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Climate conditions are known to modulate infectious disease transmission, yet their impact on measles transmission remains underexplored. In this study, we investigate the extent to which climate conditions modulate measles transmission, utilizing measles incidence data during 2005–2008 from China. Three climate-forced models were employed: a sinusoidal function, an absolute humidity (AH)-forced model, and an AH and temperature (AH/T)-forced model. These models were integrated into an inference framework consisting of a susceptible–exposed–infectious–recovered (SEIR) model and an iterated filter (IF2) to estimate epidemiological characteristics and assess climate influences on measles transmission. During the study period, measles epidemics peaked in spring in northern China and were more diverse in the south. Our analyses showed that the AH/T model better captured measles epidemic dynamics in northern China, suggesting a combined impact of humidity and temperature on measles transmission. Furthermore, we preliminarily examined the impact of other factors and found that population susceptibility and incidence rate were both positively correlated with migrant worker influx, suggesting that higher susceptibility among migrant workers may sustain measles transmission. Taken together, our study supports a role of humidity and temperature in modulating measles transmission and identifies additional factors in shaping measles epidemic dynamics in China.
Let $(X,\Delta )$ be a normal pair with a projective morphism $X \to Z$ and let A be a relatively ample $\mathbb {R}$-divisor on X. We prove the termination of some minimal model program on $(X,\Delta +A)/Z$ and the abundance conjecture for its minimal model under assumptions that the non-nef locus of $K_{X}+\Delta +A$ over Z does not intersect the non-lc locus of $(X,\Delta )$ and that the restriction of $K_{X}+\Delta +A$ to the non-lc locus of $(X,\Delta )$ is semi-ample over Z.
In recent years, the question of naturalism in the study of religions has been increasingly debated. Primarily, these discussions converge in the widely held view that naturalism is the only way for religious studies as an academic enterprise to exclude supernaturalist assumptions from its methodology. While I fully agree with this view, I argue that naturalism is usually formulated with the help of metaphysical assumptions, which are problematically embodied in the location problem, that is, the problem of how to locate certain phenomena, such as meanings and values, in the order of nature. By unfolding the dynamic between the elements of the location problem, I show that the kind of naturalism based on Wittgenstein’s thought prevents the location problem from arising and can serve as a balanced version of naturalism for use in the study of religion. While metaphysical naturalism often leads to dilemmas, within Wittgenstein’s kind of naturalism, it seems possible both to maintain anti-supernaturalism in the study of religion and to resist the metaphysical temptations hidden in our assumptions about language. These two features make Wittgenstein’s naturalism truly methodological.
Reducing crude protein in amino acid-adequate diets for broiler chickens is effective in reducing nitrogenous emissions and competition for resources between the food and feed sectors. This review provides a comprehensive analysis of the literature on the relevance of nonessential amino acids in low protein diets for broiler chickens. Glycine and serine, owing to their interconvertibility summarised as glycine equivalents (Glyequi), limit growth when dietary crude protein is reduced below 19% in up to 3-week-old birds. Considering essential amino acids and the variable Glyequi requirements enables the reduction of dietary crude protein to ∼16% without compromising growth. Variation in Glyequi requirements likely occurs predominantly from the varying amounts of uric acid formed. Other influences seem to exert lower impacts on dietary Glyequi requirements. Asparagine or glutamine is probably the growth-limiting amino acid when crude protein is reduced below 16%. Alternatively, nonspecific amino-nitrogen may be lacking in such diets. The current potential to reduce dietary crude protein when using free essential and nonessential amino acids enables to increase the efficiency of nitrogen utilisation to a value above 80%. This coincides with reduced uric acid synthesis and energy expenditure for nitrogen excretion. The lower nitrogen excretion via the urine results in a lower energy expenditure. Hence, dietary energy may prospectively be reduced once the energy-sparing effect is quantified, thereby further reducing the competition for resources between food and feed.
Scholars increasingly conceptualize populism by whether politicians use people-centric and anti-elite appeals that pit a homogeneous people against a corrupt elite. These appeals reflect “thin” ideology because they offer no programmatic content and thus politicians must pair these appeals with more substantive positions, termed their “host” (or thick) ideology, which often consists of nativism on the right (e.g., espousing anti-immigrant positions) and socialism on the left (e.g., prioritizing redistribution). An emerging literature has thus sought to estimate whether populists garner support due to their thin ideology or their substantive host ideology. To date, no research has validated whether populism treatments (1) truly operationalize populist thin ideology, and (2) do so without manipulating host ideology. Results from three conjoint validation experiments fielded in both the United States and the United Kingdom show that thin ideology treatments successfully manipulate the underlying concepts but caution that some operationalizations also affect perceptions of host ideology.
