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We present the first results from the COS-EDGES survey, targeting the kinematic connection between the interstellar medium and multi-phase circumgalactic medium (CGM) in nine isolated, near-edge-on galaxies at $z\sim0.2$, each probed along its major axis by a background quasar at impact parameters of $D=13-38$ kpc. Using VLT/UVES and HST/COS quasar spectra, we analyse Mgi, Mgii, Hi, Cii, Ciii, and Ovi absorption relative to galaxy rotation curves from Keck/LRIS and Magellan/MagE spectra. We find that low ionisation absorption for 8/9 galaxies lies below the halo escape velocity, indicating bound inflow or recycling gas, while 6/9 galaxies have high ionisation gas reaching above the halo escape velocity, suggesting some unbound material. We find that at lower $D/R_{\textrm{vir}}$ ($0.12\leq D/R_{\textrm{vir}} \leq0.20$), over 80% of absorption in all ions lies on the side of systemic velocity matching disk rotation, and the optical-depth–weighted median velocity ($v_{abs}$) is consistent with the peak rotation speed. At higher $D/R_{\textrm{vir}}$ ($0.21\leq D/R_{\textrm{vir}} \leq0.31$), the kinematics diverge by ionisation state: For the low ionisation gas, the amount of co-rotating absorption remains above 80%, yet $v_{abs}$ drops to roughly 60% of the galaxy rotation speed. For the high ionisation gas (Ovi), only 60% of the absorption is consistent with co-rotation and $v_{abs}$ drops to 20% of the galaxy rotation speed. Furthermore, the velocity widths, corresponding to 50% of the total optical depth ($\Delta v_{50}$) for low ionisation gas is up to 1.8 times larger in the inner halo than at larger radii, while for Ciii and Ovi$\Delta v_{50}$ remains unchanged with distance. The 90% optical-depth width ($\Delta v_{90}$) shows a modest decline with radius for low ionisation gas but remains constant Ciii and Ovi. At high $D/{R}_{\textrm{vir}}$, both $\Delta v_{50}$ and $\Delta v_{90}$ increase with ionisation potential. These results suggest a radially dependent CGM kinematic structure: the inner halo hosts cool, dynamically broad gas tightly coupled to disk rotation, whereas beyond $\gtrsim 0.2 R_{\textrm{vir}}$, particularly traced by Ovi and Hi, the CGM shows weaker rotational alignment and lower relative velocity dispersion. Therefore, low-ionisation gas likely traces extended co-rotating gas, inflows and/or recycled accretion, while high-ionisation gas reflects a mixture of co-rotating, lagging, discrete collisionally ionised structures and volume-filling warm halo, indicating a complex kinematic stratification of the multi-phase CGM.
Individuals with a family history of bipolar disorder are at increased risk of developing affective psychopathology. Longitudinal imaging studies in young people with familial risk have been limited, and cortical developmental trajectories in the progression towards illness remain obscure.
Aims
To establish high-resolution longitudinal differences in cortical structure that are associated with risk of bipolar disorder.
Method
Using structural magnetic resonance imaging data from 217 unrelated ‘Bipolar Kids and Sibs study’ participants (baseline n = 217, follow-up n = 152), we examined changes over a 2-year period in cortical area, thickness and volume, measured at each vertex across the cortical surface. Groups comprised 105 ‘high-risk’ participants with a first-degree relative with bipolar disorder (female n = 64; age in years: M (mean) = 20.9, s.d. = 5.5) and 112 controls with no familial psychiatric history (females n = 60; age in years: M = 22.4, s.d. = 3.7).
Results
Accelerated thickness and volume reductions over time were observed in ‘high-risk’ individuals across multiple cortical regions, relative to controls, including right lateral orbitofrontal thickness (β = 0.033, P < 0.001) and inferior frontal volume (β = 0.021, P < 0.001). These differences were observed after controlling for age, sex, ancestry, current medication status, lifetime psychiatric diagnoses and measures of gross brain morphology.
