We present the serendipitous radio-continuum discovery of a likely Galactic supernova remnant (SNR) G305.4–2.2. This object displays a remarkable circular symmetry in shape, making it one of the most circular Galactic SNRs known. Nicknamed Teleios due to its symmetry, it was detected in the new Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio–continuum images with an angular size of 1 320$^{\prime\prime}$$\times$1 260$^{\prime\prime}$ and PA = 0$^\circ$. While there is a hint of possible H$\alpha$ and gamma-ray emission, Teleios is exclusively seen at radio–continuum frequencies. Interestingly, Teleios is not only almost perfectly symmetric, but it also has one of the lowest surface brightnesses discovered among Galactic SNRs and a steep spectral index of $\alpha$=–0.6$\pm$0.3. Our best estimates from Hi studies and the $\Sigma$–D relation place Teleios as a type Ia SNR at a distance of either $\sim$2.2 kpc (near-side) or $\sim$7.7 kpc (far-side). This indicates two possible scenarios, either a young (under 1 000 yr) or a somewhat older SNR (over 10 000 yr). With a corresponding diameter of 14/48 pc, our evolutionary studies place Teleios at the either early or late Sedov phase, depending on the distance/diameter estimate. However, our modelling also predicts X-ray emission, which we do not see in the present generation of eROSITA images. We also explored a type Iax explosion scenario that would point to a much closer distance of $\lt$1 kpc and Teleios size of only $\sim$3.3 pc, which would be similar to the only known type Iax remnant SN1181. Unfortunately, all examined scenarios have their challenges, and no definitive Supernova (SN) origin type can be established at this stage. Remarkably, Teleios has retained its symmetrical shape as it aged even to such a diameter, suggesting expansion into a rarefied and isotropic ambient medium. The low radio surface brightness and the lack of pronounced polarisation can be explained by a high level of ambient rotation measure (RM), with the largest RM being observed at Teleios’s centre.

Soybean [Glycine max (L.) Merr.] that lack resistance to auxin herbicides [i.e., not genetically modified for resistance] have well-documented responses to those particular herbicides, with yield loss being probable. When a soybean field is injured by auxin herbicides, regulatory authorities often collect a plant sample from that field. This research attempted to simulate soybean exposures due to accidental mixing of incorrect herbicides, tank contamination, or particle drift. This research examined whether analytical testing of herbicide residues on soybean to aminocyclopyrachlor (ACP), aminopyralid, 2,4-D, or dicamba would be related to the visual observations and yield responses from these herbicides. ACP and aminopyralid were applied to R1 soybean at 0.1, 1, and 10 g ae ha−1; 2,4-D and dicamba were applied at 1, 10, and 100 g ae ha−1. Visual evaluations and plant sample collections were undertaken at 1, 3, 7, 14, and 21 d after treatment (DAT), and yield was measured. The conservative limits of detection for the four herbicides in this project were 5, 10, 5, and 5 ng g−1 fresh weight of soybean for ACP, aminopyralid, 2,4-D, and dicamba, respectively. Many of the plant samples were non-detects, especially at lower application dosages. All herbicide concentrations rapidly declined soon after application, and many reached nondetectable limits by 14 DAT. All herbicide treatments caused soybean injury, although the response to 2,4-D was markedly lower than the responses to the other three herbicides. There was no apparent correlation between herbicide concentrations (which were declining over time) and the observed soybean injury (which was increasing over time or staying the same). This research indicated that plant samples should be collected as soon as possible after soybean exposure to auxin herbicides.

Coronavirus disease 2019 can be indistinguishable from lower respiratory tract infections (LRTIs) caused by other viral and bacterial agents. This likely contributed to antimicrobial use (AU) and antimicrobial resistance (AMR) during the pandemic. Our antimicrobial stewardship program targeted the selection and duration of therapy for LRTIs and led to a reduction in AU and AMR.

