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At Ollantaytambo, in the Cusco region of Peru, the Inka (c. AD 1400–1532) built an elaborate anthropogenic landscape to facilitate intensive agriculture. After the 1532 Spanish invasion of the region, this landscape was reshaped by the introduction of new plants and animals, colonial land-management practices and demographic transformations. Here, the author employs botanical data from a derelict Inka-era reservoir to evaluate the timing and character of colonial transformations to the local agroecology. These transformations, they argue, tended towards agricultural deintensification, but this process did not begin until decades after the Spanish invasion.
It is known that hyperbolic linear delay difference equations are shadowable on the half-line. In this article, we prove the converse and hence the equivalence between hyperbolicity and the positive shadowing property for the following two classes of linear delay difference equations: (a) for non-autonomous equations with finite delays and uniformly bounded compact coefficient operators in Banach spaces and (b) for Volterra difference equations with infinite delay in finite dimensional spaces.
Clozapine therapy presents a risk of agranulocytosis, necessitating monitoring of white blood cell count. The detection of benign ethnic neutropenia (BEN), in which neutropenia can be present without an increased risk of infection, is particularly important in preventing unnecessary withdrawal of clozapine. BEN is strongly linked to the CC homozygote of the single nucleotide polymorphism rs2814778 in the atypical chemokine receptor-1 (ACKR1) gene.
Aims
We introduced voluntary genetic testing for BEN in one of our clozapine clinics, with the aim of assessing the prevalence of undiagnosed BEN in patients on clozapine.
Method
We offered genetic testing for BEN to patients undergoing medium- and long-term clozapine treatment, and conducted a comparative analysis of neutrophil counts across three identified groups: those previously diagnosed with BEN, those with newly discovered BEN and those confirmed by genetic testing not to have BEN.
Results
We conducted genetic testing for BEN on 108 patients. Of these, 16 were already registered as having BEN and had the CC homozygote. A further 26 patients (24% of the cohort) who were previously not diagnosed with BEN by standard haematological monitoring were found to have the CC homozygote on genetic testing. Unadjusted mean neutrophil counts were lowest for those with previously diagnosed BEN (2.5 × 109/L, 95% CI 2.2–2.8; P < 0.001 v. other groups), but those with newly discovered BEN had mean counts that were significantly lower (4.1 × 109/L, 95% CI 3.6–4.7) than those with TT and CT genotypes (5.1 × 109/L, 95% CI 4.7–5.4; P = 0.006).
Conclusions
Undiagnosed BEN was common in our naturalistic cohort. The integration of genetic testing into standard monitoring would enhance the management of clozapine therapy, potentially allowing for the safe reintroduction or continuation of clozapine in patients with hitherto unrecognised BEN. All current and prospective clozapine patients should be genetically tested for BEN.
Viscous gravity currents play a fundamental role in many natural and industrial applications, where practical scenarios often involve the current propagating over rigid curvilinear surfaces. In this study, we employ lubrication theory to develop low-dimensional models for such two-dimensional and axisymmetric propagation, resulting from the release of a finite volume of viscous fluid. A key dimensionless parameter is identified, representing the volume ratio between the released fluid and the curvilinear surface, which governs the current evolution. By simplifying the curvilinear surface with linear–exponential and sinusoidal shapes, we observe distinct flow behaviours. Over linear–exponential surfaces, the current may become trapped, bypass the peak or flow downward, while over sinusoidal surfaces, the propagation is hindered compared with the behaviour over horizontal straight surfaces. The low-dimensional models are validated using the volume of fluid method in computational fluid dynamics, showing consistent predictions of the current evolution over rigid curvilinear surfaces.
This article examines the local context that led to the expulsion of Jews from Eastern Thrace in 1934. Going beyond the conventional state-centric narratives, it unearths the local socio-economic tensions that triggered the locals to target their Jewish neighbors. It highlights three major factors that fueled already-existing nationalist sentiments in the region: some Jewish merchants’ involvement in usury, Turkish–Muslim agricultural producers’ growing indebtedness due to the devastating impact of the Great Depression, and the government’s failure to support producers with appropriate credit policies. Faced with the danger of indebtedness and dispossession, the locals in this context deemed the small Jewish community as “the easy target,” scapegoating it for their ongoing problems amid Turkey’s nationalist political climate in the 1930s.
Hegel’s ‘Natural Law’ essay is widely discussed but its substance and the implications of its argument are misunderstood. Hegel’s essay is most often read via other philosophers. Interpretations of this kind are useful but only illuminate those parts of Hegel’s text that intersect with other philosophers’ concerns. This article takes a different approach by focusing on the entirety of the essay and exploring the implications of its two primary arguments: firstly, that there has been a breach between philosophy and natural law; secondly, that without philosophy natural law is thrown back on its own resources, producing two schools of post-philosophical thought—empiricism and formalism—neither of which is adequate to serve as its foundation. I argue that in response to this inadequacy Hegel sublates empiricism and formalism to develop undistorted intuition as a way of thinking designed to effect the re-philosophization of natural law.
