Molnupiravir Form I crystallizes in space group C2 (#5) with a = 6.48110(17), b = 8.71848(19), c = 27.0607(19) Å, β = 91.920(4)°, V = 1528.22(12) Å3, and Z = 4 at 295 K. The crystal structure consists of supramolecular double layers of molecules parallel to the ab-plane. The layer centers consist of hydrogen-bonded rings forming a 2D network and the outer surfaces of isopropyl groups, with van der Waals interactions between the layers. Each O atom acts as an acceptor in at least one hydrogen bond. A strong O–H⋯O hydrogen bond forms between the hydroxyl group of the oxolane ring and the carbonyl group of the oxopyrimidine ring. The other oxolane hydroxyl group forms bifurcated intra- and intermolecular hydrogen bonds. The hydroxylamino group forms an intramolecular O–H⋯N hydrogen bond with an N atom of the oxopyrimidine ring. The amino group forms an intermolecular N–H⋯N hydrogen bond to the same N atom of the ring. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®).

Although research on the relationship between lean body mass and blood pressure (BP) has been inconsistent, most studies reported that measures of lean body mass are associated with a higher risk of hypertension. We explored relationships between body composition (fat and skeletal muscle mass) and BP in 1162 young adult African women. Dual-energy X-ray absorptiometry-derived measures of whole-body, central and arm fat mass were associated with higher systolic and diastolic BP, while leg fat percentage was associated with lower systolic and diastolic BP. However, only the associations with diastolic BP remained after adjusting for appendicular skeletal muscle mass (ASM). ASM was associated with higher systolic and diastolic BP, before and after adjusting for whole-body fat percentage and visceral adipose tissue. While there was no overlap in targeted proteomics of BP and body composition, REN was lower in the elevated BP than the normal BP group and was inversely associated with diastolic BP (false rate discovery adjusted P< 0·050). Several proteins were positively associated with both visceral adipose tissue and ASM (LEP, FABP4, IL6 and GGH) and negatively associated with both visceral adipose tissue and ASM (ACAN, CELA3A, PLA2G1B and NCAM1). NOTCH3, ART3, COL1A1, DKK3, ENG, NPTXR, AMY2B and CNTN1 were associated with lower visceral adipose tissue only, and IGFBP1 was associated with lower ASM only. While the associations between body fat and BP were not independent of skeletal muscle mass, the associations between muscle mass and BP were independent of overall and central adiposity in young adult African women. Future interventions targeting muscle mass should also monitor BP in this population.

Adherence to healthy diet principles and to cardiopreventive medication, both key behaviours in CVD prevention, is known to differ between women and men. Whether these adherence behaviours are differentially related among women and men has never been thoroughly assessed. The objective was to assess gender differences in the association between adherence to healthy diet principles and to cardiopreventive medication in adults free of CVD. This cross-sectional study included 268 women and 204 men from the CARTaGENE cohort (Québec, Canada) who were using antihypertensive and/or cholesterol-lowering medication. Adherence to healthy diet principles was assessed using the Alternate Healthy Eating Index (AHEI, %), calculated from a validated FFQ assessing diet in the 12-month preceding its completion. Medication adherence was assessed using the daily pharmacotherapy possession rate (DPPR, %), calculated from prescription claim data over the same 12-month period. In multivariable-adjusted analyses, an inverse association between AHEI and DPPR was observed among men (βAHEI for 10 % increment in DPPR = –0·65 %; 95 % CI −1·28 %, −0·03 %; P = 0·04), while it tended to be positive among women (β = 0·44 %; 95 % CI −0·11 %, 1·00 %; P = 0·12; Pgender×DPPR = 0·01). The negative association between AHEI and DPPR was stronger among men who never smoked or used cholesterol-lowering medication only. Among women, the positive association was stronger and statistically significant among those with obesity or using ≥ 3 medications simultaneously. Association between adherence to healthy diet principles and to cardiopreventive medication differs between women and men, with men potentially facing greater challenges in achieving optimal complementarity between these two behaviours.

This essay uses BBS Productions’ Drive, He Said (1971) to consider how New Hollywood cinema and a cluster of campus revolt films contributed to activist critiques of American sport during the Vietnam era. Drive, He Said conceptualized a “pukey jock,” an athlete who was ambivalent about sport's stereotypical embodiment of establishmentarian values. In doing so, it created a template for the emergence of a new kind of politicized athlete that emerged in the 1970s.

I discuss the right to participate in science in UNDHR (1948) and ICESCR (1966). My goal is to clarify how fulfilling this right requires engaging with varieties of local knowledges that are too often severed in scientific narratives. I tease out three main varieties of local knowledges and highlight their distinctive features and intersectionalities. I argue that a more careful appreciation of varieties of local knowledges is key for the fulfilment of the right to participate in science and other human rights too, such as e.g. the right to food, right to clean water, and also so-called rights of nature.

