducing aversive human-animal interactions within standard systems, toward improving productivity and reducing injuries to workers). Considering human-animal relations along a continuum, we review scholarship supporting the rationale for expanding the range of relationships under consideration in animal welfare research, given the impacts these relationships can have on both animals and stockpersons, increasing consumer demand for humane food products, and the goal of providing animals under our care with good lives. Looking toward traditions that encourage taking the perspective of, and learning from non-humans, we provide entry points to approaches that can enable animal welfare research to expand to investigate a broader range of human-animal relationship states. By showing the potential for close mutually beneficial human-animal relationships, this line of research highlights pathways for understanding and improving the welfare of animals used in agriculture.
The article examines hope as employed in short political speeches given by a Palestinian resident and activist, Mr. Saleh Diab, to a small audience of Jewish-Israelis, during the weekly Sheikh Jarrah protest in East Jerusalem. Informed by linguistic anthropology and sociolinguistics, hope is viewed contextually as a resource or affordance that enables indexical connection-projection from the narrative time of the present to a future that is yet unforeseeable (yet-to-become, Derrida 1990/1992). The analysis of future-facing utterances highlights the indexical semiotics that underlie hope, connecting collaborative political action performed here-and-now in the occupied Palestinian neighborhood to its future ramifications. Examining Saleh's employment of hope points at its essential moral and affective entanglement. The article seeks to contribute to a sociolinguistic understanding of hope, as collaboratively and consistently sustained (specifically within the Israeli-Palestinian context), and more broadly to supply a clearer view of the sociolinguistics of grassroot political activism resisting oppressive regimes. (Narrative, time, indexicality, Israel-Palestine, Sheikh Jarrah, protest, demonstration, political discourse)1
The rapid and efficient removal of weeds is currently a research hotspot. With the integration of robotics and automation technology into agricultural production, intelligent field-weeding robots have emerged. An overview of the development status of weeding robots based on bibliometric and scientific mapping methods is presented. Two key technologies of weeding robots are summarized, and the research progress of precision-spraying weeding robots, mechanical weeding robots, and thermal weeding robots with laser devices, categorized by weeding method, is reviewed. Finally, a summary and an outlook on the future development trends of intelligent field-weeding robots are provided, aiming to offer a reference for further promoting the development of weeding robots.
This article presents a constructional analysis of the uses of left-peripheral so in Early New High German. This element is known as a resumptive element, which takes up an adverbial clause and integrates it into a main clause. While this seems a valid analysis for constructions with preposed adverbial clauses, it is not compatible when so is preceded by adverbs or main clauses.
First, a quantitatively informed picture is presented. A network is proposed that centers around a prototype in which so connects a protasis and apodosis when so follows verb-final and verb-initial clauses. Second, it is argued that so following verb-second clauses is loosely connected to this network. Finally, it is considered whether and to what degree the use of so following adverbs should be analyzed in the same way as so following adverbial clauses. It is argued that patterns with adverbs are not in paradigmatic relation with adverbial clauses. Moreover, their function is different, as they are backward-oriented and take up earlier constituents.
We evaluated herbicides for controlling the annual grass ventenata [Ventenata dubia (Leers) Coss.], with particular interest in indaziflam, a preemergence cellulose biosynthesis inhibitor. In 2016, indaziflam was applied postemergence alone and in mixture with glyphosate, imazapic, propoxycarbazone-sodium, or rimsulfuron to an improved pasture in southwestern Montana. A non-sprayed control was included for comparison purposes. Canopy cover of each species was assessed annually for 7 yr; cover was grouped by life-form and longevity, and species richness was calculated. Five years (2021) after treatment, the seedbank was assessed. Our results indicated that treatments including indaziflam reduced V. dubia cover 1 to 3 yr and even up to 6 yr after application, with V. dubia cover being zero or close to zero. However, at 7 yr (2023) after treatment, V. dubia was low across all treatments, including the non-sprayed control. Perennial grasses and forbs and annual forbs were generally unaffected by any treatment and did not increase in cover over the 7 yr, even though V. dubia decreased. Two years after treatment, species richness was lowest in treatments that included indaziflam, but at 7 yr, species richness was similar across all treatments. Indaziflam depleted the monocot and dicot seedbank, with fewer than 5 seedlings of any species emerging from treatments that included indaziflam, while other treatments resulted in 60 to 165 seedlings per sample (40 cm3 of soil). In summary, at our study site, a single application of indaziflam controlled V. dubia for 6 yr, appeared to deplete the seedbank at 5 yr, and cover of perennial and annual vegetation and species richness was unaffected. By the end of the study, though, V. dubia cover appeared to be influenced by factors other than herbicide treatments, possibly variable precipitation over time, an exclusion of grazing, and competitive perennial grasses dominating the site.
Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.5% of people due to concerns about clozapine-associated myocarditis (CAM). The opportunity for clozapine rechallenge is important for people with TRS and CAM, due to limited alternative treatments. However, there is a lack of consensus regarding the optimal process, monitoring, and dose titration to achieve successful clozapine rechallenge. The study aimed to review the process, monitoring, and dose titration within cases of clozapine rechallenge after CAM, to identify features associated with successful rechallenge.
Methods
A systematic review of clozapine rechallenge cases following CAM was conducted. PubMed, EMBASE, Cinahl, and PsycINFO were searched for cases. Reference lists of retrieved articles and field experts were consulted to identify additional studies.
Results
Forty-five cases were identified that described clozapine rechallenge, 31 of which were successful. Successful rechallenge cases generally used a slower dose titration regime with more frequent monitoring than standard clozapine initiation protocols; however, this data was not always completely recorded within cases. Six cases referred to published rechallenge protocols to guide their rechallenge.
Conclusions
The process, monitoring, and dose titration of clozapine rechallenge are inconsistently reported in the literature. Despite this, 69% of case reports detailed a successful rechallenge post CAM; noting limitations associated with reliance on case data. Ensuring published clozapine rechallenge cases report standardised data, including titration speed and monitoring frequencies, is required to guide the development and validation of guidelines for clozapine rechallenge.
We propose a novel and unified sampling scheme, called the accelerated group sequential sampling scheme, which incorporates four different types of sampling scheme: (i) the classic Anscombe–Chow–Robbins purely sequential sampling scheme; (ii) the accelerated sequential sampling scheme; (iii) the relatively new k-at-a-time group sequential sampling scheme; and (iv) the new k-at-a-time accelerated group sequential sampling scheme. The first-order and second-order properties of this unified sequential sampling scheme are fully investigated with two illustrations on minimum risk point estimation for the mean of a normal distribution and on bounded variance point estimation for the location parameter of a negative exponential distribution. We also provide extensive Monte Carlo simulation studies and real data analyses for each illustration.
This article explores the dialectics of hope and anger as responses to what Lear (2006) called ‘devastation’, the colonial-capitalist destruction of the ontological groundings of life. Lear argues that ‘radical hope’ allows for ‘survival’ in such contexts, and his work has been influential. Yet, I want to be careful with relying on hope as a political affect. Hope is also a sociality-sanctioned emotion. Anger, by contrast, remains frowned upon and discouraged. However, anger can have liberatory potential: it constitutes a communicative act, articulating the urgent need for political change. I explore the semiotics of anger by considering the complex affective contours of a musical performance, ‘Protest’, created by Abbey Lincoln and Max Roach (1960). The expression of anger is reflexive and performative. It is a recognizable register as well as a politically passionate communicative act that resists its own foreclosure and that intersects with hope in complex ways. (Hope, anger, affect, music, negative dialectics, philosophical sociolinguistics)*
To describe the economic, lifestyle and nutritional impact of the COVID-19 pandemic on parents, guardians and children in Malaysia, Indonesia, Thailand and Vietnam.
