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Wastewater treatment is critically important and ceramic-membrane engineering is one of the most effective technologies for water filtration and purification. However, the materials used in the preparation of ceramic membranes are usually expensive, e.g. ZrO and Al2O3 membranes, reverse osmosis materials such as carbon-based thin-film nanocomposite TFNC ‘carbon nanotube, graphene-oxide’. Delicate, thin membranes employed for small-scale filtration usually require optimal supports for effective operation. The purpose of the present research, therefore, was to find a less expensive material for membrane supports while, at the same time, enhancing performance. Membrane supports were thus prepared from local clay materials and (25 wt.%) CaCO3 using an extrusion technique, which enabled the production of tubular supports. The CaCO3 is responsible for creating the pores in the samples during heat treatment due to the evolution of CO2 gas. Some characteristics of the supports were evaluated using X-ray diffraction, which identified quartz, gehlenite, sillimanite, H-bearing aluminous stishovite, and wollastonite. The support treated at 1000°C displayed significant mechanical properties (flexural strength, 11.58 MPa, measured using three-point bending tests) compared with supports treated at other temperatures. Moreover, the support sintered at 1000°C had an estimated permeability factor of 1052 L/h m2.bar after performing both time- and pressure-dependent flux measurements. Such properties make it possible to use these supports as multi-scale filtration membranes for purification and filtration applications after performing a standard filtration application on dirty water, resulting in a significant difference in terms of turbidity and waste content.
Al-Hoorie, Hiver, and In’nami (2024) offer compelling arguments for why L2 motivational self-system research is currently in a state of validation crisis. Seeking a constructive resolution to the crisis, in this response we argue that two fundamental conditions are needed for the field to emerge stronger: psychological readiness and methodological maturity. For psychological readiness, we call for a reframing of the “crisis” narrative. We highlight the need to value controversy, to normalize failure and (self-)correction, and to resist the allure of novelty. For methodological maturity, we suggest that an argument-based approach to validation can provide a constructive solution to current controversies. We present an integrated framework that can guide systematic validation efforts, and we demonstrate its application using a recent validation study as an example.
Clozapine remains the only evidence-based treatment for treatment-resistant schizophrenia, supported by guidelines from the National Institute for Health and Care Excellence (NICE) and other authorities. However, clozapine is still underutilised for treatment-resistant schizophrenia, despite its proven benefits, including reduced all-cause mortality. This is attributed mainly to its association with adverse effects, including cardiac adverse effects. This review focuses on the latter, with a detailed exploration of clozapine-induced myocarditis – a potentially fatal acute hypersensitivity reaction – and cardiomyopathy, tachycardia and conduction deficits. Among other things, we discuss their pathophysiology, diagnosis and management, with signposting to international diagnostic criteria and monitoring protocols.
In this article, I explain how peasant communities were affected by fire disasters in North Ostrobothnia in northern Finland during the seventeenth century. Unlike previous research mainly based on dendrochronological data aimed at dating these fire disasters’ scope and occurrence, I focus on the socio-economic consequences of wildfires from both a bottom-up and a top-down perspective in order to establish different factors of resilience and vulnerability. Through the analysis of local district court protocols, tax records and Swedish legislation, the article explains how and why fires occurred and what role peasant common-pool institutions and the early modern Swedish state played in this development. The results show how peasant communities were able to bounce back from recurrent events of fire disasters thanks to close cooperation between them and Swedish officials, the reinvigorated medieval relief institution of fire support (Swe. brandstod), and owing to the robustness of the peasants’ common-pool institutions.
A wall-modelled large eddy simulation approach is proposed in a discontinuous Galerkin (DG) setting, building on the slip-wall concept of Bae et al. (J. Fluid Mech., vol. 859, 2019, pp. 400–432) and the universal scaling relationship by Pradhan and Duraisamy (J. Fluid Mech., vol. 955, 2023, A6). The effect of the order of the DG approximation is introduced via the length scales in the formulation. The level of under-resolution is represented by a slip Reynolds number and the model attempts to incorporate the effects of the numerical discretization and the subgrid-scale model. The dynamic part of the new model is based on a modified form of the Germano identity -- performed on the universal scaling parameter -- and is coupled with the dynamic Smagorinsky model. A sharp modal cutoff filter is used as the test filter for the dynamic procedure, and the dynamic model can be easily integrated into any DG solver. Numerical experiments on channel flows show that grid independence of the statistics is achievable and predictions for the mean velocity and Reynolds stress profiles agree well with the direct numerical simulation, even with significant under-resolution. When applied to flows with separation and reattachment, the model also consistently predicts one-point statistics in the reverse flow and post-reattachment regions in good agreement with experiments. The performance of the model in accurately predicting equilibrium and separated flows using significantly under-resolved meshes can be attributed to several aspects that work synergistically: the optimal finite-element projection framework, the interplay of the scale separation and numerical discretization within the DG framework, and the consistent dynamic procedures for subgrid and wall modelling.
