The 1984 election of David Penman as Anglican Archbishop of Melbourne was surprising, coming at the end of a controversial process in which two better-known candidates had consistently been the front runners. His election disrupted the longstanding power base of Melbourne Diocese represented by the two men passed over. But his election disrupted more than that – it disrupted the stalemate preventing the ordination of women in the Anglican Church of Australia. His election was crucial to the struggle to have women ordained in the Australian church. As Melbourne Diocesan Synod prepares to elect its next archbishop in 2025, it is timely to re-visit the 1984 election.

It is widely agreed that Thucydides’ Melian dialogue presents the Athenian invasion of Melos, and the Athenian justification, in a negative light. Attention tends to focus on the immorality of ‘the rule of the stronger’ that the Athenians present in the dialogue. This essay argues that another feature of the dialogue triggering negative judgements of the Athenians is their criticism of the Melians’ resistance: it is voiced by the Athenians themselves and therefore provokes in readers a ‘speaker-relative’ normative judgement of the Athenians. Philosophers have explored how our normative judgements about statements often depend on the speaker. Because the Athenians have deliberately put the Melians into their perilous situation, and because part of Athenian self-mythology was heroic resistance against overwhelming numbers in the Persian Wars, Athenian criticism of the Melians is hypocritical and applies an asymmetrical ethics to the Athenians and the Melians. Reaction against these features of the dialogue exacerbates the moral abhorrence of the Athenians felt by many readers. Hence I disagree with Bosworth’s view of the dialogue as primarily critical of the Melians. Instead we see Thucydides here condemning not only the Athenian imperial project but also the rhetoric used to defend and sustain it.

One of the main challenges in weight loss programmes is compliance with diet and achievement of sustainable changes in eating habits and lifestyles. Most clients desire to lose weight quickly, rather than looking at long-term changes. The literature suggests applying telenutrition, owing to its convenience and easy access in combination with both telemonitoring and health coaching, where confounding factors in the diet are tackled. A 6-month randomised controlled trial will be conducted to compare the effectiveness of telenutrition v. telenutrition supported by weekly telemonitoring and monthly health coaching in a weight loss programme. Participants are obese and overweight adults of both sex groups, aged 20–50 years who will be randomised to join a control or an intervention group. A total of three visits will be scheduled for all participants: at baseline, after three months and after six months. This study aims to answer the question of whether participants following a weight loss programme supported by telemonitoring and health coaching will increase their weight loss and compliance to the diet in comparison with the control group. This will be the first trial to assess the impact of integrating telemonitoring and health coaching in weight loss programmes, including the evaluation of associated confounding factors such as general nutrition education, eating behaviour, sensory modalities and hunger, and stress. This trial will support dietary weight loss programmes, contribute to the emerging field of telenutrition and provide advice for clinical dietitians and health coaches to work together to help individuals lose and maintain weight.

There are mainly two types of questions asked about religious language: those about identity (e.g., what is a religious language?) and those about meaning (e.g., what do its sentences say?). Most philosophers focus on the latter because while they disagree about meaning, they agree that some sentences are religious and that our understanding of them does not depend on us knowing what makes them religious. In this article, I provide two reasons why questions about identity should receive more attention. First, theories of identity and theories of meaning share a two-way relationship where the characteristics of one influence those of the other, and so overlooking identity overlooks important characteristics of meaning. Second, the study of religious language has been shaped by this relationship for some time and being aware of it improves our understanding of conventional trends and contemporary debates. If successful, this article will motivate philosophers to reconsider the role of identity in research and to dedicate more effort to its study.

Dietary n-3 PUFA may have potential benefits in preventing peptic ulcer disease (PUD). However, data from observational epidemiological studies are limited. Thus, we conducted a Mendelian randomisation analysis to reveal the causal impact of n-3 PUFA on PUD. Genetic variants strongly associated with plasma levels of total or individual n-3 PUFA including plant-derived α-linolenic acid and marine-derived EPA, DPA and DHA were enrolled as instrumental variables. Effect size estimates of the n-3 PUFA-associated genetic variants with PUD were evaluated using data from the UK biobank. Per one sd increase in the level of total n-3 PUFA in plasma was significantly associated with a lower risk of PUD (OR = 0·91; 95 % CI 0·85, 0·99; P = 0·020). The OR were 0·81 (95 % CI 0·67, 0·97) for EPA, 0·72 (95 % CI 0·58, 0·91) for DPA and 0·87 (95 % CI 0·80, 0·94) for DHA. Genetically predicted α-linolenic acid levels in plasma had no significant association with the risk of PUD (OR = 5·41; 95 % CI 0·70, 41·7). Genetically predicted plasma levels of n-3 PUFA were inversely associated with the risk of PUD, especially marine-based n-3 PUFA. Such findings may have offered an effective and feasible strategy for the primary prevention of PUD.

