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Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
The UK has led the development of specialist perinatal mental health services since the latter half of the last century. However, new innovations in service design and delivery continue to present challenges for commissioners and providers. This chapter reviews the evolution of specialist care across the UK and in Ireland and identifies how services may need to respond to changing demand.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Postpartum psychosis is a condition of great clinical and public health importance. Severe episodes of mental illness in the perinatal period can result in significant distress, may disrupt the developing relationship between mother and child, and have long-term implications for the well-being of the woman, her baby, family and wider society.
In this chapter we will discuss what we know about this condition and its relationship to bipolar disorder, how it might best be defined, what we still need to find out, and consider how it should be managed.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Personality disorder (PD) is a complex condition, which has been the subject of both debate and research. However, maternal PD has only been the focus of research in the last two decades. In this chapter I discuss that research in the context of what is known generally about PD, as a disorder with a predictable presentation of signs and symptoms; an aetiology, and indications for effective treatment. There has been more research on maternal PD in the last 15 years, which shows that mothers with PD may struggle to care for their children, especially in the postnatal period, and their mental health may also deteriorate during pregnancy. In this chapter I describe the issues described above and discuss how clinicians approach the management of mothers with PD. I place special emphasis on the impact of maternal PD on mother-child relationships and attachment, and the implications for child health.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
During the first three years of life our brain develops exponentially, and synaptic connections are formed faster than at any other period of our lives. The organisation of its processes is directly affected by early life experiences. It is therefore vitally important that families, healthcare providers and early intervention professionals understand early brain infant development so that they can fully support infants on to achieving their full potential. This chapter provides an insight into the typical development of core occupations and sensory systems by age, in the first year of life, highlighting the essential role that parents, carers and health professionals have at each stage. Sections on sensory deprivation and carers’ mental health issues are included.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Despite increasing ethnic diversity and a rising proportion of births to migrant women, inequalities in health and care experiences for racial and ethnic minority groups have been a persistent challenge in the UK, with perinatal mental health being no exception. Whilst it is important to acknowledge that inequities in maternal health are a global phenomenon, there is a clear and alarming pattern of people from racialised groups (i.e. those who, based on their skin colour, are disadvantaged due to normalisation of an array of dynamics that favour white people) experience worse maternal outcomes in many high-income countries. Which specific groups experience worse outcomes is dependent on the sociocultural context rather than biological determinism. Childbirth has both a biological and a cultural definition. It is also a political and social phenomenon shaped by the society we live in. Humans’ actions such as the cultural creation of traditions, customs and rules affect childbirth practices directly. These actions take place through social interactions, communication and exchanges inside social institutions and can often be dismissed in the current culture of medicalisation of birth.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Leadership is a very fashionable term and firmly established in the lexicon of managers in both the private and public sectors and within domestic and international politics. As a concept, it is complex, multifaceted, dynamic and invariably influenced by the context and organisational culture in which it occurs.
The chapter begins with an overview of different ideas about leadership, examining ‘wicked’ and ‘tame’ problems, the distinction between leadership and management, psychiatrists as leaders and different leadership styles. We then delve into the emerging fields of compassionate and systemic leadership, emphasising relational trust, diversity and collaboration. We explore the role of contention, developing collaborative relationships, the centrality of developing relational trust and working with diversity. The chapter concludes with a discussion focused on the ubiquitous influence of conflict in organisations. Throughout, we will explore leadership through multiple lenses to unlock new possibilities for practice.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Suicide remains a leading cause of maternal death in the UK and in other high-income countries. While there are clear risks in severe mental disorder, those who die have experienced a range of mental illnesses and often come from more deprived communities. The Confidential Enquiries highlight the distinctive patterns of occurrence and progression in perinatal mental illness and the need for improvements in clinical evaluation of risk, effective risk management and the availability of high-quality perinatal mental healthcare as important factors in helping reduce progression to suicide.
Edited by
Liz McDonald, East London NHS Foundation Trust,Roch Cantwell, Perinatal Mental Health Service and West of Scotland Mother & Baby Unit,Ian Jones, Cardiff University
Pregnancies among individuals with schizophrenia spectrum disorders have increased in recent years. In the perinatal period, individuals with schizophrenia spectrum disorders are faced with managing the unique effects of their symptoms on pregnancy and parenting, which fluctuate through the perinatal period with the early postpartum being a high-risk time for relapse. Their pregnancies are also associated with a range of adverse pregnancy, neonatal and long-term child outcomes, the risk for which may be related in part to modifiable factors. Prejudice, discrimination and subsequent isolation of perinatal individuals with schizophrenia spectrum disorders may limit health care and social support opportunities in this group, further exacerbating the risk for negative outcomes. These issues underscore the need for comprehensive management approaches including attention to pre-conception health, medication management during pregnancy and postpartum, and multifaceted support for the parent and family. This chapter is an overview of schizophrenia spectrum disorders in the perinatal period, including a summary of the epidemiology, clinical presentation, course, outcomes and management.