The European Green Deal (EGD) provides a strategic framework for the European Union’s (EU) transition to climate neutrality by 2050. Yet, limited integration of socio-economic dimensions may hinder its long-term success and fairness. This study investigates the indirect impacts of socio-economic factors on EGD performance by constructing a Green Deal Performance Index (GDPI) using a multi-criteria decision-making approach for 22 EU countries over 2010–2020. We then apply an instrumental variable regression approach to estimate how emissions, shaped by structural socio-economic conditions, affect the GDPI. Our results show that the negative impact of emissions is nearly 47 times larger when socio-economic dynamics are ignored. These findings underscore the necessity of inclusive policymaking for achieving carbon neutrality, contributing to discussions on ensuring a just transition by highlighting the critical role of socio-economic dynamics. We also present implications for policymakers developing fair and equitable strategies promoting sustainability and social justice in this context.
Carbon credits have become increasingly important for supporting sustainable forest management and mitigating climate change. However, carbon projects can be challenging for local communities and smallholders to implement due to high expenses and complicated protocols. Forest projects often suffer from inefficiency, lack of transparency, and uneven benefit distribution. This study suggests a blockchain-based framework for aggregating forest carbon projects. This framework is the first in the forest sector to provide a reward mechanism for local communities or smallholders with a direct integration into an accredited registry protocol of Monitoring, Reporting, and Verification. The system combines digital identities, smart contracts, and automated incentives to improve transparency, responsibility, and trust among stakeholders. Two types of tokens are introduced: (i) Carbon Coin represents verified carbon credits within the system; and (ii) Forest Coin functions as a security token used to proportionally distribute project revenue among stakeholders. The revenue distribution was demonstrated in scenarios of afforestation, reforestation, and conservation. In addition, a web application was developed so that users can monitor project details. Unlike most blockchain carbon platforms that focus on investment and trading, this framework addresses upstream challenges, prioritising equitable benefit-sharing. The framework supports project aggregation and prioritises community ownership, advancing inclusive access to the carbon market. This study demonstrates how technological advantages can be transferred to community-driven ecological conservation.
Atrial septal defect is the second most common CHD in adults. This study aimed to evaluate the relationship between age and early postoperative changes in cardiac function—including right ventricular function, tricuspid regurgitation, pulmonary artery pressure, mitral regurgitation, and left ventricular ejection fraction—in adult patients undergoing surgical atrial septal defect repair.
Methods:
This retrospective study included 214 patients aged 16–65 years who underwent isolated atrial septal defect repair between 2014 and 2024. Patients were divided into five age groups. Echocardiographic parameters were compared at three time points: preoperative, 1-month, and 6-month postoperative.
Results:
Of the patients, 60.7% were female. A significant postoperative left ventricular ejection fraction decrease was observed only in the 56–65 age group. Preoperative tricuspid regurgitation severity and pulmonary artery pressure values increased with age, but both showed significant postoperative improvement across all age groups. Postoperative pulmonary artery pressure reduction was most prominent in the youngest and oldest groups. Mitral regurgitation was mildly increased in all groups, without progression to moderate severity. Tricuspid annular plane systolic excursion values, inversely correlated with age, decreased in younger patients postoperatively but improved in older patients, indicating enhanced right ventricular function after volume unloading.
Conclusion:
Surgical atrial septal defect repair leads to early improvement in several cardiac parameters. However, the benefit is more pronounced in younger patients. These findings support early surgical intervention to preserve right ventricular function and prevent long-term complications, particularly in asymptomatic adults.
Niall Crumlish (1974 – 2025) was a profoundly compassionate psychiatrist, uniquely gifted music journalist, and cherished husband, father, son, brother, and friend. He embodied humility, kindness, and compassion in all he did. Niall qualified in medicine from University College Dublin (UCD) in 1997; obtained membership of the Royal College of Psychiatrists in 2002; graduated with a Masters degree (MSc) in Transcultural Mental Healthcare from Queen Mary University of London in 2009; and obtained the degree of Doctor of Medicine (MD) from UCD in 2014. During his clinical training, Niall spent 18 months at St John of God Mental Health Services in Mzuzu, Malawi, a country which left a deep impression on him. In 2010, Niall was appointed as Consultant General Adult Psychiatrist at St James’s Hospital, Dublin with the Camac sector where his sense of humour and generosity left a lasting impression on all who worked with him. Niall was an especially gifted writer about music with an unrivalled depth of knowledge and sensibility. He wrote voraciously for Hot Press magazine from 1993 onwards, where his contributions were widely acclaimed. Through his writings in various publications and on his blog ‘Psychiatry and Songs’, Niall created a body of work that is elegant and intelligent, eloquent and heartfelt, intimate and universal.