Motivated by approaches to the word problem for one-relation monoids arising from work of Adian and Oganesian (1987), Guba (1997), and Ivanov, Margolis, and Meakin (2001), we study the submonoid and rational subset membership problems in one-relation monoids and in positive one-relator groups. We give the first known examples of positive one-relator groups with undecidable submonoid membership problem, and we apply this to give the first known examples of one-relation monoids with undecidable submonoid membership problem. We construct several infinite families of one-relation monoids with undecidable submonoid membership problem, including examples that are defined by relations of the form $w=1$ but which are not groups, and examples defined by relations of the form $u=v$ where both of u and v are nonempty. As a consequence, we obtain a classification of the right-angled Artin groups that can arise as subgroups of one-relation monoids. We also give examples of monoids with a single defining relation of the form $aUb = a$ and examples of the form $aUb=aVa$, with undecidable rational subset membership problem. We give a one-relator group defined by a freely reduced word of the form $uv^{-1}$ with $u, v$ positive words, in which the prefix membership problem is undecidable. Finally, we prove the existence of a special two-relator inverse monoid with undecidable word problem, and in which both the relators are positive words. As a corollary, we also find a positive two-relator group with undecidable prefix membership problem. In proving these results, we introduce new methods for proving undecidability of the rational subset membership problem in monoids and groups, including by finding suitable embeddings of certain trace monoids.

We define and study graphs associated to hexagon decompositions of surfaces by curves and arcs. One of the variants is shown to be quasi-isometric to the pants graph, whereas the other variant is quasi-isometric to (a Cayley graph of) the mapping class group.

Conscious but incapacitated patients need protection from both undertreatment and overtreatment, for they are exceptionally vulnerable, and dependent on others to act in their interests. In the United States, the law prioritizes autonomy over best interests in decision making. Yet U.S. courts, using both substituted judgment and best interests decision making standards, frequently prohibit the withdrawal of life-sustaining treatment from conscious but incapacitated patients, such as those in the minimally conscious state, even when ostensibly seeking to determine what patients would have wanted. In the United Kingdom, under the Mental Capacity Act of 2005, courts decide on the best interests of incapacitated patients by, in part, taking into account the past wishes and values of the patient. This paper examines and compares those ethicolegal approaches to decision making on behalf of conscious but incapacitated patients. We argue for a limited interpretation of best interests such that the standard is properly used only when the preferences of a conscious, but incapacitated patient are unknown and unknowable. When patient preferences and values are known or can be reasonably inferred, using a holistic, all-things-considered substituted judgment standard respects patient autonomy.

There are myriad techniques industry actors use to shape the public understanding of science. While a naive view might assume these techniques typically involve fraud or outright deception, the truth is more nuanced. This paper analyzes industrial distraction, a common technique where industry actors fund and share research that is accurate, often high-quality, but nonetheless misleading on important matters of fact. This involves reshaping causal understanding of phenomena with distracting information. Using case studies and causal models, we illustrate how this impacts belief and decision making even for rational learners, informing science policy and debates about misleading content.

Birds are often used as ecological indicators because they are widely distributed across diverse habitats and display distinct behavioural responses to environmental changes. The Endangered Grey Crowned Crane Balearica regulorum is regarded as a flagship species of Africa’s wetland and grassland habitats, both of which are undergoing substantial transformation to alternative land uses. The delayed reproductive strategies and habitat specialisation of this crane species makes them more vulnerable to extinction, but this risk is further compounded by data paucity. We employed traditional and contemporary survey methods to collect breeding metrics to calculate stage transition probabilities (i.e. egg–hatchling, hatchling–juvenile) and to identify possible macro-environmental factors that either promote or hinder their reproductive output in a key agricultural area in KwaZulu-Natal, South Africa. We found that Grey Crowned Cranes have a low hatching rate of 38.4% (95% confidence interval 29.3–48.4%) and show that this low hatching rate is exacerbated under high rainfall intensity. Multivariate analyses and multi-model inference revealed that successful nest-sites were generally associated with larger open water-bodies, greater distances from shore, and increased proximity to secondary roads, buildings, and natural grasslands. Although increased agricultural activities might promote greater foraging opportunities, the overall breeding outcomes of this species were poor in this key agricultural region. Our findings stress the urgent need for further fine-scale data collection and monitoring activities to better inform conservation strategies for this species. We also encourage future studies to focus on aspects affecting Grey Crowned Crane breeding in regions where proximity to human activities is inevitable.

