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The Intergovernmental Negotiating Committee (INC) on plastic pollution are United Nations member states who will convene for the second part of the fifth session of the Intergovernmental Negotiating Committee in Geneva (INC5.2) 5-14 August, 2025 to negotiate a global plastics treaty. The Scientists’ Coalition for an Effective Plastics Treaty (‘The Scientists’ Coalition’) is an international network of independent scientific and technical experts who have been contributing robust science to treaty negotiators since INC1 in 2022. The Scientists’ Coalition established a series of working groups following INC5.1 in Busan, Korea 25 November – 1 December 2024. Each working group has produced science-based responses to the selected articles of ‘the Chair’s text’ (the latest version of the draft global plastics treaty text). This Letter to the Editor summarises those responses.
Expanding crop diversity is essential to address the imminent challenges of agriculture. This is especially true for organic farming, which relies on locally adapted species and varieties. Recently, participatory research approaches have emerged as effective means to support this endeavour. In this study, we collaborated with several stakeholders in the Lyon region, France, to evaluate three minor species related to common wheat (Triticum aestivum subsp. aestivum): einkorn (Triticum monococcum subsp. monococcum), emmer (Triticum turgidum subsp. dicoccum) and spelt (Triticum aestivum subsp. spelta (L.) Thell). First, we assessed the agronomic characteristics of each species, highlighting a distinction of einkorn that was associated with high tillering, high protein content, a long phenological cycle, small kernels and low relative yields. Second, we compared intra-species variabilities, revealing greater variation in emmer and spelt. Lastly, outcomes of the participatory approach, including testing adaptive methods and fostering collective learning, may interest other participatory research groups.
The determinants of door-in-door-out metrics (DIDO) at centers referring acute ischemic stroke patients for endovascular thrombectomy (EVT) and the impact of DIDO on functional outcomes are unclear. Our primary objective was to study the association between DIDO and 90-day functional outcomes. Our secondary objective was to investigate the associations between patient clinical and workflow characteristics and DIDO.
Methods:
We conducted a province-wide multicentric retrospective cohort study in Québec, Canada, of adults with acute ischemic stroke who were transferred from a primary stroke center (PSC) to a comprehensive stroke center for EVT between 2017 and 2020. DIDO was calculated as the time spent in the PSC emergency department. Our co-primary outcomes, assessed 90 days after stroke, were a favorable functional outcome (modified Rankin score of 0–2) and death. We estimated associations between DIDO and co-primary outcomes and between patient characteristics and DIDO using logistic mixed models.
Results:
Among 790 included patients, the mean age was 69 (+/–14) years, and 400 (51%) were female. The median DIDO was 102 (80–135) minutes. DIDO was not associated with 90-day favorable functional outcome (aOR: 1.00, 95% CI [0.99–1.00], p = 0.54) or death (aOR: 1.00, 95% CI [0.99–1.01], p = 0.69). Arrival at the PSC outside daytime hours (aOR: 3.28, 95% CI [1.26–8.51], p = 0.01) was significantly associated with DIDO ≥ 60 minutes.
Conclusions:
Although DIDO are long in Québec, they are not associated with 90-day functional outcomes or mortality among patients transferred for EVT. Further research is required to develop strategies to improve modifiable determinants of DIDO, including workflow outside of daytime hours.
In Europe, organic food must comply with specific regulations which do not include nutritional criteria. The ability of organic food to meet the nutritional needs of children is not assessed. This narrative review discusses the nutritional composition (macronutrients, micronutrients) of organic food compared with conventional products and its clinical relevance with a paediatric focus, as well as the health impact of these differences and of contaminants which interfere with metabolism. Other potential differences, particularly regarding the direct/indirect exposure to other contaminants in conventional food, are not addressed in this review. The composition of some organic food may differ from conventional food. Protein content was lower in cereals and eggs. A lower n-6:n-3 polyunsaturated fat (PUFA) ratio was observed in milk, meat and eggs. Long-chain PUFA and vitamin E may be higher in milk, meat and fish, as well as some minerals and antioxidants (phenolic compounds, vitamin C) in fruits, vegetables and starchy food and carotenoids in fruits and vegetables. Epidemiological studies suggest an association between organic diets and lower prevalence of childhood obesity, type 2 diabetes and metabolic syndrome, whereas the protective effect on allergy and cancer is controversial. Some organic food may be of greater nutritional interest for children’s diet than conventional food. Standardised studies comparing food composition and diet in children are needed. Considering the lower toxicologic risk and the sustainability of organic food, the Committee on Nutrition encourages the use of organic food, provided that such food is affordable, alongside specific baby food which is subject to strict specific European Union regulations.
