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Partial anomalous left pulmonary artery sling is an exceptionally rare congenital anomaly, and its coexistence with ventricular septal defect and right lung agenesis has not been reported. We describe a neonate presenting with right lung agenesis, a large ventricular septal defect, partial anomalous left pulmonary artery sling, and congenital tracheal stenosis. Following surgical repair of the ventricular septal defect at 73 days of age, the patient showed marked improvement in respiratory status and was discharged home without respiratory support.
Closing auctions account for about 10% of daily trading volume and offer a potentially attractive alternative to trading in the continuous market. We find that the price impact is lower in closing auctions than in the continuous market for all stocks except Nasdaq microcaps. Opening auctions are illiquid. We compute trading costs for anomalies based strategies by strategically placing orders in the lower cost mechanism. The annualized trading costs for long/short portfolios based on financial ratios such as profitability and investment range from 17 to 41 basis points (bps). Excluding microcaps, these costs fall to 9–21 bps in closing auctions.
We investigate the interfacial fluid dynamics and heat transfer at nanoscales using an improved diffuse interface approach for liquid–vapour interfaces in non-equilibrium. Conventional Navier–Stokes–Korteweg (NSK) formulations often fail to accurately capture transport phenomena across extremely thin interfaces due to underestimation of interface resistances. In this work, we improve the NSK model by adding a production term in the momentum equation based on higher-order corrections. To enhance interface resistances, viscosity and thermal conductivity are made dependent on the density gradient, increasing resistance only within the interface region. The gradient-based coefficients are determined by fitting to solutions of the Enskog–Vlasov equation for Couette flow of Struchtrup & Frezzotti (2022 J. Fluid Mech., vol. 940, p. A40). Applying these fitted equations to pure heat conduction and planar evaporation problems shows that the model accurately captures interfacial transport, making it a useful tool for studying nanoscale evaporation, thermal management and the droplet dynamics on solid surfaces.
Flexible substrates are effective in suppressing splashing, but they simultaneously lead to inhibition of spreading (Howland et al. 2016 Phys. Rev. Lett. vol. 117, 184502; Vasileiou et al. 2016 Proc. Natl Acad. Sci. USA vol. 113, pp. 13307−13312). In addition, there has been limited investigation and no established scaling law for the splashing threshold in the case of flexible substrates. To address these points, this paper proposes a lotus-leaf-like disk that can effectively suppress droplet splashing without inhibiting the maximum spreading of droplets. This situation is numerically studied in this paper. Five dynamic modes of the impacting droplet are identified with various Weber numbers (defined as the inertia force relative to the surface tension force) and different disk’s stiffnesses. The threshold Weber number of splashing is developed by considering the flexibility of substrates. Finally, the results demonstrate that the proposed method not only suppresses the splashing but also maintains the maximum spreading.
Three-dimensional total-flow visualization obtained by superposing the 2D mean flow with the resolvent-based standing-wave model at St = 0.01, using the spanwise wavelength corresponding to the leading SPOD mode found in the experimental data. The red u=0 iso-surface shows the separation bubble.
This study investigates the low-frequency dynamics of a turbulent separation bubble (TSB) forming over a backward-facing ramp, with a focus on large-scale coherent structures associated with the so-called `breathing motion’. Using time-resolved particle image velocimetry (PIV) in both streamwise and spanwise planes, we examine the role of sidewall confinement, an aspect largely overlooked in previous research. Spectral proper orthogonal decomposition (SPOD) of the streamwise velocity field reveals a dominant low-rank mode at low Strouhal numbers ($St \lt 0.05$), consistent with prior observations of TSB breathing. Strikingly, the spanwise-oriented PIV data uncover a previously unreported standing-wave pattern, characterised by discrete spanwise wavenumbers and nodal/antinodal structures, suggesting the presence of spanwise resonance. To explain these observations, we construct a resolvent-based model that imposes free-slip conditions at the sidewall locations by superposing left- and right-travelling three-dimensional modes. The model accurately reproduces the spanwise structure and frequency content of the measured SPOD modes, demonstrating that sidewall reflections lead to the formation of standing-wave-like patterns. Global stability analysis reveals a zero-frequency eigenmode originating from a centrifugal instability, giving rise to the observed low-frequency breathing. Downstream, the associated coherent structures are further amplified through non-modal lift-up mechanisms. Our findings highlight the critical influence of spanwise boundary conditions on the selection and structure of low-frequency modes in TSBs. This has direct implications for both experimental and numerical studies relying on spanwise-periodic boundary conditions and offers a low-order framework for predicting sidewall-induced modal dynamics in separated flows.
This study investigates teacher candidates’ transcultural awareness development in an English language teacher education program in Argentina. Baker’s recently revised model of intercultural and transcultural awareness was used retrospectively as theoretical and analytical foundation in an online project undertaken in 2013 between 100 Argentinian and 75 Italian language undergraduates who communicated online using English as Lingua Franca (ELF) to address the theme of mural art and graffiti. Data was comprised of recorded Skype conversations, collaboratively created murals and graffiti, the Autobiography of Intercultural Encounters, and civic action artefacts. Findings show that students deployed the various components of transcultural awareness in their intercultural encounters in fluid and dynamic ways. The study fills two gaps in the literature, namely the little existing research beyond the Asian Pacific region and Europe, and methodological limitations. Implications for the potential of Baker’s updated model in methodological and pedagogical terms are considered.