Research on parasite-induced regulation has identified the conditions under which parasites can destabilise host population dynamics: high levels of aggregation, delayed density-dependence, and moderate negative effects on fitness (reproduction, survival). Gastrointestinal helminths with direct life cycles and a single definitive host provide ideal systems to test these predictions. In this study, we first determined which helminths infect common voles (Microtus arvalis) in NW Spain, where populations are cyclic. We showed that the helminth community is dominated by Syphacia sp., a gut-restricted, directly transmitted nematode.
We then examined how the prevalence and abundance of Syphacia sp. varied with host sex, season, and population cycle phase (increase, peak, or crash), and tested if vole condition (relative body mass and organ hypertrophy) and female fecundity (litter size) correlated with the prevalence of Syphacia sp. Infections were highly aggregated in Syphacia sp. and parasite abundance peaked during the crash phase of the vole cycle. We found that vole condition did not vary with the prevalence of Syphacia sp., but vole litter size showed a season-dependent association, with infected females producing smaller litters in spring and summer.
These findings suggest that even low-pathogenic, directly transmitted parasites could exert reproductive effects, potentially shaping host population dynamics in combination with ecological and demographic factors. Experimental approaches are required to clarify causality and potential regulatory feedback.
Providing psychosocial support to pediatric patients and their families at the end of life represents one of the most challenging yet vital aspects of healthcare practice. Despite the presence of grief and loss training in many pediatric healthcare professionals’ educational backgrounds, opportunities for practical training experience in delivering end-of-life care remain limited. This study explored the use of simulation-based training to enhance the self-reported knowledge, skills, and comfort levels of child life specialists in providing psychosocial care during end-of-life situations.
Methods
Forty-three child life specialists participated in the simulation-based training, which was combined with traditional didactic instruction, and the associated research study. Pre- and post-training surveys were used to assess impact of the training on child life specialists’ self-reported knowledge of end-of-life care and comfort in providing this care.
Results
A statistically significant increase was seen in all measured aspects of self-reported knowledge and comfort in providing end-of-life care following the training.
Significance of results
Simulation combined with traditional instruction methods provides an effective way to train healthcare professionals in providing high-stakes psychosocial care while protecting patients and families from the added strain of trainees and excess staff presence during sensitive times.
To identify stakeholders’ perceptions of the role of the nurse educator in Hospital Disaster Management (HDM), determine the core competencies required for their effective participation, and establish training areas to enhance their participation during disasters.
Methods
A qualitative hermeneutic-phenomenological design was adopted with 38 stakeholders comprising doctors, clinical nurses, nurse administrators, and nurse educators in tertiary hospitals and nursing colleges in Kerala, India. The responses were collected through in-depth interviews with 15 respondents and focus group discussions with 4 different groups in December 2023.
Results
Themes identified included preparedness gaps, underuse of secondary stakeholders, training and coordination capabilities, training needs, fear of clinical competence and safety, role confusion, elitism, and social responsibility, totaling 7 themes. Participants identified roles, preparedness, variable clinical exposure, and the necessity of planned competency development as unsatisfactory. The nurse educators were able to contribute to training, supervision, documentation, and psychosocial support, provided they are well prepared.
Conclusion
Nurse educators can be of great help to HDM, but are not being used to their full potential due to unclear role expectations and limited readiness. Their competencies can be enhanced and incorporated into institutional disaster plans to build surge capacity and improve coordination in hospital disaster responses.
A systematic review and meta-analysis were conducted, and published estimates determined the pooled prevalence of gastrointestinal nematode parasites affecting free-ranging chickens in Africa. Peer-reviewed articles published between 1993 and 2024 were systematically searched and screened. Prevalence estimates based on 76 eligible articles showed that of the 74,789 free-ranging chickens screened, 13,625 were infected with gastrointestinal nematodes with an overall pooled prevalence of 15% (95% CI: 13–18%). Twenty-seven nematode species were recorded, of which Ascaridia galli and Heterakis gallinarum were the commonly reported species. Southern Africa recorded the highest pooled prevalence (22%; 95% CI: 13–33%), and western Africa had the lowest (5%; 95% CI: 0–2%) despite recording the highest nematode species diversity. Tetrameridae had the highest family-level pooled prevalence of 46% (95% CI: 28–64%), and Spiruridae had the lowest 1% (95% CI: 0–3%). Most studies were conducted between the period 2014 and 2024; however, the highest pooled prevalence was observed between 1993 and 2002 (17%; 95% CI: 11–24%). The necropsy technique recorded the highest pooled prevalence (17%; 95% CI: 14–20%) compared to coproscopy (10%; 95% CI: 7–14%). The quality effects model revealed a high heterogeneity and publication bias among studies due to the diagnostic method used (P <0.05). This systematic review provided insightful information on the occurrence and potential burden of gastrointestinal nematode species of free-ranging chickens in Africa, highlighting the need for enhanced biosecurity and further research to safeguard their health, production, and food security of rural economies.
