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This study presents the first Korean records of two subtropical fish species, Pseudojuloides paradiseus and Diplogrammus xenicus, collected around Jeju-do Island, as well as one boreal fish species, Erilepis zonifer, collected in Busan (approximately 200 km away from Jeju-do Island). In this study, we discuss the implications of the species’ habitat range expansion. Previously, P. paradiseus was known as an endemic species of Japan, while D. xenicus was known to inhabit the Eastern Indian Ocean and the Pacific Ocean excluding around the equator, and E. zonifer was only known to inhabit the Pacific Ocean between eastern Japan and the western USA. Their habitat range expansions might be attributed to the expansion of the Tsushima Warm Current at the surface layer and/or the North Korean Cold Current at the bottom layer. Our findings may suggest that habitat of marine fish is being changed continuously by climate change or oceanic currents. Therefore, it needs to conduct integrated and systematic monitoring of fish fauna to response changing marine biodiversity.
Although mesopelagic fish dominate the oceanic ecosystem, they remain one of the least investigated components. From the vertically stratified sample collections, we investigated community structure, vertical distribution and diel/ontogenetic vertical migration covering four seasons for larval and juvenile/adult mesopelagic fish at the time-series station K2 in the Western Subarctic Gyre of the North Pacific. We collected 10 and 20 species of larval and juvenile/adult fish, respectively. Among the larval fish community, Leuroglossus schmidti was the most abundant; total abundances except L. schmidti were low throughout the year; species richness of myctophids were low. Among the 20 species of juvenile/adult fish, larvae of only six species were collected; thus, most mesopelagic fish species do not use the Western Subarctic Gyre as their nursery. In the juvenile/adult fish community, Stenobrachius leucopsarus and Stenobrachius nannochir were abundant. Species diversity and total abundance in the warm seasons (summer and autumn) were higher than in the cold seasons (winter and spring). The decreasing of species diversity and total abundance during the cold seasons was probably affected by horizontal migrations of fish for reproduction toward the southern transition or subarctic slope areas. Stenobrachius leucopsarus was distributed at shallow depths with opportunistic diel vertical migration (DVM); in contrast Stenobrachius nannochir occurred at greater depths, without DVM. The distribution depths of S. leucopsarus during day and those of S. nannochir changed seasonally and synchronously; shallowest in autumn, deepest in spring.
This study provides the first records of the upside-down jellyfish Cassiopea andromeda (Forskål, 1775) in the eastern Atlantic supported by molecular analysis. Specimens were observed, recorded, and sampled in an inland aquaculture facility in September 2023 in Tenerife Island (Canary Islands). This new record officially demonstrates the geographical expansion of C. andromeda, and the introduction of a new potential invasive species in the Macaronesia oceanic island system.
Management of paediatric non-tuberculous mycobacteria cervicofacial lymphadenitis (NTMCL) is variable without standard practice in the U.K. We undertook a survey to evaluate current U.K. practice in tertiary paediatric units.
Methods
A survey of twenty-one tertiary paediatric centres to evaluate NTMCL management.
Results
We received over 90% response rate. Only 21% have local guidelines, with the majority believing that written national guidance would improve management. Surgery is the most common management choice (69%), with a more limited procedure if skin is involved and/or in proximity to important structures. Observation alone is favoured (32%) when there is no skin involvement but in close proximity to the facial nerve. When treated medically, rifampicin and clarithromycin for 3 months was the commonest choice. Over 25% of respondents state their management has changed following previous adverse outcomes within their own practice or department.
Conclusion
This survey consolidates the current management of NTMCL in U.K. tertiary paediatric units.
