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This study investigates the formation and evolution of fishbone patterns in oblique impinging liquid microjets through high-speed imaging experiments and numerical simulations. The results identify periodic oscillations in the upper region of the liquid sheet as the primary mechanism driving fishbone instabilities, which induce rim disturbances and lead to bifurcations into diverse fishbone morphologies. Transitions between stable and unstable flow patterns are systematically mapped across varying Weber numbers and impingement angles, providing a comprehensive framework for understanding this interfacial dynamics. Two critical transitions – marking the onset and disappearance of fishbone patterns – are characterised, offering insights into the underlying physics governing the stability and instability of these flow structures.
A dual-band dual-polarized wearable antenna that applies to two different operating modes of wireless body area networks is proposed in this letter. The antenna radiates simultaneously in the ISM band at 2.45 and 5.8 GHz. It consists of a rigid button-like radiator and a flexible fabric radiator. At 2.45 GHz, an omnidirectional circularly polarized pattern is radiated by the flexible radiator, which is suitable for the on-body communication. At the same time, a linearly polarized broadside pattern for off-body communication is generated by button radiator at 5.8 GHz. The antenna has been validated in free space and human body environments. The impedance bandwidth at 2.45 and 5.8 GHz are 5% and 35%, and the gain is measured to be 0.15 and 5.95 dBi, respectively. Furthermore, the specific absorption rates are simulated. At 2.45 and 5.8 GHz, the results averaged over 1 g of body tissue are 0.128 and 0.055 W/kg. The maximum value at both bands is below the IEEE C95.3 standard of 1.6 W/kg.
Over-expansion flow can generate asymmetric shock wave interactions, which lead to significant lateral forces on a nozzle. However, there is still a lack of a suitable theory to explain the phenomenon of asymmetry. The current work carefully investigates the configurations of shock wave interactions in a planar nozzle, and proposes a theoretical method to analyse the asymmetry of over-expansion flows. First, various possible flow patterns of over-expansion flows are discussed, including regular and Mach reflections. Second, the free interaction theory and the minimum entropy production principle are used to analyse the boundary layer flow and main shock wave interactions, establish the relationship between the separation shock strength and separation position, and predict asymmetric configurations. Finally, experiments are conducted to validate the theoretical method, and similar experiments from other studies are discussed to demonstrate the effectiveness of the proposed method. Results demonstrate that the direction of asymmetric over-expansion flow is random, and the separated flow strives to adopt a pattern with minimal total pressure loss. Asymmetric interaction is a mechanism through which the flow can achieve a more efficient thermodynamic balance by minimising entropy production.
Automatic visual localization of electric vehicle (EV) charging ports presents significant challenges in uncertain environments, such as varying surface textures, reflections, lighting and observation distance. Existing methods require extensive real-world training data and well-focused images to achieve robust and accurate localization. However, both requirements are difficult to meet under variable and unpredictable conditions. This paper proposes a 2-stage vision-based localization approach. Firstly, the image synthesis technique is used to reduce the cost of real-world data collection. A task-oriented parameterization protocol (TOPP) is proposed to optimize the quality of the synthetic images. Secondly, an autofocus and servoing strategy is proposed. A hybrid detector is employed to enhance sharpness assessment performance, while a visual servoing method based on single exponential smoothing (SES) is developed to enhance stability and efficiency during the search process. Experiments were conducted to evaluate image synthesis efficiency, detection accuracy, and servoing performance. The proposed method achieved 99% detection accuracy on the real-world port images, and guided the robot to the optimal imaging position within 16 s, outperforming comparable approaches. These results highlight its potential for robust automated charging in real-world scenarios.
Human milk oligosaccharides offer unique benefits for infant growth and development. Buffalo milk, characterized by a mild flavor and high nutritional value, has attracted considerable interest. To characterize the oligosaccharide profile and composition of buffalo milk, we conducted qualitative and quantitative analysis of milk oligosaccharides at the early- and late-lactation stages of crossbred (Nili-Ravi × Murrah × local) buffaloes from Guangxi, China. The results revealed a total of 97 oligosaccharides including 17 novel oligosaccharides, with concentrations of 416.6 ± 25.86 and 368.3 ± 10.29 mg/L in milk from early- and late-lactation stages, respectively. The most abundant oligosaccharides were 3’-sialyllactose (3’-SL), difucosyllactose (DFL), 6’-sialyllactose (6’-SL), and a newly discovered compound, 2142. The oligosaccharides in crossbred (Nili-Ravi × Murrah × local) buffaloes demonstrated greater diversity than those found in the milk of other dairy animals, highlighting its potential as a high-quality nutritional resource for adults and infants.
