The formation of iddingsite by the oxidative weathering of Fo80 olivine begins by solution of Mg from planar fissures, 20 Å wide and spaced 200 Å apart, parallel to (001). Oxidation of Fe within the remaining olivine provides nuclei for the topotactic growth of goethite. Cleavage cracks < 50 Å in diameter allow Na, Al, and Ca from adjacent minerals, particularly plagioclase, to enter the altering olivine while Mg and Si diffuse away. In the early stages of weathering, strips of Fe-rich smectite (saponite), 20–50 Å wide and 1–7 layers thick, form bridges 50–100 Å long across the planar fissures. Dioctahedral smectite crystallizes on the margins of wider cleavage-controlled fissures; with further weathering halloysite is formed away from the fissure walls. In the ultimate stages of alteration, the saponite and dioctahedral smectite are lost, leaving a porous, oriented aggregate of goethite crystals each measuring about 50 × 100 × 200 Å (X, Y, Z, respectively), with sporadic veins of halloysite crossing the pseudomorph.

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major cause of bloodstream infection among hospitalized patients in low- and middle-income countries (LMICs). CRAB infections can be difficult to treat and are devastating in neonates (~30% mortality). CRAB outbreaks are hypothesized to arise from reservoirs in the hospital environment, but outbreak investigations in LMICs seldom incorporate whole-genome sequencing (WGS). Methods: WGS (Illumina NextSeq) was performed at the National Institute for Communicable Diseases (South Africa) on 43 preserved A. baumannii isolates from a 530-bed referral hospital in Gaborone, Botswana, from March 2021–August 2022. This included 23 blood-culture isolates from 21 unique patients (aged 2 days–69 years) and 20 environmental isolates collected at the 36-bed neonatal unit in April–June 2021. Infections were considered healthcare-associated if the culture was obtained >72 hours after hospital arrival (or sooner in inborn infants). Blood cultures were incubated using an automated system (BACT/ALERT, BioMérieux) and were identified using manual methods. Environmental isolates were identified using selective or differential chromogenic media (CHROMagarTM). Taxonomic assignment, multilocus sequence typing (MLST), antimicrobial resistance gene identification, and phylogenetic analyses were performed using publicly accessible analysis pipelines. Single-nucleotide polymorphism (SNP) matrices were used to assess clonal lineage. Results: All 23 blood isolates and 5 (25%) of 20 environmental isolates were confirmed as A. baumannii; thus, 28 A. baumannii isolates were included in the phylogenetic analysis. MLST revealed that 22 (79%) of 28 isolates were sequence type 1 (ST1), including all 19 healthcare-associated blood isolates and 3 (60%) of 5 environmental isolates. Genes encoding for carbapenemases (blaNDM-1, blaOXA-23) and biocide resistance (qacE) were present in all 22 ST1 isolates; colistin resistance genes were not identified. Phylogenetic analysis of the ST1 clade demonstrated spatial clustering by hospital unit. Related isolates spanned wide ranges in time (>1 year), suggesting ongoing transmission from environmental sources (Fig. 1). An exclusively neonatal clade (0–2 SNPs) containing all 8 neonatal blood isolates was closely associated with 3 environmental isolates from the neonatal unit: a sink drain, bed rail, and a healthcare worker’s hand. Conclusions: WGS analysis of clinical and environmental A. baumannii revealed the presence of unit-specific CRAB clones, with evidence of ongoing transmission likely driven by persistent environmental reservoirs. This research highlights the potential of WGS to detect hospital outbreaks and reaffirms the importance of environmental sampling to identify and remediate reservoirs (eg, sinks) and vehicles (eg, hands and equipment) within the healthcare environment.

Disclosures: None

In post-Brexit and post-devolution Britain, relationships among the four nations appear fragile. This article aims to discover where British citizens draw the symbolic boundaries that define in-group and out-group members between nations—in particular, England, Scotland, and Wales—and within England. Within England, we also examine class divides and the North–South divide. We operationalize symbolic boundaries through a set of new innovative measures administered in an online survey in 2019. Questions ascertain agreement that the various groups “share my values,” are “people I could get on with,” and are “straightforward and honest.” Results of our descriptive analysis suggest that boundaries are blurred between the British and the Welsh but sharper for the Scottish. We also find sharp but asymmetrical boundaries within England, between the working class and the middle class, and between Northerners and Southerners. Regional differences in perceptions of Southerners map closely onto those of how well Westminster looks after regional interests, which suggests that power imbalances reduce social cohesion.

People with psychosis in Malawi have very limited access to timely assessment and evidence-based care, leading to a long duration of untreated psychosis and persistent disability. Most people with psychosis in the country consult traditional or religious healers. Stigmatising attitudes are common and services have limited capacity, particularly in rural areas. This paper, focusing on pathways to care for psychosis in Malawi, is based on the Wellcome Trust Psychosis Flagship Report on the Landscape of Mental Health Services for Psychosis in Malawi. Its purpose is to inform Psychosis Recovery Orientation in Malawi by Improving Services and Engagement (PROMISE), a longitudinal study that aims to build on existing services to develop sustainable psychosis detection systems and management pathways to promote recovery.

