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Intellectual property rights - and the very concept of such rights - are coming under attack in our modern world, in which there is widespread sharing of content across a spectrum which extends from agreed open access to outright piracy. Institutions and legal systems that protect intellectual property, both domestically and internationally, stand in need of justification. In this book five different philosophical justifications for intellectual property are presented and defended. Additionally, all of the major criticisms of intellectual property are examined and ultimately rejected. The discussion includes the issues and controversies surrounding generative artificial intelligence and the challenges which it poses to current systems of intellectual property protection. As a result of this thorough and wide-ranging analysis, readers in philosophy, law, political science, information science, and media studies will be in a better position to determine the benefits and burdens of patents, copyrights, trademarks, and trade secrets.
Afrodescendant religious music in the Caribbean and Latin America typically foregrounds drumming and centuries-old songs of praise to spirit deities. In recent years, a new form of worship, known as a violín or toque de violín, which features the violin alongside the guitar, electronic piano, and/or other instruments commonly associated with popular music, has gained popularity in Cuba. Violines can be understood as loosely defined spaces for performance that developed in a context of cultural oppression and dominance. They can be viewed as a concession to Eurocentric and secular tastes, or as a blackening/creolizing of those same practices, or both. They express religious faith in pluralistic ways, incorporating repertoire from various Black religions alongside influences from folk Catholicism, and classical, commercial, and folkloric music. Drawing from an encyclopedic knowledge of Cuban music, ethnographic work, and interviews, Robin D. Moore's groundbreaking book is the first to explore the compelling violín ceremony in detail.
This is a book about the encounters that contemporary North American fiction stages with distinct strands of self-help. Its central argument is that the varied practices of ever-expanding and diversifying self-help cultures are generatively elastic sites of inspiration as well as antagonism for contemporary authors: spaces where they can explore what it means to be better on personal, ethical, and societal terms. It offers new perspectives on the work of nine very different writers by exploring how they play different forms of self-help off against one another. This book shows how in the clashes between practices ranging from commencement speeches and grassroots communitarian self-help to time-management productivity manuals, trauma recovery theories, pop-neuroscience, and makeover cultures, contemporary writers try to find ways of reimagining authority and agency beyond individualism, asking how - and if - it is possible to live and write 'better' in our compromised neoliberal world.
The presence of glufosinate-resistant Palmer amaranth (Amaranthus palmeri S. Watson) is of concern for Arkansas farmers. The objective of this study was to understand the distribution of glufosinate resistance among A. palmeri accessions collected in 2023 from locations surrounding MSR2 (a highly glufosinate-resistant accession) in 2020, focusing on the distance and direction patterns. Additionally, the cytosolic (GS1) and chloroplastic (GS2) glutamine synthetase copy number were quantified in glufosinate survivors. In 2023, a total of 66 A. palmeri samples were collected within a 15-km radius of MSR2. Amaranthus palmeri seedlings were treated with glufosinate at 590 g ai ha−1. Plant tissues were collected, and gene copy number assays were conducted with survivors from accessions showing less than 96% mortality. Glufosinate provided ≥80% mortality in most of the accessions evaluated. Nonetheless, a few accessions showed low mortality rates, with values as low as 34%. Within and among accessions, there was no variation for GS1.1 and GS1.2, while the GS2.1 and GS2.2 copy numbers varied greatly. There was no evidence that the geographic distance between samples and MSR2 impacted mortality or gene copy number. However, there was strong evidence that direction, relative to MSR2, affected both mortality and GS2.1 copies. Samples collected north from MSR2 showed lower average mortality rates (83%) with a higher number of GS2.1 copies (2.3). For comparison, average mortality ranged from 90% to 95% and GS2.1 copy number ranged from 1 to 1.2 in the other directions. The predominant summer and fall wind directions do not explain the movement of resistance in a specific direction. These findings indicate that there are multiple A. palmeri accessions capable of surviving a label recommended use rate of glufosinate in northeast Arkansas, and resistance distribution needs to be further investigated.
