Spatial neglect is a heterogeneous post-stroke disorder with subtypes differing in reference frames, processing stages, and spatial domains. While egocentric peri-personal neglect recovery has been studied, recovery trajectories of allocentric peri-personal visuospatial and personal neglect remain unclear. This study investigated recovery time courses of egocentric and allocentric peri-personal visuospatial and personal neglect during the first 12 weeks post-stroke; whether initial severity predicts recovery and defines distinct patient clusters; and how subtypes interrelate over time.

Forty-one first-ever stroke patients were evaluated at weeks 3, 5, 8, and 12 post-stroke using the Broken Hearts Test, Line Bisection Test, Visuospatial Search Time Test, and Fluff Test. Recovery was analyzed using linear mixed models, clustering with Gaussian finite mixture models, and interrelationships using Spearman correlations.

Significant improvements occurred in egocentric and allocentric peri-personal visuospatial and personal neglect, primarily between weeks 3 and 5, followed by a plateau. The Line Bisection Test detected no changes. Higher initial severity predicted greater residual impairment. Cluster analysis identified near-normal, mild, and moderate-to-severe baseline subgroups with distinct recovery trajectories. Moderate-to-good correlations (ρ = 0.33 – 0.55) emerged between egocentric and allocentric neglect at week 3 and when timepoints were pooled.

Neglect improved mainly between weeks 3 and 5 after which recovery plateaued, mirroring motor and language recovery and suggesting a shared time-limited window. Initial severity was a determinant of recovery, highlighting the value of early severity stratification to monitor and support recovery potential after stroke. As subtypes are distinctive, assessment should include multiple neglect tests.

Clinical progression during psychosis has been closely associated with grey matter abnormalities resulting from atypical brain development. However, the complex interplay between psychopathology and heterogeneous maturational trajectories challenges the identification of neuroanatomical features that anticipate symptomatic decline.

To investigate cortical volume longitudinal deviations in first-episode psychosis (FEP) using normative modelling, exploring their relationship with long-term cognitive and symptomatic outcomes, as well as their cytoarchitectural and neurobiological underpinnings.

We collected magnetic resonance imaging (MRI), cognitive and symptomatic data from 195 healthy controls and 357 drug-naïve or minimally medicated FEP individuals that were followed up 1, 3, 5 and 10 years following the first episode (1209 MRI scans and assessments in total). Using normative modelling, we derived subject-specific centile scores for cortical volume to investigate atypical deviations in FEP and their relationship to long-term cognitive and symptomatic deterioration. The resulting centile association maps were further characterised by examining their cytoarchitectural and neurobiological attributes using normative atlases.

FEP centiles demonstrated a widespread reduction at treatment initiation, with longitudinal analysis showing an increase during treatment time, indicating convergence towards normal maturation trajectories. Interestingly, this effect was reduced in highly medicated individuals. Additionally, we found that cognitive impairments experienced during early FEP stages worsened under long-term medication. Positive symptomatology was negatively associated with regional centiles, and individuals with higher centiles benefited most from treatment. Cytoarchitectural and neurobiological analyses revealed that regional centiles related to FEP, as well as to symptomatology, were associated with specific molecular features, such as regional serotonin and dopamine receptor densities.

Collectively, these findings underscore the potential use of centile-based normative modelling for a better understanding of how atypical cortical development contributes to the long-term clinical progression of neurodevelopmental conditions.

Human actions are causing climate change, pollution, and the loss of biodiversity, making our planet less safe. To address these problems, solutions must be developed from current and future research, involving different scientific fields and respecting diverse knowledge systems. It is essential to engage with society, as the relationship between science and society drives progress. Studying coasts as complex systems requires input from the natural sciences, social sciences, and humanities.

In the coastal zone, the triple planetary crisis manifests as accelerating losses and changes and increasing challenges and risks for people and livelihoods. Acceptance of a future existential crisis compels the urgency of corrective action to cause an inverse positive societal response to bend the negative trajectories of loss and damage. The rate and extent of corrective societal action (policies, laws, practices, knowledge, etc.) should at least keep pace with the projected rate of loss and environmental degradation. This urgency and acceleration of action are major societal challenges, especially considering the overwhelming evidence of impacts. In this paper, we offer three propositions for accelerating urgent actions and fostering innovation in coastal research and management, focusing on emerging trends and foundational changes. Scientists need to (1) reflect on the performativity of their research and perceptions of neutrality in anticipating the future of coasts; (2) think and act equitably in local and global partnerships; and (3) improve their engagement and willingness to innovate with society. This is not a call for linear or incremental change, but a call for the radical. The relationship between society and science drives progress and shapes our collective future.

Human actions drive climate change, pollution, and biodiversity loss, threatening our planet. To address these crises, we need solutions that blend current and future research, span multiple scientific fields, and respect diverse knowledge systems. Engaging with society is key. The bond between human society and science shapes our future. Coastal studies must integrate natural sciences, social sciences, and humanities.