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Post the great financial crisis (GFC) of 2008–2009, there has been a surge in the macroeconomics literature on aggregate uncertainty. Although the recent literature has recognized the adverse real effects of global uncertainty shocks in emerging market economies (EMEs), the role of monetary policy in offsetting these adverse effects and their link with the exchange rates is not explored in the literature. We find that the currently followed interest rate rules (IRRs) under a flexible inflation-targeting regime are ineffective in stabilizing the domestic economy during periods of high global uncertainty in the EMEs. Using a small open economy new Keynesian DSGE model with Epstein–Zin preferences and second-moment demand shocks, we compare and propose alternate monetary policy rules that significantly reduce welfare losses. We find that the best monetary policy rule in terms of welfare depends on the nature of shock that is, first-moment or second-moment shock.
Vitamin D deficiency has previously been linked to higher rates of exacerbation and reduced lung function in asthmatics. Previous randomised controlled trials investigating the effect of vitamin D supplementation have mainly focused on children with asthma. Trials involving adults have typically used bolus dosing regimens, and the main outcomes have been patient-focused without investigating underlying inflammation. The present study aimed to conduct a 12-week placebo-controlled randomised controlled trials administering a daily 125 µg vitamin D3 supplement to adults with mild to moderate asthma. A total of 32 participants were randomised to receive either the 125 μg vitamin D3 supplement or an identical matching placebo. The primary outcome of the study was lung function measured by the ratio of FEV1:FVC (effect size 2·5) with secondary outcomes including asthma symptoms and inflammatory biomarkers. There was a small but statistically significant higher increase in the mean (±sd) ratio of FEV1:FVC from baseline to post-intervention in the vitamin D group (+0·05 ± 0·06) compared with the placebo group (+0·006 ± 0·04, P = 0·04). There was no effect of the intervention on asthma control test scores, or the inflammatory biomarkers measured. There was a moderate, significant association between baseline plasma 25(OH)D concentration and baseline plasma IL-10 (r = 0·527, P = 0·005) and TNF-α (r = −0·498. P = 0·008) concentrations. A daily vitamin D3 supplement led to slightly improved lung function in adult asthmatics and may be a useful adjunct to existing asthma control strategies, particularly for individuals with suboptimal vitamin D status.
This paper presents a dictionary-based study of French loanwords in contemporary English in order to investigate the location of primary stress in these loanwords. Four factors are found to be significant predictors of the position of primary stress: endings, word complexity, the segmental structure of the final syllable, and syllable count. Moreover, this study confirms previous observations on the tendency for American English to have more final stress in French loanwords than British English. Finally, the implications of our findings are discussed in light of a model that assumes that English phonology consists of distinct interacting subsystems.
We investigate the statement “all automorphisms of ${\mathcal {P}}(\lambda )/[\lambda ]^{<\lambda }$ are trivial.” We show that MA implies the statement for regular uncountable $\lambda <2^{\aleph _0}$, that the statement is false for measurable $\lambda $ if $2^\lambda =\lambda ^+$, and that for “densely trivial” it can be forced (together with $2^\lambda =\lambda ^{++}$) for inaccessible $\lambda $.
China has constructed a rigorous state apparatus to control its online social content. To date, research has largely focused on the central government's cyber control, but the less studied local cyberspace administrative forces are also important. Our fieldwork and interviews at a county-level cyberspace administration office (CAO) in east China reveal that the local CAO had been rendered a “toothless tiger” with insufficient technology, power and labour. However, it has made up for these deficiencies by utilizing systems such as outsourced surveillance, organized mass reporting and personnel secondment. We contend that these practices, which we label “extra-institutional governance” (EIG), emerge when bureaucracies with limited resources face external pressures. The findings shed light on how censorship machines operate in local governments in China and reveal the general dynamics of how bureaucratic organizations adapt to environmental pressures.
