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Political scientist Dr. Paula D. McClain is an exemplary scholar who has dedicated much of her career to building diverse and inclusive scholarly communities in tandem with growing political science scholarship. Among Dr. McClain’s most enduring intellectual contributions is her pioneering work, Can We All Get Along? Racial and Ethnic Minorities in American Politics?, coauthored first with Dr. Joseph Stewart, Jr., and later with Dr. Jessica Johnson-Carew. Among the first comprehensive treatments of American racial and ethnic minority group politics, Can We All Get Along? still implores us to ponder a question that remains as critical as it has ever been to global and national politics, as well as to the academy and the discipline of political science, more than 30 years after its publication. The contributions to this special issue are dedicated to honoring the enduring significance of Can We All Get Along? and the extraordinary work and legacy of Dr. Paula McClain.
Maternal deficiency of vitamin B12 (B12) is associated with neural tube defects, fetal growth restriction, and future risk of non-communicable disease in the offspring. Little is known about the molecular basis of these associations. We hypothesized that B12 regulates the expression of fetal genes, thereby influencing fetal growth and fetal programming. We investigated the association of B12 and other micronutrient concentrations in the cord blood with gene expression in the cord blood mononuclear cells. We performed a Weighted Gene Co-expression Network Analysis (WGCNA) on cord blood transcriptome of babies born in a pre-conception trial Pune Rural Intervention in Young Adolescents of B12 and multi-micronutrients (MMN). The gene modules (clusters) in WGCNA that showed a significant correlation with cord blood B12 and MMN were subjected to gene ontology (GO) analysis. WGCNA generated 23 different modules. Cord blood B12 concentrations were strongly correlated with modules of genes involved in methylation reactions and gene regulation. Cord B2 concentrations correlated with gene modules associated with demethylation reactions. Vitamins B6 and B9 did not show a unique association either with gene modules or specific GO terms. Our results demonstrate that maternal B12 may regulate expression of fetal genes involved in methylation reaction. This is a novel suggestion for the role of B12 in fetal growth, development, and the Developmental Origins of Health and Disease paradigm.
Food texture influences eating rate (ER), and slower ERs are associated with reduced energy intake within a meal. However, it remains unclear whether this acute effect of ER on intake is sustained over time. We investigated whether texture-based differences in meal ER can have a sustained effect on food and energy intake across 11 consecutive days. In a randomised cross-over feeding trial, Dutch adults (n 20) were randomised to an 11-d ‘fast’ and an 11-d ‘slow’ ER diet, followed by a 17-d washout period before completing the alternate diet-arm. Participants consumed ad libitum breakfast and dinners of which ER was manipulated using food texture and received the same lunch meals on both diets served in regular-sized fixed portions. Diets were matched for served total weight (gram), energy (kcal) and energy density (kcal/gram) and were equivalent for visual volume, meal liking and meal variety. Meal ER on the ‘slow diet’ was on average 32 % slower compared with the ‘fast diet’ (P < 0·01). On days when texture led to significant differences in ER, food intake was reduced by 121 (se 24) g/d (P < 0·001), and this effect did not attenuate over time (P = 0·25). Cumulative food intake was 6 % lower for the slow compared with the fast diet (P < 0·001) with no significant difference in energy intake. On 8 of the 11 test days, meal texture reduced ER and supported a consistent reduction in food intake. Further research should test whether a whole diet approach to lowering ER by modifying meal textures could help to moderate food and energy intakes.
I offer a novel dispositional reply to Derk Pereboom’s four-case manipulation argument. Drawing on recent work in the metaphysics of dispositions, I argue that manipulated agents’ rational abilities are masked—prevented from manifesting as they otherwise would—by neuroscientists’ manipulation. I argue that masking better explains why manipulated agents are not responsible for their actions than causal determinism does, as we ordinarily take masks to explain why agents are not morally responsible for their actions or inaction. Because causal determinism is not a mask, there is a relevant difference between manipulation and causal determinism, and the four-case argument fails.