The negative role of malnutrition in patients with Crohn’s disease is known; however, many coexisting disease-related factors could cause misinterpretation of the real culprit. This study aimed to describe the role of malnutrition using a novel methodology, entropy balancing. This was a retrospective analysis of consecutive patients undergoing elective major surgery for Crohn’s disease, preoperatively screened following the European Society for Clinical Nutrition guidelines. Two-step entropy balancing was applied to the group of malnourished patients to obtain an equal cohort having a null or low risk of malnutrition. The first reweighting homogenised the cohorts for non-modifiable confounding factors. The second reweighting matched the two groups for modifiable nutritional factors, assuming successful treatment of malnutrition. The entropy balancing was evaluated using the d-value. Postoperative results are reported as mean difference or OR, with a 95 % CI. Of the 183 patients, 69 (37·7 %) were at moderate/high risk for malnutrition. The malnourished patients had lower BMI (d = 1·000), Hb (d = 0·715), serum albumin (d = 0·981), a higher lymphocyte count (d = 0·124), Charlson Comorbidity Index (d = 0·257), American Society of Anaesthesiologists (d = 0·327) and Harvey-Bradshaw scores (d = 0·696). Protective loop ileostomy was more frequently performed (d = 0·648) in the malnourished group. After the first reweighting, malnourished patients experienced a prolonged length of stay (mean difference = 1·9; 0·11, 3·71, days), higher overall complication rate (OR 4·42; 1·39, 13·97) and higher comprehensive complication index score (mean difference = 8·9; 2·2 15·7). After the second reweighting, the postoperative course of the two groups was comparable. Entropy balancing showed the independent role of preoperative malnutrition and the possible advantages obtainable from a pre-habilitation programme in Crohn’s disease patients awaiting surgery.

Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age, associated with increased risks of metabolic disorders, depression and reduced quality of life. This study examined the impact of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on mental health, PCOS-related quality of life (PCOSQ), anthropometric indices, hirsutism, and metabolic/hormonal parameters in women with PCOS. Total of 52 women with PCOS, aged between 18 and 45 years, were randomly assigned to either the low calorie MIND diet group or the control group. Anthropometric data, depression and anxiety scores, serum levels of gonadotropins (luteinizing hormone [LH], follicle-stimulating hormone [FSH]), PCOSQ, and Ferriman-Gallwey score were evaluated before and after the intervention. Outcomes were assessed at baseline and at the end of the 8-week follow-up period. After 8 weeks, the MIND diet significantly reduced depression (β –3·03; 95 % CI: [–5·36, –0·70]; P = 0·011) and anxiety (β –3·54; 95 % CI: [–6·60, –0·49]; P = 0·024) scores compared with the control group. The MIND diet group exhibited significant increases in the emotion (β 0·63; 95 % CI: [0·18, 1·08]; P = 0·007) and body hair (β 0·65; 95 % CI: [0·03, 1·28]; P = 0·04) domains of the PCOSQ compared to the control group. The changes in other parameters did not show significant differences between the two groups. Both the MIND diet and control groups showed improvements in weight and BMI, with a slight advantage for the MIND diet group. These findings suggest that the MIND diet may be beneficial for improving mental health and some aspects of PCOSQ in women with PCOS.

The diagnosis of central nervous system tumours has been transformed in recent years from a microscopic morphology-based process to one dominated by the identification of somatic genetic alterations in tumour cells. This switch requires implementing radically different methods, for which appropriate training and financial resources must be allocated. The Canadian Association of Neuropathologists (CANP) has followed a process based on the scientific literature and consensus to develop recommendations for molecular testing of tumours of the brain and spinal cord, aiming to balance the need for treatment-determinant accurate diagnosis and the current limitations inherent in the transition to a new paradigm. The Professional Affairs Committee was charged with this task. A draft was discussed during the CANP general assembly, along with presentations from groups who had implemented molecular technologies, as well as others who relied on external laboratories. The Professional Affairs Committee summarised the consensus and submitted their recommendation to the CANP’s Executive Committee. A final report was posted on the CANP website for a month to allow all members to comment. The recommendations below apply to intrinsic tumours of the central nervous system and do not include metastatic disease or tumours impinging upon the nervous system from outside. These recommendations should be considered clinically relevant, as the results have direct consequences on the patient’s treatment, either through the use of targeted therapies or the trial-proven best application of radiation and/or chemotherapy.

We combine newly collected election data with records of public denials of the results of the 2020 election to estimate the degree to which election-denying Republican candidates over- or underperformed other Republicans in 2022 in statewide and federal elections. We find that the average vote share of election-denying Republicans in statewide races was approximately 3.2 percentage points lower than their co-partisans after accounting for state-level partisanship. However, we find no such underperformance on aggregate for U.S. House elections, perhaps due to the more-partisan nature of many House districts. Together, the results suggest that the types of candidates in American elections who take more-extreme positions tend to underperform, but that these performance gaps are relatively small in the present, polarized political environment.