Conclusions
Longitudinal group differences suggest the presence of thicker cortex in familial ‘high-risk’ individuals at earlier developmental stages, followed by accelerated thinning towards the typical age of bipolar disorder onset. Future examination of genetic and environmental components of familial risk and the mechanistic nature (pathological or protective) of cortical-trajectory differences over time may facilitate the identification of prodromal biomarkers and opportunities for early clinical intervention.
Loneliness is a common public health concern, particularly among mid- to later-life adults. However, its impact on early mortality (deaths occurring before reaching the oldest old age of 85 years) remains underexplored. This study examined the predictive role of loneliness on early mortality across different age groups using data from the Health and Retirement Study (HRS).
Methods
A retrospective cohort study was conducted using data from the 2010–2020 waves of the HRS, restricted to participants aged 50–84 years at baseline. Loneliness was measured using the 11-item UCLA Loneliness Scale, categorized into four levels: low/no loneliness (scores 11–13), mild loneliness (14–16), moderate loneliness (17–20) and severe loneliness (21–33). Cox proportional hazards models and time-varying Cox regression models with age as the time scale were created to evaluate the relationship between loneliness and early mortality, adjusting for sociodemographic, lifestyle, and physical and mental health factors.
Results
Among 6,392 participants, the overall mortality rate before the age of 85 years was 19.1 per 1,000 person-years. A dose–response relationship was observed, with moderate and severe loneliness associated with 23% (adjusted hazard ratio [aHR]: 1.23, 95% confidence interval [CI] = 1.02–1.48) and 36% (aHR: 1.36, 95% CI = 1.13–1.65) higher mortality risk, respectively. Significant associations existed for the 65–74-year-old (aHR = 1.37, 95% CI = 1.03–1.83) and 75–84-year-old (aHR = 1.77, 95% CI = 1.23–2.56) age groups in the fully-adjusted models, but not for the 50–64-year-old age group. Time-varying Cox models showed a stronger association for severe loneliness (aHR = 1.65, 95% CI = 1.37–1.99).
Conclusions
Loneliness is a significant predictor of mortality among older adults. Preventive and interventional programs targeting loneliness may promote healthy ageing.
A growing literature explores the representational detail of infants’ early lexical representations, but no study has investigated how exposure to real-life acoustic-phonetic variation impacts these representations. Indeed, previous experimental work with young infants has largely ignored the impact of accent exposure on lexical development. We ask how routine exposure to accent variation affects 6-month-olds’ ability to detect mispronunciations. Forty-eight monolingual English-learning 6-month-olds participated. Mono-accented infants, exposed to minimal accent variation, detected vowel mispronunciations in their own name. Multi-accented infants, exposed to high levels of accent variation, did not. Accent exposure impacts speech processing at the earliest stages of lexical acquisition.
While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored. This study examines associations between UPF consumption and dietary greenhouse gas emissions (GHGe), land use and food biodiversity.
Design:
Prospective cohort study. Linear mixed models estimated associations between UPF intake (g/d and kcal/d) and GHGe (kg CO2-equivalents/day), land use (m2/d) and dietary species richness (DSR). Substitution analyses assessed the impact of replacing UPF with unprocessed or minimally processed foods.
Participants:
368 733 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Setting:
Europe.
Results:
Stronger associations were found for UPF consumption in relation with GHGe and land use compared with unprocessed or minimally processed food consumption. Substituting UPF with unprocessed or minimally processed foods was associated with lower GHGe (8·9 %; 95 % CI: –9·0, –8·9) and land use (9·3 %; –9·5; –9·2) when considering consumption by gram per day and higher GHGe (2·6 %; 95 % CI: 2·5, 2·6) and land use (1·2 %; 1·0; 1·3) when considering consumption in kilocalories per day. Substituting UPF by unprocessed or minimally processed foods led to negligible differences in DSR, both for consumption in grams (–0·1 %; –0·2; –0·1) and kilocalories (1·0 %; 1·0; 1·1).
