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Taste plays a fundamental role in an animal’s ability to detect nutrients and transmits key dietary information to the brain, which is crucial for its growth and survival. Providing alternative terrestrial ingredients early in feeding influences the growth of rainbow trout (RT, Oncorhynchus mykiss). Thus, the present study aimed to assess the influence, via long-term feeding (from the first feeding to 8 months), of alternative plant ingredients (V diet for vegetable diet v. C diet for a control diet) in RT on the mechanism of fat sensing at the gustatory level. After the feeding trial, we studied the pathways of the fat-sensing mechanism in tongue tissue and the integrated response in the brain. To this end, we analysed the expression pattern of free fatty acid receptors (ffar) 1 and 2, markers of calcium-signalling pathways (phospholipase Cβ, Orai, Stim or Serca), the serotonin level (a key neurotransmitter in taste buds) and the expression pattern of appetite-regulating neuropeptides in the hypothalamus (central area of appetite regulation). The results revealed that the V diet modified the expression pattern of ffar1 and paralogs of ffar2 genes in tongue tissue, along with differential regulation of calcium-signalling pathways and a defect in serotonin level and brain turnover, without influencing neuropeptide expression. This study is the first to support that changes in feeding behaviour of RT fed a V diet could be due to the difference in nutrient sensing and a decrease in hedonic sensation. We revealed that RT have similar fat-detection mechanisms as mammals.
The collection of facial action data is essential for the accurate evaluation of a patient’s condition in the intensive care unit, such as pain evaluation. An automatic face-tracking system is demanded to reduce the burden of data collection on the medical staff. However, many previous studies assume that the optimal trajectory of a robotic tracking system is reachable which is inapplicable for large-amplitude head motions. To tackle this problem, we propose a region-based face-tracking algorithm for large-amplitude head motion with a 7-DOF manipulator. A configuration-based optimization algorithm is proposed to trade-off between theoretical optimal pose and workspace constraints through the assignment of importance weights. To increase the probability of recapturing the face exceeding the reachable workspace of the manipulator, the camera is directed toward the center of the head, named the facial orientation center (FOC) constraint. Furthermore, a region-based tracking approach is designed to stabilize the manipulator for small amplitude head motions and smooth the tracking trajectory by adjusting the joint angle in the null space of the 7-DOF manipulator. Experimental results demonstrate the effectiveness of the proposed algorithm in tracking performance and finding an appropriate configuration for the unreachable theoretical optimal configuration. Moreover, the proposed algorithm with FOC constraint can successfully follow the head motion as losing 33.2% of the face during the tracking.
For decades, human rights organizations have exposed egregious abuses carried out by states across the globe. Yet, simultaneously, other national and transnational civil society actors have waged war on these human rights organizations to shield rights-abusive states from accountability. These assaults have increasingly resulted in the normative claims of human rights organizations being sidelined while rights-abusive laws and policies gain further ground. This article uses Israel as its primary case study to interrogate these civil society wars and their effects on human rights. Examining the work of Israeli and pro-Israeli civil society actors in bolstering apartheid and shielding the state from criticism, I highlight three strategies—native dispossession, lawfare, and advocacy—that civil society actors use to enable apartheid. I go on to show how these actors adopt liberal tactics to protect, reproduce, and facilitate apartheid and to attack human rights defenders. By way of conclusion, I argue that the dominant paradigm informing human rights NGOs needs to be modified and their remit needs to be extended to include civil society actors that contribute to the perpetuation of social wrongs.
The COVID-19 pandemic has exposed a global health and political crisis like no other in recent history. As ground zero of the virus outbreak, significant criticism and blame have been directed at China for covering up the outbreak. Yet a systematic assessment of China's responses to international opprobrium of its pandemic measures has been largely lacking in the literature. Drawing on the concept of “blame” from public administration, this article seeks to fill this gap by investigating China's COVID-19 crisis and blame (mis)management practices. We make two key contributions in this article. First, we highlight how Beijing engaged in the politics of blame and outline three modes (defensive, aggressive and proactive benevolence) of its blame management practices. Second, we suggest that China sought to articulate and refine its identity during the COVID-19 pandemic, providing insights into a China that is increasingly assertive yet vulnerable to reputational damage. We contend that China's efforts to counter international opprobrium and shift strategic narratives speak directly to issues of autocratic legitimation and its conceived “responsible great power” identity, with greater success among domestic rather than global audiences.
