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Normal aging often leads to cognitive decline, and oldest old people, over 80 years old, have a 15% risk of developing neurodegenerative diseases. Therefore, it is important to have appropriate tools to assess cognitive function in old age. The study aimed to provide new norms for neuropsychological tests used to evaluate the cognitive abilities in people aged 80 years and older in France, focusing on the impact of education and gender differences.
Method:
107 healthy participants with an average age of 85.2 years, with no neurological history or major cognitive deficits were included. A comprehensive neuropsychological assessment was performed, covering several cognitive functions such as memory, visuospatial abilities, executive functions, attention, processing speed, and praxis.
Results:
Individuals with lower levels of education performed poorly on some tests and took longer to complete. Gender differences were observed, with women outperforming men in verbal episodic memory, while men showed better performance in visuoconstructive tasks. The participants showed lower performance in verbal episodic memory compared to norms established in previous French studies. In relation to executive functions, participants were slower to perform complex tasks than participants in previous studies.
Conclusion:
This study provides cognitive norms specifically adapted to the oldest old population, which differ from established norms for younger aging adults. It highlights the importance of including these norms in future clinical and scientific investigations. The findings underscore the importance of education on cognitive abilities and emphasize the need to consider gender differences when assessing cognitive functions in aging populations.
The background potential energy (BPE) is the only reservoir that double diffusive instabilities can tap their energy from when developing from an unforced motionless state with no available potential energy (APE). Recently, Middleton and Taylor linked the extraction of BPE into APE to the sign of the diapycnal component of the buoyancy flux, but their criterion can predict only diffusive convection instability, not salt finger instability. Here, we show that the problem can be corrected if the sign of the APE dissipation rate is used instead, making it emerge as the most fundamental criterion for double diffusive instabilities. A theory for the APE dissipation rate for a two-component fluid relative to its single-component counterpart is developed as a function of three parameters: the diffusivity ratio, the density ratio, and a spiciness parameter. The theory correctly predicts the occurrence of both salt finger and diffusive convection instabilities in the laminar unforced regime, while more generally predicting that the APE dissipation rate for a two-component fluid can be enhanced, suppressed, or even have the opposite sign compared to that for a single-component fluid, with important implications for the study of ocean mixing. Because negative APE dissipation can also occur in stably stratified single-component and doubly stable two-component stratified fluids, we speculate that only the thermodynamic theory of exergy can explain its physics; however, this necessitates accepting that APE dissipation is a conversion between APE and the internal energy component of BPE, in contrast to prevailing assumptions.
Let G be a connected semisimple real algebraic group. For a Zariski dense Anosov subgroup $\Gamma <G$ with respect to a parabolic subgroup $P_\theta $, we prove that any $\Gamma $-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $. More generally, we prove that for a Zariski dense $\theta $-transverse subgroup $\Gamma <G$, any $(\Gamma , \psi )$-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $, provided the $\psi $-Poincaré series of $\Gamma $ diverges at its abscissa of convergence. In particular, our result also applies to relatively Anosov subgroups.
Amputation as a life-saving measure for earthquake-trapped patients is supported by WHO and INSARAG guidelines. However, implementing these guidelines in highly stressful contexts can complicate decision-making. This report presents a case of life-saving amputation during the 2023 Turkey earthquake, adhering to recommended guidelines. The 16-year-old patient was trapped for 55 hours in a narrow corridor. Extensive interdisciplinary discussions led to the decision for a field amputation after alternative rescue attempts failed. Consent was obtained from the family, given the patient’s delirium. Meticulous planning and anesthesia using midazolam and ketamine ensured successful amputation with minimal blood loss. Challenges encountered during the disaster response were discussed. Delays in administering antibiotics, a lack of cervical protection, ethical dilemmas, psychological concerns, and legal implications were highlighted. Continued improvement and addressing ethical, legal, and psychological aspects are essential for optimal disaster response outcomes.
To capture the distortion of exploratory activity typical of patients with spatial neglect, traditional diagnostic methods and new virtual reality applications use confined workspaces that limit patients’ exploration behavior to a predefined area. Our aim was to overcome these limitations and enable the recording of patients’ biased activity in real, unconfined space.
