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An increasing number of older adults require residential care. Concurrently, older adults’ alcohol use is increasing. This review explored the perspectives of all relevant stakeholders on older adults’ alcohol use within residential care settings, through a systematic review and thematic synthesis of qualitative studies. Eight databases were searched for qualitative studies focusing on older adults’ alcohol consumption (defined as aged ≥ 50) within residential care settings, sampling any involved stakeholders, published up until January 2024. Quality appraisal utilised the Critical Appraisal Skills Programme checklist and included 15 studies of mainly moderate quality across seven high-income countries, reporting data from a range of stakeholders and representing varied older adults’ alcohol histories. Three themes were identified: alcohol use by older adults is socially acceptable and purposeful in residential care settings; alcohol helps in the pursuit of an ‘ideal’ outcome; and decision-making around older adults’ alcohol use varies depending on the involvement, knowledge, skills and beliefs of the participating stakeholders, who also vary. Reports of problematic alcohol use were rare and older adults in residential care settings should be supported to exercise their own choice in determining their alcohol use. However, residential care settings face particular challenges in managing the alcohol intake of older adults with limited mental capacity and alcohol dependency; owing to a lack of guidance, front-line staff make subjective decisions. Future research should develop guidance that involves all relevant stakeholders, including family members. Limitations include lack of generalisability to low- and middle-income countries and limited availability of raw data.
Amidst the global digital transformation and the expanding IT sector, particularly in Ukraine, it is essential to examine how digitalization affects structural shifts within the national economy. This study aims to analyze the impact of digitalization on the growth of Ukraine’s IT sector, focusing on comparing the economic metrics of freelancing and outsourcing and providing strategic recommendations to enhance entrepreneurial activity in this area. During the research, the methods of expert evaluations, economic-mathematical modelling, comparative analysis, and statistical data analysis were used. The research revealed that digitalization significantly influences structural changes in the national economy, particularly through the advancement of the IT sector. It was established that outsourcing has significant advantages compared to freelancing in terms of such indicators as the share of the GDP of the IT sector and the volume of exports of IT services. By analyzing the economic indicators of freelancing and outsourcing, specific recommendations were developed for the continued growth of Ukraine’s IT sector, aimed at boosting entrepreneurial activity and creating new job opportunities. The key factors influencing IT specialists’ employment choices were summarized, which is crucial for the continued development of the national economy in the context of digitalization. The practical value of this research is that its findings can be utilized to enhance Ukraine’s IT sector, particularly by backing outsourcing businesses and promoting the expansion of freelance platforms.
In this study, the propagation behaviour of detonation waves in a channel filled with stratified media is analysed using a detailed chemical reaction model. Two symmetrical layers of non-reactive gas are introduced near the upper and lower walls to encapsulate a stoichiometric premixed H2–air mixture. The effects of gas temperature and molecular weight of the non-reactive layers on the detonation wave’s propagation mode and velocity are examined thoroughly. The results reveal that as the non-reactive gas temperature increases, the detonation wave front transitions from a ‘convex’ to a ‘concave’ shape, accompanied by an increase in wave velocity. Notably, the concave wave front comprises detached shocks, oblique shocks and detonation waves, with the overall wave system propagating at a velocity exceeding the theoretical Chapman–Jouguet speed, indicating the emergence of a strong detonation wave. Furthermore, when the molecular weight of non-reactive layers varies, the results qualitatively align with those obtained from temperature variations. To elucidate the formation mechanism of different detonation wave front shapes, a dimensionless parameter $\eta$ (defined as a function of the specific heat ratio and sound speed) is proposed. This parameter unifies the effects of temperature and molecular weight, confirming that the specific heat ratio and sound speed of non-reactive layers are the primary factors governing the detonation wave propagation mode. Additionally, considering the effect of mixture inhomogeneity on the detonation reaction zone, the stream tube contraction theory is proposed, successfully explaining why strong detonation waves form in stratified mixtures. Numerical results show good agreement with theoretical predictions, validating the proposed model.