The Ottoman-Safavid war of 1578–1590 marked the first time the Caucasus emerged as a primary battleground in the struggle between the Ottomans, Iran, and Russia. The war’s first campaign, led by Lala Muṣṭafā Paşa in Shirvan, also saw the rise of Özdemiroġlu ʿOs̱mān Paşa, commander of the Ottoman troops that wintered in Daghestan in 1578–1579. This campaign has been extensively recounted in contemporary chronicles, particularly in ġazavātnāme such as Muṣṭafā ʿĀlī’s Nuṣretnāme (c. 1584) and Āṣafī Dāl Meḥmed Çelebi’s Şecāʿatnāme (c. 1586–1587), both authored by high-ranking officials who took part in the campaign. However, a different perspective emerges when one considers the experiences of rank-and-file soldiers, voiceless yet central actors in the events chronicled in these narratives. This study focuses on the so-called Tārīḫ-i ʿOs̱mān Paşa, a war memoir composed in Turkish between 1580–1584 by Ebūbekir b. ʿAbdullāh, a cavalryman in the Ottoman army.
In addition to adopting a more prosaic tone than his prestigious contemporaries, Ebūbekir also gives prominence to his personal experiences and observations, particularly when recounting his one-year stay in the region of Derbent. In this passage, he describes the peoples of Daghestan and briefly discusses their history, sociopolitical organization, beliefs, and customs. In this article, I present a translation and analysis of this passage of the book. In introducing this text to an English-speaking audience, this work contributes to our historical understanding of Daghestan and the Caucasus and provides valuable material for studying Ottoman mentalities, moving beyond the authorized narratives of state-employed chroniclers.
Founded in 228/227 BCE, the Carthaginian city of Qart Hadasht in southern Spain became the principal Punic political centre and military port in the western Mediterranean. Its defensive architecture featured a robust casemate wall composed of an outer sandstone face and inner mudbrick walls. Here, the authors present the geoarchaeological analysis of the earthen materials used in the construction of this wall. The results reveal differences in composition and provenance between mudbricks and mud mortars, with the former sourced across distances of 7–8km, highlighting the detailed knowledge of hinterland resources and complex political organisation involved in the wall’s construction.
Despite the recent advances in its diagnosis (heralded by the revisions in ICD-11 and DSM-5) and the introduction of new approaches to treatment, managing personality disorder remains challenging to the psychiatric practitioner. I believe that one of the main reasons for this is that the condition lacks an overall theory that might guide practitioners in their assessment of it and what they might do to intervene. In this article, I suggest that interpersonal theory might be such a candidate, enabling practitioners to manage this condition more effectively. My aim is to provide a brief introduction to this theory in the hope that practitioners might be encouraged to explore its implications more fully.
Specimens of shrimp Heptacarpus maxillipes (Thoridae) infected by parasitic barnacle Sylon hippolytes (Rhizocephala) were found for the first time along the Kuril Islands at a depth of 241–670 m. It is the second host from the genus Heptacarpus. Total number of hosts of S. hippolytes is currently 24. Carapace length of the infected shrimps ranged from 3 to 10 mm. Hosts had one or two parasitic externae of S. hippolytes. The size of the externa ranged from 1.5 to 9.0 mm in length and from 1.0 to 4.0 mm in height. Retinacula were not found. A single colleteric gland was present. Receptacles were absent. Regeneration of the ovary in the ovigerous externa was not observed. Sylon hippolytes produces only one larval generation. Larvae are hatched as small cyprids. Phylogenetic reconstruction confirmed the belonging of our specimens to the monophyletic clade of S. hippolytes with genetic distances between subclades from 6.96 to 8.4%. High values of intraspecific distances in S. hippolytes from different areas may point to cryptic speciation within this rhizocephalan.
Health care workers (HCWs) are vital in disaster response. This study explores HCWs’ experiences delivering care in the earthquake-affected zone in Türkiye.
Methods
A qualitative study with a phenomenological design was conducted. Eighteen HCWs, including physicians, nurses, and National Medical Rescue Team (UMKE) members, were selected through maximum variation sampling. Data were collected through semi-structured interviews and analyzed thematically using Braun and Clarke’s 6-phase approach, following COREQ guidelines.
Results
Three periods (pre-arrival, in the earthquake zone, and post-departure) and 8 themes were identified. In the pre-arrival phase, emotional symptoms and general organization were the main themes. In the earthquake zone, physical symptoms, basic needs, health care organization, health care delivery, and other services were prominent. The post-departure phase focused on emotional symptoms and return to routine work. Overall, emotional difficulties persisted throughout all phases, while organizational problems were concentrated in the pre-arrival and in the earthquake zone periods.
Conclusion
HCWs experienced emotional challenges across all periods and organizational problems in the pre-arrival and in the earthquake zone period. Clear information before arrival, structured orientation upon arrival, balanced staff distribution, and continuous psychological support throughout all phases are essential to protect HCWs’ well-being and sustain health care delivery during disasters.