We investigated whether an observed reduction in overall childhood cancer risk (<15 years of age) in twins has been sustained, and how this extends into young adulthood. We searched for English language publications reporting childhood cancer risk in twins, obtained unpublished data directly from some authors, and updated a meta-analysis. We used the Swedish Multigeneration Register to investigate the age to which the reduced overall risk of childhood cancer (observed previously using that Swedish dataset and in this and earlier meta-analyses) persisted into the teenage/young adult years, and which specific tumors accounted for the overall risk reduction beyond childhood. Our meta-analysis of studies of aggregate childhood cancer risk in twins confirmed their approximate 15% reduction in cancer mortality and incidence. Further analysis of Swedish Multigeneration Register data for 1958 to 2002 suggested these reduced risks of cancer (particularly leukaemias and renal tumors) extended from childhood to young adult ages. Reduced risks of these and some other specific tumor types occurring across childhood/teenage/young adult years appeared to account for most of the overall risk reduction. Our results suggest a persistent reduction of overall childhood cancer risk in twins and that this extends into young adulthood. Risk reductions for several specific tumors might account for this and, although there are several potential explanations, intrauterine growth patterns of twins might be a major contributor.

Fetal brain size is decreased in some children with complex CHDs, and the distribution of blood and accompanying oxygen and nutrients is regionally skewed from early fetal life dependent on the CHD. In transposition of the great arteries, deoxygenated blood preferentially runs to the brain, whereas the more oxygenated blood is directed towards the lungs and the abdomen. Knowledge of whether this impacts intrauterine organ development is limited. We investigated lung, liver, and total intracranial volume in fetuses with transposition of the great arteries using MRI.

Eight fetuses with dextro-transposition and without concomitant disease or chromosomal abnormalities and 42 fetuses without CHD or other known diseases were scanned once or twice at gestational age 30 through 39 weeks. The MRI scans were conducted on a 1.5T system, using a 2D balanced steady-state free precession sequence. Slices acquired covered the entire fetus, slice thickness was 10 mm, pixel size 1.5 × 1.5 mm, and scan duration was 30 sec.

The mean lung z score was significantly larger in fetuses with transposition compared with those without a CHD; mean difference is 1.24, 95% CI:(0.59;1.89), p < 0.001. The lung size, corrected for estimated fetal weight, was larger than in the fetuses without transposition; mean difference is 8.1 cm3/kg, 95% CI:(2.5;13.7 cm3/kg), p = 0.004.

In summary, fetuses with dextro-transposition of the great arteries had both absolute and relatively larger lung volumes than those without CHD. No differences were seen in liver and total intracranial volume. Despite the small number of cases, the results are interesting and warrant further investigation.

This article reads Jules Verne’s Extraordinary Voyages series (1863–1905) through a worldmaking lens. It argues that, rather than simply reflecting 19th-century ideologies of progress, Verne was engaged in creative global ordering. The article argues that Verne constructed global order as technocratic, anti-political, and necessarily violent. This space was ambiguously but persistently appropriated by white, male engineers and scientists. This generates two important insights for International Relations (IR). First, Verne’s global order was not about states, sovereignty, or political community: it was about an elite vanguard of technocratic adventurers roaming the globe. At a time when colonial incursions frequently emerged out of interventions by explorers and engineers and other ‘people with projects’, this understanding resonated deeply. It is also worth recovering as a current of technocratic thought not centred on bureaucracy and strong government but on private enterprise. Second, Verne’s fiction constituted a powerful conception of global order, and contemporaries drew upon this as an inspiration for real-world interventions. At the French Société de Géographie, of which Verne was a long-time member, as well as among imperialists across Europe, the Voyages became a casual frame of reference in justification of colonial expansion. Better understanding this typically downplayed aspect of the modern international imagination not only promises to enrich IR’s understanding of the role of speculative fiction in global ordering but also puts the current revival of techno-colonial projects – from Seasteading to the colonisation of Mars – into needed perspective.

While employees actively seek out workplaces that offer meaningful work experiences, the concept of meaningful work remains notably underexplored within the turnover literature. The present study addresses this gap by examining the role of work meaningfulness among knowledge workers and its direct and indirect effects on turnover intentions and job satisfaction through the lens of self-determination theory. Our findings show significant effects on turnover intentions and job satisfaction, with work meaningfulness emerging as a stronger predictor of job satisfaction, while still contributing to reducing turnover intentions. Most extant literature focuses on sources and ways to enhance work meaningfulness. We contribute to more recent research on its relationship with its outcomes especially the link with turnover intentions, offering insight into a relationship that has produced few, but conflicting,results.

The aim of this study is to estimate the minimum prevalence of intestinal parasites in the population of Roman London through analysis of pelvic sediment from 29 third- to fourth-century burials from the 1989 excavations of the western cemetery at 24–30 West Smithfield, 18–20 Cock Lane and 1–4 Giltspur Street (WES89). Microscopy was used to identify roundworm eggs in 10.3 per cent of burials. We integrate these results with past palaeoparasitological work in the province of Britannia to explore disease, hygiene and diet. The most commonly found parasites (whipworm and roundworm) were spread by poor sanitation, but other species caught from animals were also present (fish tapeworm, beef/pork tapeworm and liver flukes). Parasite diversity was highest in urban sites. The health impacts of these infections range from asymptomatic to severe.