Several proposals to modernize obligations and contracts law in the Spanish Civil Code have not succeeded. However, Spanish contract law has evolved through judicial interpretation, which has reformulated existing rules and recognized new ones. This article deals with major transformations in general contract law and special contracts. Additionally, the Civil Code has been affected by its interaction with EU law, as interpreted by the CJEU. Updating the Civil Code in this manner has created conceptual obscurity and has increased legal uncertainty. Formal modernization of the Civil Code would be welcome, provided it treats Spanish private law as an integral part of the pluralistic legal order of the EU.
This paper investigates the acoustic correlates of word-level stress and phrase-level focus-related prominence in Mankiyali, a highly endangered Indo-Aryan language spoken in Northwest Pakistan that utilizes a weight-sensitive stress system. Of the acoustic properties measured (duration, f0, intensity, spectral tilt, and vowel quality), duration was the only feature found to robustly and consistently correlate with word-level stress across syllable types. In contrast, phrase-level focus-related prominence corresponded to an amplification of all five acoustic features measured. Given that vowel duration serves a vital role in preserving lexical contrast in Mankiyali, these findings present difficulties for a strong version of the Functional Load Hypothesis, which claims that acoustic properties bearing a high functional load in a language will not be used to mark prominence. In addition, results support an analysis of Mankiyali’s stress system as having five distinct levels of weight, a pattern which is extremely rare, if not unattested, elsewhere in the world’s languages.
The history of early modern scholarship was long written as a subject set at some remove from the rest of early modern society. Learning was the common property of like-minded scholars in the ‘Republic of Letters’, linked by shared codes of elite sociability and united by a mutual concern to transcend religious boundaries. Recent years have seen such views challenged, with studies demonstrating how much scholarly activity was undertaken to achieve confessional objectives. Yet, these contributions have chiefly focused on orthodox clerical scholars. This article uses the case of John Locke to present a new perspective on the place and significance of erudition in the early modern period. It is based on a thoroughgoing examination of Locke’s lifetime of religious reading, bringing together evidence from his manuscript notebooks and journals, his library catalogues and annotated books, and his correspondence and published works. It coins the notion of ‘everyday erudition’ to reveal how learning was not an abstruse concern. Instead, for Locke and his contemporaries at multiple points on the socio-cultural scale, it was a kind of common currency, a tool to be used to come to terms with the historical reality of Christian revelation.
Larinus minutus Gyllenhal (Coleoptera: Curculionidae) has been credited with the successful biological control of Centaurea diffusa Lamarck (Asteraceae) in British Columbia, Canada. However, another seed head-feeding weevil agent, Bangasternus fausti Reitter (Coleoptera: Curculionidae), has recently been detected on C. diffusa in British Columbia, and it is unclear how it is interacting with L. minutus. If phenological differences between the two species allow B. fausti to exclude L. minutus from seedheads, and if B. fausti continues to have a low survival rate, populations of C. diffusa may begin to resurge. As a first step in studying the interactions of L. minutus and B. fausti, we compared their phenology and life histories across their known Canadian range and explored the relationship between their abundance and environmental predictors. We quantified adult abundance in the field and collected seed heads from which we reared each species. We found that B. fausti is active earlier than L. minutus, but it is generally found in lower abundance. The abundance of B. fausti had a positive relationship with mean annual precipitation, whereas L. minutus did not have any significant relationship with environmental predictors. Taken together, our study clarifies the life history of B. fausti in Canada in relation to L. minutus. If B. fausti precludes colonisation of seedheads by L. minutus but remains a less effective agent, continued range expansion of B. fausti may reduce the efficacy of C. diffusa biological control.
Weeds pose a significant threat to Oregon field crops by reducing yields and compromising the quality of the harvested products. In fall 2024, Oregon stakeholders were surveyed to identify the key challenges and needs related to weed management in field crops. The survey consisted of eight questions, developed based on expert input and review of relevant literature, divided into three sections: respondent demographics, resource and support needs, and current weed management challenges and economic impacts. A total of 184 responses were collected statewide, with growers and crop consultants as the primary participants. Most respondents were from western Oregon, which may introduce a geographic bias to the findings. Respondents expressed particular interest in new herbicide technologies and herbicide resistance. Field days were the most preferred method for receiving weed management information. Annual bluegrass, Italian ryegrass, and roughstalk bluegrass were reported as the most problematic grass weeds, while wild carrot was the most problematic broadleaf weed. Most respondents reported an average weed control cost of US$125 to US$250 per hectare, and the majority indicated they were very concerned about herbicide resistance in their fields. The results from this survey will help guide future research and outreach efforts to improve weed management strategies in Oregon’s field crops.