In many technical and geomechanics applications, for example tire and ski design or avalanche prediction, the capability to model the mechanical behaviour of snow is of high importance. To this end, we propose in the present study to extend the 3-D H-model, a multi-scale constitutive law originally developed for granular materials, to densely packed snow. In the model, single ice grains are described by spherical particles bonded by brittle elasto-viscoplastic bridges. Snow is thus described explicitly through its ice skeleton microstructure. As a validation, confined compression test results from the litterature are used to assess the suitability of the model to correctly describe snow behaviour. Multiple parameter studies were conducted to demonstrate the capability of the model to capture the behaviour of different snow types over a significant range of temperatures and loading rates at small deformations. Notably, the initial bond radius emerges as an effective proxy for snow aging under isothermal conditions, with stress levels increasing directly with the initial bond radius. Additionally, low strain rates and elevated temperatures are shown to influence the viscous response of ice bonds, their failure rates and the overall stress within the snow material.
Prolonged grief is a chronic and debilitating condition that affects millions of persons worldwide. The aim of this study was to use a qualitative approach to better understand how relatives with prolonged grief disorder perceive what does or not help them and whether they were able to make recommendations.
Methods
Participants were all relatives of deceased patients admitted to 26 palliative care units involved in the FamiLife study; relatives were included if diagnosed with prolonged grief symptoms (i.e., Inventory Complicated Grief (ICG) questionnaire with a cut-off >25), and volunteered to participate. Semi-directed telephone interviews were conducted by psychologists between 6 and 12 months after the patient’s death. The interviews were open-ended, without a pre-established grid, then transcribed and analyzed using a thematic approach.
Results
Overall, 199/608 (32.7%) relatives were diagnosed with prolonged grief symptoms, i.e., with an ICG score >25, and 39/199 (20%) agreed to be interviewed. The analysis yielded 4 themes: (1) the experience of mourning: intense sadness and guilt (reported by 35/39 participants, 90%); (2) aggravating factors (38/39, 97%): feeling unprepared for death and loneliness, presence of interpersonal barriers to adjustment, external elements hindering the mourning progress; (3) facilitating factors (39/39, 100%): having inner strength or forcing oneself to get better, availability of social and emotional support; and (4) the suggestions grieving relatives had to alleviate the grief burden (36/39, 92%). The analysis enabled to identify 5 suggestions for relieving the grief burden: improving communication, developing education about death and grief, maintaining contact, offering psychological support, and choosing the right time for the palliative care team to contact the relatives.
Conclusions
This study revealed how bereaved relatives experienced the help provided by the healthcare teams, their representations, and what could be improved. These findings could be used to design intervention studies.
Diagnosis of acute ischemia typically relies on evidence of ischemic lesions on magnetic resonance imaging (MRI), a limited diagnostic resource. We aimed to determine associations of clinical variables and acute infarcts on MRI in patients with suspected low-risk transient ischemic attack (TIA) and minor stroke and to assess their predictive ability.
Methods:
We conducted a post-hoc analysis of the Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) study, a prospective, multicenter cohort study investigating the frequency of acute infarcts in patients with low-risk neurological symptoms. Primary outcome parameter was defined as diffusion-weighted imaging (DWI)-positive lesions on MRI. Logistic regression analysis was performed to evaluate associations of clinical characteristics with MRI-DWI-positivity. Model performance was evaluated by Harrel’s c-statistic.
Results:
In 1028 patients, age (Odds Ratio (OR) 1.03, 95% Confidence Interval (CI) 1.01–1.05), motor (OR 2.18, 95%CI 1.27–3.65) or speech symptoms (OR 2.53, 95%CI 1.28–4.80), and no previous identical event (OR 1.75, 95%CI 1.07–2.99) were positively associated with MRI-DWI-positivity. Female sex (OR 0.47, 95%CI 0.32–0.68), dizziness and gait instability (OR 0.34, 95%CI 0.14–0.69), normal exam (OR 0.55, 95%CI 0.35–0.85) and resolved symptoms (OR 0.49, 95%CI 0.30–0.78) were negatively associated. Symptom duration and any additional symptoms/symptom combinations were not associated. Predictive ability of the model was moderate (c-statistic 0.72, 95%CI 0.69–0.77).
