To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Transcranial direct current stimulation (tDCS) has emerged as a promising neuromodulation technique for managing obsessive-compulsive disorder (OCD). Early intervention with tDCS may lead to improved treatment outcomes for individuals with OCD, offering hope for more effective and timely intervention strategies. This study aimed to evaluate the safety and efficacy of tDCS as an early augmentation strategy in adults with OCD.
Methods
Drug-free adult patients with OCD were randomized into active and sham groups and received fluoxetine 20 mg (up to 60 mg). The protocol involved placing the cathode over the left supplementary motor area and the anode over the left dorsolateral prefrontal cortex, using a 2-mA current for 20 minutes, with a ramp time of 10 seconds. A total of 10 sessions were given over 2 weeks. Following the baseline assessment, both illness severity and side effects were measured periodically at 2, 4, and 6 weeks.
Results
A total of 40 patients completed this study (20 in each group). The active group demonstrated a significant reduction in Yale-Brown Obsessive-Compulsive Scale scores at 2, 4, and 6 weeks compared with the sham group, with a number needed to treat of 2.5. Additionally, the effect size of the intervention at 2 weeks was calculated to be 0.58, indicating a moderate effect according to Cohen’s d. Side effects were milder, tolerable, and uncommon.
Conclusion
Early augmentation with tDCS is a safe and effective method for rapidly reducing symptom severity in adult patients with OCD.
DSM-5 specifies bulimia nervosa (BN) severity based on specific thresholds of compensatory behavior frequency. There is limited empirical support for such severity groupings. Limited support could be because the DSM-5’s compensatory behavior frequency cutpoints are inaccurate or because compensatory behavior frequency does not capture true underlying differences in severity. In support of the latter possibility, some work has suggested shape/weight overvaluation or use of single versus multiple purging methods may be better severity indicators. We used structural equation modeling (SEM) Trees to empirically determine the ideal variables and cutpoints for differentiating BN severity, and compared the SEM Tree groupings to alternate severity classifiers: the DSM-5 indicators, single versus multiple purging methods, and a binary indicator of shape/weight overvaluation.
Methods
Treatment-seeking adolescents and adults with BN (N = 1017) completed self-report measures assessing BN and comorbid symptoms. SEM Trees specified an outcome model of BN severity and recursively partitioned this model into subgroups based on shape/weight overvaluation and compensatory behaviors. We then compared groups on clinical characteristics (eating disorder symptoms, depression, anxiety, and binge eating frequency).
Results
SEM Tree analyses resulted in five severity subgroups, all based on shape/weight overvaluation: overvaluation <1.25; overvaluation 1.25–3.74; overvaluation 3.75–4.74; overvaluation 4.75–5.74; and overvaluation ≥5.75. SEM Tree groups explained 1.63–6.41 times the variance explained by other severity schemes.
Conclusions
Shape/weight overvaluation outperformed the DSM-5 severity scheme and single versus multiple purging methods, suggesting the DSM-5 severity scheme should be reevaluated. Future research should examine the predictive utility of this severity scheme.
This article explores whether Russia’s war against Ukraine represents a geopolitical turning point for the European Union’s enlargement policy. By applying the concepts of historical institutionalism and turning points, the study examines a potential shift in EU priorities from normative to geopolitical considerations. Through a bibliometric analysis of academic literature and a quantitative analysis of progress reports from 2013 to 2023, the findings reveal that while the EU has increasingly incorporated geopolitical factors into its enlargement strategy, these changes do not yet constitute a definitive turning point.
The moderating roles of friendship and contextual variables on associations between social withdrawal and peer exclusion and growth curves of depressed affect were studied with a three-wave multilevel longitudinal design. Participants were 313 boys and girls aged 10–12 from Canada (n = 139), mostly of European and North African descent, and Colombia (n = 174), mostly mestizo, afrocolombian, and European descent. Depressed affect, peer exclusion, social withdrawal and friendship were assessed with peer-reports, and collectivism and individualism with self-reports. Group-level scores included gender, place and means of social withdrawal, peer exclusion, friendship, collectivism and individualism for each child’s same-gender classroom peer-group. Results indicated that being friended weakened associations between peer exclusion and social withdrawal and depressed affect. The strength of this effect varied across peer-group contexts.
