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Developing reduced-order models for the transport of solid particles in turbulence typically requires a statistical description of the particle–turbulence interactions. In this work, we utilize a statistical framework to derive continuum equations for the moments of the slip velocity of inertial, settling Lagrangian particles in a turbulent boundary layer. Using coupled Eulerian–Lagrangian direct numerical simulations, we then identify the dominant mechanisms controlling the slip velocity variance, and find that for a range of Stokes number ${S{\kern-0.5pt}t}^+$, Settling number ${S{\kern-0.5pt}v}^+$ and Reynolds number $\textit{Re}_\tau$ (based on frictional scales),the slip variance is primarily controlled by local differences between the ‘seen’ variance and the particle velocity variance, while terms appearing due to the inhomogeneity of the turbulence are subleading until ${S{\kern-0.5pt}v}^+$ becomes large. We also consider several comparative metrics to assess the relative magnitudes of the fluctuating slip velocity and the mean slip velocity, and we find that the vertical mean slip increases rapidly with ${S{\kern-0.5pt}v}^+$, rendering the variance relatively small – an effect found to be most substantial for ${S{\kern-0.5pt}v}^+\gt 1$. Finally, we compare the results with a model of the acceleration variance (Berk & Coletti 2021 J. Fluid Mech.917, A47) based the concept of a response function described in Csanady (1963 J. Atmos. Sci.20, 201–208), highlighting the role of the crossing trajectories mechanism. We find that while there is good agreement for low ${S{\kern-0.5pt}v}^+$, systematic errors remain, possibly due to implicit non-local effects arising from rapid particle settling and inhomogeneous turbulence. We conclude with a discussion of the implications of this work for modelling the transport of coarse dust grains in the atmospheric surface layer.
Ewe and Guin-Mina people in Togo often use festival and ritual events as forums for cultural exchange and as opportunities to reinterpret and repurpose images and objects imported from India. Instead of focusing on large-scale commercial interactions, this article illustrates Afro-Indian cultural exchanges enacted microcosmically upon the canvas of West African bodies. I examine small-scale encounters between Ewe and Guin-Mina Vodun practitioners and South Asian merchants, paying close attention to ritual performances for Mami Wata – a pantheon of Pan-African water spirits often depicted as mermaids and venerated for their dominion over maritime trade. Specifically, I consider how ritual specialists devoted to Mami Wata index histories of trade with Indian merchants through performances that embody Hindu chromolithograph images of deities like Dattatreya and Shiva as depictions of local water spirits. Focusing on movements, gestures and transoceanic flows of currency, goods and objects present in Togolese Mami Wata veneration, this article teases out the threads of critical consumerism, gender fluidity and choreographic practices that accompany such ceremonies, especially during moments of transformative copresence with spirits. Exploring ways Ewe and Guin-Mina performers in Togo use stylized gestures and adornments to transform understandings of commercial relations with foreigners into sources of agency and transformation, I examine ritual choreographies in public festivals and private rituals as oceanic intersections: material representations of desires for social, transcultural and transnational mobility.
An adverse in utero experience negatively impacts perinatal growth in livestock. Maternal heat stress (HS) during gestation reduces placental growth and function. This progressive placental insufficiency ultimately leads to fetal growth restriction (FGR). Studies in chronically catheterized fetal sheep have shown that FGR fetuses exhibit hypoxemia, hypoglycemia, and lower anabolic hormone concentrations. Under hypoxic stress and nutrient deficiency, fetuses prioritize basal metabolic requirements over tissue accretion to support survival. Skeletal muscle is particularly vulnerable to HS-induced placental insufficiency due to its high energy demands and large contribution to total body mass. In FGR fetuses, skeletal muscle growth is reduced, evidenced by smaller myofiber size and mass, reduced satellite cell proliferation, and slower rate of protein synthesis. Disruptions in skeletal muscle growth are associated with mitochondrial dysfunction, including reduced pyruvate flux into the mitochondrial matrix and lower complex I activity in the mitochondrial electron transport chain. This review summarizes current research on the mechanisms by which HS-induced placental insufficiency affects skeletal muscle growth in the fetus, with an emphasis on myogenesis, hypertrophy, protein synthesis, and energy metabolism. The evidence presented is primarily drawn from experiments using chronically catheterized fetal sheep exposed to maternal HS during mid-gestation. Additionally, we explore emerging nutritional strategies aimed at enhancing skeletal muscle growth in animals with FGR. These strategies hold promise not only for improving reproductive efficiency in livestock affected by prenatal stress but also for their translational relevance to human pregnancies complicated by placental insufficiency.
