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Pollen analysis was carried out on the infilling succession of the Fossa San Vito sinkhole, at the NE foothills of the Sarno Plain (Italy). Four 14C dates and six tephra layers constrain the pollen sequence between ca. 6000 and 500 cal yr BP. A forested environment, with a few signs of human activities, characterizes the pre-protohistoric period (ca. 6000–2750 yr BP). Stability of the arboreal pollen grains to non-arboreal pollen grains (AP/NAP) curve is due to climate-related opposite oscillations of deciduous and evergreen forest. In this period, the pyroclastic products from Neapolitan volcanoes that reached the upper Sarno Plain seem to have affected neither vegetation nor human activities. In the archaic and classic periods (ca. 2750–1500 yr BP), intensive deforestation and increase in anthropogenic indicators indicate the occurrence of grazing and crop activities managed by the main urban centers located in the plain: Pompeii, Stabiae, and Nuceria. After the Pompeii eruption in CE 79, a rapid re-afforestation and decline in all anthropogenic indicators testify to the temporary abandonment of the area, linked to the disastrous demise of the main economic centers. The upper plain was repopulated and exploited in the Late Ancient and Middle Ages (ca. 1700–500 yr BP), as indicated by the increase in all crop and grazing indicators.
The purpose of this study was to examine the potential for sustained almond consumption to reduce HbA1c concentrations among individuals with elevated values. A 16-week randomised, parallel-arm, controlled trial was conducted. Eighty-one adults with elevated HbA1c concentrations (> 5·7 %) were randomly assigned to incorporate 2 oz of raw almonds (A: n 39) or energy-matched snacks (C: n 42) into their daily diets. Body weight, body composition, plasma lipids, HbA1c, plasma vitamin E, glycaemia (by meal tolerance test and continuous glucose monitoring), dietary intake and hedonic responses to test foods were measured at stipulated time points. Participants consuming almonds ingested 253 kcal/d more than participants in the control group (P = 0·02), but this did not result in a significant difference in body weight. No statistically significant differences were observed in HbA1c concentrations, blood chemistries, body composition or glycaemia over time or between groups. However, Healthy Eating Index scores improved within the almond group as compared with the control group (P < 0·001). Additionally, the hedonic rating of almonds within the almond group did not decline as markedly as the control group’s reduced liking of the pretzel snack. Alpha-tocopherol increased significantly, and gamma tocopherol tended to decrease in the almond group, indicating compliance with the dietary intervention. Overall, daily ingestion of 2 oz of raw almonds in a self-selected diet for 16 weeks did not alter short-term or longer-term glycaemia or HbA1c concentrations in adults with elevated HbA1c concentrations, but they were well-tolerated hedonically and improved diet quality without promoting weight gain.
Characterised by the extensive use of obsidian, a blade-based tool inventory and microblade technology, the late Upper Palaeolithic lithic assemblages of the Changbaishan Mountains are associated with the increasingly cold climatic conditions of Marine Isotope Stage 2, yet most remain poorly dated. Here, the authors present new radiocarbon dates associated with evolving blade and microblade toolkits at Helong Dadong, north-east China. At 27 300–24 100 BP, the lower cultural layers contain some of the earliest microblade technology in north-east Asia and highlight the importance of the Changbaishan Mountains in understanding changing hunter-gatherer lifeways in this region during MIS 2.
The present study aimed to measure an association between the caloric test and vestibulo-ocular reflex gain and refixation saccades in individuals with auditory neuropathy spectrum disorders.
Methods
Twenty individuals (9 males and 11 females), in the age range of 17 to 38 years, diagnosed with auditory neuropathy spectrum disorders, and 20 normal-hearing individuals (age and gender matched) participated in the study. All the individuals underwent case history, pure tone audiometry, immittance evaluation, otoacoustic emissions, auditory brainstem response, caloric tests and video head impulse tests.