This study presents an experimental investigation on the drag reduction (DR) over air-fed hydrophobic surfaces (AFHS) with longitudinal grooves in a turbulent boundary layer (TBL). The AFHS, designed with longitudinal grooves and air supplement channels, enables active maintenance and reversible restoration of the plastron in TBL. The shear stress sensor, particle image velocimetry (PIV) and interfacial visualization are applied for simultaneous measurement of the skin friction drag, TBL velocity profiles and plastron coverage. The AFHS demonstrated the ability to control plastron shape and enhance its sustainability with friction Reynolds numbers up to 1723. Drag reductions ranging from 14.8–35.8 % are obtained over the AFHS. At same designed air fraction, the AFHS exhibits higher DR than the conventional hydrophobic surface. By minimizing influences of the degradation of plastron coverage and the shape, the monotonic increase in DR and slip velocity with Reynolds number is confirmed, which corroborates trends from direct numerical simulations. Turbulence statistics measured by PIV reveal an apparent decrease in near-wall viscous shear stress, and corresponding slip velocities both in the viscous sublayer and log-law region. The Reynolds shear stress and streamwise velocity fluctuations over the AFHS are larger than those over a smooth wall, where near-wall vortex cores of the AFHS are found to be shifted 10 % towards the wall. This study presents the first simultaneous experimental quantification of skin friction, plastron coverage and turbulence statistics under sustained plastron conditions in TBL. The results demonstrate the efficacy of the plastron control strategy on hydrophobic surfaces and address a critical gap in validating numerical predictions for turbulent flows in practical applications.
Cardiac complications after haematopoietic cell transplantation in paediatric patients are significant yet under-recognised. Pericardial effusion has been associated with worse outcomes and transplant-related mortality.
Objectives:
We aimed to evaluate the incidence, risk factors, and clinical course of pericardial effusion after paediatric allogeneic haematopoietic cell transplantation. We identified transplantation recipients “at risk” for clinically significant pericardial effusion based on our definition, described our clinical experience and provided recommendations for screening and management.
Study Design:
Clinical data of children who underwent allogeneic haematopoietic cell transplantation at Texas Children’s Hospital from January 2010 to April 2021 were analyzed retrospectively. Factors potentially contributing to time to pericardial effusion, time to pericardial effusion resolution, and overall survival were evaluated.
Results:
We included 629 haematopoietic cell transplantation recipients with a median age at transplantation of 8.5 years (0.1–24.3). Seventy-three patients (11.6%) developed pericardial effusion within a median time of 102 days (1–403) post-haematopoietic cell transplantation, and 50 (68.5%) had resolution of pericardial effusion at the time of last evaluation. Older age at the time of haematopoietic cell transplantation, transplant-associated thrombotic microangiopathy, and cytomegalovirus diagnoses independently increased the risk of pericardial effusion development, while cytomegalovirus diagnosis decreased the likelihood of pericardial effusion resolution. Both non-significant pericardial effusion development and clinically significant effusion development were significantly associated with post-haematopoietic cell transplantation mortality, compared to no pericardial effusion development.
Conclusions:
Paediatric haematopoietic cell transplantation recipients with malignant diseases, older age at the time of transplantation, cytomegalovirus infection, or transplant-associated thrombotic microangiopathy are at higher risk for pericardial effusion development, which in turn predicts worse outcomes with increased risk of death. We propose a model for improved detection, evaluation, and management of pericardial effusion post-haematopoietic cell transplantation.
This study aimed to examine the relationship between FGF19 and depressive symptoms, measured by BDI scores and investigate the moderating role of smoking.
Methods:
This study involved 156 Chinese adult males (78 smokers and 78 non-smokers) from September 2014 to January 2016. The severity of depressive symptoms was evaluated using the BDI scores. Spearman rank correlation analyses were used to investigate the relationship between CSF FGF19 levels and BDI scores. Additionally, moderation and simple slope analyses were applied to assess the moderating effect of smoking on the relationship between the two.
Results:
FGF19 levels were significantly associated with BDI scores across all participants (r = 0.26, p < 0.001). Smokers had higher CSF FGF19 levels and BDI scores compared to non-smokers (445.9 ± 272.7 pg/ml vs 229.6 ± 162.7 pg/ml, p < 0.001; 2.7 ± 3.0 vs 1.3 ± 2.4, p < 0.001). CSF FGF19 levels were positively associated with BDI scores in non-smokers (r = 0.27, p = 0.015), but no similar association was found among smokers (r = -0.11, p = 0.32). Linear regression revealed a positive correlation between FGF19 and BDI scores (β = 0.173, t = 2.161, 95% CI: 0.015- 0.331, p < 0.05), which was negatively impacted by smoking (β = -0.873, t = -4.644, 95% CI: -1.244 to -0.501, p < 0.001).
