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Historians of the Cold War and the nuclear age have largely overlooked the existence of tabletop role-playing games (TTRPGs), while films, comics, novels, and television programmes that tackled the challenging imaginary, yet all-too-possible, wastes of a post-nuclear landscape have been abundantly analysed. As cultural products and tools through which to imagine other worlds, TTRPGs offer powerful insights into how, where, and why certain groups thought about the spectre of the nuclear age and how they dealt with this threat by gaming within make-believe postapocalyptic worlds. This article draws together several threads in its analysis of the American-designed and -produced Twilight: 2000 TTRPG’s historical significance. Through analysing Twilight: 2000 as a case study of how a TTRPG functions as a specific nuclear-cultural object in its own right, the article also locates this game as a part of a wider-reaching dystopian fantasy rooted in the massive everyday reality of atomic annihilation. Likewise, the game, its mechanics, setting, and artwork are analysed here as part of a distinctive Cold War culture that permitted participants to derive pleasure and affirmation from fictional “adventures” in the postapocalyptic environment.
Haritalodes derogata (Fabricius) (Lepidoptera: Crambidae), commonly known as the cotton leaf roller, is an important polyphagous pest that causes damage to various agricultural and forest plants, especially those of the Malvaceae family, but also to crops such as cotton, cashew, bamboo, oats, and jute. While microbial control agents are known for their efficacy and environmental friendliness, there are few studies demonstrating their effect on H. derogata. The aim of this study was to evaluate the bioefficacy of microbial agents from different pathogen groups against this pest. To this end, we investigated the insecticidal potential of fifteen indigenous microbial isolates from our entomopathogen collection. These included five Bacillus thuringiensis strains (Bn1, MnD, Mm2, Xd3, Lyd8), five entomopathogenic fungi (Metarhizium flavoviride As2, M. anisopliae KTU-51 and Beauveria bassiana Pa4, Pa5, Hp5), and five baculoviruses (HycuGV-Hc1, LdMNPV-T2, AcMNPV, DapuNPV-T1, SeMNPV-U), applied at concentrations of 1.8 × 109 cfu/mL, 1 × 107 conidia/mL, and 1 × 107 PIB/mL, respectively, against H. derogata larvae under laboratory conditions. Among these, B. thuringiensis subsp. kurstaki Bn1, B. bassiana Pa4, Hyphantria cunea granulovirus (HycuGV-Hc1), and Spodoptera exigua nucleopolyhedrovirus (SeMNPV-U) showed strong insecticidal activity and were selected for virulence assays, each achieving 100% mortality in third instar larvae. The median lethal concentrations (LC50) were determined to be 7.1 × 104 cfu/mL, 3.3 × 103 conidia/mL, 1.2 × 103 PIB/mL, and 1 × 103 PIB/mL, respectively. These results indicate that indigenous microbial agents are a promising environmentally friendly alternative to chemical pesticides in the control of H. derogata.
This article analyses how forms of private cooperation between East and West were reshaped during the late Cold War and beyond. It does so by studying an elitist East–West club, called the International Vienna Council, which brings together leaders of multinational companies and leaders of the planned economy. While the permeability of the iron curtain has been well documented, little is known about the evolution of East–West circulation patterns during that time or the role played by economic elites. The International Vienna Council, initially a forum for ‘parallel diplomacy’, gradually became a platform for concrete business cooperation. The club’s activities continued after 1989, but it struggled with the transition from an East–West club to an interest group within the European Union. These dynamics shed light on the gradual autonomy of a private East–West cooperation group and its contribution to defining a pan-European economic space since the 1970s.
The Pósa–Seymour conjecture determines the minimum degree threshold for forcing the $k$th power of a Hamilton cycle in a graph. After numerous partial results, Komlós, Sárközy, and Szemerédi proved the conjecture for sufficiently large graphs. In this paper, we focus on the analogous problem for digraphs and for oriented graphs. We asymptotically determine the minimum total degree threshold for forcing the square of a Hamilton cycle in a digraph. We also give a conjecture on the corresponding threshold for $k$th powers of a Hamilton cycle more generally. For oriented graphs, we provide a minimum semi-degree condition that forces the $k$th power of a Hamilton cycle; although this minimum semi-degree condition is not tight, it does provide the correct order of magnitude of the threshold. Turán-type problems for oriented graphs are also discussed.