Autism spectrum disorder (ASD) is a population-scale condition with life-course health consequences, yet nutrition support remains inconsistently embedded in routine pathways. Food selectivity is common in ASD and is associated with restricted dietary variety, nutritional imbalance, gastrointestinal morbidity and cardiometabolic vulnerability. Current responses are predominantly clinic-and family-centred and are difficult to scale equitably. This commentary argues that institutional food services (schools, day-care and residential settings) are an underused public health platform to improve inclusion and accountability through sensory-accessible, nutritionally adequate meals. Because these services are commissioned, standardised and audited, sensory accessibility can be operationalised via procurement specifications and quality indicators, enabling benchmarking across sites. Evidence from sensory-informed menu adaptation and implementation work suggests feasibility within routine operations and supports evaluation using system-relevant outcomes (acceptability, nutritional adequacy, waste, feasibility and maintenance). Three policy actions are proposed: embed sensory accessibility in institutional standards, integrate nutrition across sectors and fund scale-up using implementation science.
To estimate the incidence of healthcare-associated infections (HAIs) in Italian long-term care facilities (LTCFs) and to evaluate whether an artificial intelligence (AI) approach, through unsupervised machine learning (ML), could stratify residents into clinically distinct groups with differing susceptibility to HAIs.
Design:
Prospective cohort study with 12-month follow-up.
Setting:
24 LTCFs in Italy, participating in the European Centre for Disease Prevention and Control 12-month longitudinal study on HAIs in LTCFs, 2022–2023.
Participants:
395 residents enrolled across the participating LTCFs.
Methods:
Incidence measures of HAIs (rate and ratio) were estimated, using generalized estimating equations. A hierarchical cluster analysis based on residents’ clinical and demographic characteristics was implemented as an unsupervised ML approach.
Results:
Overall, 75 HAIs per 100 residents (95% CI, 70.3–78.3) and 0.23 HAIs per 1,000 resident-days (95% CI, 0.11–0.76) were estimated. Respiratory tract infections (29.5%, 95% CI 24.2–31.1), COVID-19 (26.3%, 95% CI 22.1–28.4), and urinary tract infections (15%, 95% CI 11.0–35.4) were the most frequent. Clustering identified two reproducible resident groups: Group 1 (39%), more independent and cognitively preserved, with fewer comorbidities and lower infection incidence; and Group 2 (61%), more dependent and clinically complex, with higher incidence of HAIs. Cluster stability was high (mean ARI = 0.83).
Conclusions:
This study confirms the high burden of HAIs in Italian LTCFs and provides exploratory evidence that AI-based clustering can identify reproducible HAI susceptibility profiles in a setting where such approaches have been scarcely applied.
Haemonchus contortus is considered the most pathogenic gastrointestinal nematode of sheep and, due to the increasing resistance to synthetic anthelmintics, it poses a serious challenge to small ruminant production systems. The aim of this work was to evaluate the in vivo and in vitro anthelmintic activity of quebracho-chestnut tannin extract against Haemonchus contortus in lambs. The in vitro assays (egg hatching inhibition and larval migration inhibition) were performed to determine the effective concentrations required to inhibit 50% of egg hatching and larval migration (EC50), which were 3.8 and 1.4 mg/mL, respectively. For the in vivo trial, 18 lambs used were divided into three groups: Group 1 (control), Group 2 (a tannin dose equivalent to 0.3% of dry matter intake), and Group 3 (a tannin dose equivalent to 3% of dry matter intake). No significant differences (p > 0.05) were observed among treatments in faecal egg counts, larval counts from coprocultures, or adult H. contortus recovery. The tannin extract was effective in inhibiting egg hatching and larval migration in vitro at low concentrations. However, when administered in vivo at 0.3% and 3% of dry matter intake, it failed to show any effect on faecal egg counts, larval counts in coproculture, or adult worm burden. Adult worms, eggs, and infective larvae were further examined using scanning electron microscopy. The observations revealed significant cuticular alterations in adult worms, which could potentially interfere with normal feeding and reproductive processes. Additionally, eggs and infective larvae exhibited shell rupture and cuticle damage.