Christianity is a religion of the book, and in particular of one book, the Bible. More precisely, it is a religion of a library of plural books (biblia) that eventually became one single book. It is possible to view the history of all Christian traditions, and not Protestantism alone, as a history of the canonical formation, liturgical and devotional use, cultural influence, contested theological interpretation and geographical diffusion of the Bible. In view of the magnitude of the subject, it is not surprising that very few historians have set out to encapsulate this grand narrative in a single volume. Bruce Gordon, the distinguished historian of early modern European Protestantism, has now made the attempt, and it is a valiant effort of stupendous chronological and geographical range, extending across the entire span of Christian history and covering all continents, though Australasia receives only a paragraph, oddly devoted to the New Hebrides. Not quite so rare are historians who have set out to chart the impact of one translation of the Bible on a single nation or family of nations – notably the role of the King James Bible of 1611 (the Authorised Version) in shaping the language and religious culture of English-speaking peoples, including those in the New World of North America.1
With more than 1 million children in the United States living with a heart defect or condition, it is important to identify interventions that may minimise the long-term impacts of repeated medical surveillance and care. Thus, the purpose of this quasi-experimental study was to examine relationships between facility dog intervention and young children’s anxiety during outpatient echocardiogram.
Methods:
Participants were seventy children aged 18 months to 8 years undergoing echocardiogram in a paediatric cardiology clinic. Child anxiety was scored by a trained nurse observer pre- and post-procedure using the modified Yale Preoperative Anxiety Scale. Facility dog intervention included individualised play, positioning, therapeutic conversation and touch, and emotional support throughout to promote coping and compliance. Parents and staff completed a post-procedural perceptions survey about their experiences.
Results:
Paired samples t-tests demonstrated child anxiety levels were significantly lower post-procedure compared to pre-procedure (Z = −3.974, p < .001). This direction held for nearly all participants; however, those with prior echocardiogram history demonstrated significantly higher anxiety levels at the pre-procedural timepoint (z = −2.442, p = .015). Caregivers (97.2%) and staff (87.9%) agreed or strongly agreed that facility dog intervention was helpful in this context.
Conclusions:
Facility dog intervention was associated with a significant reduction in young children’s anxiety across procedural timepoints in outpatient echocardiography. The intervention was perceived as helpful by families and staff; no workflow changes or barriers were noted. Thus, facility dog intervention may be a well-received and promising care innovation for this vulnerable chronic population.
This cross-sectional study evaluated the nutritional composition and labelling of commercial foods in Canada targeted to infants up to 18 months of age. Front-of-package labelling requirements were assessed based on daily values identified by Health Canada for saturated fatty acids, sugars, and sodium for children aged one year and older. Infant commercial food products were identified from online and in-person records of retailers across Canada. A total of 1,010 products were identified. Products aimed at older infants (12–18 months) contained significantly more calories, macronutrients, sugars, saturated fat, and trans fat compared to those targeted at younger infants (<12 months). In addition, 40% of products for children aged 12–18 months required a ‘high in sugar’ front-of-package label, while less required a ‘high in saturated fats’ (13%) and ‘high in sodium’ (5%) label. Organic products had higher added sugar and fibre, while they were lower in calories, total fat, saturated fat, and protein. Plant-based products, including vegetarian/vegan products, contained fewer calories, fat, saturated fat, trans fat, and protein, but more fibre. Gluten-containing products had more calories, macronutrients, sugar, fibre, and saturated fat. Non-GMO labelled products had more calories, carbohydrates, and sugar, but less saturated fat. Significant differences were observed for vitamins and minerals across food categories (p < 0.05). Our findings offer valuable guidance for parents, caregivers, and healthcare professionals on infant nutrition, highlighting the importance of selecting foods that align with infants’ specific dietary needs.
Neonates with ductal-dependent CHD rely on the patency of the ductus arteriosus to maintain circulation. Alprostadil is utilised to maintain ductal patency, although optimal dosing has not been determined. This study aims to describe alprostadil dosing in neonates with ductal-dependent CHD.
Methods:
This is a single-centre retrospective study including neonatal patients with ductal-dependent CHD who received alprostadil from January 2015 to December 2015 (cohort 1) and January 2021 to December 2021 (cohort 2). The primary objective was to describe alprostadil dosing in the two study periods. Secondary objectives included clinical outcomes and adverse events associated with different alprostadil dosing strategies.
Results:
Sixty-five patients met eligibility for inclusion in this study: thirty-eight patients in cohort 1 and twenty-seven patient s in cohort 2. Baseline demographics were similar between cohorts. Initial alprostadil dosing in cohort 1 and cohort 2 was 0.006 mcg/kg/min and 0.025 mcg/kg/min (p = < 0.001), respectively. Patients in cohort 2 were found to have a higher incidence of apneic events, apneic events requiring respiratory support, and the incidence of fever ≥38 °C.