Conclusion:
UPF consumption was strongly associated with GHGe and land use as compared with unprocessed or minimally processed food consumption, while associations with food biodiversity were marginal. Substituting UPF with unprocessed or minimally processed foods resulted in differing directions of associations with environmental impacts, depending on whether substitutions were weight or energy based.
Situated at the junction of Cognitive Semantics and Experimental Phenomenology, this study investigates how participants perceive the structure of 18 perceptual dimensions of opposites across the visual, auditory, tactile, gustatory and olfactory sensory modalities. The structures include three components: two poles (high; low) and an intermediate (neither high nor low). Participants were asked to provide examples of contexts for each dimension for which they could experience the five sensory modalities and then describe their experiences of the structures with respect to whether the poles were experienced as a single property (Point), or a range of properties with or without a precise limit (Bounded Range or Unbounded Range respectively). For the intermediate region, they described if they experienced a single property (Point) or many (Range) or none (No Intermediates). The study centres on two main questions. Is the perceptual structure invariant across the sensory modalities? If not, how do the structures differ? The study shows that the overall structure of all dimensions was stable in at least two of the modalities, and many structures were stable across more than two modalities. Stability was particularly pertinent across the visual and tactile modalities, and the gustatory and olfactory modalities.
Despite its geographic correspondence with a key fourteenth-century BC port, the tell of Yavneh-Yam has yielded only meagre evidence for Late Bronze Age occupation. The recent discovery of a sealed monumental rock-cut burial cave with hundreds of grave goods provides the first clear evidence for a significant polity.
The seed science community currently defines germination as radicle emergence of 2 mm from the dispersal unit. Consequently, most seed researchers abruptly terminate germination experiments after radicle emergence, concluding that the seed has germinated. However, this approach underestimates epicotyl dormancy and often leads to dormancy misclassification, or worse, a failure to identify epicotyl dormancy altogether. To address these limitations, we propose extending germination studies to the point of first leaf emergence; we term this the “full germination” period. Our methodology involves germinating fully matured, freshly collected seeds and depending on the time required for radicle emergence, the seeds are categorized into (1) viviparous, where seeds germinate prematurely while they are still attached to the parent plant or within the fruit; (2) Morphological dormancy (MD) or Non-dormant (ND), where seeds germinate within 30 days; and (3) physiological dormancy (PD) and morphophysiological dormancy (MPD), where germination does not occur within 30 days. The absence of shoot emergence within 30 days following radicle protrusion indicates the presence of epicotyl dormancy. Thus, species initially classified as ND, MD, or viviparous may be miscategorized if shoot emergence is not assessed. Likewise, seeds exhibiting PD or MPD may possess an additional epicotyl dormancy component, possibly leading to placing them in incorrect subclass or level. A comprehensive assessment of shoot development is imperative for accurate dormancy characterization. We strongly recommend monitoring seed germination until first true leaf emergence should be adopted to ensure correct conclusions about dormancy, plant life cycles and ecological adaptations.
Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot], a pernicious weed in wheat (Triticum aestivum L.) fields, has evolved severe resistance to the acetolactate synthase (ALS)-inhibiting herbicides, like pyroxsulam. Here, the derived cleaved amplified polymorphic sequence (dCAPS) markers were developed to detect two distinct mutations at the 197th position of the ALS gene. The method was used to examine and purify the resistant population. Homozygous populations with different 197 site mutations from the same population were obtained, and the target site–resistance mechanisms were investigated. Whole-plant dose–response bioassays show that the resistance index (RI) of the Pro-197-Thr mutant population to pyroxsulam was 508.92, whereas that of the Pro-197-Gln population was 9.75. Similar trends were observed for different herbicides within same mode of action. In vitro ALS assays demonstrated that the Pro-197-Thr population exhibited lower sensitivity to pyroxsulam than the Pro-197-Gln population, consistent with plant bioassays. Furthermore, ALS gene expression of the Pro-197-Thr population analysis is significantly higher than that in the Pro-197-Gln population, which may also explain why the Pro-197-Thr population exhibits a higher resistance level than the Pro-197-Gln population. Our findings suggest that different amino acid substitutions at one ALS gene locus can confer herbicide resistance with different levels in L. perenne ssp. multiflorum. This study provides valuable insights into the mechanisms of herbicide resistance in L. perenne ssp. multiflorum.