Conclusion:
Detailed clinical information is helpful in assessing the risk of ischemia in patients with low-risk neurological events, but a predictive model had only moderate discriminative ability. Patients with clinically suspected low-risk TIA or minor stroke require MRI to confirm the diagnosis of cerebral ischemia.
Fall-sown cereal rye has gained popularity as a cover crop in vegetable production due to its weed-suppressive capabilities. However, previous research has shown that replacing preemergence and/or postemergence herbicide applications with roller-crimped rye has variable success at controlling weeds and maintaining vegetable cash crop yields. The objective of this research was to determine whether roller-crimped rye can provide season-long weed control and maintain sweet corn yield. Two rye cultivars (early vs. standard maturity) were compared at three seeding rates (150, 300, and 600 seeds m−2) for their effect on weed control and sweet corn yield. The trial was conducted at three locations: Harrow, ON, and St. Jean-sur-Richelieu, QC, from 2019 to 2021; and Agassiz, BC, in 2019 and 2021. Results suggest that although the early-maturing cultivar allowed for earlier roller crimping in some locations, it was inferior at weed control and resulted in lower sweet corn yield than local standard cultivars. The average rye biomass was lower than the current literature recommendations, and the resulting level of weed control was not high enough to prevent sweet corn yield loss in cover crop treatments. Weed control provided by roller-crimped rye peaked between crimping and 8 wk after crimping and was highest in the standard cultivars sown at 300 and 600 seeds m−2. Preliminary testing of supplemental postemergence weed control showed evidence for sweet corn yields comparable to the weed-free no-cover crop check. However, more research is needed. Overall, with the cultivars and seeding rates tested, roller-crimped rye is not a suitable stand-alone weed control option in sweet corn production. Given the benefits of cover crops, further research should evaluate its potential as a component of an integrated weed management program.
In February, the emergence of COronaVIrus Disease 2019 (COVID - 19) in France made it necessary to rapidly adapt emergency and SAMU services in order to take care of many infected patients. To respond to the increase in the number of calls in the dispatch centers, reinforcements were necessary on the fronts of the Medical Regulation Assistants (ARM). The aim of this study was to assess the relevance of medical students’ responses to first calls exclusively concerning COVID-19.
Methods:
This prospective, observational cohort study was carried out at the University Hospital Centre (CHU) in Angers. Twenty medical students mostly in the 5th year were voluntarily enrolled in the first line COVID-19 call taker team. Calls on the 1st, 3rd, and 5th starting day for each medical student, and randomly selected calls from the experienced first-line call taker were listened to by a medical expert to assess the adequate level of prioritization and orientation (emergency physician or general practitioner). The percentage of agreement between the expert, students, and experienced first-line call handlers were assessed. All participants gave their free consent to participate. The study was approved by the Ethics Committee of Angers (N° 2020-48).
Results:
From March 18 to April 23, 2020, 302 calls from medical students (n = 20 students) and 40 calls from experienced first-line call handlers were analyzed. The average prioritization agreement rate between the expert and students was 76.16% (95% Confidence Interval: 71.04 to 80.62%) (n = 230/302) compared to 87.50% (95% CI: 73.9 to 94.5%) (n = 45/50) for the experienced first-line call handlers (P = 0.15). Medical students took more time per call with an absolute difference of 2 minutes 16 seconds (P < 0.001).
Conclusion:
The lessons to be observed from this COVID-19 crisis are that in the early days of increasing calls heralding a strain on the healthcare system, support by medical students must be considered.
We analytically derive an amplitude equation for the weakly nonlinear evolution of the linearly most amplified response of a non-normal dynamical system. The development generalizes the method proposed in Ducimetière et al. (J. Fluid Mech., vol. 947, 2022, A43), in that the base flow now arbitrarily depends on time, and the operator exponential formalism for the evolution of the perturbation is not used. Applied to the two-dimensional Lamb–Oseen vortex, the amplitude equation successfully predicts the nonlinearities to weaken or reinforce the transient gain in the weakly nonlinear regime. In particular, the minimum amplitude of the linear optimal initial perturbation required for the amplitude equation to lose a solution, interpreted as the flow experiencing a bypass (subcritical) transition, is found to decay as a power law with the Reynolds number. Although with a different exponent, this is recovered in direct numerical simulations, showing a transition towards a tripolar state. The simplicity of the amplitude equation and the link made with the sensitivity formula permits a physical interpretation of nonlinear effects, in light of existing work on Landau damping and on shear instabilities. The amplitude equation also quantifies the respective contributions of the second harmonic and the spatial mean flow distortion in the nonlinear modification of the gain.