Healthcare-associated infections (HAIs) are a major global health concern, affecting millions of patients each year across a variety of healthcare settings. Originally known as nosocomial infections, HAIs now include infections acquired during medical care other than acute-care hospital admissions. These infections, which range from traditional (eg, CLABSI, CAUTI, SSI, VAP) to non-traditional (eg, outbreaks, EIDs, MDROs), pose a variety of challenges and have a significant impact on patient care outcomes. According to studies, patients with HAIs have longer hospital stays, higher mortality rates (ranging from 7% to 64.6%), and higher healthcare costs as a result of their extended care needs. This review will delve into the prevalence, consequences, and management strategies for both traditional and non-traditional HAIs.
This article provides a brief introduction (or recapitulation) of what variable types are and how the choice of the variable type may affect which research questions can be answered and the data analysis. The nine-item Patient Health Questionnaire and a simulated data-set are used as an illustration throughout.
Dengue, the most prevalent urban arbovirus in the world, has triggered recurrent epidemics in Rio de Janeiro, Brazil, since the 1980s. This study aimed to describe the spatial–temporal patterns of dengue spread during the epidemic years of 2002, 2008, 2011, 2012, 2013, and 2024 in Rio de Janeiro. This is an ecological study using secondary data on notified confirmed dengue cases aggregated by neighbourhood. The incidence rates were estimated via the local empirical Bayes method. The local spatial autocorrelation indicators assessed incidence clusters, and the monthly geographic trajectory was outlined for each year. The results revealed changes in the spatial distribution of dengue over time, with clusters of high incidences predominating in the northern and central neighbourhoods in 2002 and 2008, and in the western zone in 2011, 2012, and 2013. In 2024, the distribution was predominant throughout the city, with emphasis in the central and western zones. The monthly geographic centre of dengue cases shifted from the west to the north during the peak of the epidemic. These results highlight the heterogeneous nature of dengue transmission in Rio de Janeiro. The incorporation of spatial and temporal analyses in epidemiological studies can enhance targeted and localized dengue control strategies.
This article raises some questions about the intuitionist response to skepticism developed by Michael Bergmann in Radical Skepticism and Epistemic Intuition, with a focus on Bergmann’s contention that epistemic intuitions serve as justifying evidence in support of anti-skepticism. It raises three main concerns: that an intuitionist conception of evidence is overly narrow, that it has undesirable implications for cases of disagreement, and that the evidential role that epistemic intuitions play in Bergmann’s version of anti-skepticism undercuts his claim that an intuitionist particularist response to skepticism is superior to disjunctivist responses.
This article explores the social history of Sandakan and Jesselton (Kota Kinabalu) by studying how their urban environments were organized and navigated. Although the neighbourhood was not officially recognized as a category of space, it argues that analogous quarters existed within the towns during the early twentieth century. As the commercial capitals of British North Borneo, the towns contained migrant people of various ethnicities that formed separate communities. The socio-spatial boundaries of these quarters were nevertheless permeable, enabling cross-communal interactions. Life in Sandakan and Jesselton was characterized by a contingency and complexity suitable for comparison with larger colonial cities.
Global food security worsened during the COVID-19 pandemic. In Nigeria, food security indicators increased in the first months of the pandemic and then decreased slightly but never returned to their pre-pandemic levels. We assess if savings groups provided household coping mechanisms during COVID-19 in Nigeria by combining the in-person LSMS-ISA/GHS-2018/19 with four rounds of the Nigerian Longitudinal Phone Survey collected during the first year of the pandemic. A quasi-difference-in-differences analysis setup leveraging the panel nature of the data indicates that savings group membership reduces the likelihood of skipping a meal but finds no statistically significant effect on the likelihood of running out of food or eating fewer kinds of food. Given theoretical priors and other literature positing a relationship, we also implement an OLS regression analysis controlling for baseline values finding that having at least one female household member in a savings group is associated with a 5–15% reduction in the likelihood of reporting skipping meals, running out of food, and eating fewer kinds of food. This analysis is not able to establish causality, however, and may in fact overestimate the effects. Together, the results indicate that savings group membership is positively associated with food security after COVID-19, but the causal effect is statistically significant for only one of the three food security indicators. To conclude, considering the interest in savings groups and expectations of continued food security shocks, the importance of collecting better gender-disaggregated longitudinal household data combined with experimental designs and institutional data on savings groups.
This study assessed beta-lactam allergy labels in 300 hospitalized adults using validated scores. Over 50% with penicillin and 21% with cephalosporin allergies were classified as low risk. Among those receiving alternative antibiotics due to inappropriate allergy labels, 44% were low-risk. Findings support structured allergy delabeling programs to enhance antimicrobial stewardship.