Multiple herbicide–resistant (MHR) Palmer amaranth is among the most problematic summer annual broadleaf weeds in Nebraska and several other states. A new MHR corn cultivar (resistant to 2,4-D/glufosinate/glyphosate, also known as Enlist corn) has been commercially available in the United States since 2018. Growers are searching for herbicide programs for control and reduce seed production of MHR Palmer amaranth among Enlist corn crops. The objectives of this study were to evaluate herbicides applied preemergence, early postemergence, or preemergence followed by (fb) late postemergence for the management of MHR Palmer amaranth in Enlist corn fields and to assess their effect on Palmer amaranth biomass, density, seed production, and corn yield. Field experiments were conducted near Carleton, NE, in 2020 and 2021, in a grower’s field of Enlist corn infested with acetolactate synthase–inhibitor/atrazine/glyphosate–resistant Palmer amaranth. Herbicides applied preemergence, such as flufenacet/isoxaflutole/thiencarbazone-methyl, acetochlor/clopyralid/flumetsulam, or acetochlor/clopyralid/mesotrione, provided 75% to 99% control of Palmer amaranth 30 d after preemergence. Preemergence fb late postemergence herbicides resulted in 94% Palmer amaranth control 90 d after late postemergence, reduced weed density to 0 to 8 plants m−2 30 d after late postemergence, and reduced biomass to 2 to 14 g m−2 15 d after late postemergence compared to preemergence-only (59% control, 0 to 15 plants m−2, and 4 to 123 g m−2) and early postemergence–only herbicides (78% control, 6 to 30 plants m−2, and 8 to 25 g m−2). Based on contrast analysis, Palmer amaranth seed production was reduced to 14,050 seeds m–2 in preemergence fb late postemergence herbicide programs compared with 325,490 seed m–2 in preemergence-only and 376,750 seed m–2 in early postemergence–only programs. Based on orthogonal contrast, higher corn yield of 12,340 and 11,730 kg ha−1 was obtained with preemergence fb late postemergence herbicide programs compared with preemergence-only (10,840 and 11,510 kg ha−1) and early postemergence–only programs (10,850 and 10,030 kg ha−1) in 2020 and 2021, respectively.

Broad-spectrum antimicrobials are commonly used without indication and contribute to antimicrobial resistance (AMR). We implemented a syndrome-based stewardship intervention in a community hospital that targeted common infectious syndromes and antipseudomonal beta-lactam (APBL) use. Our intervention successfully reduced AMR, C. difficile rates, use of APBLs, and cost.

Recent research has shown the potential of speleothem δ13C to record a range of environmental processes. Here, we report on 230Th-dated stalagmite δ13C records for southwest Sulawesi, Indonesia, over the last 40,000 yr to investigate the relationship between tropical vegetation productivity and atmospheric methane concentrations. We demonstrate that the Sulawesi stalagmite δ13C record is driven by changes in vegetation productivity and soil respiration and explore the link between soil respiration and tropical methane emissions using HadCM3 and the Sheffield Dynamic Global Vegetation Model. The model indicates that changes in soil respiration are primarily driven by changes in temperature and CO2, in line with our interpretation of stalagmite δ13C. In turn, modelled methane emissions are driven by soil respiration, providing a mechanism that links methane to stalagmite δ13C. This relationship is particularly strong during the last glaciation, indicating a key role for the tropics in controlling atmospheric methane when emissions from high-latitude boreal wetlands were suppressed. With further investigation, the link between δ13C in stalagmites and tropical methane could provide a low-latitude proxy complementary to polar ice core records to improve our understanding of the glacial–interglacial methane budget.

Understanding the distribution and extent of suitable habitats is critical for the conservation of endangered and endemic taxa. Such knowledge is limited for many Central African species, including the rare and globally threatened Grey-necked Picathartes Picathartes oreas, one of only two species in the family Picathartidae endemic to the forests of Central Africa. Despite growing concerns about land-use change resulting in fragmentation and loss of forest cover in the region, neither the extent of suitable habitat nor the potential species’ distribution is well known. We combine 339 (new and historical) occurrence records of Grey-necked Picathartes with environmental variables to model the potential global distribution. We used a Maximum Entropy modelling approach that accounted for sampling bias. Our model suggests that Grey-necked Picathartes distribution is strongly associated with steeper slopes and high levels of forest cover, while bioclimatic, vegetation health, and habitat condition variables were all excluded from the final model. We predicted 17,327 km2 of suitable habitat for the species, of which only 2,490 km2 (14.4%) are within protected areas where conservation designations are strictly enforced. These findings show a smaller global distribution of predicted suitable habitat forthe Grey-necked Picathartes than previously thought. This work provides evidence to inform a revision of the International Union for Conservation of Nature (IUCN) Red List status, and may warrant upgrading the status of the species from “Near Threatened” to “Vulnerable”.