Epidemiological evidence suggests that a higher intake of sugar during pregnancy is associated with a higher risk of childhood asthma and atopy. However, randomised trial evidence supporting such a link is lacking. This study aimed to examine whether a low glycaemic index (GI) dietary intervention during pregnancy decreases the risk of childhood asthma and eczema. This is a secondary analysis of 514 children from the ROLO trial. Healthy women were randomised to receive an intervention of low GI dietary advice or routine care from early pregnancy. Mothers reported current doctor-diagnosed eczema in their children at 2 years (n 271) and current doctor-diagnosed asthma and eczema in their children at 5 (n 357) and 9–11 years (n 391) of age. Multivariable logistic regression models were used test the effect of the intervention on child outcomes overall and stratified by maternal education. There was a suggestion of a reduction in asthma at 5 years of age in children whose mothers received the low GI dietary intervention during pregnancy compared with usual care (adjusted OR 0·46 (95 % CI 0·19, 1·09); P = 0·08). In stratified adjusted analyses, the intervention was associated with a reduced risk of asthma at 5 years of age in children born to mothers with incomplete tertiary level education but not in those with complete tertiary level education (OR 0·14 (95 % CI 0·02, 0·69); P = 0·010 and OR 1·03 (95 % CI 0·34, 3·13); P = 0·94, respectively). A low GI diet in pregnancy may reduce the risk of developing asthma in childhood, particularly amongst children born to mothers with lower educational attainment.
In Northeast Brazil, the poorest region of the country, indigenous communities face critical health care challenges. Despite legal entitlements to the Unified Health System (SUS), systemic barriers persist, exacerbating health disparities and mortality. This ecological study analyzed mortality trends and causes of death within the Special Indigenous Sanitary District (DSEI) Alagoas-Sergipe over a decade.
Methods
Data on deaths from 2012 to 2022 were obtained from the Indigenous Health Secretariat. Causes of death were classified into 13 categories. Mortality rates per 1,000 indigenous inhabitants were calculated, and trends were analyzed using the Mann-Kendall test. The study also compared causes of death by age group.
Results
Mortality rates ranged from 3.3 to 5.2 per 1,000, showing a moderate upward trend over time (τ = 0.5, p = 0.042). Predominant causes included heart and vascular disorders (24.3%), external causes (12.4%), respiratory issues (11.1%), and infections (10.9%). About one-third of pediatric deaths were associated with general neonatal complications.
Conclusions
This study highlights increasing mortality in indigenous communities in Northeast Brazil. The predominant causes of death reflect broader public health concerns. These trends emphasize the urgency for more effective, culturally sensitive public health policies and improved health care access.
When placed at the surface of a volatile liquid, a sphere of hot dense non-volatile material remains suspended until it cools sufficiently. The duration of this ‘inverse Leidenfrost’ phenomenon depends on the Nusselt number $Nu$ of the sphere, itself determined by flow in the film of vapour separating particle and liquid. It is shown that provided the Nusselt number is large, it can be calculated numerically using only the Laplace relation and the equations governing the thin film; patching to a solution for the outer thick film is not necessary. This method is demonstrated by using it to determine $Nu$ for a sphere sufficiently small that in the governing equations, the acceleration due to gravity is negligible except where multiplied by the density of the sphere. Numerical results giving $Nu$ as a function of a dimensionless measure of sphere weight are supplemented with analysis showing that, when the weight is of the order of the maximum supportable by surface tension alone, the film consists of a spherical bubble cap bounded by its contact rim. The solutions for these regions are coupled: although the apparent contact angle $\chi$ for the cap is determined within the rim, its value depends on the flow rate arriving from the cap as well as on the additional evaporation from the rim. The latter acts to reduce $\chi$ from the value it would otherwise have, thereby reducing the thickness of the entire cap. For the example treated here, the value of $Nu$ is doubled by this mechanism.
The 1984 election of David Penman as Anglican Archbishop of Melbourne was surprising, coming at the end of a controversial process in which two better-known candidates had consistently been the front runners. His election disrupted the longstanding power base of Melbourne Diocese represented by the two men passed over. But his election disrupted more than that – it disrupted the stalemate preventing the ordination of women in the Anglican Church of Australia. His election was crucial to the struggle to have women ordained in the Australian church. As Melbourne Diocesan Synod prepares to elect its next archbishop in 2025, it is timely to re-visit the 1984 election.