The use of explosive weapons in populated areas (EWIPA) has a disproportionate impact on civilians. Many humanitarian organizations utilize varying sheltering guidelines to recommend safe positions for civilians affected by explosive threats. It is not known whether these recommendations are standardized or derived from evidence. This study aimed to identify existing recommendations and potential gaps in literature relevant to sheltering guidelines for civilians during explosive events.
Methods
A scoping review was conducted of the literature including indexed databases and grey literature to identify reports that described sheltering guidelines for civilians during explosive events. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) methodology was followed.
Results
The search identified 3582 peer-reviewed records. After title/abstract and full text screening, only 2 peer-reviewed reports remained eligible. These were combined with 13 gray literature reports obtained from humanitarian organizations and internet searches. The peer-reviewed reports included mine and unexploded ordnance guidelines, not guidelines for EWIPA or aerial bombardments. There is a substantial knowledge gap and heterogeneity in existing sheltering guidelines from explosive events, particularly those appropriate for protection from EWIPA.
Conclusions
Findings from this scoping review demonstrate a need for the creation and standardization of evidence-based civilian sheltering guidelines to mitigate the threat of explosive weapons to civilians in conflict.
Assessment of regional glucose metabolism by [18F]fluorodeoxyglucose position emission tomography ([18F]FDG PET) serves as a biomarker for differential diagnosis of dementia. Conversely, depressive cognitive impairment shows no abnormalities on cerebral [18F]FDG PET.
Aims
This study validates the diagnostic value of [18F]FDG PET in addition to clinical diagnosis in a real-life gerontopsychiatric clinical population.
Method
Ninety-eight consecutive patients with depression and cognitive impairment were included. Baseline clinical diagnoses were independently established before and after disclosure of [18F]FDG PET, and dichotomised into neurodegenerative or non-neurodegenerative diseases (level 1). Subsequently, neurodegenerative cases were allocated to diagnostic subgroups (Alzheimer’s disease, Lewy body diseases, frontotemporal lobar degeneration, neurodegenerative other; level 2). An interdisciplinary, biomarker-supported consensus diagnosis after a median follow-up of 6.6 month after [18F]FDG PET served as reference. Changes of clinical diagnoses and diagnostic accuracy were assessed.
Results
After disclosure of [18F]FDG PET, level-1 clinical diagnoses changed in 23% (95% CI 16–33%) of cases, improving the diagnostic accuracy from 72% (95% CI 62–81%) to 92% (95% CI 84–96%) (P < 0.001). [18F]FDG PET was of particular value for exclusion of neurodegenerative disease. Concerning level-2 decisions, the clinical diagnoses changed in 30% (95% CI 21–40%) of cases, increasing its accuracy from 64% (95% CI 54–74%) to 85% (95% CI 76–91%) (P < 0.001). A major fraction of incorrect level-2 diagnoses comprised Alzheimer’s disease misdiagnosed as Lewy body diseases.
Conclusions
[18F]FDG PET provides a significant incremental diagnostic value beyond the clinical diagnosis in depressive cognitive impairment. Thus, [18F]FDG PET should be considered in the diagnostic work-up of patients with mental disorders and cognitive impairment.
Research quality assessment is a cornerstone of academic practice, yet the criteria that inform such judgments are often assumed rather than critically examined through empirical research. This article draws on a global survey of international relations (IR) scholars (N = 820) to analyze the cognitive dimensions underlying research quality evaluation and their variation across sociological and epistemological factors. We identify seven distinct quality factors: theoretical significance, logical style and structure, practical significance, methodological rigor, contribution and value for future research, interest and topicality, and challenge to existing knowledge. Our results suggest that, while personal preferences, disciplinary norms, and professional practices—shaped by variables such as gender, nationality, and political orientation—influence evaluations, research quality judgments are ultimately grounded in shared cognitive frameworks. Our study offers robust evidence that quality assessments, though subject to sociological variation, reflect deeper, common cognitive structures across scholarly communities.