Onion is sensitive to soil water stress and nitrogen limitations, causing a marked reduction in yield and bulb quality. A field trial was set in the winter seasons of 2016–17 and 2017–18 to evaluate the effects of three micro-sprinkler irrigation levels at 0.6, 0.9 and 1.2 ratios of crop evapotranspiration (ETc) and four nitrogen levels at 0, 75, 100 and 120% of the recommended nitrogen dose (RDN), including surface irrigation at 40 mm cumulative pan evaporation (CPE) with 100% RDN (SN) using an augmented strip plot design on water and N distribution in soil, their productivities, onion yield and economics. Results indicated that the root zone water content increased by 5.2% for 1.2 ETc, and 1.4% for 0.9 ETc over the cropping period, but declined by 1.5% for 0.6 ETc with micro-sprinkler irrigation compared to surface irrigation with nitrogen fertilization (SN). The largest total root zone water depletion was in 1.2 ETc (16.7%), followed by SN (15.3%) and 0.9 ETc (15.0%). The high irrigation regime produced the maximum yield and nitrogen productivity, whereas deficit irrigation displayed the greatest water productivity. However, the coupling of micro-sprinkler irrigation at 1.2 ETc and 120% RDN led to an increase of onion bulb yield (22.6%), water productivity (42.7%), plant N uptake (29.0%) and net income (30.6%) with maximum benefit-cost ratio (3.19) compared to SN. However, as this study was only based on two seasons, more field trials will be needed to confirm the optimum amount of water and nitrogen for winter onion.

Although the relationship between gaming addiction (GA) and attention deficit hyperactivity disorder (ADHD) is well established, the causal mechanism of this relationship remains ambiguous. We aimed to investigate whether common genetic and/or environmental factors explain the GA-ADHD relationship. We recruited 1413 South Korean adult twins (837 monozygotic [MZ], 326 same-sex dizygotic [DZ], and 250 opposite-sex DZ twins; mean age = 23.1 ± 2.8 years) who completed an online survey on GA and related traits. Correlational analysis and bivariate model-fitting analysis were conducted. Phenotypic correlation between GA and ADHD in the present sample was 0.55 (95% CI [0.51, 0.59]). Bivariate model-fitting analysis revealed that genetic variances were 69% (95% CI [64%, 73%]) and 68% (95% CI [63%, 72%]) for ADHD and GA respectively. The remaining variances (ADHD: 31%; GA: 32%) were associated with nonshared environmental variances, including measurement error. Genetic and nonshared environmental correlations between ADHD and GA were 0.68 (95% CI [0.62, 0.74]) and 0.22 (95% CI [0.13, 0.30]) respectively, which indicates that shared genes can explain 82% of the phenotypic correlation between ADHD and GA. Our study demonstrated that the ADHD-GA association was largely due to shared genetic vulnerability.

It is a reasonable worry that God would not truly love us and want our salvation if He fixed a definite point after which He will no longer offer us the graces to repent of our sins. I propose that Thomas Aquinas succeeds in showing us that God would not be cruel or arbitrary in setting up a world where embodied agents end up after death in a state where they will inevitably fail to repent of their sins. Aquinas proposes that being disembodied is to be in a state where a person cannot be mistaken about what they want, given that they know themselves perfectly. If the disembodied state were like this, it would not be surprising that being in that state makes repentance impossible, since a soul would become fully integrated around whatever one desired, without any conflicting desires that could prompt repentance. Thus, humans would persist in whatever desires they had at the moment of death and disembodiment. I conclude by arguing that, while this scenario stands in need of fuller theodicy, Aquinas’s scenario is helpful in defending a view that God is not cruel or arbitrary for creating a world in which post-mortem repentance is impossible.

Paternal exposures (and other non-maternal factors) around pregnancy could have important effects on offspring health. One challenge is that data on partners are usually from a subgroup of mothers with data, potentially introducing selection bias, limiting generalisability of findings. We aimed to investigate the potential for selection bias in studies using partner data.

We characterise availability of data on father/partner and mother health behaviours (smoking, alcohol, caffeine and physical activity) around pregnancy from three UK cohort studies: the Avon Longitudinal Study of Parents and Children (ALSPAC), Born in Bradford and the Millennium Cohort Study. We assess the extent of sample selection by comparing characteristics of families where fathers/partners do and do not participate. Using the association of parental smoking during pregnancy and child birthweight as an example, we perform simulations to investigate the extent to which missing father/partner data may induce bias in analyses conducted only in families with participating fathers/partners.

In all cohorts, father/partner data were less detailed and collected at fewer timepoints than mothers. Partners with a lower socio-economic position were less likely to participate. In simulations based on ALSPAC data, there was little evidence of selection bias in associations of maternal smoking with birthweight, and bias for father/partner smoking was relatively small. Missing partner data can induce selection bias. In our example analyses of the effect of parental smoking on offspring birthweight, the bias had a relatively small impact. In practice, the impact of selection bias will depend on both the analysis model and the selection mechanism.