Oxymorons combine two opposite terms in a paradoxical manner. They are closely intertwined with antonymy, since the union of antonymous items creates the paradoxical effect of the oxymoron and generates a new meaning. Compared to other forms of figurative language, oxymorons are largely underinvestigated. We explored what makes good oxymorons through a crowdsourcing task in which we asked participants to judge the acceptability, comprehensibility, effectiveness/aptness, commonness, pleasantness, and humoristic connotation of Italian adjective–noun oxymorons. We hypothesized that oxymorons featuring morphologically related antonyms (felice infelicità ‘happy unhappiness’) may be perceived to be better than oxymorons featuring morphologically unrelated antonyms (felice tristezza ‘happy sadness’) and that oxymorons constructed by complementaries (esatta inesattezza ‘exact inexactness’) may be perceived to be better than oxymorons constructed by contraries (bella bruttezza ‘beautiful ugliness’). The results confirmed only partially our hypotheses: oxymorons with complementaries were perceived as more acceptable, comprehensible, effective/apt, common, whereas no strong trend was found for the other two dimensions. Surprisingly, our analyses revealed that oxymoronic constructions containing morphologically unrelated words were perceived as more acceptable, comprehensible, effective/apt, common, pleasant, contradicting our initial expectations.

In the Mediterranea area, major effects of climate change are a modification in rainfall patterns, an increase in temperature with an intensify in tropical nights, and an increase in incoming radiations, especially UV-Bs. Despite the various adaptation strategies, grapevines are sensitive to altered climatic conditions. This paper aims to assess the benefits of applying a new sustainable product to the soil that can implement farmers’ resources to adapt to this changing situation. Zeowine was realized by combining the properties of zeolite, which has excellent potential in many sectors such as in agriculture, with the organic substance of a compost obtained on a company scale from the reuse of waste processing grapes, pomace and stalks. The effects of two different soil management (Z – Zeowine, 30 t/ha dose and C – Compost, 20 t/ha dose) on vine physiology and berry compositions in Sanforte grapevines (new plantation) were studied during the 2019–2020–2021 growing seasons in the San Miniato area, Italy. The following physiological parameters of grapevines were measured: leaf gas exchange, leaf temperature, stem water potential and chlorophyll fluorescence. The results showed that Z increased single leaf photosynthesis, reduced leaf temperature and water stress. In addition, phenolic and technological parameters were studied. The Z-treated vines had higher sugar content and total and extractable anthocyanin content as well as berry weight. These results suggested that the application of zeolites added to compost in the vineyard to the soil can be a valid tool to mitigate the effects of climate change.

The physical mechanism governing the onset of transonic shock buffet on swept wings remains elusive, with no unequivocal description forthcoming despite over half a century of research. This paper elucidates the fundamental flow physics on a civil aircraft wing using an extensive experimental database from a transonic wind tunnel facility. The analysis covers a wide range of flow conditions at a Reynolds number of around $3.6\times 10^{6}$. Data at pre-buffet conditions and beyond onset are assessed for Mach numbers between 0.70 and 0.84. Critically, unsteady surface pressure data of high spatial and temporal resolution acquired by dynamic pressure-sensitive paint is analysed, in addition to conventional data from pressure transducers and a root strain gauge. We identify two distinct phenomena in shock buffet conditions. First, we highlight a low-frequency shock unsteadiness for Strouhal numbers between 0.05 and 0.15, based on mean aerodynamic chord and reference free stream velocity. This has a characteristic wavelength of approximately 0.8 semi-span lengths (equivalent to three mean aerodynamic chords). Such shock unsteadiness is already observed at low-incidence conditions, below the buffet onset defined by traditional indicators. This has the effect of propagating disturbances predominantly in the inboard direction, depending on localised separation, with a dimensionless convection speed of approximately 0.26 for a Strouhal number of 0.09. Second, we describe a broadband higher-frequency behaviour for Strouhal numbers between 0.2 and 0.5 with a wavelength of 0.2 to 0.3 semi-span lengths (0.6 to 1.2 mean aerodynamic chords). This outboard propagation is confined to the tip region, similar to previously reported buffet cells believed to constitute the shock buffet instability on conventional swept wings. Interestingly, a dimensionless outboard convection speed of approximately 0.26, coinciding with the low-frequency shock unsteadiness, is found to be nearly independent of frequency. We characterise these coexisting phenomena by use of signal processing tools and modal analysis of the dynamic pressure-sensitive paint data, specifically proper orthogonal and dynamic mode decomposition. The results are scrutinised within the context of a broader research effort, including numerical simulation, and viewed alongside other experiments. We anticipate our findings will help to clarify experimental and numerical observations in edge-of-the-envelope conditions and to ultimately inform buffet-control strategies.