An often-used normative argument for increasing judicial diversity is that it will enhance public confidence in courts. This paper tests competing perspectives about whether the descriptive representation of women in the federal judiciary will improve institutional trust, using a nationally representative survey experiment. The findings suggest that, in the post-Dobbs era, descriptive representation for gender on low visibility courts yields a positive effect on institutional trust, but that the magnitude of the effect is quite small, time limited, and restricted to Democrats and to those who already have higher levels of trust.
The flow behind impulsively started circular and polygonal plates is investigated experimentally, using particle image velocimetry at several azimuthal angles. Observing plates accelerating up to a steady Reynolds number $Re=27\,000$, the three invariants of the motion, circulation $\Gamma$, hydrodynamic impulse $I$ and kinetic energy $E$, were scaled against four candidate lengths: the hydraulic diameter, perimeter, circumscribed diameter and the square root of the area. Of these, the square root of the area was found to best collapse all the data. Investigating the three-dimensionality of the flow, it is found that, while a single-plane measurement can provide a reasonable approximation for $\Gamma$ behind plates, multiple planes are necessary to accurately estimate $E$ and $I$.
The current study provides a holistic analysis of voice quality and how it is employed via affective stancetaking through high performance of non-player characters on Critical Role, a popular Dungeons and Dragons digital media ‘actual-play’ series. Specifically, we ask how a character's moral stance is indexed through improvised performed speech. We show that current acoustic methods for voice quality have the potential for underrepresentation of sociolinguistically meaningful variation when relying solely on acoustic data. By incorporating both acoustic and auditory data, we find that constricted laryngeal settings (and whisperiness in particular) are used to signal evilness and negative moral stance, while unconstricted laryngeal settings (breathiness in particular) are employed to signal friendliness and positive moral stance. The two general vocal settings show nuanced variation linked to affective stancetaking, including one-off changes in characters’ stances as well as their habitual styles. (Voice quality, stance, methods, affect, morality)*
From particle lifting in atmospheric boundary layers to dust ingestion in jet engines, the transport and deposition of inertial particles in wall-bounded turbulent flows are prevalent in both nature and industry. Due to triboelectrification during collisions, solid particles often acquire significant charges. However, the impacts of the resulting electrostatic interaction on the particle dynamics remain less understood. In this study, we present four-way coupled simulations to investigate the deposition of charged particles onto a grounded metal substrate through a fully developed turbulent boundary layer. Our numerical method tracks the dynamics of individual particles under the influence of turbulence, electrostatic forces and collisions. We first report a more pronounced near-wall accumulation and an increased wall-normal particle velocity due to particle charging. In addition, contrary to predictions from the classic Eulerian model, the wall-normal transport rate of inertial particles is significantly enhanced by electrostatic forces. A statistical approach is then applied to quantify the contributions from turbophoresis, biased sampling and electrostatic forces. For charged particles, a sharper gradient in wall-normal particle fluctuation velocity is observed, which substantially enhances turbophoresis and serves as the primary driving force of near-wall particle accumulation. Furthermore, charged particles are found to sample upward-moving fluids less frequently than neutral particles, thereby weakening the biased-sampling effect that typically pushes particles away from the wall. Finally, the wall-normal electric field is shown to depend on the competition between particle–wall and particle–particle electrostatic interactions, which helps to identify the dominant electrostatic force across a wide range of scenarios.
Delaying the laminar–turbulent transition of a boundary layer reduces the skin-friction drag and can thereby increase the efficiency of any aerodynamic device. A passive control strategy that has reaped success in transition delay is the introduction of boundary layer streaks. Surface-mounted vortex generators have been found to feature an unstable region right behind the devices, which can be fatal in flow control if transition is triggered, leading to an increase in drag with respect to the reference case without devices. In a previous proof of concept study, numerical simulations were employed to place artificial vortices in the free stream that interact with the boundary layer and accomplish transition delay. In the current study, we present experimental results showing the feasibility of generating free-stream vortices that interact with the boundary layer, creating high- and low-speed boundary layer streaks. This type of streaky base flow can act as stabilizing if introduced properly. We confirm the success of our flow control approach by artificially introducing two-dimensional disturbances that are strongly attenuated in the presence of streaks, leading to a transition delay with respect to the reference case of approximately 40 %.