The sixth annual meeting of the African Studies Association was held at the Sir Francis Drake Hotel in San Francisco. The opening plenary session included three papers concerned with North African affairs. Benjamin Rivlin of Brooklyn College, considering “The Maghreb and Pan-Arabism,” began with a series of questions. Were the aspirations of the Maghreb states for Arab unity incompatible with their African vocation? Ought the Maghreb to be considered as a part of Africa, or was this precluded by the region's commitment to the Arab East? What was the extent of this commitment, and what identity did the Maghreb seek?
Most mental health difficulties have their onset in early adolescence. Increasingly, community based primary care is recognised as a critical pathway to early intervention. Despite encouraging initial evaluations, there is an ongoing need for evidence of the outcomes of primary care youth mental health programmes delivered at scale. This brief report examines reliable improvements in psychological distress and user satisfaction data from a national primary care youth mental health programme in the sustainment phase of implementation.
Methods:
This report takes a multi-methods approach to routine evaluation data. Young people (aged 12–25; N = 8,721) completed Clinical Outcomes Routine Evaluation (CORE-10 and YP-CORE) pre- and post-treatment. Clinical cut offs and a reliable change index (based on established guidelines) were used to report rates of reliable improvement. The analysis examined differences in outcomes based on age, gender, and clinical need. Satisfaction was measured using the youth service satisfaction survey (N = 4,267). Natural language processing techniques were employed to objectively analyse qualitative user feedback.
Results:
Most young people presented in the clinical range, with almost two-thirds reporting moderate to severe distress. Statistically significant reductions in distress were observed with large effect sizes (d = 1.08–1.28). Young people in the clinical range demonstrated significantly higher rates of reliable improvement compared to those who presented in the healthy range. In line with similar evaluations, young adults were more likely to achieve improvement and report higher satisfaction. Sentiment analysis of satisfaction data indicated a strong skew towards positive sentiment, with trust, anticipation and joy being predominant. Qualitative feedback pointed to waiting times as an improvement area.
Conclusion:
The absence of a control group limits our ability to evaluate the effectiveness of the service interventions. Nonetheless after a decade of service delivery, these results indicate that large scale national youth mental health programmes can achieve satisfaction and clinical outcomes in line with international standards. Further research is needed on the predictors of reliable change, differences across demographic groups and approaches to improving waiting times in primary care.
Background: Analysis of 20 pairs is the traditional standard when using SFEMG to diagnose MG. Some studies show that fewer pairs are needed if results are normal. We examined what impact this might have on long-term outcomes. Methods: Hospital charts of 239 consecutive patients who underwent SFEMG between January 2011, and July 18th, 2024, were reviewed. Results: 201 patients were identified; 128 had normal SFEMGs. Of the patients with normal SFEMGs, 58 (45.31%) had 12 pairs observed and 69 (53.91%) had 20 or more pairs observed. In the 12 pair group, 1(1.72%) patient had delayed MG diagnosis, and 2 (3.45%) patients were referred for repeat SFEMGs; in the 20 or more group, 2 (2.90%) patients belong in each aforementioned category. No patients from either group were hospitalized for MG after SFMEG. Conclusions: Preliminary results demonstrate no difference in frequency of poor outcomes between patients who had 20 or more pairs observed and those who had 12 pairs observed, supporting the safety of shortening the test in appropriate situations.
Diagnosing HIV-Associated Neurocognitive Disorders (HAND) requires attributing neurocognitive impairment and functional decline at least partly to HIV-related brain effects. Depressive symptom severity, whether attributable to HIV or not, may influence self-reported functioning. We examined longitudinal relationships among objective global cognition, depressive symptom severity, and self-reported everyday functioning in people with HIV (PWH).
Methods:
Longitudinal data from 894 PWH were collected at a university-based research center (2002–2016). Participants completed self-report measures of everyday functioning to assess both dependence in instrumental activities of daily living (IADL) and subjective cognitive difficulties at each visit, along with depressive symptom severity (BDI-II). Multilevel modeling examined within- and between-person predictors of self-reported everyday functioning outcomes.
Results:
Participants averaged 6 visits over 5 years. Multilevel regression showed a significant interaction between visit-specific global cognitive performance and mean depression symptom severity on likelihood of dependence in IADL (p = 0.04), such that within-person association between worse cognition and greater likelihood of IADL dependence was strongest among individuals with lower mean depressive symptom severity. In contrast, participants with higher mean depressive symptom severity had higher likelihoods of IADL dependence regardless of cognition. Multilevel modelling of subjective cognitive difficulties showed no significant interaction between global cognition and mean depressive symptom severity (p > 0.05).