Design:
Data from the SEANUTS II cohort were used. Questionnaires, including a COVID-19 questionnaire, were used to study the impact of the pandemic on parents/guardians and their children with respect to work status, household expenditures and children’s dietary intake and lifestyle behaviours.
Setting:
Data were collected in Malaysia, Indonesia, Thailand and Vietnam between May 2019 and April 2021.
Participants:
In total, 9203 children, aged 0·5–12·9 years, including their parents/guardians.
Results:
Children and their families were significantly affected by the pandemic. Although the impact of lockdown measures on children’s food intake has been relatively mild in all countries, food security was negatively impacted, especially in Indonesia. Surprisingly, in Malaysia, lockdown resulted in overall healthier dietary patterns with more basic food groups and less discretionary foods. Consumption of milk/dairy products, however, decreased. In the other countries, intake of most food groups did not change much during lockdown for households based on self-reporting. Only in rural Thailand, some marginal decreases in food intakes during lockdown persisted after lockdown. Physical activity of children, monthly household income and job security of the parents/guardians were negatively affected in all countries due to the pandemic.
Conclusion:
The COVID-19 pandemic has significantly impacted societies in South-East Asia. To counteract negative effects, economic measures should be combined with strategies to promote physical activity and eating nutrient-adequate diets to increase resilience of the population.
The modern history of Tianjin, a northern port city in China, offers an intriguing urban case for scholars interested in comparative colonial practices. From the 1860s to the 1940s, Tianjin was home to up to nine foreign concessions and a sequence of different Chinese municipalities. While much scholarship on colonial history has focused on the interactive dynamics between the colonizer and the colonized, Tianjin’s colonial past draws attention to the multiplicity, multilateralism and multilayered trajectories at the heart of the colonial experiences of both imperialist powers and the Chinese. At the heart of this short survey are some reflections on the multi-imperial dimensions of the city of Tianjin. It also explains how the multi-imperial dimensions operated in Tianjin in its treaty-port incarnation and offers some considerations of how the Tianjin case contributes to broader historiographical conversations germane to the imperial–global–urban complex.
This proof-of-concept study evaluated an optimization strategy for the Community Case Detection Tool (CCDT) aimed at improving community-level mental health detection and help-seeking among children aged 6–18 years. The optimization strategy, CCDT+, combined data-driven supervision with motivational interviewing techniques and behavioural nudges for community gatekeepers using the CCDT. This mixed-methods study was conducted from January to May 2023 in Palorinya refugee settlement in Uganda. We evaluated (1) the added value of the CCDT+ in improving the accuracy of detection and mental health service utilization compared to standard CCDT, and (2) implementation outcomes of the CCDT+. Of the 1026 children detected, 801 (78%) sought help, with 656 needing mental health care (PPV = 0.82; 95% CI: 0.79, 0.84). The CCDT+ significantly increased detection accuracy, with 2.34 times higher odds compared to standard CCDT (95% CI: 1.41, 3.83). Additionally, areas using the CCDT+ had a 2.05-fold increase in mental health service utilization (95% CI: 1.09, 3.83). The CCDT+ shows promise as an embedded quality-optimization process for the detection of mental health problems among children and enhance help-seeking, potentially leading to more efficient use of mental health care resources.
Cognitive therapy for PTSD (CT-PTSD) is an efficacious treatment for children and adolescents with post-traumatic stress disorder (PTSD) following single incident trauma, but there is a lack of evidence relating to this approach for youth with PTSD following exposure to multiple traumatic experiences.
Aims:
To assess the safety, acceptability and feasibility of CT-PTSD for youth following multiple trauma, and obtain a preliminary estimate of its pre–post effect size.
Method:
Nine children and adolescents (aged 8–17 years) with multiple-trauma PTSD were recruited to a case series of CT-PTSD. Participants completed a structured interview and mental health questionnaires at baseline, post-treatment and 6-month follow-up, and measures of treatment credibility, therapeutic alliance, and mechanisms proposed to underpin treatment response. A developmentally adjusted algorithm for diagnosing PTSD was used.