It is widely agreed that Thucydides’ Melian dialogue presents the Athenian invasion of Melos, and the Athenian justification, in a negative light. Attention tends to focus on the immorality of ‘the rule of the stronger’ that the Athenians present in the dialogue. This essay argues that another feature of the dialogue triggering negative judgements of the Athenians is their criticism of the Melians’ resistance: it is voiced by the Athenians themselves and therefore provokes in readers a ‘speaker-relative’ normative judgement of the Athenians. Philosophers have explored how our normative judgements about statements often depend on the speaker. Because the Athenians have deliberately put the Melians into their perilous situation, and because part of Athenian self-mythology was heroic resistance against overwhelming numbers in the Persian Wars, Athenian criticism of the Melians is hypocritical and applies an asymmetrical ethics to the Athenians and the Melians. Reaction against these features of the dialogue exacerbates the moral abhorrence of the Athenians felt by many readers. Hence I disagree with Bosworth’s view of the dialogue as primarily critical of the Melians. Instead we see Thucydides here condemning not only the Athenian imperial project but also the rhetoric used to defend and sustain it.
We consider the two-dimensional Rayleigh–Bénard convection problem between Navier-slip fixed-temperature boundary conditions, and present a new upper bound for the Nusselt number (${\textit {Nu}}$). The result, based on a localization principle for the Nusselt number and an interpolation bound, exploits the regularity of the flow. On one hand our method yields a shorter proof of the celebrated result of Whitehead & Doering (Phys. Rev. Lett., vol. 106, 2011, 244501) in the case of free-slip boundary conditions. On the other hand, its combination with a new, refined estimate for the pressure gives a substantial improvement of the interpolation bounds in Drivas et al. (Phil. Trans. R. Soc. A, vol. 380, issue 2225, 2022, 20210025) for slippery boundaries. A rich description of the scaling behaviour arises from our result: depending on the magnitude of the Prandtl number (${\textit {Pr}}$) and slip length, our upper bounds indicate five possible scaling laws (where ${\textit {Ra}}$ is the Rayleigh number): ${\textit {Nu}}\sim (L_s^{-1}\,{\textit {Ra}})^{{1}/{3}}$, ${\textit {Nu}}\sim (L_s^{-2/5}\,{\textit {Ra}})^{{5}/{13}}$, ${\textit {Nu}}\sim {\textit {Ra}}^{{5}/{12}}$, ${\textit {Nu}}\sim {\textit {Pr}}^{-1/6}(L_s^{-4/3}\,{\textit {Ra}})^{{1}/{2}}$ and ${\textit {Nu}}\sim {\textit {Pr}}^{-1/6}(L_s^{-1/3}\,{\textit {Ra}})^{{1}/{2}}$.
One of the main challenges in weight loss programmes is compliance with diet and achievement of sustainable changes in eating habits and lifestyles. Most clients desire to lose weight quickly, rather than looking at long-term changes. The literature suggests applying telenutrition, owing to its convenience and easy access in combination with both telemonitoring and health coaching, where confounding factors in the diet are tackled. A 6-month randomised controlled trial will be conducted to compare the effectiveness of telenutrition v. telenutrition supported by weekly telemonitoring and monthly health coaching in a weight loss programme. Participants are obese and overweight adults of both sex groups, aged 20–50 years who will be randomised to join a control or an intervention group. A total of three visits will be scheduled for all participants: at baseline, after three months and after six months. This study aims to answer the question of whether participants following a weight loss programme supported by telemonitoring and health coaching will increase their weight loss and compliance to the diet in comparison with the control group. This will be the first trial to assess the impact of integrating telemonitoring and health coaching in weight loss programmes, including the evaluation of associated confounding factors such as general nutrition education, eating behaviour, sensory modalities and hunger, and stress. This trial will support dietary weight loss programmes, contribute to the emerging field of telenutrition and provide advice for clinical dietitians and health coaches to work together to help individuals lose and maintain weight.