Disk megamasers are a unique tool to study active galactic nuclei (AGN) sub-pc environment, and precisely measure some of their fundamental parameters. While the majority of disk megamasers are hosted in heavily obscured (i.e., Seyfert 2, Sy2) AGN, the converse is not true, and disk megamasers are very rarely found even in obscured AGN. The very low detection rate of such systems in Sy2 AGN could be due to the geometry of the maser beaming, which requires a strict edge-on condition. We explore some other fundamental factors which could play a role in a volume-limited survey of disk megamasers in Sy2 galaxies, most importantly the radio luminosity.

Work on thermal pools at Poggetti Vecchi in Grosseto, Italy, exposed an up to 3-meter-thick succession of seven sedimentary units. Unit 2 in the lower portion of the succession contained vertebrate bones, mostly of the straight-tusked elephant, Palaeoloxodon antiquus, commingled with stone, bone, and wooden tools. Thermal carbonates overlying Unit 2 are radiometrically dated to the latter part of the middle Pleistocene. This time span indicates that early Neanderthals produced the human artifacts from Poggetti Vecchi. The elephant bones belong to seven individuals of different ages. Sedimentary facies analysis and paleoecological evidence suggest a narrow lacustrine-palustrine embayment affected by water-level fluctuations and, at times, by hydrothermal water. Cyclic lake-level variations were predominantly forced by the rapid climatic fluctuations that occurred at Marine Isotope Stage (MIS) 6–7 transition and throughout the MIS 6. Possibly an abrupt, intense, and protracted cold episode during the onset of MIS 6 led to the sudden death of the elephants, which formed an unexpected food resource for the humans of the area. The Poggetti Vecchi site adds new information on the behavioral plasticity and food procurement strategies that early Neanderthals were able to develop in Italy during the middle to the late Pleistocene transition.

The Rupicaprini originated during the Miocene in Asia and dispersed during the late Miocene-early Pliocene, the Villafranchian, and the middle Pleistocene. Rupicapra and Oreamnos spread respectively to Europe and to North America in the middle Pleistocene. The Villafranchian Procamptoceras may be considered to be the closest known form to Rupicapra's ancestor. Rupicapra evolved during the middle and late Pleistocene in west Eurasia. At the beginning of the Würm glaciation the two closely related species R. pyrenaica and R. rupicapra were in existence. The former was already geographically split into Spanish-Pyrenean and central-southern Apennines groups, while the latter species ranged from the Caucasus to the Alpine Arch. R. pyrenaica shows more conservative features and possibly differentiated directly in western Europe from older representatives of the genus that migrated to western Europe in the middle Pleistocene. The cold-adapted Alpine chamois may have differentiated in eastern Europe and then migrated west-ward because of the advent of dry climates in the east Mediterranean and Pontic regions. The Alpine chamois failed to spread to the warmer southernmost regions of Europe that became a refugium area for R. pyrenaica. This dispersal hypothesis explains the morphologic, biometric, electrophoretic, and behavioral differences among modern chamois populations.

The conservation of the architectural surfaces in the tablinum of the House of the Bicentenary at the ancient Roman site of Herculaneum is a collaborative project of the Getty Conservation Institute, the Herculaneum Conservation Project and the Soprintendenza Pompeii. The tablinum was selected as a case study given the significance, beauty, and severe deterioration of its decorated surfaces. A multi-disciplinary team with a wide range of expertise, comprised of conservators, chemists, geo-physicists, engineers, and conservation scientists, worked in partnership across a number of institutions with the objective to study the wall paintings in the tablinum. Scientists and conservators worked together to test the feasibility of portable techniques and in situ investigations to better understand Roman painting technology; identify previous restoration materials; determine the presence of alteration products; and characterize deterioration mechanisms commonly found on architectural surfaces at archaeological sites of the Vesuvian Region. The collection and interpretation of the instrumental data has been critical to the design and implementation of appropriate passive and remedial interventions to stabilize the architectural surfaces and mitigate deterioration. The paper will present the results of the investigations using portable instrumentation along with a discussion of the capabilities and limitations of each technique and the practical implications of their use for architectural surfaces on archaeological sites.