This study was undertaken to investigate the molecular detection of biofilm-producing Staphylococcus aureus (S. aureus) from goat mastitis. An overall 384 milk samples were initially screened for subclinical mastitis (SCM) followed by molecular characterization of S. aureus isolates. The biofilm formation was assessed using Congo Red agar (CRA), a microtiter plate and the presence of the icaA gene. The results revealed a molecular prevalence of 53.24% (115/216) for pathogenic S. aureus in milk samples of goats. The phenotypic prevalence of biofilm production by CRA and microtitre methods was recorded to be 38.26% (44/115) and 26.96% (31/115) respectively, while the molecularly confirmed biofilm-forming S. aureus through polymerase chain reaction targeting icaA gene was 58.26% (67/115). The phylogenetic analysis of icaA gene revealed high identity between sequences of study isolates and the isolates of other neighbouring countries. The antibiogram profiling of pathogenic S. aureus showed increased resistance to cefoxitin and oxytetracycline followed by gentamicin. Out of 115, 45.22% (52/115) were declared as multiple drug resistant with multiple antibiotic resistance index greater than 0.2. The study concluded that biofilm-producing S. aureus strains are considered to be a common cause of SCM in dairy goats of Pakistan and biofilm formation is associated with multidrug resistance of study isolates.
Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been reported, especially before the widespread treat-and-repair strategy.
Methods:
We retrospectively analysed patients aged ≥13 years who underwent repair for ventricular septal defect with pulmonary hypertension at our centre (1970–2024). Pre- and post-operative hemodynamics were assessed. Patients were grouped by preoperative pulmonary vascular resistance (≥3 vs. <3 Wood units). Residual pulmonary hypertension was evaluated by echocardiography.
Results:
We studied 115 patients (43 male, 72 female). Follow-up reached 47 years (median 18.5). Residual pulmonary hypertension occurred in 3/115 (2.6%). Median age at intracardiac repair was 5 months. No significant differences were seen between patients with and without residual pulmonary hypertension in age at surgery, preoperative estimated right ventricular pressure, mean pulmonary artery pressure, or postoperative estimated right ventricular pressure. Mean pulmonary artery pressure was higher in the pulmonary vascular resistance ≥3 group than in the <3 group (47 ± 13 vs. 38 ± 11 mmHg, p = 0.019), while postoperative estimated right ventricular pressure did not differ. Among the 3 with residual pulmonary hypertension, 2 underwent intracardiac repair after 1 year of age.
Conclusions:
Most patients with ventricular septal defect and pulmonary hypertension had resolution after intracardiac repair; however, residual pulmonary hypertension occurred in about 2.6% during long-term follow-up. Preoperative hemodynamics did not predict persistence. Long-term periodic follow-up remains important after surgery.
This review aimed to map the main ethical tensions experienced by health workers in low- and middle-income countries during infectious disease outbreaks.
Methods
We conducted a critical interpretive review of qualitative research studies. After searching 3 databases, 4445 articles were exported to Rayyan, deduplicated, and screened for eligibility. Of the 98 articles retained for full review, 25 met the inclusion criteria. Data were extracted to an Excel spreadsheet and key ethical tensions were identified using a descriptive content and thematic analysis approach.
Results
Twenty-three of the studies focused on the COVID-19 pandemic, and two addressed Ebola epidemics. Three major ethical tensions were experienced by health workers, which involved conflicts between their professional duty to patients, colleagues, and communities, as against their concerns for personal safety, the well-being of their families, and facing stigma and discrimination. Secondary tensions arose when health workers seeking to manage these primary ethical tensions experienced further uncertainty about whether to disclose information about their professional roles with family members or community.
Conclusions
Ethical tensions are unavoidable during contagions, and may be amplified due to structural features. Authorities must take steps to support health workers as they navigate ethical tensions during localized epidemics or global pandemics.
The recent advancements in digital technologies have made remote work a core aspect of modern organizations, bringing opportunities and challenges for employee well-being. Drawing on the Job Demands-Resources model, the study investigates key stressors undermining employees’ well-being within digitalized settings. Fuzzy total interpretive structural modeling (F-TISM) and MICMAC analysis are employed to understand the hierarchical interrelationship and classify the stressors according to their driving and dependence power. The findings reveal low supervisor support, unrealistic supervisor expectations, digital overload, digital fatigue, and constant connectivity as critical drivers undermining remote workers’ well-being in these work practices. The proposed health impairment process of the JD-R model provides theoretical insights into how high job demands in digitalized settings undermine the well-being of remote workers, amid the growing emphasis on digital transition and flexible work models. The developed decision model provides actionable insights for practitioners and policymakers.