This study aimed to evaluate the role of oral antibiotic stepdown therapy in patients with uncomplicated streptococcal bacteremia. Streptococcus species are known pathogens in bloodstream infections (BSIs). Traditionally, BSIs were managed with intravenous (IV) antibiotics; however, growing literature supports oral antibiotics in invasive infections including BSIs.
Design:
This was a retrospective cohort study evaluating patients with streptococcal bacteremia between September 2019 and September 2021 at an academic safety-net hospital. Clinical outcomes were compared between patients completing treatment with IV antibiotics versus an oral stepdown regimen. The primary outcome, clinical failure, was a composite of BSI recurrence and infection-related readmission.
Patients:
Adult patients with at least one positive blood culture for any Streptococcus species were included. Patients with polymicrobial BSIs or complicated bacteremia were excluded.
Results:
155 patients were included, 77 (49.7%) received a course of IV antibiotics and 78 (50.3%) received an oral antibiotic stepdown regimen. Clinical failure was not different between the IV and oral groups (15.6% vs. 15.4%, respectively; OR .99 [95% CI, .41 to 2.35]). No differences were observed in 30-day all-cause mortality. Patients that received oral antibiotics had a significantly shorter hospital length of stay by 6 days (6 vs 12 d, p < .01).
Conclusions:
Our results suggest that an oral stepdown regimen for uncomplicated streptococcal BSIs is associated with similar outcomes compared to IV antibiotics. Furthermore, oral antibiotics may offer reduced length of stay and avoidance of outpatient central line placement in patients with uncomplicated streptococcal BSIs.
Party system classifications have been central in political science, especially until Sartori's influential typology in 1976. However, recent years have seen diminished attention to such classifications. Western European party systems have significantly transformed, particularly over the last 15 years due to multiple crises, affecting their core structure, or what Sartori termed ‘patterns of interparty competition.’ This raises questions about whether these changes have undermined the very concept of systemness, making classifications irrelevant. This research note redefines party systems based on the number and composition of relevant political poles (governing alternatives) and, through a long-term analysis of Western Europe (20 countries since 1945), assesses their degree of systemness. Results indicate that many systems have become ‘non-systems,’ with fluctuating and unstable party poles. Most Western European systems have exhibited this ‘non-system’ type for at least half of legislatures since 1989, thus making classifications only short-lived snapshots and inevitably useless for long-term accounts.
Increasing interdisciplinary analysis of geoarchaeological records, including sediment and ice cores, permits finer-scale contextual interpretation of the history of anthropogenic environmental impacts. In an interdisciplinary approach to economic history, the authors examine metal pollutants in a sediment core from the Roman metal-producing centre of Aldborough, North Yorkshire, combining this record with textual and archaeological evidence from the region. Finding that fluctuations in pollution correspond with sociopolitical events, pandemics and recorded trends in British metal production c. AD 1100–1700, the authors extend the analysis to earlier periods that lack written records, providing a new post-Roman economic narrative for northern England.
Recruiting and retaining racial/ethnic minorities in research remains a significant challenge, often due to mistrust in clinical research and cultural misconceptions related to specific conditions. Despite the anonymity provided by technology-based intervention studies, difficulties in participant recruitment and retention in these studies remain. This paper addresses practical issues in recruiting and retaining Asian American breast cancer survivors with pain and depressive symptoms in a technology-based intervention study.
Methods:
To identify practical issues in participant recruitment and retention, a content analysis was conducted on all recorded materials, including research diaries of individual research team members, weekly team meeting minutes, and research team members’ posts on Microsoft Teams.