Methods:
We developed the Free Exploration Test (FET) based on augmented reality technology. Using a live stream via the back camera on a tablet, patients search for a (non-existent) virtual target in their environment, while their exploration movements are recorded for 30 s. We tested 20 neglect patients and 20 healthy participants and compared the performance of the FET with traditional neglect tests.
Results:
In contrast to controls, neglect patients exhibited a significant rightward bias in exploratory movements. The FET had a high discriminative power (area under the curve = 0.89) and correlated positively with traditional tests of spatial neglect (Letter Cancellation, Bells Test, Copying Task, Line Bisection). An optimal cut-off point of the averaged bias of exploratory activity was at 9.0° on the right; it distinguished neglect patients from controls with 85% sensitivity.
Discussion:
FET offers time-efficient (execution time: ∼3 min), easy-to-apply, and gamified assessment of free exploratory activity. It supplements traditional neglect tests, providing unrestricted recording of exploration in the real, unconfined space surrounding the patient.
Rapid technological development means that the ground on which recent academic studies and public debates about the future of work organisation are based is shifting too rapidly for predictions to be credible. Organisational studies scholars have provided a counterpoint to this futuristic, speculative debate about the world of tomorrow with studies that contextualise seemingly new trends within a longer history of industrial capitalism. In this article, using Moritz Altenried's The Digital Factory (2022) as a starting point, I further explore the historical contextualisation of two aspects of platform capitalism: its de-spatialisation and its use of “autonomy”.
More than two-thirds of women during childbearing years (20–39 years old) are overweight or obese in the United States, with protein intake among 20–49-year-old women being 1.6 times higher than recommended (75.4 g/day versus 46 g/day) that can be considered as a relatively high-protein diet (HPD). Both gestational obesity and HPDs during gestation adversely affect offspring health. This study investigates the impact of HPDs fed during gestation and lactation on obese mothers and their offspring in Wistar rats. Dams randomized to either a normal-protein diet (NPD) or HPD (n = 12/group). Pups from each maternal group were weaned to either NPD or HPD for 17 weeks (n = 12/group). No effect of maternal or weaning diet on food intake, body weight, or body fat/weight ratio was observed. However, NPD dams exhibited higher glucose area under the curve compared with HPD dams (p < 0.03). At weaning, offspring born to NPD dams showed higher fasting plasma glucose (P < 0.03) and insulin/glucose ratio (P = 0.05) than those born to HPD dams. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index was higher in offspring born to NPD dams (P < 0.04) and weaned to NPD (P < 0.05) at week 17. These findings underscore the role of high-protein maternal and weaning diets in pregnancy outcomes for obese mothers, particularly in glucose homeostasis, although gestational obesity may overshadow other parameters. Further research is needed to fully understand the impact on both maternal and offspring health and their underlying mechanisms in this context.
This study describes the presence of the royal cucumber Parastichopus regalis (Cuvier, 1817) in The Natural Park of Ria Formosa (NPRF), Portugal. A single individual was observed during a monitoring scuba dive at a depth of 3 m inside this shallow mesotidal lagoon. The most plausible explanation for this occurrence is attributed to the rejection by trawlers when returning to their home port from their fishing grounds. This marine species has a deeper distribution outside the lagoon and is commonly captured as by-catch and subsequently discarded. This study also alerts us to the growing presence of non-indigenous species and the emergent threat of new invasions, highlighting the need to adopt biosecurity measures, like good practices for fishers when dealing with discards to avoid new species introductions in this fragile coastal marine habitat.
