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Over the course of his career, Karl Barth changed his mind on the extra Calvinisticum, moving from a robust early affirmation to a final rejection in the later volumes of the Church Dogmatics. This article traces that theological shift, arguing that it was not incidental but necessitated by the internal logic of Barth’s doctrine of revelation. In contrast to recent trajectories that seek to retrieve the extra in defence of divine impassibility, Barth’s rejection was grounded in a conviction that God’s being is identical with God’s act – most fully revealed in Jesus Christ. This christological pressure led Barth to revise the scope and function of the extra until it became theologically untenable. The article situates this shift within the broader historical development of the doctrine and concludes by exploring its implications for reconciliation, kenosis, and divine ontology in contemporary theology.
During World War I, national pride in France fostered solidarity and increased patriotism. However, after the war, the principles of self-determination and nationality reignited debates among young regionalists about federal reorganization in France and Europe. Federalism was seen as a way to promote peace in Europe and to protect national minorities within the state. This movement crystallized in 1927 when representatives from Alsace, Corsica, and Brittany established the Central Committee of National Minorities in France (CCMNF). The CCMNF advocated for self-determination and international federalism, suggesting that a federation of peoples could replace the modern state system. This structure would let each nationality decide its political status and cultural development. While the CCMNF marked a milestone in uniting minorities around federalist ideas, its efforts were slowed by the 1929 economic crisis and a resurgence of political tensions. This article examines the rise of regionalist federalism in 1920s France and its connection to the broader post-war discussions on self-determination. By placing this movement within the larger national debates on reorganizing the French state, it highlights federalism’s potential as a transformative framework for addressing political and cultural diversity.
In this prospective cohort study, trimethoprim-sulfamethoxazole direct oral challenge (DOC) for hospitalized adults reporting a low-risk sulfa antibiotic allergy was safe with 75/76 (99%) inpatients delabeled. Within 90-days of DOC, immunocompromised patients were more likely to receive trimethoprim-sulfamethoxazole, compared with non-immunocompromised patients (adjusted OR 5.6 95% CI 1.3, 23.0).
During the early twentieth century the rise of professional archaeology pushed the study of deep-time oral tradition into the fringes of historiography. The development of evidence-based archaeological chronologies displaced oral tradition, relying on the assumption that transmission processes include short-term limits on durability. By the end of the century, sporadic innovative partnership experiments brought together archaeological chronology and oral tradition, suggesting the need for further research. This article advances the narrative merging of oral tradition, archaeology, and genomic analysis. After surveying research on archery technology, it explores how the integrative aligning of oral tradition and archaeology can expand meaningful insights into antiquity worldwide. Although twenty-first century inquiry into deep-time oral literature unfolds in the shadowy academic fringes, perhaps such research is on the verge of professionalizing into new scholarship and a mutual enrichment of knowledge systems. Academic scholarship may someday see “prehistory” replaced by ancient human history.
In the present study, we introduce a new temperature transformation for compressible turbulent boundary layers with adiabatic and isothermal walls. Unlike existing transformations that rely on a single invariant function for the non-dimensional temperature gradient across the entire inner layer, a composite transformation strategy is proposed by leveraging two newly proposed Mach-number and wall-temperature invariant functions for the mean temperature field. This approach not only deploys appropriate Mach-number invariant functions in the viscous sublayer and the logarithmic region, but also introduces an improved solution to the long-standing singularity challenge inherent in single invariant function models. The performance of this composite transformation is verified by extensive direct numerical simulation (DNS) datasets (26 cases) of compressible turbulent boundary-layer flows. The results demonstrate that the proposed transformation maps the mean temperature profiles to the incompressible reference without case-specific parameter tuning, exhibiting significantly reduced scatter when compared with the existing temperature transformations.
The objective of this study was to compare embryonic morphokinetic parameters and clinical outcomes of two controlled ovarian stimulation (COS) protocols in women of advanced maternal age (AMA): Pergoveris (r-hFSH:r-hLH, 2:1 ratio) versus r-hFSH monotherapy (GONAL-f). This retrospective, non-interventional descriptive study was conducted at a private university–affiliated IVF center and included 136 ICSI cycles performed in AMA patients between March 2019 and May 2020. Patients were grouped by COS protocol (GONAL-f, n = 64; Pergoveris, n = 72), and embryo morphokinetics and ICSI outcomes were extracted from the clinic’s database; the main outcome was time to complete blastulation (tB, hours). Embryos from the Pergoveris group reached tB earlier than those from the GONAL-f group (mean 109.3 h vs 112.6 h), and all morphokinetic milestones occurred sooner with Pergoveris, alongside lower multinucleation rates at the 2-cell and 4-cell stages. Although blastocyst development was higher in the GONAL-f group, Pergoveris was associated with higher oocyte yield and maturity, higher implantation, clinical and ongoing pregnancy rates, and lower miscarriage and OHSS rates; Pergoveris cycles also required higher gonadotropin doses and longer stimulation. Overall, embryos from the r-hFSH:r-hLH group exhibited faster morphokinetic timings and improved implantation and pregnancy outcomes, and prospective studies are warranted to confirm these observations.