Results:
Analysis identified six practical issues: (a) strict inclusion/exclusion criteria; (b) multiple stigmas associated with cancer, depressive symptoms, and pain; (c) lack of interest in research participation; (d) closed Asian American communities/groups; (e) frequent technological issues; and (f) potential unauthentic cases.
Conclusion:
Addressing these recruitment and retention issues can inform the design of future culturally tailored, technology-based intervention studies for racial and ethnic minority populations.
The food system is a major contributor to the global burden of disease, ecosystem destruction and climate change, posing considerable threats to human and planetary health and economic stability. Evidence-based food policy is fundamental to food system transformation at global, national and local or institutional levels. This study aimed to critically review the content of universities’ food sustainability policy documents.
Design:
A systematic search of higher education institutions’ policies, using targeted websites and internet searches to identify food sustainability policy documents, was conducted between May and August 2023. A quantitative content analysis of the identified documents was conducted independently by multiple researchers using a coding template. Inconsistencies in coding were subsequently checked and amended through researcher consensus.
Setting:
163 UK higher education institutions.
Participants:
N/A.
Results:
Approximately 50 % of universities had a publicly available food sustainability policy. The most common food sustainability commitments therein were communication and engagement (95·2 %), food waste (94·0 %) and quality standards and certification (91·7 %). The scope of policy commitments varied between institutions; however, comprehensive documents included multifaceted commitments tackling more than one dimension of sustainability, for example, waste mitigation strategies that tackled food insecurity through food redistribution. Few (17·9 %) policies included a commitment towards research and innovation, suggesting university operations are considered in isolation from academic and educational activities.
Conclusions:
Multifaceted policy commitments are capable of uniting numerous food-related actions and institutional activities. As such, they are likely to support food system transformation, with broader positive outcomes for the university, students and the wider community.
Pupils in alternative education provision, known as ‘Educated in Other Than At School’ (EOTAS) in Wales, UK, are among the most vulnerable learners and who, for reasons such as mental health or behavioural challenges, do not attend a mainstream or special school.
Aims
We compared self-harm, neurodevelopmental disorders and mental health conditions between EOTAS pupils and controls with similar characteristics, before and after being in EOTAS provision.
Method
This population-based electronic cohort study included pupils in Wales aged 7–18 years, from the academic years 2010–11 to 2018–19. We linked data from Education Wales to primary and secondary healthcare records within the Secure Anonymised Information Linkage (SAIL) Databank. Individuals included in the EOTAS data-set were identified as cases. Controls were pseudo-randomly selected based on equivalent age and academic year distribution.
Results
This study included 8056 pupils in EOTAS and 224 247 controls. Higher levels of deprivation, childhood maltreatment, self-harm, neurodevelopmental disorders and mental health conditions before EOTAS entry were linked to higher odds of being in EOTAS. Pupils in EOTAS provision had increased incidence of self-harm, neurodevelopmental disorders and mental health conditions, from 1 year after entering EOTAS provision up to 24 years of age, than pupils with similar characteristics not in EOTAS provision.
Conclusion
While EOTAS provision plays an important role, our findings indicate that it is not sufficient on its own to meet pupils’ social, emotional, behavioural and mental health needs. Additional support and better integration with health and social services are required.
Abstract screening, a labor-intensive aspect of systematic review, is increasingly challenging due to the rising volume of scientific publications. Recent advances suggest that generative large language models like generative pre-trained transformer (GPT) could aid this process by classifying references into study types such as randomized-controlled trials (RCTs) or animal studies prior to abstract screening. However, it is unknown how these GPT models perform in classifying such scientific study types in the biomedical field. Additionally, their performance has not been directly compared with earlier transformer-based models like bidirectional encoder representations from transformers (BERT). To address this, we developed a human-annotated corpus of 2,645 PubMed titles and abstracts, annotated for 14 study types, including different types of RCTs and animal studies, systematic reviews, study protocols, case reports, as well as in vitro studies. Using this corpus, we compared the performance of GPT-3.5 and GPT-4 in automatically classifying these study types against established BERT models. Our results show that fine-tuned pretrained BERT models consistently outperformed GPT models, achieving F1-scores above 0.8, compared to approximately 0.6 for GPT models. Advanced prompting strategies did not substantially boost GPT performance. In conclusion, these findings highlight that, even though GPT models benefit from advanced capabilities and extensive training data, their performance in niche tasks like scientific multi-class study classification is inferior to smaller fine-tuned models. Nevertheless, the use of automated methods remains promising for reducing the volume of records, making the screening of large reference libraries more feasible. Our corpus is openly available and can be used to harness other natural language processing (NLP) approaches.