Student motivation has been conceived as a crucial factor in the learning processes. However, research in motivation and creative learning in the secondary education music classroom has been limited. Student motivation is explored in this article through a collaborative action research study, in the form of several projects centred on the creation of music through group improvisation and cooperative composition, conducted over the course of five 1-year cycles, from 2008 to 2013. The aim of this study was to gain a deeper understanding of the aspects determining student motivation during creative learning processes. Three secondary schools in the region of Madrid (Spain), eleven third-year secondary school classes (n = 267), teachers, researchers and artists participated in the study. Data were gathered through participant and non-participant observations, interviews, a classroom diary, and a questionnaire. In the findings, six intrinsically linked connected forms of motivation are grouped in three levels and are related to different factors emerged during the teaching and learning processes and connected to creativity.
Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.
Method
Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin’ Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients’ motor function was assessed based on the Unified Huntington's Disease Rating Scale.
Results
Compared with controls, patients’ scores of all olfactory domains and their sum were significantly lower. Besides, our patients’ odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent vs 34 per cent, respectively).
Conclusion
Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.
Reducing dietary crude protein (CP) concentration while maintaining adequate amino acid (AA) supply by free AA inclusion can contribute to attenuate the negative environmental effects of animal farming. This study investigated upper limits of dietary free AA inclusions without undesirable effects including the dependence on asparagine (Asn) and glutamine (Gln) supply. Ten broilers were allocated to sixty-three metabolism units each and offered nine experimental diets from day (d) 7–21 (n 7). One diet (167 g CP/kg) contained 80 g soya protein isolate (SPI)/kg. In the other diets, 25, 50, 75 and 100 % of the digestible AA from SPI were substituted with free AA. Digestible Asn+aspartic acid (Asp) and Gln+glutamic acid (Glu) were substituted with Asp/Glu or 50/50 mixes of Asp/Asn and Glu/Gln, respectively. Total excreta were collected from d 11–14 and from d 18–21. Growth and nitrogen accretion were unaffected by 25 and 50 % substitution without and with free Asn/Gln, respectively, but decreased at higher substitution (P ≤ 0·024). Circulating concentrations of Asp, Glu and Gln were unaffected by treatment, while Asn decreased at substitution higher than 50 % when Asn/Gln were not provided (P ≤ 0·005). Blood gas analysis on d 21 indicated a compensated metabolic acidosis at substitution higher than 50 and 75 % without and with free Asn/Gln, respectively (P ≤ 0·017). Results suggest that adding Asn/Gln increased an upper limit for proportion of dietary free AA from 10 to 19 % of dietary CP and enabled higher free AA inclusion without affecting the acid–base balance.
This paper examines the influence of nuclear weapons on fantasies of racial violence. Specifically, it argues that weapons impact the emergence of social formations, producing unique patterns of thought, desire, anticipation, and identity. While the effects of nuclear power have been central to disciplinary debates in international studies, existing critical commentary has largely focused on the discriminatory nature of the global nuclear hierarchy. By focusing on the productive impact of weapons on cultural registers, this article demonstrates that nuclear power not only reinforces global structures of racism and colonialism but also creates new articulations of white supremacy. It argues that a specific fantasy of nuclear genocide, seizing nuclear power as a means for executing a global race war, is an expression germane to the nuclear age. This article concludes by arguing that this fantasy plays an important role in white supremacist approaches to politics and existing forms of racist hierarchy.
On January 5, 2023, the U.S. Justice for Victims of War Crimes (JVWC) Act was signed into law. The legislation closed long-recognized gaps in U.S. federal jurisdiction for holding accused war criminals accountable. Prior to the JVWC, the federal war crimes statute provided jurisdiction over war crime offenses committed anywhere, but only if the victim or offender was a member of the U.S. Armed Forces or a U.S. national. The baseline federal statute of limitations also applied, meaning the United States could only bring charges within five years of the crime occurring.