The endocannabinoid system in the central and peripheral nerves plays a crucial role in various physiological processes, including feeding behavior and energy metabolism. In particular, gut endocannabinoids stimulate appetite, and excessive activation of the system can induce hedonic eating, leading to obesity. Previous studies have indicated elevation of gut endocannabinoid levels in high-fat diet-induced or genetically obese rodents. The present study aimed to expand our understanding of gut endocannabinoids involved in feeding behavior during obesity by characterizing the profiles of arachidonic metabolites, including endocannabinoids, in the gut and by examining their impact on feeding behavior in KK-Ay mice, an obesity model established by crossing diabetic KK mice with lethal yellow (Ay) mice. KK-Ay mice exhibit hyperphagia compared with lean mice under either free-feeding condition or refeeding condition after 24 h of food deprivation. Meal pattern analyses revealed that hyperphagia in KK-Ay was primarily due to higher meal frequency rather than meal size or interval, suggesting a defect in hunger control. In addition, levels of endocannabinoids and other arachidonic acid metabolites such as prostaglandin E2 and F2α were elevated in KK-Ay mice. Pharmacological blockade of the peripheral cannabinoid receptor 1 and diacylglycerol lipase, but not N-acyl phosphatidylethanolamine phospholipase D, reduced food intake, as did treatment with cyclooxygenase-2 inhibitors. These findings suggest that intestinal 2-arachidonoyl glycerol-dependent cannabinoid receptor 1 activation contributes to hyperphagic behavior in KK-Ay mice and prostaglandins are involved in feeding control.
Ascaris species are common soil-transmitted helminths infecting both humans and pigs. It is recognized as one of the Neglected Tropical Diseases and is currently targeted in global eradication initiatives. This study employed mitochondrial ‘NADH dehydrogenase subunit 1 NAnad1) and Cytochrome Oxidase 1 (cox1) gene’ sequences comprising newly generated and publicly available data to investigate the genetic diversity, evolutionary relationships, and potential zoonotic transmission between Ascaris lumbricoides and Ascaris suum. Phylogenetic analysis revealed distinct clustering, with Indian A. lumbricoides sequences showing close genetic affinity to Chinese and Brazilian sequences (Human and Pigs), indicating possible historical gene flow. This genetic relatedness indicates the presence of intra-species variability and supports earlier evidence of potential hybridization between A. lumbricoides and A. suum. Haplotype network analysis based on nad1 identified 27 haplotypes, including both shared and unique variants. Hap_1 and Hap_2 were widely distributed, while several Indian haplotypes were distinct, suggesting localized diversification or genetic divergence. Cox1-based analysis identified 25 haplotypes, with human sequences forming both global and region-specific clusters, and pig-derived A. suum sequences forming a separate clade. These results highlight substantial genetic diversity and underline the importance of molecular surveillance in understanding Ascaris transmission and zoonotic risk.
A computational fluid dynamics simulation of subcooled flow boiling of water at 10.5 ${\rm bar}$, with an applied heat flux of $1\,{\rm MW}\,{\rm m}^{-2}$ and subcooling of 10 ${\rm K}$, was performed using an interface tracking method. The simulation replicated the conditions of an experiment conducted at MIT. The objectives are to elucidate heat-transfer mechanisms in moderate-pressure subcooled boiling and to validate the simulation method, with a focus on quantities that are difficult to measure experimentally, such as the distributions of velocity, temperature, bubble number density and heat-flux partitioning. Due to the small bubble size under high pressure, fine grids are required. Simulated bubble shapes, wall temperatures and vapour area fractions show good agreement with the experimental results. The simulations reveal that a very thin liquid layer (${\lt}4\,\unicode{x03BC}{\rm m}$) surrounding the bubbles is highly effective at removing heat from the surface. The local wall heat fluxes beneath medium and large bubbles, excluding the heat flux associated with seed-bubble generation, are approximately 0.9 and 0.4 ${\rm MW}\,{\rm m}^{-2}$, respectively; the latter is smaller because of the presence of thicker liquid films (14–70 $\unicode{x03BC}{\rm m}$) that thermally insulate the wall. In the single-phase liquid region, the heat transfer coefficient reaches $42\,{\rm kW}\,{\rm m}^{-2}\,{\rm K}^{-1}$ as a result of strong turbulent heat flux in the wall-normal direction; this turbulent heat flux is approximately eight times larger than in the equivalent single-phase liquid flow.
Thin liquid films play an instrumental role in the coating industry. In many cases, these films consist of multiple components and are applied in multiple layers. However, multilayer multicomponent coatings can readily develop thickness non-uniformities due to Marangoni flows driven by solute concentration gradients. Previous flow visualisation experiments have demonstrated that the addition of surfactant can suppress such non-uniformities, but the physical mechanisms underlying this suppression have not yet been definitively established. We investigate the growth of film-height non-uniformities in a two-layer multicomponent coating consisting of a solute-rich bottom layer, a solute-depleted top layer and surfactant. A lubrication-theory-based model that accounts for vertical and lateral gradients in solute and surfactant concentrations is developed. The resulting coupled nonlinear partial differential equations describing the film height, solute concentration and surfactant concentration are solved with a pseudospectral method. Our findings reveal that surfactant-induced Marangoni flows can significantly decrease film-height non-uniformities by competing with Marangoni flows due to solute concentration gradients. Several simplifications of the governing equations are explored to determine how well predictions from these simplified models compare with the full lubrication-theory-based model, thereby providing insight into dominant physical mechanisms in different parameter regimes. The role of surfactant solubility and sorption kinetics in controlling perturbation growth is also examined.