This article is about the recent transformation of two powerful, paradoxical, and inseparable narratives of progress that developed in the postwar period: aesthetic autonomy and Holocaust remembrance. As far-right and illiberal parties have gained power across Europe, they adapted these foundational narratives of the liberal-democratic West to assert their own legitimacy and to reimagine the cultural inclinations of the European Union. This article examines how this process has taken place in the reception of Jonathan Glazer's Zone of Interest (2023) and Agnieszka Holland's Green Border (2023)—both international co-productions produced during the repressive eight-year reign of the Law and Justice Party (PiS) in Poland. A close reading of these films and their reception in different contexts, exposes a world more complicated than one-dimensional dichotomies between the liberal and the illiberal. Likewise, the reception of the two films makes apparent the entanglement of the national and transnational, as well as a process of translation and mistranslation that takes place as cultural materials move across geographical and ideological boundaries. Understanding such dynamics helps us to comprehend the options for criticism available to artists working within repressive contexts.
This work compares the use of palace diplomacy and propaganda by the rulers of Constantinople and Mexico-Tenochtitlan. It builds on studies of the cultural exchange between the Roman and Sasanian empires from the third to sixth centuries a.d., which led to a diplomatic protocol shared by these two realms. This protocol and Liudprand of Cremona’s account of diplomatic receptions are the basis for comparative analysis. Drawing on Hernando Alvarado Tezozómoc’s Crónica Mexicana and other sixteenth-century sources, this study identifies key characteristics of diplomacy in Mesoamerica. It explores how Mexico-Tenochtitlan employed palace diplomacy and propaganda from the reign of Motecuhzoma Ilhuicamina to Motecuhzoma Xocoyotzin. Through this analysis, we find that the diplomatic and propaganda objectives of Constantinople and Mexico-Tenochtitlan had distinct focuses. The Byzantine rulers aimed to maintain their existing empire, while the Tenochca rulers sought not only to preserve but also to expand their domain. As a result, Constantinople’s strategy emphasized palace diplomacy, whereas Mexico-Tenochtitlan’s focused more on propaganda. Despite these differences, both approaches share several similarities. Both began with invitations, and their protocols included the same components: visual (architecture, wealth, and terror), ceremonial (including aural, olfactory, gustatory, ludic, haptic, somatic, and terror elements), and diplomatic (interviews and gift exchanges).
On an Adventide Sunday in 1523, a visitor to Milan’s Duomo witnessed something unexpected. Lay congregants halted high mass by yelling at the priests, demanding that attention remain fixed on their favoured preacher. This and similar episodes are recounted in the Cronica Milanese by the shopkeeper Giovan Marco Burigozzo. Using Burigozzo’s accounts alongside overlooked evidence from the Duomo’s archives, this article traces moments when customary rituals broke down under lay intervention. Such episodes reveal how ordinary congregants experienced, contested and redirected the cathedral’s functions, reshaping the church’s sonic and liturgical space in ways that diverged from its intended purposes.
This article discusses the question whether the use of ὄργανον as a title to designate Aristotle’s logical treatises as a unitary bibliographical entity can be traced back to the ancient commentators or emerged as late as in the Renaissance. A review of the ancient and medieval evidence locates the earliest certain traces of this use in the eleventh or twelfth century.
The legume pod borer, Helicoverpa armigera (Hübner), is one of the pervasive and destructive pests of legume crops, causing significant yield losses. In this study, we evaluated the nutritional performance and digestive enzyme activities of H. armigera when fed on ten mung bean varieties, including Baghmalek, India, Veys, Omrani, Parto, Simite1, Simite2, VC6371, VC3960, and VC6368. Additionally, biochemical profiling of these mung bean varieties, assessing starch, protein, anthocyanin, total phenolic and flavonoid content, was conducted to explore potential correlations with the nutritional physiology of H. armigera. The findings indicated that the larvae fed on Parto had lowest approximate digestibility, efficiency of conversion of ingested food, and relative growth rate, while those fed on VC6371 had the highest values. The values of efficiency of conversion of digested food were lower on Baghmalek and Parto and higher on VC6368 and VC6371. The lowest value of larval gain weight was on Parto. The highest proteolytic and amylolytic activities of larvae were observed on Veys and India, respectively; while the lowest enzyme activities were recorded on Parto. Our findings indicate that the low protein content combined with high levels of anthocyanin, total phenolics, and flavonoids may contribute to the potential tolerance of mung bean varieties against H. armigera. Cluster analysis revealed that VC6368 and VC6371 were the most suitable varieties for H. armigera development, whereas Baghmalek and Parto were nutritionally less suitable and may severe as promising candidates for breeding or cultivation to minimise damage caused by this pest.