The linear stability of the two-dimensional Taylor–Green vortices, which is a spatially periodic array of vortices, in rotating stratified fluids is investigated by local and modal stability analysis. Five types of instability appear in general: the pure hyperbolic instability, the strato-hyperbolic instability, the rotational-hyperbolic instability, the centrifugal instability and the elliptic instability. The condition for each instability and the estimate of the growth rate, which are useful in interpreting numerical results, are obtained in the framework of local stability analysis. Realizability of an instability is introduced to predict whether an unstable mode corresponding to an unstable region found in the local stability analysis exists at finite Reynolds numbers. In the absence of stratification, the pure hyperbolic instability is dominant for weak rotation; it is stabilized for strong rotation. For strong anti-cyclonic rotation, the elliptic instability or the centrifugal instability becomes dominant depending on the parameter values; further stronger rotation stabilizes both instabilities. For strong cyclonic rotation, the rotational-hyperbolic instability or the elliptic instability becomes dominant, although the growth rate is smaller than the anti-cyclonic cases. Strong stratification changes the stability properties. The strato-hyperbolic instability occurs for weak rotation. The rotational-hyperbolic instability and the elliptic instability are weakened under cyclonic rotation, while the latter survives and extends the unstable range under anti-cyclonic rotation. The pure hyperbolic instability and the centrifugal instability are less affected by stratification. The mode structures of each instability are in good agreement with the corresponding solution to local stability equations, confirming the physical mechanism of the instability.
We provide a fairly self-contained account of the localisation and cofinality theorems for the algebraic $\operatorname K$-theory of stable $\infty$-categories. It is based on a general formula for the evaluation of an additive functor on a Verdier quotient closely following work of Waldhausen. We also include a new proof of the additivity theorem of $\operatorname K$-theory, strongly inspired by Ranicki's algebraic Thom construction, a short proof of the universality theorem of Blumberg, Gepner and Tabuada, and a second proof of the cofinality theorem which is based on the universal property of $\operatorname K$-theory.
Though governments historically have been a men’s club, women are increasingly gaining access. We argue that democratic institutions are important drivers of women’s inclusion in government. This stems from the rationales of autocratic versus democratic leaders when selecting ministers. Autocrats fear a coup by inner-circle elites, who are mostly men, incentivizing them to assign ministerial positions as co-optation. In contrast, democratic leaders are accountable to the citizenry through elections and must satisfy increasing demands for gender equality. Furthermore, we argue that it is historical experience with democracy that matters, rather than the level, as it takes time to create an even playing field, change attitudes, and generate trust in democracy. To support this, we contribute with the first study using the most comprehensive dataset, WhoGov, on women’s access to cabinets. Overall, we show that democracy is a process that gradually enables women to enter the highest echelons of power.
A slip asymmetry can break the fore–aft symmetry of the local hydrodynamic force distribution on the surface of an otherwise no-slip or uniform-slip particle. Here, we use the Lorentz reciprocal theorem to demonstrate that such asymmetry, even in a fractional amount, can qualitatively alter the swimming characteristics of a self-propelled spherical squirmer, markedly different from those of no-slip or uniform-slip squirmers. Unlike the usual tangential squirming by the thrust-providing B1 mode and the type-determining B2 mode, we discover two unique features for a stick-slip squirmer. First, the squirmer can acquire a swimming velocity U without the B1 mode but simply by a symmetric extensile/contractile squirming from the B2 mode, which is able to reverse the swimming direction of the squirmer. Second, a stresslet $\boldsymbol{\mathsf{S}}$ can also be induced by a unidirectional squirming from the B1 mode, capable of inverting the squirmer's stresslet from extensile type to contractile type or vice versa to change the squirmer from puller to pusher or in a reverse manner. We further show that the two squirming modes can reinforce or compete with each other to enhance or diminish U and $\boldsymbol{\mathsf{S}}$ due to interplays between the asymmetric squirming forces on the stick and the slip faces. A phase diagram is also established to categorize a variety of newly emerging swimming states, such as an enhanced/degraded puller/pusher and a backward puller/pusher, depending on the relative strength of the squirming modes β = B2/B1, the direction of the stick-slip polarity and the degree of the slip disparity. As a result of such cooperative and competitive natures, a stick-slip squirmer can swim more or less efficiently than no-slip and uniform-slip ones. These distinctive features arising from stick-slip disparity can not only be made geometrically tuneable for steering the motion of a squirmer, but also provide new means for making efficient artificial microswimmers using amphiphilic Janus particles.