Anaemia continues to be a major public health challenge in developing countries, particularly in Sub-Saharan Africa. This study estimated the proportion of anaemia cases that could be potentially prevented among children aged 6-59 months in Togo. Data from the 2017 national Malaria Indicator survey in Togo, the last one conducted to date, was used for this study. Maternal, child and household data were collected using a standard questionnaire administered face-to-face by trained interviewers. Haemoglobin tests were conducted for children and their mothers. A total of 2796 children were included in the analyses. The prevalence of anaemia was 75.0% (95% confidence interval, CI: 72.5-88.0). Factors associated with childhood anaemia were: age [(adjusted prevalence ratio, aPR=1.46 (CI: 1.37-1.56) for 6-23 months and aPR=1.23 (1.14-1.32) for 24-42 months, ref: 43-59 months], a later birth order (≥4th position) [aPR=1.11 (1.03-1.19), ref: 1st-2nd position], malaria in children [aPR=1.30 (1.22-1.38)], maternal age ≤25 [aPR=1.17 (1.08-1.27), ref: ≥35 years], maternal anaemia [aPR=1.13 (1.07-1.19)], lack of maternal education [aPR=1.10 (1.02-1.18), ref: ≥secondary], number of children under 5 in household [aPR=1.07 (1.00-1.14) for ≥3, ref: 0-1], unimproved sanitation facilities [aPR=1.12 (1.02-1.22)] and low/middle household incomes [aPR=1.16 (1.04-1.30) and aPR=1.13 (1.01-1.26), respectively, ref: high]. The population-attributable fraction was estimated at 8.2% (6.3-10.1%) for child-related modifiable factors, 11.1% (5.7-16.3%) for maternal-related factors, 15.8% (8.6-22.5%) for household-related factors, and 30.9% (24.0-37.2%) for the combination of all modifiable factors. This study highlighted a high prevalence of childhood anaemia in Togo and showed that a high proportion of this could be prevented.

This article investigates whether environmental planning law can demonstrate ethical responsibility for its role in settler colonialism. Planning law contributes to settler colonialism by diminishing, excluding, and eliminating alternative views of land that are fundamental to First Nations culture, philosophy, and law/lore. The article adopts a transnational legal frame that recognizes and promotes First Nations as sovereign. The investigation is focused primarily on the planning law system in New South Wales (NSW), Australia, while being guided by interpretations and applications of the rights of First Nations peoples by courts in Canada. It is argued that state planning law in NSW fails to give effect to ethical responsibility because its operation continues to dominate and marginalize Aboriginal legal culture by eroding the necessary ontological and epistemic relationships with land. However, there is potential for change. Opportunities to disrupt settler colonialism have emerged through bottom-up litigation, which has promoted interpretations, applications, and implementation of law that can be performed in ways that resonate with Canadian case law. While the absence of treaty or constitution-based rights protection in NSW and Australia means that the transplant is not seamless, the article argues that laws should not be interpreted and applied in ways that perpetuate settler colonialism where alternative interpretations can lead to a different outcome.

This paper considers the planar N-body problem with a quasi-homogeneous potential given by

$$ \begin{align*}W = \sum_{1\leq k<j\leq N} \left[ \frac{ m_k m_j}{\|\boldsymbol{r}_k-\boldsymbol{r}_j\|} +\frac{m_k m_j C_{jk}}{\|\boldsymbol{r}_k-\boldsymbol{r}_j\|^p} \right], \end{align*} $$

where $ m_k>0 $ are the masses and $C_{jk}= C_{kj}$ are nonzero real constants, and the exponent g being $ p> $1. Generalizing techniques of the classical N-body problem, we first characterize the periodic solutions that form a regular polygon (relative equilibria) with equal masses ($m_k= m$, $k=1, \ldots , N$) and equal constants $C_{jk}= C$, for all $j, k=1, \ldots , N$ (for short, N-gon solutions). Indeed, for $C>0$ we prove that there exists a unique regular N-gon solution for each fixed positive mass m. In contrast, for the case $C <0$, we demonstrate that there can be a maximum of two distinct regular N-gon solutions for a fixed positive mass m. More precisely, there is a range of values for the mass parameter m for which no solutions of the form of an N-gon exist. Furthermore, we examine the linear stability of these solutions, with a particular focus on the special case $ N=3 $, which is fully characterized.

After some preliminary remarks about Plato’s use of the adverb nun, I explain what the nun is by offering a close textual analysis of the key passage in which it is explicitly addressed (Parm. 151e3–153b7). Its metaxu nature, between duration and limit, requires one to consider another temporal notion of the second part of the Parmenides that is metaxu, namely the exaiphnês. I explain why the nun does not conceptually overlap with the exaiphnês, arguing moreover that there is no model where both notions fit, but rather a model accounting for a switch and another one accounting for continuous change.