Following the report of the first COVID-19 case in Nepal on 23 January 2020, three major waves were documented between 2020 and 2021. By the end of July 2022, 986 596 cases of confirmed COVID-19 and 11 967 deaths had been reported and 70.5% of the population had received at least two doses of a COVID-19 vaccine. Prior to the pandemic, a large dengue virus (DENV) epidemic affected 68 out of 77 districts, with 17 932 cases and six deaths recorded in 2019. In contrast, the country's Epidemiology and Disease Control Division reported 530 and 540 dengue cases in the pandemic period (2020 and 2021), respectively. Furthermore, Kathmandu reported just 63 dengue cases during 2020 and 2021, significantly lower than the 1463 cases reported in 2019. Serological assay showed 3.2% positivity rates for anti-dengue immunoglobulin M antibodies during the pandemic period, contrasting with 26.9–40% prior to it. Real-time polymerase chain reaction for DENV showed a 0.5% positive rate during the COVID-19 pandemic which is far lower than the 57.0% recorded in 2019. Continuing analyses of dengue incidence and further strengthening of surveillance and collaboration at the regional and international levels are required to fully understand whether the reduction in dengue incidence/transmission were caused by movement restrictions during the COVID-19 pandemic.

We examine the redshifts of a comprehensive set of published Type Ia supernovae, and provide a combined, improved catalogue with updated redshifts. We improve on the original catalogues by using the most up-to-date heliocentric redshift data available; ensuring all redshifts have uncertainty estimates; using the exact formulae to convert heliocentric redshifts into the Cosmic Microwave Background (CMB) frame; and utilising an improved peculiar velocity model that calculates local motions in redshift-space and more realistically accounts for the external bulk flow at high-redshifts. We review 2607 supernova redshifts; 2285 are from unique supernovae and 322 are from repeat-observations of the same supernova. In total, we updated 990 unique heliocentric redshifts, and found 5 cases of missing or incorrect heliocentric corrections, 44 incorrect or missing supernova coordinates, 230 missing heliocentric or CMB frame redshifts, and 1200 missing redshift uncertainties. The absolute corrections range between $10^{-8} \leq \Delta z \leq 0.038$, and RMS$(\Delta z) \sim 3{\times 10^{-3}}$. The sign of the correction was essentially random, so the mean and median corrections are small: $4{\times 10^{-4}}$ and $4{\times 10^{-6}}$ respectively. We examine the impact of these improvements for $H_0$ and the dark energy equation of state w and find that the cosmological results change by $\Delta H_0 = -0.12\,\mathrm{km\,s}^{-1}\mathrm{Mpc}^{-1}$ and $\Delta w = 0.003$, both significantly smaller than previously reported uncertainties for $H_0$ of 1.0 $\mathrm{km\,s}^{-1}\mathrm{Mpc}^{-1}$ and w of 0.04 respectively.

De la vie d'oraison is an early and neglected work by Jacques Maritain. Exploring its major themes and biographical context reveals a tension in Maritain between his commitment to orthodox Catholic mystical theology and his belief in his godfather Léon Bloy's unique, tripartite vocation of lay mystic, prophet, and artist. This tension, I argue, has been overlooked due to Maritain's public image as an esteemed Thomist philosopher, but becomes clear when we study Maritain's defense of Bloy, especially in his dialogues with his Dominican peers and church authorities. I suggest that this tension reveals two deep-seated convictions at work in Maritain's life and writings. The first is that the reasons for the necessity of lay Catholic mysticism, and the diverse forms it may take, need to be spelled out more clearly. The second is that for Maritain, his godfather is an exemplar of such lay Catholic mysticism. Understanding Maritain's reasons for these convictions can open up a pathway for Catholic mystical theology to better accommodate and conceptualize alternative forms of mystical life among laypeople whose mystical and artistic experiences spill over traditional theological categories.

A Roman villa building at Mud Hole, Boxford, West Berkshire, was examined by excavation in 2017 and 2019, and found to be of probable fourth-century date. One room of this otherwise seemingly modest villa contained a remarkable late fourth-century figured mosaic, which features a number of rare mythological subjects not previously encountered in Britain. Inscriptions suggest the name of the villa owner (Caepio) and his wife (Fortunata), with a possible Spanish connection. The mosaic's central panel is ornamented with the triumphs of Pelops and Bellerophon, the former known only from two other mosaics, in Syria and Spain. The borders also contain depictions of stories unknown on other mosaics, but all concerned with aspects of triumph. The central panel is upheld by walking telamones (giants), otherwise only known on a mosaic from Tusculum, and the mosaicists have attempted to use foreshortening to give the floor a trompe l'oeil effect. The rare subjects depicted on the floor all relate to either Poseidon, Pelops, Bellerophon or Atlas, and suggest high standards of mythological knowledge and longevity of classical culture amongst the villa-owning inhabitants of late fourth-century Berkshire. The mosaic shows a connection to earlier depictions of the Pelops story, but is highly original in its interpretation of them and follows a contemporary trend, not previously encountered in Britain, of its subjects breaking out from their ornamental borders. The mosaic is an altogether exceptional discovery and can be considered an important example of late Roman art so far found in Britain.