We investigate the effect of water quality on the educational outcomes of children aged 8–11 in 39 districts in five states in the Ganges Basin of India. Using data from the Centre for Pollution Control Board of India and the Indian Human Development Survey (IHDS) 2011–12, we study the effect of water quality in the Ganges Basin on the performance in three test scores. Our evidence suggests that faecal coliform levels in water sources above safety thresholds negatively affect reading and writing test scores. The effects of Nitrate-N and Nitrite-N in the water appear to be weaker compared to those of faecal coliform. The results establish that water pollution caused by excessive presence of faecal coliform is an important environmental factor in determining educational outcomes of children. High levels of faecal coliform in the water could be lowering cognitive abilities of the pollution-affected children through the channel of waterborne diseases.
To investigate healthcare workers’ perceptions of the integrated disease surveillance and response (IDSR) strategy.
Methods
A cross-sectional survey of healthcare workers (HCWs) was conducted from December 2021 to June 2022 to assess their perceptions of the IDSR system attributes.
Results
Of the 409 respondents, 12 (2.9%) reported no prior training on disease surveillance. The IDSR was deemed simple, acceptable, useful, and timely by most participants. There were sharp differences in perceptions of flexibility and simplicity between doctors and the other healthcare professionals. However, acceptability, timeliness, and usefulness were uniformly perceived. Healthcare workers with at least 11 years of experience perceived the usefulness of the IDSR system significantly higher than those with lesser years of experience. However, work experience did not have an impact on HCWs perceptions of the simplicity, timeliness, and flexibility of the IDSR system.
Conclusions
Most healthcare workers have positive perceptions of the IDSR approach. However, there are reservations about how well the system can adapt to changing conditions and demands (flexibility) and how well it simplifies the implementation processes. These findings demonstrate the necessity of adopting cutting-edge strategies for capacity building as well as ongoing professional development of healthcare professionals responsible for the implementation of the IDSR strategy.
Let $\sigma _q \,:\,{{\mathbb{R}}^q} \to{\textbf{S}}^q\setminus N_q$ be the inverse of the stereographic projection with center the north pole $N_q$. Let $W_i$ be a closed subset of ${\mathbb{R}}^{q_i}$, for $i=1,2$. Let $\Phi \,:\,W_1 \to W_2$ be a bi-Lipschitz homeomorphism. The main result states that the homeomorphism $\sigma _{q_2}\circ \Phi \circ \sigma _{q_1}^{-1}$ is a bi-Lipschitz homeomorphism, extending bi-Lipschitz-ly at $N_{q_1}$ with value $N_{q_2}$ whenever $W_1$ is unbounded.
As two straightforward applications in the polynomially bounded o-minimal context over the real numbers, we obtain for free a version at infinity of: (1) Sampaio’s tangent cone result and (2) links preserving re-parametrization of definable bi-Lipschitz homeomorphisms of Valette.
Individuals with schizophrenia face high mortality risks. The effects of lipid-modifying agents on this risk remain understudied.
Aim
This study was conducted to investigate the effects of lipid-modifying agents on mortality risk in people with schizophrenia.
Method
This nationwide cohort study collected the data of people with schizophrenia from Taiwan's National Health Insurance Research Database for the period between 1 January 2001 and 31 December 2019. Multivariable Cox proportional hazards regression with a time-dependent model was used to estimate the hazard ratio for mortality associated with each lipid-modifying agent.
Results
This study included 110 300 people with schizophrenia. Of them, 22 528 died (19 754 from natural causes and 1606 from suicide) during the study period, as confirmed using data from Taiwan's national mortality database. The use of lipid-modifying agents was associated with reduced risks of all-cause (adjusted hazard ratio [aHR]:0.37; P < 0.001) and natural (aHR:0.37; P < 0.001) mortality during a 5-year period. Among the lipid-modifying agents, statins and fibrates were associated with reduced risks of all-cause mortality (aHRs:0.37 and 0.39, respectively; P < 0.001 for both) and natural mortality (aHRs: 0.37 and 0.42, respectively; P < 0.001 for both). Notably, although our univariate analysis indicated an association between the use of lipid-modifying agents and a reduced risk of suicide mortality, the multivariate analysis revealed no significant association.