Professional guidelines recommend an early switch from intravenous (IV)-to-oral antibiotics for community-acquired pneumonia (CAP) to facilitate early discharge and prevent hospital-related complications. However, it is unknown how often these IV-to-oral switches occur in clinical practice.
Design:
We performed a retrospective cohort study across 124 acute-care Veterans Administration hospitals to measure the frequency of early switches.
Patients:
Patient-admissions during 2018–2023 who had CAP and were started on IV antibiotics upon admission.
Methods:
We measured the percentage of hospitalized patients with CAP who had an early switch from IV-to-oral antibiotics, i.e., within 72 hours of admission. In addition, we calculated an observed-to-expected ratio for early switches at each hospital and compared a composite outcome (mortality and/or hospital readmission within 30 days of discharge) at hospitals with switch rates that were higher and lower than expected.
Results:
Of 31,183 patient-admissions for CAP, 17,282 (55.4%) were switched to oral antibiotics by day three of therapy. Overall, 5,629 (18.1%) died and/or were re-admitted within 30 days. The O:E ratio for early antibiotic switches ranged from 0.78 among hospitals in the lowest quartile to 1.23 in the highest quartile. There was no difference in the composite outcome across quartiles.
Conclusion:
Early switches from IV-to-oral antibiotics for CAP occurred in half of eligible cases. The frequency of these switches varied widely across facilities. Outcomes among patients at hospitals with high switch rates were comparable to outcomes at hospitals with low rates, thereby supporting the safety of early switches. More concerted efforts to promote these switches are needed.
This study tested the effects of the methylenetetrahydrofolate reductase (MTHFR) rs110692574 polymorphism and rumen-protected choline and methionine supplementation on biochemical parameters, milk yield, reproductive performance and health status during the transition period in Holstein cows raised in Türkiye. Genotypes of 356 cows were determined using the tetra-primer amplification refractory mutation system–polymerase chain reaction (ARMS-PCR) method. Following genotyping, 80 cows were selected and assigned to four groups based on nucleotide genotype at two loci (homozygous CC and heterozygous CT) and dietary supplement (choline or choline + methionine). Blood samples were collected on day 21 prepartum, on the day of parturition (day 0), and on day 21 postpartum to measure homocysteine, folic acid, vitamin B12, and non-esterified fatty acid concentrations. beta-hydroxybutyric acid (BHBA) values and production data were obtained from the farms’ routine monitoring records. Statistical analyses were performed using repeated-measures analysis of variance (ANOVA) to assess time-dependent effects, and a general linear model was used for between-group comparisons at the same time points. The frequency of the CT genotype was 12.64%. The polymorphism significantly affected folic acid and vitamin B12 concentrations across different stages of the transition period. Feed supplementation had a significant effect on folic acid concentrations on calving day and on day 21 postpartum, as well as on milk yield on days 100, 200 and 305. Moreover, the polymorphism was significantly associated with folic acid and vitamin B12 concentrations on day 21 prepartum and with BHBA values on day 7 postpartum. This variation was linked to specific health issues that could lead to decreased productivity. In conclusion, genotype-based nutritional strategies were found to play a key role in maintaining metabolic balance and enhancing productivity during the transition period.
International studies show that school food programs (SFPs) can improve children’s diets but evidence from Canada is nascent. We examined whether SFPs are linked to better dietary intake and diet quality among Canadian elementary schoolchildren. This cross-sectional study surveyed 2,366 grade 4-8 students (age 9-14 years; 48.9% girls) from 32 schools in socioeconomically disadvantaged communities in Alberta and Ontario, Canada. Students completed a 24-hour diet recall, recording foods and beverages consumed during school hours (breakfast, morning snack, lunch, afternoon snack), and their source (school, other). Multivariable linear models examined the association of accessing SFPs (≥1 meal/snack provided by school) with student daily intakes of vegetables and fruit, grains and grain products, milk and alternatives, meat and alternatives, free sugars, sodium, and diet quality, adjusting for relevant confounders. Only 293 (12.4%) students accessed SFPs. Overall, accessing SFPs was associated with higher intake of vegetables and fruit (β=0.4, 95% CI=0.1; 0.7) and better diet quality score (β=1.8, 95% CI=0.7; 3.0). Specifically, morning snacks provided by schools were associated with lower intake of free sugars (β=-8.9, 95% CI=-16.5; -1.4), while school-provided lunches were associated with higher intake of milk and alternatives (β=0.5, 95% CI=0.2; 0.8). Further, school-provided afternoon snacks were associated with higher intake of vegetables and fruit (β=1.1, 95% CI=0.6; 1.6), lower sodium intake (β=-258.4, 95% CI=-506.7; -10.0), and better diet quality (β=3.1, 95% CI=1.1; 5.1). One in eight elementary schoolchildren accessed SFPs. Students who accessed SFPs had better diets, highlighting the potential of SFPs (particularly snacks) in improving children’s diets.