Conclusion:
These results highlight the potential role of FGF19 in individuals at risk for presence of or further development of depressive symptoms and underscore the importance of considering smoking status when examining this association.
Glyphosate, the most prevalent pesticide and widely used herbicide globally, has seen much research on its potential ecological toxicity. Glyphosate-based herbicide (GBH) is directly sprayed in the field, exposing predators to the chemical through contaminated prey or direct contact. While the consequences of ingesting glyphosate have been explored, the specific impact of GBH spraying on Chrysopa pallens (Neuroptera: Chrysopidae) remains unclear. In this study, life tables were constructed to evaluate the potential effects of different stages of exposure to GBH on both the parents (F0) and offspring (F1) of C. pallens, and the expression of genes related to the insulin signalling pathway and vitellogenin (Vg1) was detected by reverse transcription-quantitative polymerase chain reaction. The results revealed that medium (10 mL/L) and high (20 mL/L) concentrations of GBH adversely affected the development and longevity of the F0 and F1 generation of C. pallens larvae. Notably, high concentrations of GBH significantly reduced the fecundity of the F0 and suppressed Vg1 transcription at both medium and high concentrations. While GBH treatment of C. pallens adults showed no harmful effects on the longevity, fecundity, population parameters, and the transcription levels of genes involved in insulin signalling and Vg1 in the F0. Nevertheless, it altered the developmental duration of the F1. Therefore, spraying GBH may lead to reduced fecundity and inhibit the Vg1 transcription, posing potential risks to both parental and offspring generations of C. pallens. These findings offer valuable insights into the proper utilisation of GBH.
The extracellular matrices, such as the haemolymph, in insects are at the centre of most physiological processes and are protected from oxidative stress by the extracellular antioxidant enzymes. In this study, we identified two secreted superoxide dismutase genes (PxSOD3 and PxSOD5) and investigated the oxidative stress induced by chlorpyrifos (CPF) in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae). PxSOD3 and PxSOD5 contain the signal peptides at the N-terminus. Structure analysis revealed that PxSOD3 and PxSOD5 contain the conserved CuZn-SOD domain, which is mainly composed of β-sheets and has conserved copper and zinc binding sites. Both PxSOD3 and PxSOD5 are predicted to be soluble proteins located in the extracellular space. After exposure to different concentrations of sublethal CPF, MDA content in P. xanthodes larvae were increased in a dose-dependent manner; SOD and CAT activities were also higher in CPF-treated groups than that in the no CPF control, indicating that sublethal CPF induces oxidative stress in P. xanthodes larvae. Furthermore, PxSOD3 and PxSOD5 expression levels and haemolymph SOD activity in the larvae were downregulated by sublethal CPF at different concentrations. Our results suggest that the PxSOD3 and PxSOD5 are putative extracellular antioxidant enzymes that may play a role in maintaining the oxidative balance in the extracellular space. Sublethal CPF may induce oxidative stress in the extracellular space of P. xanthodes by reducing the gene expression and catalytic activity of extracellular SODs.
Ultra-thin liquid sheets generated by impinging two liquid jets are crucial high-repetition-rate targets for laser ion acceleration and ultra-fast physics, and serve widely as barrier-free samples for structural biochemistry. The impact of liquid viscosity on sheet thickness should be comprehended fully to exploit its potential. Here, we demonstrate experimentally that viscosity significantly influences thickness distribution, while surface tension primarily governs shape. We propose a thickness model based on momentum exchange and mass transport within the radial flow, which agrees well with the experiments. These results provide deeper insights into the behaviour of liquid sheets and enable accurate thickness control for various applications, including atomization nozzles and laser-driven particle sources.
In this article, we take the charitable activities of the Shaolin Temple as a case study for our analysis of the Chinese Communist Party’s (CCP) management of religion under Xi Jinping. Our fieldwork and in-depth interviews reveal that the Shaolin Temple has, through its charitable work, assumed the attributes of a “cultural broker” for the CCP. And because the temple has an abundance of symbolic capital and is respected by the public, it presents the CCP with a “dictator’s dilemma.” On the one hand, the CCP allocated resources to the temple’s orphanage so that it could assist the regime with its poverty alleviation efforts; on the other hand, there is a danger that the temple may gain sufficient ideological and discursive power to threaten the CCP’s rule. So, for political security reasons, the Party bureaucracy endeavours to maintain tight control over the orphanage.
