By incorporating leading-edge (L-E) protuberances inspired by humpback whale flippers, this study enhances hydrodynamic performance, mitigates cavitation effects and develops efficient models to minimise noise emissions in aquatic systems. Experimental and numerical simulations are conducted on four semi-elliptical NACA 16020 three-dimensional (3-D) hydrofoils, including a baseline hydrofoil and three modified versions featuring sinusoidal L-E alterations. These alterations encompass amplitudes of 2 %, wavelengths of 8.33 % and 4.1667 % of the mean chord length (C), and wavenumbers of 12 and 6. Experimental analysis encompassing both cavitational and non-cavitational regimes at varying attack angles revealed significant relationships between the hydrodynamic performance and partial sheet cavitation. Hydrodynamic force analysis shows that hydrofoils with L-E protuberances generate elevated lift at moderate and high angles of attack (AOA) in cavitating and non-cavitating conditions. Under lower-severity cavitating conditions, models with L-E protuberances exhibit no significant reduction in sound pressure level. In contrast, at higher severity, the presence of L-E protuberances effectively reduces the flow-induced noise, with partial cavities covering 30 %–50 % of the chord. Numerical simulations were conducted to investigate the turbulent kinetic energy (TKE) distribution and the presence of counter-rotating vortices on each protuberance. The results reveal a significantly enhanced TKE around the trough area and the presence of counter-rotating vortices at each protuberance peak. The more realistic asymmetric design performed better than the other modifications regarding hydrodynamic force, whereas the symmetric model with wavelengths of 8.33 % excelled at cavitation and noise suppression. Therefore, this study offers promising avenues for advancing hydrofoil design in diverse engineering domains.

One barrier to patients’ compliance in following instructions to take prescription medication is their memory of those instructions. Effective communication can be challenging with older adults, since people can use ineffective strategies to compensate for older adults’ presumed communication difficulties. The purpose of this study was to test whether older adults would benefit from gestures and/or props in hearing explanations of the appropriate use of prescription medication. Participants were 181 adults 65 years or older. They evaluated pharmacy students on their communication. Each participant watched video clips of pharmacy students explaining how to use fictional medications in three conditions: (1) speech only, (2) speech and gestures, and (3) speech and props. Participants were tested on their memory and rated the effectiveness of the communication of each pharmacy student. Participants showed no differences in memory across conditions. These findings do not support the use of gestures and/or props in effective communication with older adults.

The Scientific Advisory Committee on Nutrition (SACN) provides independent advice on nutrition and related health matters to UK government organisations. In keeping with its commitment to openness and transparency, SACN follows a set ‘Framework’ to ensure a prescribed and consistent approach is taken in all its evidence evaluations. Following an update of the SACN Framework in 2020, which addressed some straightforward issues, the SACN Framework subgroup was established in 2021 to consider more complex matters that were not addressed in the 2020 update. The SACN Framework subgroup considered 4 main topics for update: 1) the different types of evidence evaluations produced by SACN, 2) interpretation of statistical data, 3) tools for assessment of study quality, 4) tools to assess the certainty of a body of evidence for exposure-outcome relationships. The Framework subgroup agreed clear definitions and processes for the different types of evidence evaluations produced by SACN and agreed that interpretation of p values should be informed by consideration of study size, power and methodological quality. The subgroup recommended use of the AMSTAR 2 tool for quality assessment of evidence from systematic reviews and use of the GRADE approach to assess the certainty of evidence. The updated Framework was published in January 2023. This was followed by publication of a further update in October 2024. As a ‘living’ document, the Framework will be subject to regular review by the Framework subgroup and continue to evolve in line with best practice.