Mechanical circulatory support, and specifically extra-corporeal membrane oxygenation, plays a critical role in managing paediatric cardiac patients with severe heart failure. Whilst these technologies are vital for bridging patients to recovery or heart transplantation, it is imperative to study the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes.
Objectives:
This systematic review aimed to evaluate the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric cardiac patients, both post-cardiotomy and non-cardiotomy patients were included.
Methodology:
A comprehensive search was conducted using PubMed, EMBASE, and PsychInfo to identify primary research articles exploring the effects of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric heart patients from inception to June 2024.
Results:
Our search yielded 5488 papers of which eight papers were included featuring 302 patients.
Conclusion:
The discussion highlights the considerable variability in neurodevelopmental outcomes and how they are measured among extra-corporeal membrane oxygenation survivors. Outcomes vary by patient factors, with recovery potential influenced by the duration and timing of follow-up. We emphasised the importance of standardised assessment tools and extended follow-ups to gain a clearer understanding of these outcomes.
The application of a tube combustion system (pyrolyzer) for the batch combustion of low carbon content environmental matrices, such as soil and sediment, for determining 14C specific activity is examined. The samples were combusted at 600°C, and the CO2 species produced were trapped in 3N NaOH, precipitated as BaCO3 by adding BaCl2, and subjected to acid-hydrolysis to transfer the CO2 species to the absorber-scintillator mixture for liquid scintillation counting (LSC). The method was validated by analyzing the samples by accelerator mass spectrometry (AMS) method. The minimum detectable activity (MDA) for the method, at 2σ confidence level, was 10 Bq kg–1C (4 pMC) for a counting time of 500 min and 7 Bq kg–1C (3 pMC) for 1000 min. The capability of the method to quantify a small excess of 14C specific activity (a few Bq kg–1C or pMC) in the environment of a nuclear facility, when compared to the ambient natural background level, was demonstrated by analyzing a total of 23 soil and 7 sediment samples from the vicinity of a pressurized heavy water reactor (PHWR) nuclear power plant (NPP) at Kaiga, India. The maximum excess 14C specific activity values recorded for soil and sediment matrices were 37 ± 7 Bq kg–1C and 11 ± 7 Bq kg–1C, respectively, confirming minimal radioecological impact of the operation of the NPP on the environment. The 14C specific activity ratio for the recently fallen leaf litter and the soil underneath at most of the sampling points in the vicinity of the NPP had a mean value of 1.03 with an associated standard deviation of 0.07. Statistical tests confirm that the mean values of the data set of 14C specific activity of leaf litter and underlying soil are not significantly different.
One of the important problems in algebraic number theory is to study the monogenity of number fields. Monogenic number fields arise from the roots of monogenic polynomials. In this article, we deal with the problem of monogenity of the composition of two monic polynomials having integer coefficients. We provide necessary and sufficient conditions for the composition to be monogenic together with a further sufficient condition. At the end of the paper, we construct an infinite tower of monogenic number fields.
A decades-long debate has sought to determine whether judicial elections are detrimental to the impartiality of judges and public support for state court systems. We contribute to that discussion by assessing whether elections work to hold errant judges accountable. We use a novel dataset of judicial scandal, including newspaper reports of misconduct against elected state supreme court justices. Our data examines the effect of scandal from 2000–2023 to determine whether controversy affects voter support for incumbents. We find voters pay attention to the harmful effects of scandal on judiciaries and that impacted incumbents experience diminished support, relative to other incumbents.