An ultra-wideband current-reused low-noise amplifier (LNA) monolithic microwave integrated circuit design is presented in this letter. Negative feedback networks are employed at both stages of the proposed LNA to expand bandwidth. Furthermore, source adaptive bias networks is designed in the first stage and combined with a current-reused construction to acquire a compact chip size and maintain low power consumption. Then, the validation of design theory is implemented by employing a 0.15-µm gallium arsenide pseudomorphic high-electron-mobility transistor process. The measured results show that the proposed LNA achieves a small signal gain of 15.5–17.8 dB, a noise figure of 3–3.65 dB, and an output 1 dB compression point (OP1 dB) of 14.5–15.5 dBm from the target bandwidth of 2–18 GHz. In addition, the fabricated LNA consumes 220 mW from a 5 V supply and occupies a chip area of 1.2 × 1.5 mm2.
Politicians frequently face toxic behaviors. We argue that these behaviors impose a double burden on women, who may not only face higher exposure to toxicity, but experience attacks that they and others understand to be motivated by prejudice and designed to push them out of office. Using large-scale image-based conjoint experiments in the United States, Denmark, Belgium, and Chile, we demonstrate that both politicians themselves and citizens regard messages targeting women politicians as more toxic than otherwise equivalent messages targeting men. This perception intensifies when messages mention gender or come from perpetrators who are men. A second experiment to investigate the mechanisms shows that hostile behaviors toward women are more frequently understood as driven by prejudice and attempts to remove women from politics. These findings highlight the importance of understanding how perceptions of perpetrators’ motives affect the severity of political toxicity, and provide insights into the gendered effects of political hostility.
The mental health of paramedics is critical for disaster response in order to provide rapid and effective interventions. This study aimed to determine the prevalence of post-traumatic stress disorder (PTSD) and related individual and occupational factors in Turkish paramedics during the eleventh month of the COVID-19 pandemic.
Methods
The “Sociodemographic Information Form,” “Life Events Checklist,” and “Post-Traumatic Stress Disorder Checklist” were used to collect data from 440 randomly selected paramedics in this cross-sectional study.
Results
The prevalence of PTSD was 59.8% in the 11th month of the COVID-19 pandemic. Multiple regression analysis revealed that approximately 25% of the total PTSD score could be independently explained by paramedics’ general health situation and sociodemographic characteristics; 27% by crisis management skills, long working hours, a lack of equipment, and intensive work; and 40% by past traumatic experiences due to difficult life events during their professional practice, such as responding to gunshot wounds, becoming a victim of a gunshot attack, or sexual assault (P < 0.05).
Conclusions
Integrating a mental health monitoring system into the health and safety program, providing paramedics with supervision and psychological assistance, and engaging them in disaster preparedness planning would be beneficial.
This article examines the evolution of bioethics over the past four decades since the publication of John Harris’ seminal work, “The Value of Life” (1985). It argues that while the core principles articulated by Harris remain relevant, bioethics has undergone significant transformation across four key domains. First, the expanding frontiers of biotechnology have necessitated engagement with complex issues beyond individual clinical ethics. Second, there has been a widening of the circle of moral concern to encompass nonhuman animals, disability rights, and global health equity. Third, bioethics has become increasingly entangled with public policy and governance. Finally, the field has seen substantial academic proliferation and institutionalization. These developments have pushed bioethics to adapt its frameworks and methodologies while maintaining fidelity to foundational principles. This article concludes by considering the future challenges and opportunities for bioethics in an increasingly complex technological and social landscape.
This paper develops a novel full-state-constrained intelligent adaptive control (FIAC) scheme for a class of uncertain nonlinear systems under full state constraints, unmodeled dynamics and external disturbances. The key point of the proposed scheme is to appropriately suppress and compensate for unmodeled dynamics that are coupled with other states of the system under the conditions of various disturbances and full state constraints. Firstly, to guarantee that the time-varying asymmetric full state constraints are obeyed, a simple and valid nonlinear error transformation method has been proposed, which can simplify the constrained control problem of the system states into a bounded control problem of the transformed states. Secondly, considering the coupling relationship between the unmodeled dynamics and other states of the controlled system such as system states and control inputs, a decoupling approach for coupling uncertainties is introduced. Thereafter, owing to the employed dynamic signal and bias radial basis function neural network (BIAS-RBFNN) improved on traditional RBFNN, the adverse effects of unmodeled dynamics on the controlled system can be suppressed appropriately. Furthermore, the matched and mismatched disturbances are reasonably estimated and circumvented by a mathematical inequality and a disturbance observer, respectively. Finally, numerical simulations are provided to demonstrate the effectiveness of the proposed FIAC strategy.