To capture prey more efficiently, cetaceans can display a wide range of foraging tactics to separate individual prey. Barrier feeding tactics are performed to restrict prey movements, using natural and non-natural barriers and some species can even create barriers with their own bodies. Mud ring feeding has been observed in bottlenose dolphins in Florida Bay and in Chetumal-Corozal Bay, where ring-maker dolphins create ring-shaped mud plumes to encircle fish schools. Here, we document for the first time Guiana dolphins performing the mud ring feeding behaviour in the Cananéia estuarine system, in the southern portion of the state of São Paulo, Brazil. A total of 11 dolphins were recorded in four expeditions through aerial footage engaging in the behaviour. These findings expand our knowledge about the behavioural plasticity of the species and builds upon existing records of mud ring feeding behaviour in cetaceans.
Identify which NIH Toolbox Cognition Battery (NIHTB-CB) subtest(s) best differentiate healthy controls (HC) from those with amnestic mild cognitive impairment (aMCI) and compare the discriminant accuracy between a model using a priori “Norm Adjusted” scores versus “Unadjusted” standard scores with age, sex, race/ethnicity, and education controlled for within the model. Racial differences were also examined.
Methods:
Participants were Black/African American (B/AA) and White consensus-confirmed (HC = 96; aMCI = 62) adults 60–85 years old that completed the NIHTB-CB for tablet. Discriminant function analysis (DFA) was used in the Total Sample and separately for B/AA (n = 80) and White participants (n = 78).
Results:
Picture Sequence Memory (an episodic memory task) was the highest loading coefficient across all DFA models. When stratified by race, differences were noted in the pattern of the highest loading coefficients within the DFAs. However, the overall discriminant accuracy of the DFA models in identifying HCs and those with aMCI did not differ significantly by race (B/AA, White) or model/score type (Norm Adjusted versus Unadjusted).
Conclusions:
Racial differences were noted despite the use of normalized scores or demographic covariates—highlighting the importance of including underrepresented groups in research. While the models were fairly accurate at identifying consensus-confirmed HCs, the models proved less accurate at identifying White participants with an aMCI diagnosis. In clinical settings, further work is needed to optimize computerized batteries and the use of NIHTB-CB norm adjusted scores is recommended. In research settings, demographically corrected scores or within model correction is suggested.
The World Health Organization declared the current monkeypox outbreak a public health emergency of international concern (PHEIC) on July 23, 2022, as it has posed a great threat to human health. This bibliometric analysis aimed to explore the current research hotspots focused on monkeypox.
Methods
A systematic search of the Web of Science Core Collection database was conducted for published articles on monkeypox from database inception to February 23, 2023. VOSviewer software was used for analysis and visualization of research results.
Results
A total of 1646 publications on monkeypox virus were included for bibliometric analysis. Results showed that (1) the number of publications about monkeypox virus increased significantly in 2022, (2) smallpox and monkeypox virus were popular research keywords, (3) the United States has made the most significant contribution to the study of monkeypox virus, (4) Journal of Virology was the most active journal in publishing articles about monkeypox, and (5) research themes mainly included the body’s reaction after monkeypox infection, epidemiology, diagnosis, and pathological mechanisms.
Conclusions
Future research should focus on early sensitive diagnostic measures of monkeypox and the development of vaccines based on the characteristics of the virus. Study findings also provided key areas for public health experts to focus on and collaborate with policymakers.
Informal music learning, pioneered by Green (2002, 2006, 2017), presents an alternative approach that integrates students’ interests in popular music, bridging the informal and traditional styles of Western music education in schools. We conducted a scoping review adhering to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to investigate informal music learning. Our scoping review encompasses 28 empirical, peer-reviewed articles published from 2006 to 2023. First, we analyse the diverse contexts, methodologies and geographic locations in which informal music learning has been investigated. Second, we explore how different stakeholders perceive and engage with informal music learning in various educational settings. Lastly, we summarise the implications derived from the analysed studies on informal music learning. Our findings reveal that across various educational contexts, informal music learning has consistently demonstrated its positive impact in motivating students. We also find that researchers have extended their investigations from programme reform to exploring pupil and teacher’s musical identities. Recommendations for future research include exploring informal music learning in ensembles and elementary music classrooms and employing quantitative or mixed methods to assess its effectiveness and impact.