Leishmaniasis is a neglected disease, which needs improvements in drug development, mainly due to the toxicity, parasite resistance and low compliance of patients to treatment. Therefore, the development of new chemotherapeutic compounds is an urgent need. This opinion article will briefly highlight the feasible use of calpain inhibitors as leading compounds to search for new therapeutic options to treat leishmaniasis. The milestone of this approach is to take advantage on the myriad of inhibitors developed against calpains, some of which are in advanced clinical trials. The deregulated activity of these enzymes is associated with several pathologies, such as strokes, diabetes and Parkinson's disease, to name a few. In Leishmania, calpain upregulation has been associated to drug resistance and virulence. Whereas the difficulties in developing new drugs for neglected diseases are more economical than biotechnological, repurposing approach with compounds already approved for clinical use by the regulatory agencies can be an interesting shortcut to a successful chemotherapeutic treatment for leishmaniasis.

We study a measurement-free, untyped λ-calculus with quantum data and classical control. This work arises from previous proposals by Selinger and Valiron, and Van Tonder. We focus on operational and expressiveness issues, rather than (denotational) semantics. We prove subject reduction and confluence, and a standardisation theorem. Moreover, we prove the computational equivalence of the proposed calculus with a suitable class of quantum circuit families.

p-Coumaric acid (3-(4-hydroxyphenyl)-2-propenoic acid; 4CA), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. The antiplatelet activity of this compound was analysed both ex vivo and in vitro. 4-CA, administered to rabbits for 2 weeks at the dose of 5 mg/kg, mixed with food, inhibited ADP-induced platelet aggregation without affecting blood coagulation. This effect was associated with a marked increase in plasma antioxidant activity, measured as ferric reducing ability of plasma, and with the reduction of thromboxane B2 production. The antiplatelet effect was confirmed by in vitro experiments on human blood: 4CA (500 μm and 1 mm) reduced ADP-induced platelet aggregation (55·2 (se 4·01) % and 35·6 (se 2·35) % relative to basal level, respectively). 4CA was able to modify platelet function, measured with PFA-100™, a shear-inducing device that simulates primary haemostasis. 4CA interfered also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (ic50 371 and 126 μm, respectively). The data show that 4CA is an antioxidant compound with good antiplatelet activity at doses that can be obtained with dietary intervention, suggesting possible applications for primary prevention of vascular disease.

An ensemble of new techniques has been developed to study cell metabolism. These include: CO2 production monitoring, cell irradiation with soft X rays produced with a laser-plasma source, and study of oscillations in cell metabolic activity via spectral analysis of experimental records. Soft X-rays at about 0.9 keV, with a very low penetration in biological material, were chosen to produce damages at the metabolic level, without great interference with DNA activity. The use of a laser-plasma source allowed a fast deposition of high doses. Monitoring of CO2 production allowed us to measure cell metabolic response immediately after irradiation in a continuous and noninvasive way. Also a simple model was developed to calculate X-ray doses delivered to the different cell compartments following a Lambert–Bouguet–Beer law. Results obtained on Saccharomyces cerevisiae yeast cells in experiments performed at Rutherford Appleton Laboratory are presented.

The use of spectrophotometers for the measurement of cell concentration in yeast suspension is critically discussed. Corrections are derived which take into account cell size, shape, cell aggregation (flocculation) and non linear effects related to sample thickness.

The technique for ultra rapid opioid detoxification is designed to shorten the detoxification period by precipitating withdrawal by the administration of opioid antagonists such as naloxone or naltrexone. This procedure is performed under deep sedation or general anaesthesia to ensure that the patient does not consciously experience the acute withdrawal phase. This strategy has aroused controversy regarding the risk of sedation or anaesthesia in this situation. In the present study, ultra rapid opioid detoxification was carried out in 12 opiate-addicted patients by infusion of naloxone 4 mg for a period of 5 h using controlled ventilation during general anaesthesia, induced and maintained with midazolam, propofol and atracurium. Invasive cardiovascular and respiratory monitoring was performed, and withdrawal signs were evaluated using a graduated scale. Anaesthesia was maintained for another hour after the completion of the naloxone infusion. The validity of this anaesthesia protocol was confirmed by the relative lack of change in the patients’ haemodynamic values associated with mild signs of withdrawal.