This study aimed to investigate the structural and metabolic changes in cumulus cells of underweight women and their effects on oocyte maturation and fertilization. The cytoplasmic ultrastructure was analyzed by electron microscopy, mitochondrial membrane potential by immunofluorescence, and mitochondrial DNA copy number by relative quantitative polymerase chain reaction. The expression of various proteins including the oxidative stress-derived product 4-hydroxynonenal (4-HNE) and autophagy and apoptosis markers such as Vps34, Atg-5, Beclin 1, Lc3-I, II, Bax, and Bcl-2 was assessed and compared between groups. Oocyte maturation and fertilization rates were lower in underweight women (P < 0.05), who presented with cumulus cells showing abnormal mitochondrial morphology and increased cell autophagy. Compared with the mitochondrial DNA copies of the control group, those of the underweight group increased but not significantly. The mitochondrial membrane potential was similar between the groups (P = 0.8). Vps34, Atg-5, Lc3-II, Bax, and Bcl-2 expression and 4-HNE levels were higher in the underweight group compared with the control group (P < 0.01); however, the Bax/Bcl-2 ratio was lower in the underweight group compared with the control group (P = 0.031). Additionally, Beclin 1 protein levels were higher in the underweight group compared with the control group but without statistical significance. In conclusion, malnutrition and other conditions in underweight women may adversely affect ovulation, and the development, and fertilization of oocytes resulting from changes to the intracellular structure of cumulus cells and metabolic processes. These changes may lead to reduced fertility or unsatisfactory reproduction outcomes in women.

We study symmetric and antisymmetric tensor products of Hilbert-space operators, focusing on norms and spectra for some well-known classes favored by function-theoretic operator theorists. We pose many open questions that should interest the field.

The exit of the United Kingdom from the European Union (EU) single market and customs union has adversely affected trade prospects of many developing economies that depended on the UK market for their exports. This paper investigates the impact of Brexit on African countries' exports to the UK. The comparison is based upon trade between the set of African countries which export most to the UK and the EU. It provides a quantitative assessment of the trade effect through the use of descriptive analysis and empirical estimations by employing the difference-in-difference (DID) estimation approach. The descriptive analysis finds that the share of African exports sent to the UK has declined since the Brexit announcement in 2016. The empirical estimations using the DID approach also demonstrate a drop of 20–30% in African countries exports to the UK relative to the EU-27 in this period. These results hold to a battery of robustness checks, including the use of an alternative estimation approach, varying sample size, and the use of alternative counterfactuals. We further show that the trade flows started to drop immediately after the announcement of the Brexit referendum in 2015 but the main drop came after the Brexit referendum results became evident. These findings imply the need for policy intervention and support for African countries to revitalize their trade flows and alleviate the unintended effects of this trade shock.

La maladie d’Alzheimer se manifeste par des troubles de la mémoire et un déclin cognitif plus général, le plus souvent associés à des troubles de l’humeur et du comportement. Les traitements médicamenteux ayant une efficacité assez modeste, il apparaît nécessaire de leur associer une prise en charge non pharmacologique. La méditation de pleine conscience, qui a des effets bénéfiques sur le fonctionnement cognitif et sur l’état émotionnel, semble être une piste intéressante. Cette revue de littérature narrative se propose de recenser les études ayant testé l’efficacité d’une intervention basée sur la pleine conscience auprès de personnes souffrant de la maladie d’Alzheimer ou à risque de développer cette maladie. Il apparaît que ces interventions présentent un intérêt pour réduire les symptômes cognitifs (troubles attentionnels et mnésiques notamment) et émotionnels (affects dépressifs et anxiété en particulier). Cependant, elles nécessitent un certain nombre de modifications pour être adaptées à ce public.