Conclusions
Lipid-modifying agents, particularly statins and fibrates, reduce the risk of mortality in people with schizophrenia. Appropriate use of lipid-modifying agents may bridge the mortality gap between these individuals and the general population.
In the context of random amenable group actions, we introduce the notions of random upper metric mean dimension with potentials and the random upper measure-theoretical metric mean dimension. Besides, we establish a variational principle for the random upper metric mean dimensions. At the end, we study the equilibrium state for random upper metric mean dimensions.
Deer hunting was heavily ritualized in medieval Europe, as indicated by historical and archaeological evidence; it also emphasized social differentiation. The butchery of a deer carcass (‘unmaking’) was integral to the ritual and led to different body parts being destined for individuals of differing status. Archaeologically, the practice is particularly visible in high-status sites in Britain, but documentary and archaeological sources are consistent in pinpointing its earliest occurrence in twelfth-century France. In Italy, late medieval evidence for such ‘unmaking’ is present but is not supported by any known historical sources. Red and fallow deer were butchered in a formalized manner, whereas the data for roe deer are unclear. Although the Normans contributed to the diffusion of the ‘unmaking’ practice, in France it is also found outside the core area of Norman influence. The extensive spread of the practice demonstrates the connectedness of the medieval hunting culture in Europe.
Tom et al. (J. Fluid Mech., vol. 947, 2022, p. A7) investigated the impact of two-way coupling (2WC) on particle settling velocities in turbulence. For the limited parameter choices explored, it was found that (i) 2WC substantially enhances particle settling compared with the one-way coupled case, even at low mass loading $\varPhi _m$ and (ii) preferential sweeping remains the mechanism responsible for the particles settling faster than the Stokes settling velocity in 2WC flows. However, significant alterations to the flow structure that can occur at higher mass loadings mean that the conclusions from Tom et al. (J. Fluid Mech., vol. 947, 2022, p. A7) may not generalise. Indeed, even under very low mass loadings, the influence of 2WC on particle settling might persist, challenging the conventional assumption. We therefore explore a much broader portion of the parameter space, with simulations covering cases where the impact of 2WC on the global fluid statistics ranges from negligible to strong. We find that, even for $\varPhi _m=7.5\times 10^{-3}$, 2WC can noticeably increase the settling for some choices of the Stokes and Froude numbers. When $\varPhi _m$ is large enough for the global fluid statistics to be strongly affected, we show that preferential sweeping continues to be the mechanism that enhances particle settling rates. Finally, we compare our results with previous numerical and experimental studies. While in some cases there is reasonable agreement, discrepancies exist even between different numerical studies and between different experiments. Future studies must seek to understand this before the discrepancies between numerical and experimental results can be adequately addressed.
The force and torque on a solid body in a viscous potential flow are often taken to be independent of viscosity. Joseph et al. (Eur. J. Mech. B/Fluids, vol. 12, 1993, pp. 97–106; J. Fluid Mech., vol. 265, 1994, pp. 1–23) proved that this holds for (i) the force (not the torque) in any two-dimensional flow, and (ii) the drag force experienced by a purely translating three-dimensional body. The remaining components of the force and torque, along with general three-dimensional flows, were not considered. Importantly, the flow was assumed to be unbounded and irrotational everywhere. We eliminate this rarely satisfied assumption and consider the viscous force and torque experienced by any closed surface where the flow is irrotational locally; this can include a body's surface. Any vorticity distribution is permitted away from the closed irrotational surface. In so doing, we complete the analysis of Joseph et al. for all components of the viscous force and torque in two and three dimensions and enable application to real flows that inevitably contain regions of vorticity.