Early nutritional and growth experiences can impact development, metabolic function, and reproductive outcomes in adulthood, influencing health trajectories in the next generation. The insulin-like growth factor (IGF) axis regulates growth, metabolism, and energetic investment, but whether it plays a role in the pathway linking maternal experience with offspring prenatal development is unclear. To test this, we investigated patterns of maternal developmental weight gain (a proxy of early nutrition), young adult energy stores, age, and parity as predictors of biomarkers of the pregnancy IGF axis (n = 36) using data from the Cebu Longitudinal Health and Nutrition Survey in Metro Cebu, Philippines. We analyzed maternal conditional weight measures at 2, 8, and 22 years of age and leptin at age 22 (a marker of body fat/energy stores) in relation to free IGF-1 and IGFBP-3 in mid/late pregnancy (mean age = 27). Maternal IGF axis measures were also assessed as predictors of offspring fetal growth. Maternal age, parity, and age 22 leptin were associated with pregnancy free IGF-1, offspring birth weight, and offspring skinfold thickness. We find that free IGF-1 levels in pregnancy are more closely related to nutritional status in early adulthood than to preadult developmental nutrition and demonstrate significant effects of young adult leptin on offspring fetal fat mass deposition. We suggest that the previously documented finding that maternal developmental nutrition predicts offspring birth size likely operates through pathways other than the maternal IGF axis, which reflects more recent energy status.
Autonomous underwater vehicles (AUVs) have played a pivotal role in advancing ocean exploration and exploitation. However, traditional AUVs face limitations when executing missions at minimal or near-zero forward velocities due to the ineffectiveness of their control surfaces, considerably constraining their potential applications. To address this challenge, this paper introduces an innovative vectored thruster system based on a 3RRUR parallel manipulator tailored for micro-sized AUVs. The incorporation of a vectored thruster enhances the performance of micro-sized AUVs when operating at minimal and low forward speeds. A comprehensive exploration of the kinematics of the thrust-vectoring mechanism has been undertaken through theoretical analysis and experimental validation. The findings from theoretical analysis and experimental confirmation unequivocally affirm the feasibility of the devised thrust-vectoring mechanism. The precise control of the vector device is studied using Physics-informed Neural Network and Model Predictive Control (PINN-MPC). Through the adoption of this pioneering thrust-vectoring mechanism rooted in the 3RRUR parallel manipulator, AUVs can efficiently and effectively generate the requisite motion for thrust-vectoring propulsion, overcoming the limitations of traditional AUVs and expanding their potential applications across various domains.
This essay explores two texts in a fifteenth-century manuscript from Thetford Priory, Norfolk (now ms 329 in the Parker Library, Corpus Christi College, Cambridge). The first is an account of Marian miracles leading to the building of the Lady Chapel in the thirteenth century, and the second is an account of the formation of its relic collection in the twelfth century, which would be housed inside a statue of the Virgin Mary. The destruction of Thetford Priory at the Dissolution lends them a special significance since they offer evidence of a minor Marian cult that would be otherwise lost to us. The texts also highlight the interactions of aristocratic patrons – the Bigod family – and their Cluniac foundation. This essay explores the texts for the first time, offers a transcription and translation of them and considers their place in the cult of the Virgin at Thetford and in England generally.
Since the onset of the COVID-19 pandemic, both viral infection and the corresponding economic turmoil have wreaked havoc across the globe, highlighting the imperative function of the state as a social protection provider. The pandemic has seemingly created favourable political circumstances for rapidly expanding social protection, but its influences on public welfare attitudes remain unclear. In this study, I argue that the impact of pandemic-driven economic risk is too limited to spur strong public support for social protection. The employed empirical analyses using panel data collected in South Korea show that unemployment induced by the pandemic is conducive to higher degrees of individual support for social protection measures, but the impact is only short-lived. Further analyses show that, once individuals are re-employed and as the time spent in economic difficulties becomes more distant, personal unemployment experiences are no longer positively associated with support for social protection. Finally, pandemic-induced unemployment experiences have a lasting impact primarily on young adults. The evidence therefore suggests that significant institutional changes in the welfare state are hard to achieve by solely relying on the impact of economic risk.