Background: Saccade and pupil responses are potential neurodegenerative disease biomarkers due to overlap between oculomotor circuitry and disease-affected areas. Instruction-based tasks have previously been examined as biomarker sources, but are arduous for patients with limited cognitive abilities; additionally, few studies have evaluated multiple neurodegenerative pathologies concurrently. Methods: The Ontario Neurodegenerative Disease Research Initiative recruited individuals with Alzheimer’s disease (AD), mild cognitive impairment (MCI), amyotrophic lateral sclerosis (ALS), frontotemporal dementia, progressive supranuclear palsy, or Parkinson’s disease (PD). Patients (n=274, age 40-86) and healthy controls (n=101, age 55-86) viewed 10 minutes of frequently changing video clips without instruction while their eyes were tracked. We evaluated differences in saccade and pupil parameters (e.g. saccade frequency and amplitude, pupil size, responses to clip changes) between groups. Results: Preliminary data indicates low-level behavioural alterations in multiple disease cohorts: increased centre bias, lower overall saccade rate and reduced saccade amplitude. After clip changes, patient groups generally demonstrated lower saccade rate but higher microsaccade rate following clip change to varying degrees. Additionally, pupil responses were blunted (AD, MCI, ALS) or exaggerated (PD). Conclusions: This task may generate behavioural biomarkers even in cognitively impaired populations. Future work should explore the possible effects of factors such as medication and disease stage.

We highlight the historical and contemporary policies that govern paleontological research on federally recognized Native American lands. The United States has a long history of fossil dispossession from Indigenous Peoples, and federal policies surrounding the management of Native American lands (i.e., reservations), and the geological resources therein, have changed through time. These changes reflect shifting popular and political ideologies regarding Native American nations’ sovereignty and self-governance. As of 2022, the United States has a government-to-government relationship with federally recognized Tribal entities, but that has not always been the case. Historians have divided post-contact Native American federal policy into distinct eras: Colonial Times to 1820, Native American Removal and Reservation (1820–1887), Allotments and Attempted Assimilation (1887–1934), Reorganization and Preservation (1934–1953), Termination and Relocation (1953–1968), and Tribal Self-Determination (1968–present). Documentation of how the federal policies from each of these eras continue to impact current paleontological research is limited. We summarize major legislative actions, court cases, and historical events that have affected paleontological resource management in Native American territory. We use this historical context to identify federal policy gaps and highlight legal nuances associated with fossil collection and ownership, particularly given the importance of fossils to some Native Americans’ cultural patrimony. Finally, we explore how these gaps affect scientific research and highlight best practices for conducting paleontological research on vertebrate, invertebrate, and paleobotanical body and trace fossils using the CARE (Collective Benefit, Authority to Control, Responsibility, Ethics) Principles for Indigenous Data Governance (https://www.gida-global.org/care).

Herbicide-resistant Palmer amaranth is a troublesome weed in several agronomic crops and is a relatively new challenge to dry bean production in western Nebraska. Objectives were to evaluate preemergence (PRE) and postemergence (POST) herbicides for control of acetolactate synthase–resistant Palmer amaranth and their effect on Palmer amaranth density and biomass as well as dry bean injury and yield in western Nebraska. Field experiments were conducted in 2017 and 2019 near Scottsbluff, NE. The experiments were arranged as a two-factor strip-plot design. The strip-plot factor consisted of no-PRE or pendimethalin (1,070 g ai ha–1) + dimethenamid-P (790 g ai h–1) applied PRE. The main-plot factor was POST herbicides, which consisted of various mixtures of imazamox, bentazon, or fomesafen applied in a single or sequential application at labeled rates, and reduced rates of imazamox (9 g ai ha–1) + bentazon (314 g ai ha–1) + fomesafen (70 g ai ha–1) applied in single or sequential (two or three) applications. PRE herbicides reduced Palmer amaranth density and biomass during both years and increased dry bean yield in 2017. POST treatments containing fomesafen improved Palmer amaranth control compared with treatments containing imazamox and bentazon only. The sequential-application reduced-rate POST system did not improve Palmer amaranth control compared to one POST application containing fomesafen at a labeled rate in either year. Using pendimethalin + dimethenamid-P PRE followed by POST treatments containing imazamox + bentazon + fomesafen at a labeled rate provided 86% and 99% Palmer amaranth control in 2017 and 2019, respectively.