During industrial processing, heat treatments applied to infant formulas may affect protein digestion. Recently, innovative processing routes have been developed to produce minimally heat-processed infant formula. Our objective was to compare the in vivo protein digestion kinetics and protein quality of a minimally processed (T−) and a heat-treated (T+++) infant formula. Sixty-eight male Wistar rats (21 d) were fed with either a diet containing 40 % T− (n 30) or T+++ (n 30), or a milk protein control diet (n 8) during 2 weeks. T− and T+++ rats were then sequentially euthanised 0, 1, 2, 3 or 6 h (n 6/time point) after ingestion of a meal containing their experimental diet. Control rats were euthanised 6 h after ingestion of a protein-free meal to determine nitrogen and amino acid endogenous losses. Nitrogen and amino acid true caecal digestibility was high for both T− and T+++ diets (> 90 %), but a tendency towards higher nitrogen digestibility was observed for the T− diet (96·6 ± 3·1 %) compared with the T+++ diet (91·9 ± 5·4 %, P = 0·0891). This slightly increased digestibility led to a greater increase in total amino acid concentration in plasma after ingestion of the T− diet (P = 0·0010). Comparable protein quality between the two infant formulas was found with a digestible indispensable amino acid score of 0·8. In conclusion, this study showed that minimal processing routes to produce native infant formula do not modify protein quality but tend to enhance its true nitrogen digestibility and increase postprandial plasma amino acid kinetics in rats.
The seedcorn maggot, Delia platura (Meigen) (Diptera: Anthomyiidae), is reported as a polyphagous pest species found in numerous crops, including onion, corn, crucifers, and soy. Two morphologically identical genetic lines of D. platura (H- and N-lines) with distinct distribution ranges were recently discovered. Although many biological traits have been described for D. platura, no study to date has been conducted on the life history strategies and reproductive behaviours of its two lines. Using laboratory-reared colonies, this project investigates the effect of group composition (sex ratio and density) on the mating success and preoviposition period of the two D. platura lines. We found a substantial increase in mating success with increasing proportion of males within mating groups for both lines, whereas we found group density had negligible effects. However, the H-line had a lower average mating probability across treatments compared to the N-line. The preoviposition period decreased as the ratio of males to female increased at low density only for the N-line, and the opposite trend was observed at high density for both lines. These results suggest differences between the mating systems of these two lines, thereby highlighting the need for further research into the factors that influence their respective mating systems.
In this paper, we construct an accurate linear model describing the propagation of both acoustic and gravity waves in water. This original model is obtained by the linearization of the compressible Euler equations, written in Lagrangian coordinates. The system is studied in the isentropic case, with a free surface, an arbitrary bathymetry, and vertical variations of the background temperature and density. We show that our model is an extension of some models from the literature to the case of a non-barotropic fluid with a variable sound speed. Other models from the literature are recovered from our model through two asymptotic analyses, one for the incompressible regime and one for the acoustic regime. We also propose a method to write the model in Eulerian coordinates. Our model includes many physical properties, such as the existence of internal gravity waves or the variation of the sound speed with depth.
The Laboratoire des Sciences du Climat et de l’Environnement (LSCE) has operated a radiocarbon dating laboratory for almost 70 years. It has evolved from a traditional ß-decay counting to an accelerator mass spectrometry facility. In 2015, the LSCE received a major upgrade with the installation of a MICADAS. This evolution required adjustments in sample preparation to match the new capability to date samples as small as a few tens of µgC. We summarize here the sample cleaning procedures and the chemical purification or extraction treatment that we apply to the samples. We also report values of blank and reference materials of different matrices that match the large diversity of samples handled at LSCE.
We present new data from the debris-rich basal ice layers of the NEEM ice core (NW Greenland). Using mineralogical observations, SEM imagery, geochemical data from silicates (meteoric 10Be, εNd, 87Sr/86Sr) and organic material (C/N, δ13C), we characterize the source material, succession of previous glaciations and deglaciations and the paleoecological conditions during ice-free episodes. Meteoric 10Be data and grain features indicate that the ice sheet interacted with paleosols and eroded fresh bedrock, leading to mixing in these debris-rich ice layers. Our analysis also identifies four successive stages in NW Greenland: (1) initial preglacial conditions, (2) glacial advance 1, (3) glacial retreat and interglacial conditions and (4) glacial advance 2 (current ice-sheet development). C/N and δ13C data suggest that deglacial environments favored the development of tundra and taiga ecosystems. These two successive glacial fluctuations observed at NEEM are consistent with those identified from the Camp Century core basal sediments over the last 3 Ma. Further inland, GRIP and GISP2 summit sites have remained glaciated more continuously than the western margin, with less intense ice-substratum interactions than those observed at NEEM.