New Zealand and Australian governments rely heavily on voluntary industry initiatives to improve population nutrition, such as voluntary front-of-pack nutrition labelling (Health Star Rating [HSR]), industry-led food advertising standards, and optional food reformulation programmes. Research in both countries has shown that food companies vary considerably in their policies and practices on nutrition(1). We aimed to determine if a tailored nutrition support programme for food companies improved their nutrition policies and practices compared with control companies who were not offered the programme. REFORM was a 24-month, two-country, cluster-randomised controlled trial. 132 major packaged food/drink manufacturers (n=96) and fast-food companies (n=36) were randomly assigned (2:1 ratio) to receive a 12-month tailored support programme or to the control group (no intervention). The intervention group was offered a programme designed and delivered by public health academics comprising regular meetings, tailored company reports, and recommendations and resources to improve product composition (e.g., reducing nutrients of concern through reformulation), nutrition labelling (e.g., adoption of HSR labels), marketing to children (reducing the exposure of children to unhealthy products and brands) and improved nutrition policy and corporate sustainability reporting. The primary outcome was the nutrient profile (measured using HSR) of company food and drink products at 24 months. Secondary outcomes were the nutrient content (energy, sodium, total sugar, and saturated fat) of company products, display of HSR labels on packaged products, company nutrition-related policies and commitments, and engagement with the intervention. Eighty-eight eligible intervention companies (9,235 products at baseline) were invited to participate, of whom 21 accepted and were enrolled in the REFORM programme (delivered between September 2021 and December 2022). Forty-four companies (3,551 products at baseline) were randomised to the control arm. At 24 months, the model-adjusted mean HSR of intervention company products was 2.58 compared to 2.68 for control companies, with no significant difference between groups (mean difference -0.10, 95% CI -0.40 to 0.21, p-value 0.53). A per protocol analysis of intervention companies who enrolled in the programme compared to control companies with no major protocol violation also found no significant difference (2.93 vs 2.64, mean difference 0.29, 95% CI -0.13 to 0.72, p-value 0.18). We found no significant differences between the intervention and control groups in any secondary outcome, except in total sugar (g/100g) where the sugar content of intervention company products was higher than that of control companies (12.32 vs 6.98, mean difference 5.34, 95% CI 1.73 to 8.96, p-value 0.004). The per-protocol analysis for sugar did not show a significant difference (10.47 vs 7.44, mean difference 3.03, 95% CI -0.48 to 6.53, p-value 0.09).In conclusion, a 12-month tailored nutrition support for food companies did not improve the nutrient profile of company products.

We aimed to compare the mean sodium content of New Zealand (NZ) packaged breads in 2013 and 2023 and assess compliance with the NZ Heart Foundation (HF) and World Health Organization (WHO) sodium reduction benchmarks. Sodium data were obtained from a supermarket food composition database. Mean differences between years were assessed using independent samples t-tests and chi-square tests. There was a significant reduction in the sodium content of all bread from 2013 (n=345) to 2023 (n=309) of 46 mg/100g (p<0.001). In 2013, 20% (n=70/345) of breads met the HF benchmarks, and 10% (33/345) met the WHO benchmarks; corresponding values for 2023 were 45% (n=138/309) and 18% (n=57/309) (p<0.001 for both). If continued, the modest reduction in sodium content and increase in the percentage of NZ breads meeting relevant sodium reduction benchmarks could positively affect public health, particularly if extended across the packaged food supply.

Surgical sterilisation practices significantly increased in contraceptive capacity as the twentieth century unfolded. Despite this prolific uptake, sterilisation is markedly absent from histories of birth control and family planning and instead has remained addressed within histories of eugenics and coercion. The purpose of this article is twofold: firstly, to demonstrate a voluntary, contraceptive history of sterilisation that is distinct from, though connected to, involuntary and eugenic sterilisation; and secondly, to explain the integral role that individual doctors and their private practice played in the rise of contraceptive sterilisation in twentieth-century Australia. Through a combination of archival material and oral history interviews with twentieth-century practitioners of tubal ligation and vasectomy, this article reframes the history of surgical sterilisation, situating it firmly within the history of birth control.