The ontological complexity of the twentieth-century Cold War motivates this special issue’s investigation of how social scientists conceptualize institutional novelty and change. We begin by noting the peculiar elision of the Cold War as an explanatory mechanism in mainstream sociology, even while sociologists have theoretical tools for making sense of the phenomenon: war, schema, field, world systems, and empire. All are useful; none are sufficient. We locate the explanatory problem in a tension between notions of structure and event that has organized debate in historical social science for several scholarly generations, and offer a new intellectual tool – medium durée – as a way forward. Medium durée describes phenomena that have sufficient cohesion as ideas and relationships to endure over time, yet remain sufficiently unfixed and ambiguous as to enable multifarious action and sensemaking. Our notion of medium durée is substantially informed by the articles and commentaries assembled for this special issue, which represent three years of dialogue among the authors as well as audiences in serial panels at the 2022 and 2023 annual meetings of the Social Science History Association.
Chinese stellara (Stellera chamaejasme L.) is an indicator plant of degraded grasslands. With its robust vitality, once it emerges in grassland ecosystems, it undergoes extensive growth and rapid expansion, inevitably leading to grassland degradation. The establishment and invasion of S. chamaejasme disrupts the ecological balance of grasslands in the Qilian Mountains. This study was conducted in a grassland on the eastern slope of the Qilian Mountains, employing point pattern analysis to investigate the spatial distribution patterns of S. chamaejasme and the relationships among different age classes. The population was categorized into three growth stages: young, subadult, and mature plants. The results revealed that the spatial distribution of this population is primarily dominated by subadult plants, accounting for up to 75.48% of the total, with an overall transition trend from aggregated to random distribution. No significant spatial correlations were observed among different age groups (young, subadult, and mature plants), indicating that mature plants do not exert significant inhibitory effects on the growth of young individuals. In high-density areas, the population exhibited a distribution radiating outward from mature plants as the center, with high-density cores predominantly concentrated within 0 to 5 m. Significant density variations were observed between regions, with the highest total density estimated at approximately 9.57 plants m−2 and the lowest at 2.68 plants m−2. The invasion mechanism of S. chamaejasme is closely associated with the spatial independence of its age groups and a distribution pattern dominated by subadult plants. During the initial invasion phase, S. chamaejasme spreads predominantly around mature plants. After securing sufficient growing space (0 to 1 m), it further competes for territory through shifts in distribution patterns—transitioning from aggregated to random distribution. Additionally, significant differences in distribution density and expansion patterns across regions provide critical theoretical foundations for targeted ecological management strategies.
Folds within layered rock systems are critical for comprehending the historical processes of deformation and the rheological behaviour of rocks. The current study employs finite element modelling to investigate the development of folds in a layered rock system, with a particular focus on the impact of thinner layers on the folding of adjacent thicker layers and their subsequent interactions. The analysis indicates that harmonic folds can evolve into polyharmonic or disharmonic configurations because of the intricate interactions occurring within the contact strain zone of the thinner layer. Our numerical findings demonstrate that the geometry of folds is significantly affected by the reciprocal interactions between thinner and thicker layers, initiated by the folding of the thinner units and their consequent influence on the thicker layers, and vice versa. This dynamic interplay, however, may frequently diverge from predictions made by more simplistic models, as suggested by earlier studies. Furthermore, this research highlights the potential of utilizing higher-order fold geometries to estimate the relative viscosity between the layers and the embedded medium.