The so-called coffee stain effect has been intensively studied over the past decades, but most of the studies have focused on sessile droplets. In this paper, we analyse the origin of the difference between the deposition of suspended particles in a sessile drop and in an axisymmetric drop deposited on a fibre. First, we model the shape of a drop on a fibre and its evaporative flux with some approximations to derive analytical calculations. Then, for pinned contact lines, we solve the hydrodynamics equations in the liquid phase under the lubrication approximation to determine the flow velocity toward the contact lines. We comment on these results by comparison to a sessile drop of similar evaporating conditions, and we show that the substrate curvature plays a role on the contact line depinning, the local evaporative flux and the liquid flow field. The competition between the advection and the Brownian motion indicates that the transport of the particles toward the contact line occurs in a volume localised in the close vicinity of the contact lines for a drop on a fibre. Thus, the fibre geometry induces a weaker accumulation of particles at the contact line compared to a sessile drop, leading to the more homogeneous deposit observed experimentally.
We consider nonlinear dynamical systems driven by stochastic forcing. It has been largely evidenced in the literature that the linear response of non-normal systems (e.g. fluid flows) may exhibit a large variance amplification, even in a linearly stable regime. This linear response, however, is relevant only in the limit of vanishing forcing intensity. As the intensity increases, the frequency distribution and the variance of the response may be strongly modified due to nonlinear effects. To go beyond this limitation, we propose a theoretical approach to derive an amplitude equation governing the weakly nonlinear evolution of these systems. This approach does not rely on the presence of an eigenvalue close to the neutral axis, applying instead to any sufficiently non-normal operator, and the Fourier components of the response are allowed to be arbitrarily different from any eigenmode. The methodology is outlined for a generic nonlinear dynamical system, and the application case highlights a common non-normal mechanism in hydrodynamics: convective non-normal amplification in the flow past a backward-facing step.
This special issue of the German Law Journal showcases through concrete examples the conceptual and methodological toolbox that social anthropology has to offer and the added value of applying an anthropologically informed approach to legal thinking, argumentation, and practice. The contributions address a wide variety of highly topical, controversial social issues that are at the heart of the human condition, including gender recognition for non-binary people, family disputes brought before international courts, non-majoritarian language use in administrative settings, forced migration, and the impact of climate change and infrastructural development on local communities worldwide. This introduction outlines the research program into which the contributions gathered here fit; the choice of topics; and finally, the challenges the authors face in the process of integrating their intellectual encounter with anthropology into their reflections on law. The article concludes that taking recourse to anthropology can help jurists trained in state law to develop a more refined understanding of today’s societal complexity and challenges and, ultimately, to reach more nuanced, sensitive, and just decisions.
We propose a theoretical approach to derive amplitude equations governing the weakly nonlinear evolution of non-normal dynamical systems, when they experience transient growth or respond to harmonic forcing. This approach reconciles the non-modal nature of these growth mechanisms and the need for a centre manifold to project the leading-order dynamics. Under the hypothesis of strong non-normality, we take advantage of the fact that small operator perturbations suffice to make the inverse resolvent and the inverse propagator singular, which we encompass in a multiple-scale asymptotic expansion. The methodology is outlined for a generic nonlinear dynamical system, and four application cases highlight common non-normal mechanisms in hydrodynamics: the streamwise convective non-normal amplification in the flow past a backward-facing step, and the Orr and lift-up mechanisms in the plane Poiseuille flow.
In this chapter, we explore the patterns of nonhuman primate exploitation in Early to Mid-Holocene East Java by looking at the faunal assemblage recovered from excavations in Braholo Cave. Cercopithecid specimens account for more than 50% of the animal remains recovered from the site. Of these, 90% were identified to represent the Javan langur (Trachypithecus auratus), suggesting deliberate hunting of this arboreal species. Age-at-death profiles demonstrate targeting of prime-aged adults and skeletal element representation suggests onsite carcass processing. We observed consistent placement of butchery marks on specific skeletal elements, indicative of routine carcass processing that also involved preparation of skeletal elements for bone tool manufacture. We discuss our findings in the framework of early hunter-gatherer subsistence economies in the region.
Keywords
Human–Nonhuman primate interactions, Holocene, Subsistence economy, Southeast Asia, Indonesia, Java