To evaluate the right ventricle function by conventional echocardiographic methods and strain analysis in the long term after balloon pulmonary valvuloplasty. In addition, we investigated the relationship between pulmonary regurgitation, demographic data at the time of the procedure, and right ventricle dysfunction in late follow-up.

The records of patients submitted to balloon pulmonary valvuloplasty from 2001 to 2015 in a single centre were reviewed. From that sample, a revised cohort was formed, and the patients were submitted to clinical and echocardiographic evaluations.

The retrospective and the revised cohort analyses included 73 and 18 patients, respectively. In the follow-up, pulmonary regurgitation was observed in all patients, and there was a significant worsening of its magnitude over time (p < 0.001); the severity of pulmonary regurgitation was associated with balloon pulmonary valvuloplasty performed in patients with weight < 3 kg (p < 0.03), body surface area < 0.3 m2 (p < 0.04), and < 1 year of age (p < 0.006). Global longitudinal systolic strain of the right ventricle was abnormal in 8 of 18 patients, and conventional methods were abnormal in 2 of 18 patients (p = 0.001). There was a significant relationship between severe pulmonary regurgitation and right ventricle dysfunction detected only by strain evaluation (p = 0.01).

The severity of pulmonary regurgitation was related to the impairment of right ventricle function detected by strain. The predictors of pulmonary regurgitation severity in late follow-up were age < 1 year, weight < 3 kg, and body surface area < 0.3 m2.

Most people at the end of life wish to die at home. Lay carers are crucial to supporting a home death and key to a good death is management of symptoms; this may prevent unwanted hospital admissions. If a dying person is too weak to swallow, regular medicines are administered continuously via subcutaneous (SC) cannula. When symptoms “break through,” additional (or as-needed) doses can be given, usually by a visiting healthcare professional. Delayed symptom control can occur due to time taken for healthcare professionals to arrive at the home.

Lay carers can be trained to administer as-needed SC medicines; the practice is safe and legal in the UK, although not widely used. The “CARer-Administration of as-needed SC medication for breakthrough symptoms in people dying at home” (CARiAD) feasibility trial of lay carer administration in the UK was the first to conduct in-depth interviews with carers trained in the practice.

The objective of this paper is to give voice to carers and show how experiences reflect benefits and challenges of lay administration at the end of life.

Qualitative interviews with carers trained in the practice. Interviews were analyzed using Interpretive Phenomenological Analysis.

Caring for a loved one at home during the last days of life is complex. Accounts reveal a desire to fulfill a loved one’s wishes by keeping them at home and having the death they wanted. Carers were afraid of uncontrolled symptoms, especially pain, empowered by the ability to help and grateful to avoid long delays. Potential for carer burden and fears of hastening death require careful reassurance from health care professionals.

We learned that carers endorsed and embraced the opportunity to do more to keep their loved ones comfortable and at home. This is significant in making the case for wider access to the practice in the UK.

The Collaborative Care Pathway (CCP-9) is a recovery orientated approach to mental health assessment, case formulation and care planning in a community mental health service. The CCP-9 has been in use for over ten years and a multi-stakeholder evaluation was timely. This study evaluates the satisfaction of service users, families/supporters and Mental Health Professionals with the operation of the CCP-9.

Surveys were circulated by post to 169 service users, 105 family members (FMs) and 33 mental health practitioners.

Response rates were 21% for service users, 24% for FMs and 39% for mental health practitioners. Approximately three-quarters of services users and FMs were satisfied with their involvement in the CCP-9 process. Two thirds of service users and three-quarters of FMs found the feedback on the case formulation and the care plan helpful. However, only a minority of both groups felt that the service user had received adequate support to prepare for discharge. Mental Health Practitioners were unanimous in recognising the CCP-9 process as important to all stakeholders, and as a useful approach to case formulation and care planning.

Those surveyed recognised the value of the collaborative approach although they did voice some key concerns. More support is required to prepare service users for discharge and to assist service users to access community supports. In addition, adequate resourcing is key to the success and feasibility of the CCP-9.

Impaired muscle function, aerobic capacity, and fatigue are common in individuals with Fontan circulation. Knowledge regarding the effects of strength training in this population is limited. Therefore, the study aimed to investigate the effects of strength training on dynamic muscle function, aerobic capacity, and fatigue in adults with Fontan circulation compared to matched controls.

In this pilot non-randomised controlled trial, nine patients with Fontan circulation (median age 28.9 years [IQR: 23.4–35.0], 44.4% women) and nine age- and sex-matched controls completed a 10-week strength training intervention. Dynamic muscle function was assessed through shoulder flexion, heel rise, elbow flexion, and knee extension tests. Aerobic capacity was evaluated using cardiopulmonary exercise testing, and fatigue using the questionnaire Multidimensional Fatigue Inventory. All assessments were conducted pre- and post-intervention. Within-group changes were analysed using the Wilcoxon signed rank test and between-group differences using the Mann–Whitney U test.

Patients showed improvements in all muscle function tests post-intervention (shoulder flexions 39.3% [IQR: 18.9–69.7], p = 0.008; heel rise 26.7% [IQR:17.5–58.1], p = 0.008; elbow flexions 57.1% [IQR: 50.0–173.8], p = 0.007; knee extensions 66.7% [24.3–92.9], p = 0.008). The improvements were at comparable levels to controls. Only controls reported reduced fatigue (–19.4% [IQR: –28.7, –10.5], p = 0.01), while patients showed no change (–5.9% [IQR: −25.5, 3.2], p = 0.1). Aerobic capacity remained unchanged. No severe adverse events occurred.