Conclusions:
The findings indicate a link between cognitive abilities and IADL dependence in PWH with low to moderate depressive symptoms. However, those with higher depressive symptoms severity report IADL dependence regardless of cognitive status. This is clinically significant because everyday functioning is measured through self-report rather than performance-based assessments.
Threat sensitivity, an individual difference construct reflecting variation in responsiveness to threats of various types, predicts physiological reactivity to aversive stimuli and shares heritable variance with anxiety disorders in adults. However, no research has been conducted yet with youth to examine the heritability of threat sensitivity or evaluate the role of genetic versus environmental influences in its relations with mental health problems. The current study addressed this gap by evaluating the psychometric properties of a measure of this construct, the 20-item Trait Fear scale (TF-20), and examining its phenotypic and genotypic correlations with different forms of psychopathology in a sample of 346 twin pairs (121 monozygotic), aged 9–14 years. Analyses revealed high internal consistency and test-retest reliability for the TF-20. Evidence was also found for its convergent and discriminant validity in terms of phenotypic and genotypic correlations with measures of fear-related psychopathology. By contrast, the TF-20’s associations with depressive conditions were largely attributable to environmental influences. Extending prior work with adults, current study findings provide support for threat sensitivity as a genetically-influenced liability for phobic fear disorders in youth.
To describe the mitigation strategies for a Candida auris outbreak in a cardiothoracic transplant intensive care unit (CTICU) and its implications for infection prevention practices.
Design:
Retrospective cohort study from July 2023 to February 2024.
Setting:
A large academic medical center.
Methods:
A multidisciplinary team convened to conduct the outbreak investigation and develop mitigation strategies in the CTICU.
Results:
From July 2023 to February 2024, 34 possible hospital-onset cases of C. auris were identified in our CTICU. Whole-genome sequencing and phylogenetic analysis based on pairwise single nucleotide polymorphism (WG-SNP) distance revealed two distinct outbreak clusters. Of the 34 patients, 11 (32.3%) were solid organ transplant recipients and 12 (35.3%) had a mechanical circulatory support device. Of the cohort, only 11/34 (32.3%) had prior exposure to high-risk healthcare facilities within six months prior to admission, as follows: acute inpatient rehabilitation facilities (AIRs) (n = 5, 14.7%), skilled nursing facilities (SNFs) (n = 3, 8.8%), and long-term acute care hospitals (LTACHs) (n = 3, 8.8%). The cohort had a median of 22.0 antibiotic-days prior to their positive results. Five (14.7%) patients had C. auris candidemia, three of whom expired likely due to infection. Infection Prevention (IP) interventions addressed several modes of transmission, including healthcare personnel hands, shared patient equipment, and the environment.
Conclusion:
Our experience suggests that the epidemiology of C. auris may be changing, pointing towards a rising prevalence in acute care settings. IP interventions targeting hand hygiene behavior and promoting centralizing cleaning and disinfection of shared patient equipment may have contributed to outbreak resolution.
We present new unconstrained simulations and constrained experiments of a pair of pitching hydrofoils in a leader–follower in-line arrangement. Free-swimming simulations with matched pitching amplitudes show self-organisation into stable formations at a constant gap distance without any control. Over a wide range of phase synchronisation, amplitude and Lighthill number typical of biology, we discover that the stable gap distance scales with the actual wake wavelength of an isolated foil rather than the nominal wake wavelength. A scaling law for the actual wake wavelength is derived and shown to collapse data across a wide Reynolds number range of $200 \leqslant Re \leqslant 59\,000$. Additionally, vortex analysis uncovers that the leader’s wake wavelength-to-chord ratio, $\lambda /c$, is the key dimensionless variable to maximise the follower’s/collective efficiency. When $\lambda /c \approx 2$ it ensures that the follower’s leading edge suction force and the net force from a nearby vortex pair act in the direction with the foil’s motion thereby reducing the follower’s power. Moreover, in both simulations and experiments mismatched foil amplitudes are discovered to increase the efficiency of hydrofoil schools by 70 % while maintaining a stable formation without closed-loop control. This occurs by (i) increasing the stable gap distance between foils to push them into a high-efficiency zone and (ii) raising the level of efficiency in these zones. This study bridges the gap between constrained and unconstrained studies of in-line schooling by showing that constrained-foil measurements can map out the potential efficiency benefits of schooling. These findings can aid in the design of high-efficiency biorobot schools.