Results:
No safety concerns or adverse effects were recorded. Suicidal ideation reduced following treatment. No participants withdrew from treatment or from the study. CT-PTSD was rated as highly credible. Participants reported strong working alliances with their therapists. Data completion was good at post-treatment (n=8), but modest at 6-month follow-up (n=6). Only two participants met criteria for PTSD (developmentally adjusted algorithm) at post-treatment. A large within-subjects treatment effect was observed post-treatment and at follow up for PTSD severity (using self-report questionnaire measures; ds>1.65) and general functioning (CGAS; ds<1.23). Participants showed reduced anxiety and depression symptoms at post-treatment and follow-up (RCADS-C; ds>.57).
Conclusions:
These findings suggest that CT-PTSD is a safe, acceptable and feasible treatment for children with multiple-trauma PTSD, which warrants further evaluation.
The discovery and development of immune checkpoint inhibitors (ICIs) has revolutionised the management of human cancers. However, only a subset of patients responds to ICI therapy, even though immune evasion is a hallmark of cancer. Initially, treatment was administered to patients on the basis of expression levels of one of the targets of ICI therapy, programmed cell death ligand 1. In clinical trials, the high response rate of melanoma and non-small cell lung cancer patients to ICI therapy supported the basic premise of cancer immunotherapy, that tumour-specific mutated proteins trigger an immune response. Tumour mutational burden subsequently emerged as a potential biomarker for response to ICI therapy. This review summarises the evidence supporting the scientific rationale for TMB as a biomarker for ICI therapy and focuses on some of the major challenges associated with incorporation of TMB into routine clinical practice.
This study explored the prospective use of the Ages and Stages Questionnaires-3 in follow-up after cardiac surgery.
Materials and Method:
For children undergoing cardiac surgery at 5 United Kingdom centres, the Ages and Stages Questionnaires-3 were administered 6 months and 2 years later, with an outcome based on pre-defined cut-points: Red = 1 or more domain scores >2 standard deviations below the normative mean, Amber = 1 or more domain scores 1–2 standard deviations below the normal range based on the manual, Green = scores within the normal range based on the manual.
Results:
From a cohort of 554 children <60 months old at surgery, 306 participated in the postoperative assessment: 117 (38.3%) were scored as Green, 57 (18.6%) as Amber, and 132 (43.1%) as Red. Children aged 6 months at first assessment (neonatal surgery) were likely to score Red (113/124, 85.6%) compared to older age groups (n = 32/182, 17.6%). Considering risk factors of congenital heart complexity, univentricular status, congenital comorbidity, and child age in a logistic regression model for the outcome of Ages and Stages score Red, only younger age was significant (p < 0.001). 87 children had surgery in infancy and were reassessed as toddlers. Of these, 43 (49.2%) improved, 30 (34.5%) stayed the same, and 13 (16.1%) worsened. Improved scores were predominantly in those who had a first assessment at 6 months old.
Discussion:
The Ages and Stages Questionnaires results are most challenging to interpret in young babies of 6 months old who are affected by complex CHD.
The relation between perception and production in social meaning is often taken to be transparent, with social meaning associations learned from observations of language use. However, recent work has suggested that this relation is often more complex than previously thought. Here, we present new data comparing the social meaning of realized variable liaison in spoken French, couched within the framework of the pragmatic sociology of critique. We recall data from a recent matched guise experiment showing that listeners associate the realization of liaison with meanings like “professionalism”, specifically in social situations where efficacy and expertise are at issue. Basing ourselves on this finding, we use a production task, presenting these same social situations to amateur and professional actors. We find that our participants do not exploit the social meaning potential of variable liaison, producing liaison at lexically-determined rates on a par with previous corpus studies. We discuss this discrepancy between perception and production, which suggests that the link between the two is dependent on the linguistic variable under investigation.