While deplatforming has become an increasingly common strategy to combat online harm and far-right extremism, its effects on the followers of extremist groups—who are key supporters and play a crucial role in spreading and sustaining these ideologies—remain underexplored. On August 10, 2018, Twitter (now X) deplatformed one such far-right extremist group, the Proud Boys, along with their affiliated accounts. Leveraging this intervention, our research addresses a key knowledge gap by examining the impact of deplatforming on the cohesion of extremist group followers. Specifically, we investigate whether deplatforming leads to fragmentation or reinforces unity among the group’s followers. We assess cohesion through three theoretical lenses: task commitment, social commitment, and sense of belonging. By analyzing over 12 million tweets from approximately nine thousand Proud Boys supporters between August 1, 2017, and September 1, 2019, we find that deplatforming had a limited effect on reducing group cohesion. Instead, it may have prompted followers to seek broader networks and external interactions, leaving overall cohesion largely intact. This study offers important insights into the resilience of online extremist communities and the limitations of deplatforming as a strategy to disrupt them. Understanding these dynamics is essential for developing more effective approaches to counter online extremism and promote safer digital spaces.
The cycling of carbon in riverine systems is a critical component of global carbon cycle research. However, the sources and performances of riverine carbon in the Qinling Mountains, a pivotal hydrological nexus in China, remain poorly understood. This study investigates the seasonal variations of dissolved organic carbon (DOC) concentration in the Tianyu River within the Qinling Mountains. By utilizing a combination of carbon isotopic signatures (Δ14C-δ13C) and the stepped-combustion method, we examined the sources of DOC and the contribution ratio of each end-member. Our findings reveal that: (1) the concentrations and dual carbon isotope ratios of DOC in the Tianyu River are influenced by regional climatic factors, exhibiting distinct seasonal patterns; (2) the 14C age of DOC in the Tianyu River is comparatively older than the global average for rivers but younger than that of China’s three major rivers (the Yellow, Yangtze, and Pearl Rivers); and (3) the DOC mainly comes from exogenous sources, with a proportion of about 85.8%–88.4%. Vegetation and riverine sediments are identified as primary contributors. These findings suggest that exemplary ecological preservation exists within the Qinling region while operating within an efficient carbon cycling system. This investigation provides initial insights into how regional climatic conditions influence riverine carbon cycles and enhances our understanding of biogeochemical processes related to carbon.
Turbulence–chemistry interaction in a Mach-7 hypersonic boundary layer with significant production of radical species is characterised using direct numerical simulation. Overriding a non-catalytic surface maintained as isothermal at 3000 K, the boundary layer is subject to finite-rate chemical effects, comprising both dissociation/recombination processes as well as the production of nitric oxide as mediated by the Zel’dovich mechanism. With kinetic-energy dissipation giving rise to temperatures exceeding 5300 K, molecular oxygen is almost entirely depleted within the aerodynamic heating layer, producing significant densities of atomic oxygen and nitric oxide. Owing to the coupling between turbulence-induced thermodynamic fluctuations and the chemical-kinetic processes, the Reynolds-averaged production rates ultimately depart significantly from their mean-field approximations. To better characterise this turbulence–chemistry interaction, which arises primarily from the exchange reactions in the Zel’dovich mechanism, a decomposition for the mean distortion of finite-rate chemical processes with respect to thermodynamic fluctuations is presented. Both thermal and partial-density fluctuations, as well as the impact of their statistical co-moments, are shown to contribute significantly to the net chemical production rate of each species. Dissociation/recombination processes are confirmed to be primarily affected by temperature fluctuations alone, which yield an augmentation of the molecular dissociation rates and reduction of the recombination layer’s off-wall extent. While the effect of pressure perturbations proves largely negligible for the mean chemical production rates, fluctuations in the species mass fractions are shown to be the primary source of turbulence–chemistry interaction for the second Zel’dovich reaction, significantly modulating the production of all major species apart from molecular nitrogen.
Animals routinely suffer violence by humans, especially during war, but it is unclear how much people in conflict environments express concern for animal welfare. Based on a 2,008-person survey in Ukraine in May 2024, we find that respondents are anthropocentric, prioritizing human over animal suffering; biocentric, regarding both as important; or, in a small minority, zoocentric, emphasizing animal over human suffering. Experimental priming on violence against animals during the Russia–Ukraine war has limited effect on changing attitudes toward animal welfare, but it does increase resource allocation to animal relief organizations. A war crimes punishment experiment also shows that while respondents sanction perpetrators of human suffering more severely than perpetrators of animal suffering, violence against animals is still strongly penalized, indicating appreciation for animal rights, justice, and accountability. We reflect on the implications of our findings for speciesist versus posthumanist understandings of suffering during war.