This article examines why, beginning in 1946, the Brazilian government under President Eurico Dutra supplied arms to Dominican dictator Rafael Trujillo, fuelling a regional arms race and reshaping Caribbean Basin dynamics at the onset of the Cold War. It argues that these transfers bypassed conventional diplomatic channels, reflected radical anti-communist currents within Dutra’s inner circle and undercut US non-proliferation efforts. Far from a passive ally, Brazil emerged as a pivotal, if under-recognised, actor in the continental polarisation that led to democratic collapse in Venezuela (1948), Cuba (1952) and Guatemala (1954). The article challenges assumptions of Brazil’s limited Latin American engagement and repositions Dutra’s foreign policy within broader continental strategies of ideological alignment and regional influence. Drawing on Brazilian diplomatic and press sources, as well as archival and printed materials from across Latin America, Europe and the United States, it addresses historiographical gaps around Dutra’s agency and reveals the material underpinnings of Trujillo’s aggression, contributing to a revised understanding of Brazil’s Cold War trajectory.
Pulmonary regurgitation leading to right ventricular enlargement may occur after repaired tetralogy of Fallot (rTOF) or balloon dilation for pulmonary valve stenosis. Cardiac magnetic resonance imaging (CMR) guidelines to identify the timing of valve replacement in rTOF are not necessarily applicable to isolated pulmonary regurgitation. This study aims to compare deformation parameters of isolated pulmonary regurgitation and rTOF at comparable right ventricular volume loads.
Methods:
Adopting a quantitative retrospective analytic framework, CMR was performed in 44 patients (0–30 years), 22 in each of the isolated pulmonary regurgitation and rTOF study arms, matched for age (±12 months), and Right ventricular end-diastolic volume z-score (±1). Right ventricular longitudinal strain/strain rate and circumferential strain/strain rate were measured. Comparisons between groups were analysed using two-tailed T-tests and one-way ANOVA.
Results:
Both groups showed predominance of longitudinal over circumferential strain. Circumferential strain was significantly greater in rTOF compared to isolated pulmonary regurgitation (–26.5% versus –22.3%, p < 0.05). Longitudinal strain did not differ between groups. The longitudinal:circumferential strain ratio was significantly lower in rTOF compared to isolated pulmonary regurgitation (1.24 versus 1.53, p = 0.05). Circumferential and longitudinal strain rates did not differ between groups.
Conclusions:
The right ventricles in rTOF demonstrate greater reliance on circumferential strain in response to increased volumes. The decrease in longitudinal:circumferential strain ratio suggests rTOF right ventricles display a greater adaptive response to the volume load than isolated pulmonary regurgitation, highlighting the importance of the relative contributions of both circumferential and longitudinal strain in order to understand the mechanisms of right ventricular dysfunction in pulmonary regurgitation.
Powerful lasers may be used in the future to produce magnetic fields that would allow us to study turbulent magnetohydrodynamic inverse cascade behaviour. This has so far only been seen in numerical simulations. In the laboratory, however, the produced fields may be highly anisotropic. Here, we present corresponding simulations to show that, during the turbulent decay, such a magnetic field undergoes spontaneous isotropisation. As a consequence, we find the decay dynamics to be similar to that in isotropic turbulence. We also find that an initially pointwise non-helical magnetic field is unstable and develops magnetic helicity fluctuations that can be quantified by the Hosking integral. It is a conserved quantity that characterises magnetic helicity fluctuations and governs the turbulent decay when the mean magnetic helicity vanishes. As in earlier work, the ratio of the magnetic decay time to the Alfvén time is found to be approximately $50$ in the helical and non-helical cases. At intermediate times, the ratio can even reach a hundred. This ratio determines the endpoints of cosmological magnetic field evolution.