Adolescents face increased vulnerability to mental health conditions, particularly when exposed to multidimensional poverty and trauma and pronounced treatment gaps. Waves for Change, a Sport for Development (SfD) intervention, employs task-sharing through its ‘5-Pillar Method’ to build resilience and prevent mental health conditions among at-risk adolescents in South Africa. This study assessed the implementation outcomes of this Method using a mixed-methods design, incorporating interviews, focus groups, self-report questionnaires, document reviews and routine site assessments, with 69 stakeholders including staff, peer coaches, mental healthcare providers, social workers, teachers, and adolescents. A thematic analysis revealed key facilitators to successful implementation, including: a year-long preventative approach, creation of safe spaces for learning self-regulation skills, employment of youth coaches from local communities, incorporation of fun, group-based physical activities, modelling and repetition of desired skills, provision of transport and meals, government partnerships, and consistent weekly training and supervision. Implementation challenges included coach capacity, due to their education levels and own trauma experiences, measurement of fidelity to the Method and of adolescents’ emotional experiences, and some concerns around ocean safety. These findings provide valuable insights for implementing community-based SfD interventions for adolescents facing adversity, and contributes towards global evidence supporting task-shared mental health approaches in LMICs.
This paper describes the development and initial implementation of the Compendium of D&I Catalogs, a tool created by a Clinical and Translational Science Awards (CTSA) consortium working group to streamline navigation of the proliferating online resources, catalogs and interactive tools designed to guide application of dissemination and implementation (D&I) science. The Compendium is a curated, dynamically-updated list of 35 D&I resource catalogs organized into eight categories: comprehensive resources; frameworks, theories, and models; methods and measures; funding; practitioner resources; training; CTSA infrastructure; health equity. Eight CTSA hubs volunteered to serve as “early adopters” for the tool and completed an evaluation of its initial implementation. Among these “early adopters,” half had implemented the Compendium within their websites, describing the web implementation process as “easy.” Remaining “early adopter” respondents cited institutional web development capacity concerns and competing priorities as reasons for delayed implementation. All respondents valued the Compendium’s dynamic updates. Among implementing sites, roughly two-thirds directly embedded the Compendium into their institutional websites, with the others providing a link to the Compendium. For CTSAs striving to meet the rising demand for D&I expertise and resources, the Compendium of D&I Catalogs represents a simple, low-cost tool to enhance accessibility of D&I capacity-building resources.
This study investigates screening practices for antimicrobial-resistant organisms (AROs) in seventy-five hospitals participating in the Canadian Nosocomial Infection Surveillance Program (CNISP). Screening practices varied with widespread MRSA screening, selective carbapenemase-producing organisms (CPO) screening, and limited vancomycin-resistant Enterococcus (VRE) screening. These findings may help interpret ARO rates within CNISP hospitals and inform screening practices.
Loneliness is a global public health concern. Investigating loneliness in the general population offers a greater generalizability across various levels of health-related impairments, the identification of at-risk individuals, the detection of different loneliness severity levels, and broader insights into social determinants. Previous studies have shown that loneliness might be a transient or chronic experience, depending on how consistently it is reported across at least two timepoints. This study aimed to assess differential associations of chronic and transient with various domains of psychopathology.
Methods
Participants were enrolled from the general population and assessed at two timepoints spanning 6–7 months. Depressive symptoms, generalized anxiety, social anxiety, and paranoid thoughts were measured using self-reports. The data were analyzed using binary logistic regressions.
Results
Altogether, 3,275 participants completed both assessments with a retention rate of 64.2%. Chronic loneliness was associated with higher baseline and follow-up scores across all symptom domains. The strongest association was observed for social anxiety. Transient loneliness was not robustly associated with symptom scores. It was not significantly associated with depressive symptoms (at either of timepoints) and paranoid ideation (at baseline). The strongest association was observed for generalized anxiety. Chronic loneliness, compared to transient loneliness, was associated with significantly higher odds of social anxiety, depressive symptoms, and paranoid ideation, but not generalized anxiety.
Conclusions
Both transient and chronic loneliness are associated with mental health outcomes, with the latter one showing generally stronger associations. Risk stratification and early intervention among individuals experiencing loneliness might be needed to prevent the development of more severe psychopathology.