Results
All the patients with auditory neuropathy spectrum disorders in the present study had hypoactive caloric responses, which suggested peripheral vestibular lesions. The mean vestibulo-ocular reflex gain was reduced in few patients with auditory neuropathy, whereas few patients had normal vestibulo-ocular reflex gain.
Conclusions
The present study revealed a discrepancy between the caloric and video head impulse test results in auditory neuropathy spectrum disorders. The vestibular evaluation should be done for all patients with auditory neuropathy spectrum disorders to understand the various types of vestibular nerve lesions.
The healthcare industry is estimated to contribute 4.4 per cent of global greenhouse gas emissions. This pilot study aimed to investigate the impact of rationalising surgical instruments in tonsillectomy trays on greenhouse gas emissions and costs.
Method
We conducted a prospective observational study over a six-month period. All patients who underwent tonsillectomy were included. The instruments used during the procedure and their frequency of use were counted, with the operating surgeon being unaware of the study.
Results
During the 6-month timeframe, 46 tonsillectomies were performed. From the standard tonsillectomy tray containing 38 pieces, 9 pieces were never used. The removal of unused reusable instruments resulted in an estimated total reduction of 594 g of carbon dioxide equivalents and a saving of €9.63 per operation.
Conclusion
Rationalising the contents of the surgical instrument tray can have a positive environmental impact by reducing greenhouse gas emissions. There are also pecuniary benefits for the National Health Service because of the potential for cost savings.
This study aimed to assess the impact of the scutum on oval window accessibility during stapedotomy surgery. Radio-clinical correlation was applied to determine the impact.
Methods
This was a prospective observational case-series study that included 127 candidates for stapedotomy surgery. The oval fossa was classified into two types according to the accessibility of the stapes footplate.
Results
Both study groups showed a statistically significant difference in pre-operative radiological length as the p value was less than 0.001. The Spearman correlation coefficient revealed that the intra-operative oval window fossa was only significantly related to the radiological scutum length because the p value was less than 0.001.
Conclusion
Our results revealed that the pre-operative radiological length can predict the intra-operative oval fossa type with high sensitivity and specificity. Patients with a pre-operative scutum length of less than 2.35 mm were predicted to have an easily accessible oval window without requiring intra-operative scutum curettage.
Paediatric ear and hearing services in the UK are currently facing significant challenges leading to increased waiting times for patients. This letter aims to explore teleotology, focusing on ear health care delivered via telemedicine, as a potential solution to alleviate service pressures and improve care delivery.
Methods
The current state of paediatric ear and hearing services in the UK was reviewed and the potential for teleotology to improve service delivery by reducing face-to-face consultations and improving triage processes was explored.
Results
Evidence from studies conducted in adults in the UK suggests that teleotology can optimise the allocation of resources, ensure timely treatment, and enhance the quality of care, aligning with the NHS Long Term Plan and recommendations from the GIRFT report.
Conclusions
The findings from adult teleotology are encouraging, but further research is required to demonstrate the efficacy of teleotology for children and young people in NHS settings.
Discussions of George Berkeley often dismiss his Notebooks remarks that (1) bodies are powers that cause perceivers to have thoughts, and (2) bodies exist even when they are not perceived. I have previously noted these claims but have not explained how bodies are infinitely linked as thoughts (vs. ideas), and Melissa Frankel treats bodies as archetypes perceived individually by God but does not explain how they are individuated. I argue that because bodies identify objects only for finite minds, they are derivative powers by which individuated objects are related to one another infinitely.
This study aims to outline Clostridioides difficile infection (CDI) trends and outcomes in Mexican healthcare facilities during the COVID-19 pandemic.
Design:
Observational study of case series.
Setting:
Sixteen public hospitals and private academic healthcare institutions across eight states in Mexico from January 2016 to December 2022.
Patients:
CDI patients.
Methods:
Demographic, clinical, and laboratory data of CDI patients were obtained from clinical records. Cases were classified as community or healthcare-associated infections, with incidence rates calculated as cases per 10,000 patient days. Risk factors for 30-day all-cause mortality were analyzed by multivariate logistic regression.