Beta blocker non-adherence is a key factor in precipitating cardiac events in patients affected by congenital long QT syndrome. Adherence has been examined in adults affected by congenital long QT syndrome but not in a large paediatric group.
Method:
Patients with congenital long QT syndrome types 1 and 2 were identified using a database curated by the Inherited Cardiac Conditions team in Northern Ireland. Medication adherence was reviewed by contacting the patient’s GP. A medication possession ratio was then calculated for the year. Adequate adherence was defined as a ratio of ≥0.8, and ideal adherence was defined as a ratio of ≥1.0. Risk factor analysis for poor adherence was performed using multivariable binary logistic regression.
Results:
99 patients’ data was suitable for analysis, 71 had LQT1 (78%) and 28 had LQT2 (28%). The median age of the children involved was ten years old. Over 36,135 days the median medication possession ratio of this patient group was 0.92. 56 patients (57%) had at least adequate adherence, of these 44 patients (44%) had ideal adherence. In contrast 43 patients (43%) had less than adequate adherence and of these six patients (6%) were completely non-adherent. Increased deprivation was significantly associated with “less than” ideal adherence Odds Ratio (OR) 1.2 95% confidence intervals CI (1.1–1.4).
Conclusion:
Adherence in the paediatric cohort was mostly in the “adequate range.” Increased deprivation is a risk factor for “less than” ideal adherence. A small minority of patients can be identified as completely non-adherent by checking prescription records. Future studies should focus on elucidating barriers and enablers to ideal adherence in this population.
For hypersonic inlets, buzz is a self-sustained oscillatory flow characterised by strong nonlinear and unsteady behaviour. Our recent study shows that, unlike conventional alterations in flow conditions at the inlet entrance or exit, flexible lip deformation is a newly identified trigger for buzz. However, the mechanism by which this fluid–structure interaction (FSI) behaviour induces buzz remains unclear. To clarify how FSI acts as a dominant factor in triggering flow instability leading to buzz, this study investigates a more general flexible plate model within the inlet. The results show that the plate FSI introduces a prolonged instability accumulation process for buzz evolution, resulting in a ‘gradual-onset’ characteristic differing from previous studies. During this process, plate FSI amplifies downstream flow oscillations while accumulating unstable energy. Eventually, the excessive unstable energy causes the shock train to destabilise and be disgorged from the inlet, initiating a complete instability process dominated by buzz. Notably, buzz induced by plate FSI exhibits unsteady characteristics similar to those observed in rigid inlets. Therefore, as an internal self-excited disturbance source, plate FSI produces relatively weaker disturbances than conventional flow modifications, but exhibits highly persistent accumulation effects and distinct multistage characteristics. This study reveals the buzz evolution mechanism under plate FSI, providing new insights into flow instability in hypersonic inlets.
Dietary patterns are prerequisites for health and integral components of ecological systems. For over a century researchers have been building a body of evidence of associations between dietary patterns and health and sustainability outcomes while policymakers have been synthesising and translating this evidence into policies to promote public health. During this period, food systems have dramatically changed and driven the emergence of food supplies and dietary behaviours with no ecological or evolutionary precedent. Now, the relevance of conventional nutrition research and policymaking approaches for understanding food system transitions and protecting against unhealthy and unsustainable diets is being questioned. This review aims to examine how the ecological nutrition paradigm might guide a transformed approach to nutrition research and policymaking to promote healthy and sustainable diets. It shows the ecological nutrition paradigm is transdisciplinary integrating biological, social and environmental dimensions into nutrition research and policymaking. The paradigm operates to a ‘fit-for-purpose’ policymaking orientation. It draws on ecological and evolutionary theories to provide insights to conceptualise the causes of, and solutions to, nutrition problems and help design relevant decision-making processes. These research and policymaking features contrast with the ‘one-size-fits-all’ policymaking orientation and prescriptive decision-making processes of the conventional medical nutrition paradigm. Their attention to a relevance criterion engenders confidence in the likely effectiveness, and ability to avoid unintended consequences, of policies informed within an ecological nutrition paradigm. The review proposes a shift to the ecological nutrition paradigm to transform nutrition research and policymaking for promoting healthy and sustainable diets is overdue.