The proliferation of Artificial Intelligence (AI) is significantly transforming conventional legal practice. The integration of AI into legal services is still in its infancy and faces challenges such as privacy concerns, bias, and the risk of fabricated responses. This research evaluates the performance of the following AI tools: (1) ChatGPT-4, (2) Copilot, (3) DeepSeek, (4) Lexis+ AI, and (5) Llama 3. Based on their comparison, the research demonstrates that Lexis+ AI outperforms the other AI solutions. All these tools still encounter hallucinations, despite claims that utilizing the Retrieval-Augmented Generation (RAG) model has resolved this issue. The RAG system is not the driving force behind the results; it is one component of the AI architecture that influences but does not solely account for the problems associated with the AI tools. This research explores RAG architecture and its inherent complexities, offering viable solutions for improving the performance of AI-powered solutions.
Surgical site infections (SSI) result in significant patient morbidity and excess healthcare costs. Colorectal surgeries have the highest SSI risk, as they manipulate the organ with the largest endogenous bioburden. This risk can be mitigated through complex prevention bundles, shown effective at reducing SSI in multiple studies, although little is known about their “real-world” use.
Methods:
To obtain further insight into the implementation of SSI prevention bundles consisting of guideline-recommended infection control elements in colorectal surgery, we distributed a multiple-choice survey to the hospitals within the Society for Healthcare Epidemiology of America Research Network from November 2022 to December 2023.
Results:
A total of 42 (45%) hospitals completed the survey. The bundle elements most used were intravenous pre-operative antibiotic prophylaxis (88%) and skin prep with an alcohol-chlorhexidine solution (86%). Infection control elements of surgical closure such as glove change and separate instrument tray were reported by 67% and 64%, respectively. Combined oral antibiotics with mechanical bowel prep were reported by 52%. Less than 50% of hospitals reported consistent bundle audit and feedback to frontline surgical staff. The most persistent barriers to implementation were a general culture resistant to change (40%) and clinicians’ lack of compliance with the institutional bundle (38%).
Conclusions:
Our study found significant variability in the implementation of bundles consisting of multiple infection control elements to prevent SSI in clinical practice. Further research is needed to determine the strategies most effective in optimizing high-fidelity adoption of complex prevention bundles and to study their effect on SSI in colorectal surgery.
To estimate the cost-effectiveness of methicillin-resistant Staphylococcus aureus (MRSA) nares poymerase chain reaction (PCR) use in pediatric pneumonia and tracheitis.
Methods:
We built a cost-effectiveness model based on MRSA prevalence and probability of empiric treatment for MRSA pneumonia or tracheitis, with all parameters varied in sensitivity analyses. The hypothetical patient cohort was <18 years of age and hospitalized in the pediatric intensive care unit for community-acquired pneumonia (CAP) or tracheitis. Two strategies were compared: MRSA nares PCR-guided antibiotic therapy versus usual care. The primary measure was cost per incorrect treatment course avoided. Length of stay and hospital costs unrelated to antibiotic costs were assumed to be the same regardless of PCR use. Both literature data and expert estimates informed sensitivity analysis ranges.
Results:
When estimating the health care system willingness-to-pay threshold for PCR testing as $140 (varied in sensitivity analyses) per incorrect treatment course avoided, reflecting estimated additional costs of MRSA targeted antibiotics, and MRSA nares PCR true cost as $64, PCR testing was generally favored if empiric MRSA treatment likelihood was >52%. PCR was not favored in some scenarios when simultaneously varying MRSA infection prevalence and likelihood of MRSA empiric treatment. Screening becomes less favorable as MRSA PCR cost increased to the highest range value of the parameter ($88). Individual variation of MRSA colonization rates over wide ranges (0% – 30%) had lesser effects on results.
Conclusions:
MRSA nares PCR use in hospitalized pediatric patients with CAP or tracheitis was generally favored when empiric MRSA empiric treatment rates are moderate or high.
We examine whether decriminalization of suicide in India following the 2017 Mental Health Act corresponds with changes in suicide mortality overall and by level of state development. Our study utilizes counts of suicides from the National Crime Records Bureau (NCRB) across 35 Indian states from 2001 to 2020. The exposure variable is a binary indicator for the decriminalization of suicide following 2018. We use fixed-effect Poisson regression models that include population offsets and adjust for time trends, literacy, gross state domestic product and infant mortality. We find no relation between decriminalization of suicides and overall suicide mortality (Incidence Rate Ratio (IRR): 1.037; 95% CI (0.510–2.107)). Stratification by level of state development shows that less developed states saw an increase in suicide mortality by 1.9 times following decriminalization, compared to prior years (IRR: 1.859; 95% CI (1.028–3.364)). Our findings thus indicate that decriminalization did not coincide with a decline in suicide mortality in the country, thereby highlighting the need for improved mental health infrastructure and support in India, especially in less developed states.