Results:
We identified 2,356 CDI cases: 2,118 (90%) were healthcare-associated, and 232 (10%) were community-associated. Common comorbidities included hypertension, diabetes, and cancer. Previous high use of proton-pump inhibitors, steroids, and antibiotics was observed. Recurrent infection occurred in 112 (5%) patients, and 30-day mortality in 371 (16%). Risk factors associated with death were a high Charlson score, prior use of steroids, concomitant use of antibiotics, leukopenia, leukocytosis, elevated serum creatine, hypoalbuminemia, septic shock or abdominal sepsis, and SARS-CoV-2 coinfection. The healthcare-associated CDI incidence remained stable at 4.78 cases per 10,000 patient days during the pre-and pandemic periods. However, the incidence was higher in public hospitals.
Conclusions:
Our study underscores the need for routine epidemiology surveillance and standardized CDI classification protocols in Mexican institutions. Though CDI rates in our country align with those in some European countries, disparities between public and private healthcare sectors emphasize the importance of targeted interventions.
The Well-being of Future Generations (Wales) Act 2015 is a landmark piece of sustainable development legislation and marks a significant development in the emerging legal identity of Wales. Despite the Act's significance and ambition, it has been criticized as merely ‘aspirational’ – as ‘non-law-bearing’ and unenforceable by legal means. The Act is not without difficulties. However, it also has notable legal and other qualities that are often not captured within the standard justiciability-enforceability frame of analysis. Our aim here is to broaden the context for examining the Act and other ‘aspirational’ legislation like it. To that end, we identify three sets of questions that help to bring out different ideas around the Act's varied enforceability, its possible constitutional status, and its potential role as a bearer of hope.
We report the existence of two new limiting turbulent regimes in horizontal convection (HC) using direct numerical simulations at intermediate to low Prandtl numbers. In our simulations, the flow is driven by a step-wise buoyancy profile imposed at the surface, with free-slip, no-flux conditions along all other boundaries, except along the spanwise direction, where periodicity is assumed. The flow is shown to transition to turbulence in the plume and the core, modifying the rate of heat and momentum transport. These transitions set a sequence of scaling laws that combine theoretical arguments from Shishkina, Grossmann and Lohse (SGL) and Hughes, Griffiths, Mullarney and Peterson (HGMP). The parameter range extends through Rayleigh numbers in the range [$6.4\times 10^5, 1.92\times 10^{15}$] and Prandtl numbers in the range [$2\times 10^{-3},2$]. At low Prandtl numbers and intermediate Rayleigh numbers, a core-driven regime is shown to follow a Nusselt-number scaling with $Ra^{1/6}Pr^{7/24}$. For Rayleigh numbers larger than $10^{14}$, the Nusselt number scales with $Ra^{0.225}Pr^{0.417}$. For these particular regimes, the Reynolds number is found to scale as $Ra^{2/5}Pr^{-3/5}$ for the low-Prandtl-number regime and $Ra^{1/3}Pr^{1}$ for Rayleigh numbers larger than $10^{14}$. These results embed the HGMP model in the SGL theory and extend the known regime diagram of HC at high Rayleigh numbers. In particular, we show that HC and Rayleigh–Bénard share similar turbulent characteristics at low Prandtl numbers, where HC is shown to be ruled by its core dynamics and turbulent boundary layers. This new scenario confirms that fully turbulent HC enhances the transport of heat and momentum with respect to previously reported regimes at high Rayleigh numbers. This work provides new insights into the applicability of HC for geophysical flows such as overturning circulations found in the atmosphere, the oceans, and flows near the Earth's inner core.
The objective of the study is to examine the current state of research and technology related to objective olfactory assessment, highlighting the merits and demerits of the techniques. It aims to specifically explore olfactory event-related potentials, discussing their potential applications, benefits, drawbacks, and prospects in the field.
Methods
A five-month narrative review examined English-language articles from PubMed, Scopus, and Google Scholar, critically summarising titles, abstracts, and full texts, while excluding non-English and methodologically weak studies.