This study explored whether lifestyle therapy that promoted adherence to a Mediterranean-style diet as a treatment for depression led to environmental co-benefits. Participants (n 75 complete case) were Australian adults in the Curbing Anxiety and Depression using Lifestyle Medicine non-inferiority, randomised controlled trial, which showed that lifestyle therapy was non-inferior to psychotherapy in reducing depressive symptoms, when delivered in group format via video conferencing over an 8-week treatment period. In this secondary analysis, we hypothesised that the lifestyle arm would be superior to the psychotherapy arm in reducing the environmental impact of self-reported diet over time. Dietary intake derived from FFQ at baseline and 8 weeks was transformed into environmental impact scores by calculating global warming potential (GWP)*. GWP* was calculated for total dietary intake and distinct food groups (Australian Dietary Guidelines and NOVA classifications). Within-arm changes in GWP* over time were calculated using the median difference. Neither arm showed significant changes. Between-arm differences in percentage change in GWP* scores over time were analysed using generalised estimating equations models. No between-arm difference for total GWP* score was found (β = 11·06 (–7·04, 29·15)). When examining distinct food groups, results were mixed. These novel findings contribute to the sparse evidence base that has measured the environmental impact of diets in a clinical trial context. Whilst lifestyle therapy that reduced depressive symptoms did not have clear environmental benefits relative to psychotherapy, nutritional counselling that focuses on the environmental impact of food choices may drive more pronounced planetary co-benefits.

This study investigates heritage speakers (HSs) of Spanish in the U.S. and potential areas of divergence in speech from homeland speakers. To examine the relative contribution of prosody and segments in perceived heritage accent, we conducted an accent rating task with speech samples of second language learners (L2s), HSs and homeland speakers presented in three conditions: original, prosody-only and segments-only. The stimuli were rated by two groups: HSs and homeland speakers. The results revealed that HSs and homeland speakers had similar global accent perceptions, rating HSs as more native-like than L2s but less native-like than homeland speakers. We found that both rater groups aligned with a dominant language ideology of Spanish; speakers who were judged as more native-like were perceived as residing in a Spanish-speaking country. Our findings also demonstrate that prosody contributes more to perceived heritage accent than segments, while segments contribute more to L2 foreign accent than prosody.

We investigate the evolution of active galactic nucleus jets on kiloparsec-scales due to their interaction with the clumpy interstellar medium (ISM) of the host galaxy and, subsequently, the surrounding circumgalactic environment. Hydrodynamic simulations of this jet–environment interaction are presented for a range of jet kinetic powers, peak densities of the multiphase ISM, and scale radii of the larger-scale environment – characteristic of either a galaxy cluster or poor group. Synthetic radio images are generated by considering the combination of synchrotron radiation from the jet plasma and free-free absorption from the multiphase ISM. We find that jet propagation is slowed by interactions with a few very dense clouds in the host galaxy ISM, producing asymmetries in lobe length and brightness which persist to scales of tens of kpc for poor group environments. The classification of kiloparsec-scale jets is highly dependent on surface brightness sensitivity and resolution. Our simulations of young active sources can appear as restarted sources, showing double-double lobe morphology, high core prominence (CP $\gt 0.1$), and the expected radio spectra for both the inner- and outer-lobe components. We qualitatively reproduce the observed inverse correlation between peak frequency and source size and find that the peak frequency of the integrated radio spectrum depends on ISM density but not the jet power. Spectral turnover in resolved young radio sources therefore provides a new probe of the ISM.

Background: Glioma trials may use selective criteria, limiting their generalizability to real-world patients. This systematic review and meta-analysis quantifies the prevalence of these criteria and evaluates their impact on trial outcomes, assessing whether reducing selectivity to improve generalizability and applicability is feasible without compromising safety or efficacy. Methods: 51 glioma trials were extracted from the National Clinical Trial (NCT) database on June 1st, 2024. Eligibility criteria were classified as selective—defined as likely to exclude patients who could benefit, or generalizable—justified due to potential harm or trial focus. The selective criteria were analyzed for correlation with median overall survival (mOS). Results: The average number of selective criteria per study was 6.8 (range: 0–14, median: 7). The most common were “No prior malignancy with a specified disease-free period” (N=29), “Exclusion based on Karnofsky score” (N=27), and “No prior brain radiotherapy” (N=16). Meta-analysis showed no significant correlation between the number of selective criteria and mOS (p = .327). Conclusions: Selective criteria are common in glioma trials, particularly exclusions based on prior malignancies, performance status, and past treatments. However, their lack of correlation with mOS indicates minimal impact on outcomes. These findings suggest reducing selectivity in trial criteria may improve generalizability and applicability without compromising safety or efficacy.