There are mainly two types of questions asked about religious language: those about identity (e.g., what is a religious language?) and those about meaning (e.g., what do its sentences say?). Most philosophers focus on the latter because while they disagree about meaning, they agree that some sentences are religious and that our understanding of them does not depend on us knowing what makes them religious. In this article, I provide two reasons why questions about identity should receive more attention. First, theories of identity and theories of meaning share a two-way relationship where the characteristics of one influence those of the other, and so overlooking identity overlooks important characteristics of meaning. Second, the study of religious language has been shaped by this relationship for some time and being aware of it improves our understanding of conventional trends and contemporary debates. If successful, this article will motivate philosophers to reconsider the role of identity in research and to dedicate more effort to its study.
Dietary n-3 PUFA may have potential benefits in preventing peptic ulcer disease (PUD). However, data from observational epidemiological studies are limited. Thus, we conducted a Mendelian randomisation analysis to reveal the causal impact of n-3 PUFA on PUD. Genetic variants strongly associated with plasma levels of total or individual n-3 PUFA including plant-derived α-linolenic acid and marine-derived EPA, DPA and DHA were enrolled as instrumental variables. Effect size estimates of the n-3 PUFA-associated genetic variants with PUD were evaluated using data from the UK biobank. Per one sd increase in the level of total n-3 PUFA in plasma was significantly associated with a lower risk of PUD (OR = 0·91; 95 % CI 0·85, 0·99; P = 0·020). The OR were 0·81 (95 % CI 0·67, 0·97) for EPA, 0·72 (95 % CI 0·58, 0·91) for DPA and 0·87 (95 % CI 0·80, 0·94) for DHA. Genetically predicted α-linolenic acid levels in plasma had no significant association with the risk of PUD (OR = 5·41; 95 % CI 0·70, 41·7). Genetically predicted plasma levels of n-3 PUFA were inversely associated with the risk of PUD, especially marine-based n-3 PUFA. Such findings may have offered an effective and feasible strategy for the primary prevention of PUD.
The negative role of malnutrition in patients with Crohn’s disease is known; however, many coexisting disease-related factors could cause misinterpretation of the real culprit. This study aimed to describe the role of malnutrition using a novel methodology, entropy balancing. This was a retrospective analysis of consecutive patients undergoing elective major surgery for Crohn’s disease, preoperatively screened following the European Society for Clinical Nutrition guidelines. Two-step entropy balancing was applied to the group of malnourished patients to obtain an equal cohort having a null or low risk of malnutrition. The first reweighting homogenised the cohorts for non-modifiable confounding factors. The second reweighting matched the two groups for modifiable nutritional factors, assuming successful treatment of malnutrition. The entropy balancing was evaluated using the d-value. Postoperative results are reported as mean difference or OR, with a 95 % CI. Of the 183 patients, 69 (37·7 %) were at moderate/high risk for malnutrition. The malnourished patients had lower BMI (d = 1·000), Hb (d = 0·715), serum albumin (d = 0·981), a higher lymphocyte count (d = 0·124), Charlson Comorbidity Index (d = 0·257), American Society of Anaesthesiologists (d = 0·327) and Harvey-Bradshaw scores (d = 0·696). Protective loop ileostomy was more frequently performed (d = 0·648) in the malnourished group. After the first reweighting, malnourished patients experienced a prolonged length of stay (mean difference = 1·9; 0·11, 3·71, days), higher overall complication rate (OR 4·42; 1·39, 13·97) and higher comprehensive complication index score (mean difference = 8·9; 2·2 15·7). After the second reweighting, the postoperative course of the two groups was comparable. Entropy balancing showed the independent role of preoperative malnutrition and the possible advantages obtainable from a pre-habilitation programme in Crohn’s disease patients awaiting surgery.
Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age, associated with increased risks of metabolic disorders, depression and reduced quality of life. This study examined the impact of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on mental health, PCOS-related quality of life (PCOSQ), anthropometric indices, hirsutism, and metabolic/hormonal parameters in women with PCOS. Total of 52 women with PCOS, aged between 18 and 45 years, were randomly assigned to either the low calorie MIND diet group or the control group. Anthropometric data, depression and anxiety scores, serum levels of gonadotropins (luteinizing hormone [LH], follicle-stimulating hormone [FSH]), PCOSQ, and Ferriman-Gallwey score were evaluated before and after the intervention. Outcomes were assessed at baseline and at the end of the 8-week follow-up period. After 8 weeks, the MIND diet significantly reduced depression (β –3·03; 95 % CI: [–5·36, –0·70]; P = 0·011) and anxiety (β –3·54; 95 % CI: [–6·60, –0·49]; P = 0·024) scores compared with the control group. The MIND diet group exhibited significant increases in the emotion (β 0·63; 95 % CI: [0·18, 1·08]; P = 0·007) and body hair (β 0·65; 95 % CI: [0·03, 1·28]; P = 0·04) domains of the PCOSQ compared to the control group. The changes in other parameters did not show significant differences between the two groups. Both the MIND diet and control groups showed improvements in weight and BMI, with a slight advantage for the MIND diet group. These findings suggest that the MIND diet may be beneficial for improving mental health and some aspects of PCOSQ in women with PCOS.
The diagnosis of central nervous system tumours has been transformed in recent years from a microscopic morphology-based process to one dominated by the identification of somatic genetic alterations in tumour cells. This switch requires implementing radically different methods, for which appropriate training and financial resources must be allocated. The Canadian Association of Neuropathologists (CANP) has followed a process based on the scientific literature and consensus to develop recommendations for molecular testing of tumours of the brain and spinal cord, aiming to balance the need for treatment-determinant accurate diagnosis and the current limitations inherent in the transition to a new paradigm. The Professional Affairs Committee was charged with this task. A draft was discussed during the CANP general assembly, along with presentations from groups who had implemented molecular technologies, as well as others who relied on external laboratories. The Professional Affairs Committee summarised the consensus and submitted their recommendation to the CANP’s Executive Committee. A final report was posted on the CANP website for a month to allow all members to comment. The recommendations below apply to intrinsic tumours of the central nervous system and do not include metastatic disease or tumours impinging upon the nervous system from outside. These recommendations should be considered clinically relevant, as the results have direct consequences on the patient’s treatment, either through the use of targeted therapies or the trial-proven best application of radiation and/or chemotherapy.
We combine newly collected election data with records of public denials of the results of the 2020 election to estimate the degree to which election-denying Republican candidates over- or underperformed other Republicans in 2022 in statewide and federal elections. We find that the average vote share of election-denying Republicans in statewide races was approximately 3.2 percentage points lower than their co-partisans after accounting for state-level partisanship. However, we find no such underperformance on aggregate for U.S. House elections, perhaps due to the more-partisan nature of many House districts. Together, the results suggest that the types of candidates in American elections who take more-extreme positions tend to underperform, but that these performance gaps are relatively small in the present, polarized political environment.
Onion is sensitive to soil water stress and nitrogen limitations, causing a marked reduction in yield and bulb quality. A field trial was set in the winter seasons of 2016–17 and 2017–18 to evaluate the effects of three micro-sprinkler irrigation levels at 0.6, 0.9 and 1.2 ratios of crop evapotranspiration (ETc) and four nitrogen levels at 0, 75, 100 and 120% of the recommended nitrogen dose (RDN), including surface irrigation at 40 mm cumulative pan evaporation (CPE) with 100% RDN (SN) using an augmented strip plot design on water and N distribution in soil, their productivities, onion yield and economics. Results indicated that the root zone water content increased by 5.2% for 1.2 ETc, and 1.4% for 0.9 ETc over the cropping period, but declined by 1.5% for 0.6 ETc with micro-sprinkler irrigation compared to surface irrigation with nitrogen fertilization (SN). The largest total root zone water depletion was in 1.2 ETc (16.7%), followed by SN (15.3%) and 0.9 ETc (15.0%). The high irrigation regime produced the maximum yield and nitrogen productivity, whereas deficit irrigation displayed the greatest water productivity. However, the coupling of micro-sprinkler irrigation at 1.2 ETc and 120% RDN led to an increase of onion bulb yield (22.6%), water productivity (42.7%), plant N uptake (29.0%) and net income (30.6%) with maximum benefit-cost ratio (3.19) compared to SN. However, as this study was only based on two seasons, more field trials will be needed to confirm the optimum amount of water and nitrogen for winter onion.