Strength training is safe and improves dynamic muscle function in patients with Fontan circulation, with changes comparable to those of healthy controls. However, the effect of strength training on fatigue and aerobic capacity requires further investigation.

ClinicalTrials.gov, ID: NCT05454254, https://clinicaltrials.gov.

In Jishishan County, Linxia Prefecture, Gansu Province, China, the altitude ranges from 1,787 meters to 4,308 meters. At 23:59 Beijing time on December 18, 2023, a magnitude 6.2 earthquake struck Jishishan County. The objective is to report the injury characteristics and medical treatments of those injured in the earthquake.

The injury and treatment data were retrospectively collected and analyzed for earthquake-related injuries among patients admitted to the People’s Hospital of Linxia Hui Autonomous Prefecture and the Traditional Chinese Medicine Hospital of Linxia Hui Autonomous Prefecture.

A total of 166 patients were hospitalized: 142 at the People’s Hospital of Linxia Hui Autonomous Prefecture and 24 at the Traditional Chinese Medicine Hospital of Linxia Hui Autonomous Prefecture. Among the injured, 40.3% presented with a single injury. The others had multiple injuries: 28.3% had two injuries, 14.5% had three injuries, 12.1% had four injuries, 4.2% presented with five injuries, while only 0.6% were diagnosed with six injuries. Additionally, 78.9% involved fractures alone, 36.8% involved lung contusions, and 34.9% involved both fractures and lung contusions. Conservative treatment was used slightly more than surgery (54.8% versus 45.2%). Among the 75 surgical cases, internal fixation and sutures were the most common (17.4% each). In total, 53.0% of the injured were treated and discharged and 47.0% were transferred to provincial hospitals. In addition, the outcome of injured patients with differing injury conditions was different.

Fractures and multiple injuries were the primary injury types in this study. Suturing and internal fixation were the most common surgical interventions. The core findings of this study provide an important reference for regionalized prevention and treatment of rural earthquake injuries in high-altitude regions.

Patients with advanced cancer, their caregivers, and healthcare professionals can differ in their preferences for patient treatment and care. The objectives of this study were to (1) identify what healthcare professionals in specialist palliative care feel aids or challenges patients with advanced cancer and their caregivers to manage their discordance, and (2) decipher what is helpful or challenging for healthcare professionals themselves to manage discordance between patients with advanced cancer and their caregivers.

A qualitative study was conducted comprising online focus groups with 19 healthcare professionals from different professions in specialist palliative care. Participants were purposively and snowball sampled, and recruited from specialist palliative care settings, including hospital, hospice, and community-based care. The data were member checked and analyzed using thematic analysis.

Trust and consistent communication between the patient, caregiver, and healthcare professional, were considered by participants as helpful for patients and caregivers to manage discordance. Emotional and psychological burden for both the patient and caregiver together with preexisting conflict between the patient and caregiver, were perceived as barriers for patients and caregivers to manage their discordance. Knowledge and expertise gained from practice combined with professional resilience and peer support enabled participants to help patients and caregivers navigate discordance. Relational conflict between the patient and caregiver combined with participants’ own uncertainty about ethical and legal connotations of helping the patient and caregiver resolve their differences, were barriers to helping the patient and caregiver manage their discordance.

Interventions focused on assisting patients with advanced cancer in palliative care and their caregivers manage their differences in decision-making could serve to alleviate emotional burden for both the patient and caregiver. Healthcare professionals in specialist palliative care value the perspective of both patients with advanced cancer and their caregivers when helping them manage their discordance in decision-making.

Stroke remains a major public health issue globally. Tele-rehabilitation, incorporating internet-based interventions and wearable devices, offers an accessible strategy for post-discharge rehabilitation. This study evaluates their effectiveness in stroke patients.

A total of 160 subacute stroke patients hospitalized between November 2022 and September 2023 were enrolled and randomly allocated to four groups at discharge (n = 40 per group): a control group receiving conventional rehabilitation, an internet-based tele-rehabilitation (ITR) group, a wearable-device-assisted (WDA) group and a combined intervention (IWT) group, which received both ITR and WDA training. The primary outcome was assessed by the Modified Barthel Index (MBI) at discharge, 4 weeks and 12 weeks post-discharge, with the 12-week score prespecified as the primary endpoint. Secondary outcomes included Berg Balance Scale (BBS), simplified Fugl-Meyer Assessment (sFMA), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE) and Zarit Burden Interview (ZBI), all assessed at discharge, 4 weeks and 12 weeks post-discharge.

At baseline, no significant differences were observed among groups (P > 0.05). Over 12 weeks, all intervention groups demonstrated significant improvements in MBI, BBS and sFMA compared to the control group (P < 0.05), with the IWT group achieving the greatest gains (P < 0.01). Anxiety, depression and caregiver burden significantly decreased across intervention groups, with the IWT group showing the most pronounced reductions (P < 0.01). Cognitive function also improved significantly, particularly in the IWT group (P < 0.01).

ITR and WDA training enhances functional and psychological recovery in stroke patients, highlighting its potential clinical significance in managing stroke recovery.