The Middle Mississippian component at Aztalan was a mixed, Late Woodland / Mississippian occupation sited within a heavily fortified habitation and mound center that is located on a tributary of the Rock River in Wisconsin. It represents the northernmost large Cahokian-related village recorded. The Oneota Lake Koshkonong Locality of the Rock River drainage is located approximately 20 km south of Aztalan, and it consists of a 25 km2 area along the northwest shore with a small cluster of habitation settlements. Sixty-eight radiocarbon measurements have been obtained from Aztalan, and 52 from Oneota settlements in the Lake Koshkonong Locality. We discuss how to best interpret this dataset, and we use Bayesian chronological modeling to analyze these dates. The results suggest that (1) Aztalan's Late Woodland (Kekoskee phase) occupation began in the AD 900s or early AD 1000s, (2) Aztalan's Mississippian occupation ceased in the AD 1200s, (3) Oneota occupations at Lake Koshkonong began after AD 1050 and were established by the AD 1200s, and (4) Oneota occupations at Lake Koshkonong continued after Aztalan's Mississippian abandonment until at least the late AD 1300s. Additionally, the results demonstrate that Aztalan was fortified with a palisade with bastions for much of the Mississippian occupation, suggesting a contested presence in a multiethnic landscape.

Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is inversely associated with type 2 diabetes mellitus (T2DM) risk. Metabolic changes due to DASH adherence and their potential relationship with incident T2DM have not been described. The objective is to determine metabolite clusters associated with adherence to a DASH-like diet in the Insulin Resistance Atherosclerosis Study cohort and explore if the clusters predicted 5-year incidence of T2DM. The current study included 570 non-diabetic multi-ethnic participants aged 40–69 years. Adherence to a DASH-like diet was determined a priori through an eighty-point scale for absolute intakes of the eight DASH food groups. Quantitative measurements of eighty-seven metabolites (acylcarnitines, amino acids, bile acids, sterols and fatty acids) were obtained at baseline. Metabolite clusters related to DASH adherence were determined through partial least squares (PLS) analysis using R. Multivariable-adjusted logistic regression was used to explore the associations between metabolite clusters and incident T2DM. A group of acylcarnitines and fatty acids loaded strongly on the two components retained under PLS. Among strongly loading metabolites, a select group of acylcarnitines had over 50 % of their individual variance explained by the PLS model. Component 2 was inversely associated with incident T2DM (OR: 0·89; (95 % CI 0·80, 0·99), P-value = 0·043) after adjustment for demographic and metabolic covariates. Component 1 was not associated with T2DM risk (OR: 1·02; (95 % CI 0·88, 1·19), P-value = 0·74). Adherence to a DASH-type diet may contribute to reduced T2DM risk in part through modulations in acylcarnitine and fatty acid physiology.

The protected Tel-Dor coastal embayment in the eastern Mediterranean preserves an unusually complete stratigraphic record that reveals human–environmental interactions throughout the Holocene. Interpretation of new seismic profiles collected from shallow marine geophysical transects across the bay show five seismic units were correlated with stratigraphy and age dates obtained from coastal and shallow-marine sediment cores. This stratigraphic framework permits a detailed reconstruction of the coastal system over the last ca. 77 ka as well as an assessment of environmental factors that influenced some dimensions of past coastal societies. The base of the boreholes records lowstand aeolian deposits overlain by wetland sediments that were subsequently flooded by the mid-Holocene transgression. The earliest human settlements are submerged Pottery Neolithic (8.25–7 ka) structures and tools, found immediately above the wetland deposits landward of a submerged aeolianite ridge at the mouth of the bay. The wetland deposits and Pottery Neolithic settlement remains are buried by coastal sand that records a middle Holocene sea-level rise ca. 7.6–6.5 ka. Stratigraphic and geographic relationships suggest that these coastal communities were displaced by sea-level transgression. These findings demonstrate how robust integration of different data sets can be used to reconstruct the geomorphic evolution of coastal settings as well as provide an important addition to the nature of human–landscape interaction and cultural development.

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

I examine Jacques Maritain's assertion that his godfather, the Catholic writer Léon Bloy, was both an artist and a mystic, capable of reaching the heights of mystical contemplation of God. First examining this assertion in light of Maritain's mystical theology and philosophy of creativity, I show that a conventional reading of their operative principles renders mystical experience and artistic experience essentially different in their respective modes and objects of knowledge. Drawing on Maritain's personal reflections on Bloy and recent developments in Maritain scholarship, however, I then make the case that by virtue of relatively unexplored elements in Maritain's testimony and theoretical principles, the Christian artist can also have the experience of the Christian mystic when they direct their work to the mysteries of the Christian faith. I call this convergence ‘Infused-Poetic Contemplation’.