Background: Eye movements reveal neurodegenerative disease processes due to overlap between oculomotor circuitry and disease-affected areas. Characterizing oculomotor behaviour in context of cognitive function may enhance disease diagnosis and monitoring. We therefore aimed to quantify cognitive impairment in neurodegenerative disease using saccade behaviour and neuropsychology. Methods: The Ontario Neurodegenerative Disease Research Initiative recruited individuals with neurodegenerative disease: one of Alzheimer’s disease, mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson’s disease, or cerebrovascular disease. Patients (n=450, age 40-87) and healthy controls (n=149, age 42-87) completed a randomly interleaved pro- and anti-saccade task (IPAST) while their eyes were tracked. We explored the relationships of saccade parameters (e.g. task errors, reaction times) to one another and to cognitive domain-specific neuropsychological test scores (e.g. executive function, memory). Results: Task performance worsened with cognitive impairment across multiple diseases. Subsets of saccade parameters were interrelated and also differentially related to neuropsychology-based cognitive domain scores (e.g. antisaccade errors and reaction time associated with executive function). Conclusions: IPAST detects global cognitive impairment across neurodegenerative diseases. Subsets of parameters associate with one another, suggesting disparate underlying circuitry, and with different cognitive domains. This may have implications for use of IPAST as a cognitive screening tool in neurodegenerative disease.

Biotypes of Palmer amaranth that are resistant to acetolactate synthase (ALS) inhibitor are becoming widespread in western Nebraska. There are limited effective postemergence (POST) herbicides labeled for ALS-inhibitor-resistant Palmer amaranth control in dry edible bean. The objective of this study was to evaluate the efficacy of dimethenamid-P in a sequential preemergence (PRE) fb followed by (fb) POST program at two POST application timings, the first and third trifoliate stages (V1 and V3, respectively), for controlling ALS-inhibitor-resistant Palmer amaranth in dry edible bean. A field study was conducted in 2019, 2020, and 2021 in Scottsbluff, NE. PRE-alone applications of pendimethalin + dimethenamid-P provided inconsistent Palmer amaranth control. Dimethenamid-P applied POST following a PRE application of pendimethalin + dimethenamid-P provided effective (>90%) Palmer amaranth control at 4 wk after V3 only at the V1 application timing in 2019. In 2020 and 2021 dimethenamid-P applied POST at V1 and V3 following a PRE application of pendimethalin + dimethenamid-P provided 99% and 98% Palmer amaranth control at 4 wk after V3, and 98% and 94% Palmer amaranth control at harvest, respectively. Palmer amaranth biomass was reduced by 95% to 99% and by 96% to 98% compared with the -nontreated control when dimethenamid-P was applied POST at V1 and V3, respectively, following a PRE application of pendimethalin + dimethenamid-P in 2020 and 2021. Application of a mixture of dimethenamid-P with imazamox + bentazon POST provided similar results to those of the fomesafen-containing treatments and dimethenamid-P alone POST. Dimethenamid-P applied POST following a PRE application of pendimethalin + dimethenamid-P resulted in similar yield as the fomesafen-containing treatments. If fomesafen is not an option due to the crop rotation interval restriction, using dimethenamid-P in a sequential PRE fb POST program is the only effective alternative to control ALS-inhibitor–resistant Palmer amaranth in Nebraska. The use of dimethenamid-P in a sequential PRE fb POST program, alone or mixed with foliar-active herbicides should be considered by dry edible bean growers who are dealing with ALS-inhibitor-resistant Palmer amaranth.