Results
This study provides a detailed investigation into various objective methods utilised and the applicability of olfactory event-related potentials for assessing olfaction. We reviewed key elements, such as techniques, stimulus delivery methods, optimal electrode placement, and waveform analysis.
Conclusion
Olfactory event-related potentials offers substantial promise in enhancing the diagnostic accuracy of olfactory dysfunction across various clinical contexts. This thorough review highlights the utility and potential of olfactory event-related potentials in improving the precision and efficacy of olfactory assessments.
Focusing on the achievements and failures of the 2017 Crans-Montana negotiations, this study examines the research question of how and why the last talks failed to resolve the Cyprus issue. It argues that progress in the negotiations was hindered by the enduring mistrust between the community leaders and the inadequacy of their resolve to reach common ground by reconciling their respective differences about the security and guarantees issue. The study suggests the process that helped bring about the Northern Ireland Good Friday Agreement offers a practical and effective approach to compare with the case of a seemingly intractable situation such as the Cyprus problem. The Irish–British negotiations were open to and involved a wide range of parties including the government, civil society, and international stakeholders. Moreover, they benefited from the decision to set a firm deadline for the conclusion of the negotiations. The findings of this study stress that because the previous Cyprus talks lacked an inclusive and transparent negotiation process – one with stated deadlines complete with alternative scenarios in the event of a referendum – they failed to address the broad gap of trust between the two Cypriot communities.
Over the past two decades in the applied linguistics subfield of second language (L2) writing, there has been considerable interest in the topic of collaborative writing (CW). Studies in this domain have investigated different phenomena such as the nature of learner-to-learner interactions, the learning outcomes of CW, and students' perceptions of these activities when implemented in the classroom. Despite the large number of studies that have been published to date, replication research has been scarce. As such, the current article opens by making a case for replication work in the area of L2 CW, arguing why such research is both important and necessary. Following this, the article turns to a discussion of two key CW studies that have been highly influential in the L2 writing sphere. These studies are described in detail, and suggestions are provided as to how and why these studies might be replicated in the future.
The purpose of this study is to investigate whether sex plays a role in donor-site dysfunction after head and neck reconstruction.
Methods
In this retrospective case series, 76 patients were assessed for donor-site morbidity using the Short Form 36, Short Musculoskeletal Function Assessment, disabilities of the arm, shoulder, and hand, and lower-limb core scale. Differences by sex were compared using t-tests. Multivariable linear regression analysis was conducted to adjust for potential confounders.
Results
Females observed significantly greater disability for the SF-36 mental component summary score with a mean of 45.9 (standard deviation 10.5) compared to males, with a mean of 51.8 (standard deviation 10.2), p = 0.02. Sex is significantly related to SF-36 mental component summary score after controlling for neuropsychiatric disease and tracheostomy status.
Conclusion
Females reported significantly worse mental component scores compared to males undergoing free flap reconstruction of the head and neck.
Head and neck cancer has a 5 per cent incidence of synchronous primary cancer. Synchronous primary cancers are commonly detected with imaging and flexible nasoendoscopy. Routine panendoscopy is still being used to screen for synchronous primary cancers. The aim was to establish the method of detection of synchronous primary cancer.
Methods
A retrospective cohort study of newly diagnosed head and neck cancer patients with a synchronous primary cancer, presented at the West of Scotland Head and Neck Multidisciplinary Team from December 2020 to August 2022. This study is Level 3 evidence.
Results
A total of 2325 patients were presented to the Multi-Disciplinary Team with head and neck cancer and 54 (2.3 per cent) had SPC; 63.8 per cent (30) of patients had a panendoscopy. All patients with comprehensive out-patient assessment had their synchronous primary cancer detected on examination or imaging, without the need for panendoscopy.
Conclusion
Panendoscopy did not detect any new synchronous primary cancer in patients assessed with flexible nasoendoscopy and imaging. With modern high-resolution imaging and fibreoptics, panendoscopy does not play a role in the detection of synchronous primary cancers.