Conclusions:
In this single-centre study, we report that higher doses of alprostadil were associated with an increased risk of adverse events, which should be validated by prospective multicentre studies.
The Pain Recognition and Evaluation to Validate Effective Neck and back Treatment (PREVENT) study aims to identify cognitive, behavioral, and treatmentrelated predictors of chronic musculoskeletal pain (CMP) development following emergency department (ED) care for acute neck or back pain after trauma.
Background:
CMP is a leading cause of global disability, yet early risk factors for its development remain poorly characterized, particularly in ED settings. This prospective observational study will recruit 246 adult patients presenting with acute (≤ 4 weeks) neck or back pain after a recent trauma. Pain beliefs – measured using pain and attitude questionnaires – serve as the primary independent variable. Mediating variables include catastrophic thinking, fear-avoidance behaviors, low physical activity, poor recovery expectations, and low self-efficacy for pain management. Covariates include demographics, social determinants of health, mental health disorders, and high-risk substance use. The primary outcome is the presence of CMP at six months, defined as pain on most or every day for at least three months. Participants will complete follow-ups at 1, 3, and 6 months. Multivariable logistic regression, mediation analyses, and interaction testing will explore effects of pain beliefs on CMP development. As a secondary aim, a subset of participants will complete Think Aloud cognitive interviews to assess response process validity for the Neck Pain Attitudes Questionnaire (Neck-PAQ), a region-specific adaptation of the Back Pain Attitude Questionnaire, analyzed using a deductive content analysis framework.
Discussion:
This study is among the first to investigate the cognitive and behavioral predictors of pain chronification in the ED. Ethical approval has been obtained from The George Washington University Institutional Review Board. Findings will inform the design of targeted, ED-based screening and intervention strategies, including adaptation of a pain-specific Screening, Brief Intervention, and Referral to Treatment (SBIRT) model. Results will be disseminated through peer-reviewed publications, conferences, and stakeholder engagement.
A reassessment of radiocarbon counting statistics in accelerator mass spectrometry (AMS) at the Andre E. Lalonde National Facility revealed that the traditionally assumed Poisson distribution may not always apply. An extensive analysis of 2.5 years of 14C and 12C data was conducted on a MICADAS™ AMS. This study found that only 63% of results adhered to Poisson statistics, while 34.2% showed slight deviations, and 2.8% exhibited strong non-Poisson behavior. This finding challenges the classic assumption that radiocarbon AMS is inherently a Poisson process. This study recommends considering non-Poisson models, specifically quasi-Poisson and negative binomial models, to better account for internal error and improve the accuracy of the reported error. Integrating 12C current noise into error calculations is also suggested as it plays a significant role in measurement variability. We would like to ignite curiosity on other AMS laboratories to test the non-Poisson error framework with the broader aim of assessing its applicability in improving conventional statistical models, error expansion methods, and in ensuring more accurate and reliable 14C results.
This study examines the resolved Kennicutt-Schmidt (rK-S) relation, defined as the connection between the star formation rate surface density ($\Sigma_{SFR}$) and the molecular gas mass surface density ($\Sigma_{H_2}$) in the high-density central regions of three nearby barred spiral galaxies hosting AGN: NGC 1365, NGC 1433, and NGC 1566. Utilising high-resolution archival data from AstroSat/UVIT for UV imaging and Atacama Large Millimetere/submillimetre Array (ALMA) for CO(2-1) molecular gas mapping, we explore recent star formation and gas distribution with a spatial resolution of $\sim$120–132 pc. Our findings reveal a sublinear rK-S law, with slopes ranging from $\sim$0.17 to $\sim$0.71. Notably, NGC 1566 exhibits a robust rK-S relation consistent with previous studies, while NGC 1365 and NGC 1433 exhibit weaker correlations. These differences are likely due to the smaller number of identified star-forming regions in these galaxies compared to NGC 1566, as well as the central molecular gas concentrations and varying star formation activity in their bars and nuclear regions. These results also support the idea that the rK-S relation deviates from linearity in extreme environments, such as starburst galaxies and galactic centres. Additionally, we find a generally low median star formation efficiency (SFE) within the bars of these galaxies, suggesting that while bars may drive nuclear starbursts and contribute to bulge growth, they do not significantly increase SFE. Furthermore, a negative correlation between SFE and $\Sigma_{H_2}$ is observed across the sample, both within and outside the bar regions, suggesting that higher $\Sigma_{H_2}$ may lead to lower SFE in the central regions of these galaxies. Our findings highlight that $\Sigma_{H_2}$ plays a primary role in shaping the observed trends in SFE, rather than the presence of a bar itself.