Age dynamics of the ability of cercariae of two digenean species, Himasthla elongata (Himasthlidae) and Renicola parvicaudatus (Renicolidae), to infect the second intermediate host (SIH), mussels (Mytilus edulis), was investigated experimentally. This is the first study of this kind made on cercariae transmitted in the intertidal of the northern seas. The larvae of all tested ages (from 0.5 to 6 hr) were equally successful in infecting mussels. This finding disagrees with the literature data on cercariae of several freshwater digeneans, which are practically incapable of infecting the SIH during the first 1–3 hr of life. The presence of a time delay before the attainment of the maximum infectivity (TDMI) may be associated with the need for physiological maturation of cercariae in the very beginning of their life in the environment, the need for their broad dispersion, and the prevention of superinfection of the downstream host. The absence of TDMI in the cercariae examined in our study could be associated with the instability of environmental factors in the marine intertidal (wave impact, tidal currents). These factors promote a broad dispersion of cercariae in the intertidal biotope and prevent superinfection of potential SIHs. Biological and behavioural features may also play a role. We hypothesize that the presence or absence of TDMI does not depend on the taxonomic affiliation of the cercariae but is determined by the transmission conditions.

We prove some conditions for higher-dimensional algebraic fibering of pro-p group extensions, and we establish corollaries about incoherence of pro-p groups. In particular, if $1 \to K \to G \to \Gamma \to 1$ is a short exact sequence of pro-p groups, such that $\Gamma $ contains a finitely generated, non-abelian, free pro-p subgroup, K a finitely presented pro-p group with N a normal pro-p subgroup of K such that $K/ N \simeq \mathbb {Z}_p$ and N not finitely generated as a pro-p group, then G is incoherent (in the category of pro-p groups). Furthermore, we show that if K is a finitely generated, free pro-p group with $d(K) \geq 2$, then either $\mathrm{Aut}_0(K)$ is incoherent (in the category of pro-p groups) or there is a finitely presented pro-p group, without non-procyclic free pro-p subgroups, that has a metabelian pro-p quotient that is not finitely presented, i.e., a pro-p version of a result of Bieri–Strebel does not hold.

In recent decades, secularism has emerged as one of the most studied concepts in sociocultural anthropology, and Egypt a primary site of its analysis. This article considers trends in Egypt’s modern and contemporary history in order to complicate the great explanatory power some anthropological works have granted to secularism. Above all else, it interrogates the manner in which the state’s regulation of religion (which is the defining feature of Asadian conceptions of secularism) has unfolded in recent Egyptian history. First, I survey the different ways scholars have portrayed secularism in Egypt, focusing in particular on the insights and limitations of Asadian theories. A second section employs ethnographic data to uncover how ordinary Egyptians in the provincial capital of Beni Suef have experienced state power, religion, and secularism in their everyday lives. Contextualizing these ethnographic perspectives alongside several prominent instances of state violence between 2011 and 2013, I elucidate how, rather than typifying a secular state, Egyptian politics, above all else, have been driven by an opportunistic realpolitik. My final section brings historical and ethnographic perspectives into sustained conversation to argue that the state regulation anthropologists sometimes frame as secularism is better conceptualized as a form of state centralization. I conclude, in turn, that political developments in modern Egypt have most often been shaped by flexible national and imperial interests.

A breeding programme of aromatic vanilla, dating back to 1944, was conducted in Ambohitsara, Antalaha, SAVA (Sambava, Antalaha, Vohemara, Andapa) – Madagascar. Imported, local, wild and cultivated vanillas were used as progenitors and thousands of hybrids were generated. However, this germplasm has not undergone any genetic evaluation, and it appears that these valuable genetic resources have been dispersed or lost after the end of the programme (2000). This study aims to investigate the genetic diversity and structure of rescued genotypes currently held in a local collection in Antalaha. Double digest restriction associated-site (RAD)-seq (ddRAD)-seq protocol was applied, providing 865 million read sequences from 56 accessions. The ddRAD sequences have been deposited to the SRA archive of NCBI. From the data, 23,701 filtered concordant common Single Nucleotide Polymorphisms (SNPs) were identified using the three widely used tools (Stacks, BCFtools, Genome Analysis ToolKit - GATK) for short-read library sequencing. These SNPs were used for germplasm evaluation. Clustering analysis segregated samples into five genetic groups: Vanilla planifolia, Vanilla pompona, hybrid Tsitaitra, Vanille Banane and the phenotype Tsivaky. Our analysis revealed distinct subgroups within V. pompona and Tsitaitra, emphasizing the importance of further characterization to accurately reflect the genetic diversity and facilitate better utilization of these accessions in future research and germplasm management. The presence of private alleles in all groups (from 487 to 2866) indicated that populations were diverging and represented a large gene pool that could be useful for future breeding efforts. The genetic data obtained from this study offers valuable insights into the genetic diversity and structure of the vanilla population, with potential applications in breeding and conservation efforts.