Recent years have witnessed a “juridical turn” in Chinese environmental governance, emphasising and encouraging legal mobilisation and litigation deployment by citizens to address environmental grievances in either individual or collective forms. This legalisation movement has spawned a budding, socio-legal field of Chinese environmental justice (CEJ), with an ostensible trend towards the legal empowerment of community organisations as “autonomous” litigants representing public interests. Drawing on extensive qualitative data, this study examines how plural, fluid state–society relations are manifested, animated, and permeated in the interactive processes of the CEJ. The analysis reveals four emergent modes of political–organisational connections—the state’s challengers, allies, servants, and subordinates—all of which depend on how the Chinese state interprets their motives for using the law and engaging in litigations, and anticipated effects their legal mobilisation can generate or diffuse in society. The bounded community mobilisation within the CEJ has also embodied the continuing state supremacy and the growing legal responsiveness in the Chinese approach to modernisation. Future theoretical and policy implications for the participatory effectiveness of community organisations in the CEJ are also discussed.
Adults with mood and/or anxiety disorders have increased risks of comorbidities, chronic treatments and polypharmacy, increasing the risk of drug–drug interactions (DDIs) with antidepressants.
Aims
To use primary care records from the UK Biobank to assess DDIs with citalopram, the most widely prescribed antidepressant in UK primary care.
Method
We classified drugs with pharmacokinetic or pharmacodynamic DDIs with citalopram, then identified prescription windows for these drugs that overlapped with citalopram prescriptions in UK Biobank participants with primary care records. We tested for associations of DDI status (yes/no) with sociodemographic and clinical characteristics and with cytochrome 2C19 activity, using univariate tests, then fitted multivariable models for variables that reached Bonferroni-corrected significance.
Results
In UK Biobank primary care data, 25 508 participants received citalopram prescription(s), among which 11 941 (46.8%) had at least one DDI, with an average of 1.96 interacting drugs. The drugs most commonly involved were proton pump inhibitors (40% of co-prescription instances). Individuals with DDIs were more often female and older, had more severe and less treatment-responsive depression, and had higher rates of psychiatric and physical disorders. In the multivariable models, treatment resistance and markers of severity (e.g. history of suicidal and self-harm behaviours) were strongly associated with DDIs, as well as comorbidity with cardiovascular disorders. Cytochrome 2C19 activity was not associated with the occurrence of DDIs.
Conclusions
The high frequency of DDIs with citalopram in fragile groups confirms the need for careful consideration before prescribing and periodic re-evaluation.
First minted by polities in north-central Myanmar as early as the fourth century AD, silver coins bearing Rising Sun and Srivatsa motifs have been found in numerous archaeological contexts across Southeast Asia from Vietnam to Bangladesh. Strong standardisation in the design of these coins highlights patterns of trade and cultural interaction across this region that are otherwise underexplored. Here, the authors draw on a dataset of 245 coins from museums in Cambodia, Vietnam, Thailand and Myanmar, identifying die links that support trade routes between widely disparate areas, and illuminating the utility of die studies in counteracting the illicit trafficking of antiquities.
Dengue virus (DENV) remains a pressing global health challenge, primarily transmitted by Aedes aegypti mosquitoes. This review synthesizes current knowledge on the biological, environmental, and molecular factors influencing DENV transmission, drawing upon 120 peer-reviewed studies. The narrative analysis highlights the mosquito’s vector competence, shaped by genetic variability, midgut barriers, and immune responses. Environmental drivers particularly temperature, humidity, and urbanization emerge as critical determinants of transmission dynamics. A meta-analysis of 30 studies reveals a strong positive correlation (r = 0.85, p < 0.01) between temperature (25 °C–30 °C) and transmission efficiency. Proteomic studies further detail molecular interactions facilitating viral entry and replication. Although novel interventions such as Wolbachia-based biocontrol and genetic modification show promise, context-specific implementation remains challenging, especially in low-resource settings. Key research gaps include the impact of climate change, co-infections with other arboviruses, and the long-term efficacy of vector control innovations. Prioritizing interdisciplinary approaches and adapting strategies to local contexts are vital to reducing the dengue burden and informing future public health responses.