This article analyses a domestic litigation matter seeking to establish accountability for air pollution-related human rights violations. It examines how the judiciary applied national and international law to dismiss the case on procedural grounds. It argues that the domestic case deserves careful reading for a number of reasons that can be distilled into two premises. Firstly, the national legal framework and its respective judicial interpretation impede access to justice for victims of state and/or corporate human rights violations. Secondly, it is essential that the state develops laws and policies in line with the United Nations Guiding Principles on Business and Human Rights, which would allow claimants to focus their argumentation on material, rather than procedural issues relevant to proving the merits of the case.
This paper presents the effects of wing kinematics on both normal forward flight and escape flight of a dragonfly. A Navier–Stokes-based numerical model has been adopted, and results have been substantiated by experimental data. The wing kinematics of tethered specimens and the prescribed wing morphology of a free-flying dragonfly were used in the simulation. To shed light on the interplay between kinematics and aerodynamics, a parametric study of the kinematics has been conducted. It is found that in escape flight, the dragonfly generates additional lift while the thrust reduces and the overall efficiency drops. Compared with normal forward flight, the escape mode produces larger lift force peaks. When the kinematics change to facilitate escape flight, the aerodynamic forces are affected by not only the flapping kinematics but, in the case of the hindwing, the varied wing–wing vortex interactions. The direction of the resultant force on each wing changes according to the change of the mean of pitching angle and stroke plane angle. We found that in the studied configurations, the varied phasing of the wings has a marginal effect on the aerodynamics of the dragonfly. It reduces lift and increases thrust, and this force modulation is slightly more efficient when the local angle of attack also changes. On the other hand, the change of angle of attack played a major role in leading-edge vortex formations and directing the resultant forces of the wings. The results can be useful in developing flight control strategies for micro air vehicle design.
In studies that contain repeated measures of variables, longitudinal analysis accounting for time-varying covariates is one of the options. We aimed to explore longitudinal association between diet quality (DQ) and non-communicable diseases (NCDs). Participants from the 1973–1978 cohort of the Australian Longitudinal Study on Women’s Health (ALSWH) were included, if they; responded to survey 3 (S3, 2003, aged 25–30 years) and at least one survey between survey 4 (S4, 2006) and survey 8 (S8, 2018), were free of NCDs at or before S3, and provided dietary data at S3 or S5. Outcomes were coronary heart disease (CHD), hypertension (HT), asthma, cancer (except skin cancer), diabetes mellitus (DM), depression and/or anxiety, and multimorbidity (MM). Longitudinal modelling using generalised estimation equation (GEE) approach with time-invariant (S4), time-varying (S4–S8) and lagged (S3–S7) covariates were performed. The mean (± standard deviation) of Alternative Healthy Eating Index-2010 (AHEI-2010) of participants (n = 8022) was 51·6 ± 11·0 (range: 19–91). Compared to women with the lowest DQ (AHEI-2010 quintile 1), those in quintile 5 had reduced odds of NCDs in time-invariant model (asthma: OR (95 % CI): 0·77 (0·62–0·96), time-varying model (HT: 0·71 (0·50–0·99); asthma: 0·62 (0·51–0·76); and MM: 0·75 (0·58–0·97) and lagged model (HT: 0·67 (0·49–0·91); and asthma: 0·70 (0·57–0·85). Temporal associations between diet and some NCDs were more prominent in lagged GEE analyses. Evidence of diet as NCD prevention in women aged 25–45 years is evolving, and more studies that consider different longitudinal analyses are needed.
This article investigates the role of foreign technical experts in developing China's aviation infrastructure from the 1980s to the present. Focusing on a series of training and technical aid programmes, it traces the influx of critical know-how from Europe, Japan and North America during the period of reform and opening up. Through fieldwork conducted at airports in Beijing, Hong Kong and Shanghai – and expert interviews with architects, planners and engineers – the article sheds light on the instrumental role played by foreign technical experts. By establishing a leading-edge set of airport planning practices, these aviation professionals accelerated the modernization of China's transport infrastructure and its reintegration into the world economy. Moreover, by positioning China as a global leader in infrastructure development, they laid the technical foundations for Chinese foreign policy endeavours that seek to export an infrastructure-led model of economic development to Africa, Asia and the former Soviet sphere.