This article examines the migration and expropriation policies of Guatemala's revolutionary governments toward Germans present in the country during the postwar years and the start of the Cold War. It reconstructs the challenges around the domestic and international articulations of their strategy. Revolutionary governments’ concerted efforts to confiscate valuable land and condition the return of German-Guatemalans classified as ‘dangerous’ can be interpreted as part of a cohesive plan to regain control of strategic domestic resources for future redistribution. It also reflects financial policies that have both electoral and financial purposes. The article is built around newly available judicial, legislative, and consular (France) Guatemalan sources, along with personal letters from Guatemala's top politicians, and complemented by Mexican, Chilean, Argentine, British, and US diplomatic documents. In methodological terms, this article shows the importance of articulating long-term processes, here the nineteenth-century German presence in Guatemala, in the context of historical junctures such as the end of World War II and the beginning of the Cold War. It also draws attention to the importance of analyzing events on domestic, regional and global scales to understand foreign policy-making. This article enriches an already complex set of global, regional, and domestic interactions of the postwar period, as well as the role of Guatemala during that time.

The present paper deals with the non-real eigenvalues for singular indefinite Sturm–Liouville problems. The lower bounds on non-real eigenvalues for this singular problem associated with a special separated boundary condition are obtained.

Of the total 47 species in the subgenus Acanthosentis, 43 have been reported from the freshwater fishes of Asia. Amin et al. (2017) provided a key to the 23 species of the genus Acanthogyrus reported from the Indian subcontinent. The present study reports two new species: Acanthogyrus bispinosa n. sp. and A. garciai n. sp. from Cirrhinus mrigala Hamilton and Labeo calbasu Hamilton, respectively, and two previously described species: A. golvani Gupta and Jain, 1980 and A. hereterospinus Khan and Bilqees, 1990 from L. rohita Hamilton and L. catla Hamilton, respectively. A. bispinosa n. sp. comprises 3 circles of 6 proboscis hooks each. Trunk spines in A. bispinosa n. sp are divided into two groups: anterior and posterior separated by unarmed region, which has not been previously reported in the subgenus. Anterior spines are present in 7–8 and 7–10 circles in females and males, respectively, whereas posterior spines are in 23–28 and 31–38 circles in males and females, respectively. A. garciai n. sp. comprises 3 circles of 6–8 hooks each and a single set of trunk spines is present in A. garciai n. sp., comprising 35–42 and 25–45 circles in males and females, respectively. All four species were also characterised based on the 18S, 28S, and ITS1-5.8S-ITS2 rRNA molecular markers. The Bayesian inference tree generated based on these markers showed distinct identities of all the species, with a significant molecular divergence, ranging from 3.2 to 53.6%.

Through ethnography of a performatively Western-inspired coffeehouse in a “traditionally” identifying town of Hargeisa in Somaliland, Serunkuma uses Cup of Art Italian Coffeehouse to debate the political-conceptual dilemma—and potential dangers—of the renewed longing for cultural authenticity and “total revolution” in post-colonial Africa. While acknowledging the failure of the dreams that animated the anti-colonial struggle, manifest in the collapse in public service delivery, governance challenges, and civil war, Serunkuma contends that taking this to be the product of the “legacy of late colonialism,” and thus seeking to protect supposedly “authentic” African traditions and religious practices from Western corruption is itself a poisoned chalice. Using Cup of Art, Serunkuma urges humility toward the permanence of a colonial modernity and constant awareness of the new “problem space,” in which actors exercise their agency.