Describing the evolution of a wind turbine's wake from a top-hat profile near the turbine to a Gaussian profile in the far wake is a central feature of many engineering wake models. Existing approaches, such as super-Gaussian wake models, rely on a set of tuning parameters that are typically obtained from fitting high-fidelity data. In the current study, we present a new engineering wake model that leverages the similarity between the shape of a turbine's wake normal to the streamwise direction and the diffusion of a passive scalar from a disk source. This new wake model provides an analytical expression for a streamwise scaling function that ensures the conservation of linear momentum in the wake region downstream of a turbine. The model also considers the different rates of wake expansion that are known to occur in the near- and far-wake regions. Validation is presented against high-fidelity numerical data and experimental measurements from the literature, confirming a consistent good agreement across a wide range of turbine operating conditions. A comparison is also drawn with several existing engineering wake models, indicating that the diffusion-based model consistently provides more accurate wake predictions. This new unified framework allows for extensions to more complex wake profiles by making adjustments to the diffusion equation. The derivation of the proposed model included the evaluation of analytical solutions to several mathematical integrals that can be useful for other physical applications.
AMS radiocarbon ages of organic matter from ice wedges and enclosing peat were determined for the polygonal peatland at the Lorino site on the eastern coast of the Chukchi Peninsula. The study’s goal was to fill a knowledge gap about the dynamics of polygonal peatlands with ice wedges and winter climate conditions during the Holocene in this easternmost region of the Russian Arctic. It has been found that peatland accumulated during the Younger Dryas and early Holocene, mostly between 14 and 9.9 cal ka BP, while ice wedges were dated from 7.7 to 6.6 cal ka BP. Since ice wedges have features of syngenetic growth, the discrepancy in the age of ice wedges and enclosing peatland may result from the significant presence of early and pre-Holocene peat. It is assumed that the older polygonal peatland deeply thawed during the Holocene optimum, and subsequently, when the permafrost aggraded, a new generation of ice wedges was formed. The AMS 14C age (18.1 cal ka BP) of the ice wedge exposed below the peat indicates the presence of a Late Pleistocene generation of ice wedges at the study site. Paleotemperature reconstructions based on the stable isotope composition of ice wedges show that the mean January air temperature during the Northgrippian stage of the Holocene varied from –27 to –23°C, and at the end of the Late Pleistocene, from –32 to –26°C.
As the most populous city in China, Shanghai’s human waste disposal underwent a dramatic transition between 1949 and 2010. While human waste continued to be sold to farmers as fertilizer, the authorities attempted to modernize the methods of manual removal, promoting nightsoil dump stations and vacuum trucks from the early 1970s. These new methods soon became widespread. However, urban human waste gradually lost its value as fertilizer from the late 1970s, chiefly because of the popularization of chemical fertilizers, at which point Shanghai was faced with serious human waste issues. Encountering this unforeseen shift, the municipality had to accept the reality that there were no longer rural markets for urban human waste, and that it would have to start treating human waste as refuse. In contrast to the Western model, Shanghai’s approach to modernizing human waste disposal was distinctive, having been influenced by factors beyond the city.
This article examines the intertwined history of local divination schools and divination instructors during the Yuan–Ming transition through a microhistory of the Zhu family—a diviner family who, as newcomers to Suzhou, carefully navigated the turbulent dynastic transition. Based on broader prosopographical research of Yuan and Ming divination school instructors, this study draws two main conclusions regarding social and institutional history during this crisis period. First, the Zhu family, representing lesser elites whose status depended on state institutions, survived the Yuan–Ming transition by building local networks, transforming their expertise, and manipulating narratives of their family history. Second, despite the Ming founder's order for the re-establishment of local divination schools, it was the diviner families, seeking to recover from the dynastic transition, who played a key role in restoring the local institution. This study extends our understanding of the scope of the fourteenth-century crisis, its diverse manifestations across social groups, and the manipulation of crisis narratives for various purposes. It also proposes a bottom-up approach to engage with the Yuan–Ming social and institutional continuity and rupture.
We evaluated the prevalence and risk factors for child maltreatment in multiples aged 3 years and compared them to singletons in Japanese population-based data. Records on child maltreatment and health check-ups at 3 years of age from 17,125 singletons, 488 twins and 18 triplets were collected from a Public Health Center between April 2007 and March 2011. The associations of child maltreatment with potential risk factors were analyzed using the logistic regression model. Out of all children, 76 (4.31 per 1000) children had documented maltreatment including 69 (4.03 per 1000) singletons and seven (14.31 per 1000) twins. All of the cases in twins were physical abuse (100%) and nearly half of the cases (43%) included emotional abuse. Among twins, 86% of the biological mothers were suspected. The alleged perpetrators of twins showed a significantly higher rate of maternal depression compared to those of singletons. After adjusting the results for a number of potential biological and social risk factors, twins or triplets had a higher risk for maltreatment than singletons (OR 3.39, 95% CI [1.17, 9.83]). Healthcare providers should be aware that a multiple birth can place considerable stress on a family leading to child maltreatment and should provide appropriate support and intervention for mothers with multiples.