To evaluate the feasibility and preliminary efficacy of a clinical program designed to teach informal caregivers of older Veterans with pain and mild-to-moderate dementia or mild cognitive impairment (MCI), pain management, pain coping and pain communication skills.
Methods
Twenty caregivers of older Veterans with pain and dementia or MCI and the Veterans themselves participated in a 5-session program taught by trained Veterans Affairs (VA) clinicians. All sessions were conducted remotely using video-technology, with caregivers and Veterans. Two sessions were conducted with individual Veteran-caregiver dyads, and three sessions were conducted with caregiver groups. Caregivers and Veterans completed baseline and post-intervention measures. Qualitative interviews of 10 caregivers who completed the program were also conducted and focused on identifying themes related to caregiving for their loved ones with pain and dementia and related to participating in the program.
Results
The program was well received and almost all caregivers identified videoconferencing as the preferred venue for participating in such a program. They most valued learning about dementia and participating with other caregivers. Pre-post analyses revealed significant improvements in perceived caregiving competence and self-efficacy for managing pain. Challenges encountered included scheduling related to caregivers’ multiple competing responsibilities and lack of familiarity with tele-conferencing technology.
Significance of results
Patients with pain and mild to moderate dementia or MCI have been relatively ignored in current literature. Our preliminary findings suggest that a program delivered by trained healthcare professionals to caregivers and Veterans using tele-conferencing could benefit caregivers.
Hazardous materials (HazMat) incidents pose significant risks to public health, safety, and the environment. This study aimed to characterize the temporal trends, geographic distribution, operational settings, and incident types of HazMat events reported in Oman.
Methods
This retrospective descriptive study analyzed data from the national HazMat incident records maintained by the Civil Defence and Ambulance Authority (CDAA). All reported chemical, biological, or radiological incidents between June 1, 2019, and November 30, 2024, were included.
Results
A total of 55 HazMat incidents were recorded during the study period. Reported incidents increased over time, with the highest annual counts observed in 2023 (14 incidents) and 2024 (17 incidents). Muscat Governorate accounted for 39 incidents (71%). Residential neighborhoods were the most common operational setting (26/55, 47%), followed by other public areas (9/55, 16%), while airports, educational institutions, industrial areas, and transportation corridors each accounted for 5 incidents (9%). Gas leaks were the most frequently reported incident type, involved in 28 incidents (51%).
Conclusions
HazMat incidents in Oman increased over the study period and were concentrated in Muscat Governorate. Incidents occurred across diverse operational settings, particularly residential and public environments, while gas leaks represented the most frequently reported incident type.
Governance structures in radiotherapy are central to ensuring patient safety, yet significant variation exists in how errors are reported, analysed and mitigated globally. This literature review evaluates current international approaches to radiotherapy error governance, highlighting barriers to consistent reporting and opportunities for system-wide improvement.
Methods:
A structured search of peer-reviewed literature and policy documents was undertaken using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. The search yielded 42 relevant articles, reviewed for themes relating to governance frameworks, safety culture, incident reporting systems and technology’s role in error reduction.
Results:
Findings reveal inconsistent adoption of Safety I and Safety II models, underreporting due to blame culture, and limited integration of artificial intelligence (AI) into governance frameworks. Successful strategies included pre-treatment peer review, multidisciplinary safety boards and AI-assisted risk management tools. Despite advancements, gaps persist in standardising incident definitions, fostering transparency and promoting a just culture.
Conclusion:
The review suggests the need for international alignment on governance practices, wider integration of AI and proactive learning from near misses. Radiographers and radiation oncology teams are urged to engage in shaping safety governance through open reporting, system design and education. Implications for practice: Improved governance not only reduces harm but also supports continuous quality improvement in radiotherapy services.
Structural equation modeling (SEM) is a flexible statistical technique with multiple applications, including behavioral genetics and social sciences. Building on the original design of the umx package, which improved accessibility to OpenMx by specifying a concise syntax, umx v4.5 extends functionality for longitudinal and causal twin designs while improving interoperability with graphical modeling tools such as Onyx. New capabilities include: classic and modern cross-lagged panel models; Mendelian Randomization Direction-of-Causation (MR-DoC) twin models incorporating polygenic scores as instruments; support for definition variables directly in umxRAM(); a workflow for importing paths from Ωnyx; a dedicated function for incorporating censored variables’ data into models, particularly valuable in biomarker research; improved covariate placeholder handling for definition variables; sex-limitation modeling across five twin groups, accommodating quantitative and qualitative sex differences; and covariate residualization in wide- or long-format data. These new functionalities accelerate reproducible, reliable, publication-ready twin and family modeling, and integrated journal-quality reporting, thereby lowering barriers to genetic epidemiological analyses