According to Shelly Kagan, the moral status of an individual is determined by the extent to which the individual has (has now, might/will have, or could have had) certain psychological capacities. Roughly speaking, the greater one's relevant psychological capacities, the higher their moral status. In this paper, I offer a twofold critique of Kagan's hierarchicalism. On the one hand, I argue against the primary argument in favor of Kagan's view (the argument from distribution) by challenging the key intuition on which the argument relies, thereby reducing the appeal of Kagan's position. On the other hand, using Kagan's general methodology, I argue that a good reason to reject Kagan's account of moral status is that he fails to explain away the counterintuitive result of his theory in the case of normal variation.

The walk matrix associated to an $n\times n$ integer matrix $\mathbf{X}$ and an integer vector $b$ is defined by ${\mathbf{W}} \,:\!=\, (b,{\mathbf{X}} b,\ldots, {\mathbf{X}}^{n-1}b)$. We study limiting laws for the cokernel of $\mathbf{W}$ in the scenario where $\mathbf{X}$ is a random matrix with independent entries and $b$ is deterministic. Our first main result provides a formula for the distribution of the $p^m$-torsion part of the cokernel, as a group, when $\mathbf{X}$ has independent entries from a specific distribution. The second main result relaxes the distributional assumption and concerns the ${\mathbb{Z}}[x]$-module structure.

The motivation for this work arises from an open problem in spectral graph theory, which asks to show that random graphs are often determined up to isomorphism by their (generalised) spectrum. Sufficient conditions for generalised spectral determinacy can, namely, be stated in terms of the cokernel of a walk matrix. Extensions of our results could potentially be used to determine how often those conditions are satisfied. Some remaining challenges for such extensions are outlined in the paper.

By examining social media interactions, the analysis that is presented in this article reveals how hashtags are adeptly used to reframe the lithium mining issue, embedding it within wider narratives. The article investigates narratives surrounding lithium mining protests in Serbia, using digital ethnography and narrative analysis to study the discourse of ecology activists on the social platform X (formerly known as Twitter). It illuminates the fluid, rhizomatic, and puzzle-like nature of hashtags that helps to achieve online visibility, mobilize audiences for street protests, and appear as narrative building blocks. Hashtags operate as algorithmic signifiers that create additional layers of meaning and fine-tune narratives toward either the left or right side of the political spectrum. This article focuses on how activists use hashtags not just as tools for categorizing content but also as essential components in shaping their narratives. This approach reveals the dynamic engagement of a broad political spectrum in the lithium mining debate, forging connections between different actors. The analysis demonstrates how interconnected hashtags modulate the narratives so that they can transgress from the right to the left side of the political spectrum, indicating that lithium mining is a global rather than a local problem.

Gregory the Great's Moralia in Job has been said to mark a transitional phase in the development of atonement doctrine. I argue that the Moralia cohesively portrays Christ's redemptive work as achieving something in two directions: towards God, a vicarious payment of humanity's debt of punishment; towards humanity, an efficaciously convicting and restorative example. This sustains a spirituality in which exacting and self-denying moral effort rests on freedom from judgement and on the death accomplished by the Mediator. Engaging the Moralia in this manner illuminates patristic exegetical sensibilities and proves instructive about how the fathers fit into later taxonomies of atonement models.

The low value of reproductive labor, and the related “crisis of care,” are often attributed to gendered attitudes about work. This article traces this explanation to the attempted synthesis of Marxist and feminist theories of ideology in the 1970s and offers a sympathetic critique with implications for both contemporary theories of labor and the “new ideology critique.” It reconstructs the explanatory role of ideology in feminist analyses of unwaged housework and tracks its uptake in theories of “reproductive labor” more broadly, via what I call the “naturalization thesis.” While these analyses have been influential, I show that they do not provide a convincing account of either gender oppression or the low value of reproductive labor. I offer an alternative explanation for the latter rooted in labor processes and patterns of capital accumulation and argue for the reintegration of ideology critique with the critique of political economy.

Egalitarian theories assess when and why distributive inequalities are objectionable. How should egalitarians assess inequalities between generations? One egalitarian theory is (telic) distributive egalitarianism: other things being equal, equal distributions of some good are intrinsically better than unequal distributions. I first argue that distributive egalitarianism produces counterintuitive judgements when applied across generations and that attempts to discount or exclude intergenerational inequalities do not work. This being so, intergenerational comparisons also undercut the intragenerational judgements that made distributive egalitarianism intuitive in the first place. I then argue that egalitarians should shed distributive egalitarianism: relational and instrumental arguments against inequality likely suffice to capture egalitarian concerns – including across generations – without encountering the problems produced by distributive egalitarianism.

I would like to thank the editors of Nationalities Papers for providing a forum for the discussion of my book and for facilitating the symposium. I would also like to express my deep gratitude to Lisa Blaydes, Anastasia Shesterinina, and Dan Slater for taking the time to read the book and for offering their insightful comments and questions. Their scholarship was an inspiration and a source of wisdom for my research in almost all its aspects, from the art of theory-building to their methodological input on survey research and qualitative fieldwork (Belge and Blaydes 2014; Blaydes 2018; Shesterinina 2019, 2021; Slater 2010). It was a wonderful feeling to read their engagement with my work. I believe that the ways the authors of the symposium presented some of the central ideas of my book were often better than the ways I did it myself. In this response, I’ll address some of the central questions and comments raised by the reviewers.

This guest editorial describes the importance of converging genetics and psychosocial epidemiology research methods to understand the biopsychosocial etiology of psychiatric phenotypes.