A theoretical framework has been established to investigate the modulational instability of electromagnetic waves in magnetized electron–positron plasmas. The framework is capable of analyzing electromagnetic waves of any intensity and plasmas at any temperature. A fully relativistic hydrodynamic model, incorporating relativistic velocities and thermal effects, is used to describe the relativistic dynamics of particles in plasmas. Under the weakly magnetized approximation, a modified nonlinear Schrödinger equation, governing the dynamics of the envelope of electromagnetic waves in plasmas, is obtained. The growth rate of the modulational instability is then given both theoretically and numerically. By analyzing the dependence of the growth rate on some key physical parameters, the coupled interplay of relativistic effects, ponderomotive forces, thermal effects and magnetic fields on electromagnetic waves can be clarified. The findings demonstrate that specific combinations of physical parameters can significantly enhance modulational instability, providing a theoretical basis for controlling the propagation of electromagnetic waves in plasmas. This framework has broad applicability to most current laser–plasma experiments and high-energy radiation phenomena from stellar surfaces.
Manganese (Mn) is a crucial trace element that actively participates in a diverse array of physiological processes. Mn is maintained at appropriate levels in the body by absorption and excretion by the body. Dysregulation of Mn homeostasis can lead to a variety of diseases, especially the accumulation of Mn in the brain, resulting in toxic side effects. We reviewed the metabolism and distribution of Mn at multiple levels, including organ, cellular and sub-cell levels. Mitochondria are the main sites of Mn metabolism and energy conversion in cells. Enhanced Mn superoxide dismutase activity reduces mitochondrial oxidative stress and inhibits cancer development. In addition, Mn enhances anti-cancer immune responses through the cGAS–STING pathway. We introduced various delivery vectors for Mn delivery to cancer sites for Mn supplementation and anti-cancer immunity. This review aims to provide new research perspectives for the application of Mn in the prevention and treatment of human diseases, especially by enhancing anti-cancer immune responses to inhibit cancer progression.
Rare earth elements (REEs) preserved in speleothems have garnered increasing attention as ideal proxies for the paleoenvironmental reconstruction. However, due to their typically low contents in stalagmites, the availability of stalagmite-based REE records remains limited. Here we present high-resolution REEs alongside oxygen isotope (δ18O) records in stalagmite SX15a from Sanxing Cave, southwestern China (110.1–103.3 ka). This study demonstrates that REE records could provide useful information for the provenance and formation process of the stalagmite, due to consistent distribution pattern across different periods indicating stable provenance. More interestingly, the total REE (ΣREE) record could serve as an effective indicator to reflect local hydrological processes associated with monsoonal precipitation. During Marine Isotopic Stage (MIS) 5d, a relatively low ΣREE content is consistent with the positive SX15a δ18O and negative NGRIP δ18O, reflecting a dry-cold environment; while during MIS 5c, a generally high ΣREE content suggests a humid-warm circumstance. Furthermore, the ΣREE record captured four prominent sub-millennial fluctuations within the Greenland interstadial 24 event, implying a combined influence by the regional climate and local soil redox conditions. Our findings indicate that the stalagmite-based REE records would be a useful proxy for better understanding of past climate and environment changes.
Food insecurity (FIS) is a critical public health issue, particularly among older adults. This study investigates the association between FIS with diet quality and anthropometric indices in the US older adults. A cross-sectional analysis was conducted using NHANES data from 2017 to 2020, involving 2592 participants aged ≥ 60 years. FIS was assessed using the USDA Household Food Security Survey Module. Diet quality was assessed using the Healthy Eating Index (HEI)-2020 and adherence to Mediterranean diet (MedDiet) score. Anthropometric measures were calculated following standardised protocols. Multivariable logistic regression models, adjusted for demographic, socio-economic and behavioural factors examined the association between FIS and the higher quartile and tertile of anthropometric and diet quality indices, respectively. Of the participants, 27·4 % experienced FIS. FIS participants were younger and had lower education and income levels compared with FS individuals (P < 0·05). In the adjusted model, FIS was associated with lower adherence to both the Mediterranean Diet (OR: 0·48, 95 % CI: 0·31, 0·67) and HEI-2020 (OR: 0·61, 95 % CI: 0·37, 0·84), indicating poorer diet quality in older adults. In adjusted analyses, FIS was significantly associated with higher A Body Shape Index quartiles (Q3: OR: 1·44, 95 % CI: 1·06, 1·95; Q4: OR: 1·46, 95 % CI: 1·07, 2·01), the waist-to-hip ratio (Q4: OR: 1·44, 95 % CI: 1·01, 2·06) and the Conicity index (Q4: OR: 1·36, 95 % CI: 1·02, 1·81). FIS in older adults is associated with unfavourable diet quality and body composition patterns, particularly central obesity measures. Addressing FIS may mitigate health risks related to obesity and its complications.