This article examines the influence of the American Medical Association’s (AMA) campaign against national health insurance between 1945 and 1950. Although previous research has focused on the AMA’s professional influence and its opposition to national health care proposals, I argue that the AMA’s efforts played an essential role in the widespread adoption of private health insurance in the postwar era. Managed by the political consulting firm Whitaker and Baxter, the campaign actively promoted so-called “voluntary” health insurance and mobilized its member physicians and medical societies to support this alternative. Drawing on new archival research, I also highlight the significance of state-level innovations and medical society insurance plans, particularly in California. Ultimately, the article shows how the AMA’s campaign not only prevented the adoption of national health care but also entrenched private health insurance as a cornerstone of the American welfare state.
The roles and responsibilities of the public health emergency preparedness (PHEP) and response workforce have changed since the last iteration of competencies developed in 2010. This project aims to identify current competencies (i.e., knowledge, skills, and abilities) for the PHEP workforce, as well as all public health staff who may contribute to a response.
Methods
Five focus groups with members of the PHEP workforce across the US focused on their experiences with workforce needs in preparedness and response activities. Focus group transcripts were thematically analyzed using qualitative methods to identify key competencies needed in the workforce.
Results
The focus groups revealed 7 domains: attitudes and motivations; collaboration; communications; data collection and analysis; preparedness and response; leadership and management; and public health foundations. Equity and social justice was identified as a cross-cutting theme across all domains.
Conclusions
Broad validation of competencies through ongoing engagement with the PHEP practice and academic communities is necessary. Competencies can be used to inform the design of PHEP educational programs and PHEP program development. Implementation of an up-to-date, validated competency model can help the workforce better prepare for and respond to disasters and emergencies.
Chronic diseases such as cardiovascular disease and diabetes are a leading cause of disability and death in Australia. These conditions are often heralded by biomarkers from blood and urine samples which indicate risk or presence of disease. The development of chronic conditions remains influenced by a set of modifiable risk factors, which includes diet. The level of food processing has recently been linked with disease risk factors and poor health outcomes(1), yet there is limited research into the direct associations between food processing and chronic disease biomarkers. This study aims to investigate the associations between varying levels of ultra-processed food consumption and chronic disease biomarkers. Participants ≥ 18 years with biomedical data who participated in both the National Nutritional and Physical Activity Survey and the National Health Measures Survey 2011–2013 were included in this secondary analysis. Chronic disease biomarkers were categorised as normal or abnormal according to cut-off values from the Royal College of Pathologists of Australasia. Dietary intake was classified according to the NOVA system for level of food processing. Data were then stratified into quintiles of daily energy share of ultra-processed foods. Associations between chronic disease biomarkers across quintiles of energy share of ultra-processed foods were examined. A significant positive trend was found between ultra-processed food consumption and high-density lipoprotein (HDL) cholesterol (p < 0.01). An inverse association was observed between ultra-processed food consumption and total cholesterol (p < 0.001). The highest consumers of ultra-processed foods were more likely to be younger, less educated, more disadvantaged, not meeting physical activity guidelines, and currently smoking (all ps < 0.001). In conclusion, ultra-processed food consumption was associated with significant changes in total and HDL cholesterol levels. This provides insight into possible interactions at a biochemical level and may help to guide future dietary recommendations on ultra-processed foods for disease management and prevention.
Some scholars have treated overconfidence as an individual difference—that is, assuming the tendency to be overconfident is stable within a person and differs meaningfully from person to person. We question this assumption. We investigate consistency within individuals between its three forms—overestimation, overplacement, and overprecision—in multiple domains (Study 1a and 1b), at multiple times (Study 1b and 2), and with multiple measures (Study 3a and 3b). We find mixed evidence of trait-like consistency. We do find some evidence of within-individual stability across domains and time points. However, we find little consistency across different measures of the same form of overconfidence—specifically overprecision. Instead, we find more consistent evidence that overconfidence varies situationally and contextually.