Although Palmer amaranth is currently not widespread in most dry edible bean−producing states in the United States, it is widespread in western Nebraska, a major dry edible bean−producing region. There is currently a lack of research on management and biology of Palmer amaranth within dry edible bean production. The objective of this study was to quantify the impact of season-long Palmer amaranth interference on yield of dry edible bean and seed production of Palmer amaranth. A field study was conducted in Scottsbluff, NE, in 2020 and 2021. Palmer amaranth interference at densities of 0, 0.2, 0.3, 0.5, 1, and 2 plants m−1 row of dry edible bean was evaluated. Palmer amaranth interference reduced dry edible bean yield by 77% at a weed density of 2 plants m−1 row compared to the weed-free control, and a 5% yield reduction threshold was estimated to occur at a Palmer amaranth density of 0.02 plants m−1 row. Yield reduction occurred primarily through a reduction in the number of pods per plant as Palmer amaranth density increased. Palmer amaranth plants produced 91,000 to 376,000 seeds per plant depending on densities, and as many as 140,000 seeds m−2. Study results will help farmers and other stakeholders estimate Palmer amaranth interference within their fields, and may help justify the economic cost of incorporating additional Palmer amaranth management practices.

The critical timing of weed removal (CTWR) is the point in crop development when weed control must be initiated to prevent crop yield loss due to weed competition. A field study was conducted in 2018 and 2020 near Scottsbluff, NE, to determine how the use of preemergence herbicides affects the CTWR in dry bean. The experiment was arranged as a split plot, with herbicide treatment and weed removal timing as main and sub-plot factors, respectively. Herbicide treatments consisted of no-preemergence application, or pendimethalin (1,070 g ai ha–1) + dimethenamid-P (790 g ai ha–1) applied preemergence. Sub-plot treatments included season-long weed-free, weed removal at: V1, V3, V6, R2, and R5 dry bean growth stages, and a season-long weedy control. A four-parameter logistic model was used to estimate the impact of time of weed removal, for all response variables including dry bean yield, dry bean plants m–1 row, number of pods per plant, number of seeds per pod, and seed weight. The CTWR based on 5% yield reduction was estimated to range from the V1 growth stage [(16 d after emergence (DAE)] to the R1 growth stage (39 DAE) in the no-preemergence herbicide treatment. In the preemergence-applied treatment, the CTWR began at the R2 growth stage (47 DAE). Number of dry bean plants m–1 row was reduced in the no-preemergence treatment when weed removal was delayed beyond the R2 growth stage in the 2020 field season. The use of preemergence herbicides prevented a reduction in the number of pods per plant in 2020, and the number of seeds per pod in 2018 and 2020. In 2018, the number of pods per plant was reduced by 73% when no preemergence herbicide was applied, compared to 26% in the preemergence-applied treatment. The use of preemergence-applied soil-active herbicides in dry bean delayed the CTWR and preserved yield potential.

Late-emerging summer annual weeds are difficult to control in dry bean production fields. Dry bean is a poor competitor with weeds, due to its slow rate of growth and delayed canopy formation. Palmer amaranth is particularly difficult to control due to season-long emergence and resistance to acetolactate synthase (ALS)-inhibiting herbicides. Dry bean growers rely on PPI and preemergence residual herbicides for the foundation of their weed control programs; however, postemergence herbicides are often needed for season-long weed control. The objective of this experiment was to evaluate effect of planting date and herbicide program on late-season weed control in dry bean in western Nebraska. Field experiments were conducted in 2017 and 2018 near Scottsbluff, NE. The experiment was arranged in a split-plot design, with planting date and herbicide program as main-plot and subplot factors, respectively. Delayed planting was represented by a delay of 15 d after standard planting time. The treatments EPTC + ethalfluralin, EPTC + ethalfluralin followed by (fb) imazamox + bentazon, and pendimethalin + dimethenamid-P fb imazamox + bentazon, resulted in the lowest Palmer amaranth density at 3 wk after treatment and the highest dry bean yield. The imazamox + bentazon treatment provided poor Palmer amaranth control and did not consistently result in Palmer amaranth density and biomass reduction compared with the nontreated control. In 2018, the delayed planting treatment had reduced Palmer amaranth biomass with the pendimethalin + dimethenamid-P treatment, as compared with standard planting. Delaying planting did not reduce dry bean yield and had limited benefit in improving weed control in dry bean.