We consider laminar forced convection in a shrouded longitudinal-fin heat sink (LFHS) with tip clearance, as described by the pioneering study of (Sparrow, Baliga & Patankar 1978 J. Heat Trans.100). The base of the LFHS is isothermal but the fins, while thin, are not isothermal, i.e. the conjugate heat transfer problem is of interest. Whereas Sparrow et al. numerically solved the fully developed flow and thermal problems for a range of geometries and fin conductivities, we consider the physically realistic asymptotic limit where the fins are closely spaced, i.e. the spacing is small relative to their height and the clearance above them. The flow problem in this limit was considered by (Miyoshi et al. 2024, J. Fluid Mech.991, A2), and we consider the corresponding thermal problem. Using matched asymptotic expansions, we find explicit solutions for the temperature field (in both the fluid and fins) and conjugate Nusselt numbers (local and average). The structure of the asymptotic solutions provides further insight into the results of Sparrow et al.: the flow is highest in the gap above the fins, hence heat transfer predominantly occurs close to the fin tips. The new formulas are compared with numerical solutions and are found to be accurate for practical LFHSs. Significantly, existing analytical results for ducts are for boundaries that are either wholly isothermal, wholly isoflux or with one of these conditions on each wall. Consequently, this study provides the first analytical results for conjugate Nusselt numbers for flow through ducts.
Specific phobias are common in the community, and much is known from epidemiological surveys about their subtypes and sex ratio.
Aims
To determine the subtypes and sex ratio in a treatment-seeking sample of people with a specific phobia.
Method
Patients with a specific phobia were identified by a retrospective search of clinical case records from patient notes in electronic health records at the South London and Maudsley NHS Foundation Trust (the largest secondary mental healthcare provider in Europe).
Results
We identified 1017 patients over 5 years as having a specific phobia. The adult female to male sex frequency ratio for having any specific phobia was 3.9, with the ratio of specific phobia subtypes ranging from 2.4 (natural environment) to 8.2 (animal). The child female to male ratio of specific phobia subtypes ranged from 0.7 (natural environment) to 1.8 (other subtypes). Phobia of vomiting was the most common specific phobia presenting in both adults (n = 161, 17.8% of all specific phobias) and children (n = 26, 23.4%). In adults with a phobia of vomiting, the female to male ratio was 9.1 compared with 3.4 in all other specific phobias, and 4.2 versus 0.98 for children.
Conclusions
There is a stark contrast between the apparent prevalence of phobia of vomiting in epidemiological surveys and being the most common presentation clinically. A very high female to male ratio in phobia of vomiting and animals in adults seeking treatment is also in contrast to findings in the community. This has implications for clinician training and public education.
We aimed to identify therapeutic approaches for managing schizophrenia in different phases and clinical situations – the prodromal phase, first-episode psychosis, cognitive and negative symptoms, pregnancy, treatment resistance, and antipsychotic-induced metabolic side effects – while assessing clinicians’ adherence to guidelines.
Methods
A cross-sectional online survey was conducted in 2023 as part of the Ambassador project among psychiatrists and trainees from 35 European countries, based on a questionnaire that included six clinical vignettes (cases A–F). Additionally, a review of multiple guidelines/guidance papers was performed.
Results
The final analysis included 454 participants. Our findings revealed a moderate to high level of agreement among European psychiatrists regarding pharmacological treatment preferences for first-episode psychosis and cognitive and negative symptoms, prodromal symptoms and pregnancy, with moderate adherence to clinical guidelines. There was substantial similarity in treatment preferences for antipsychotic-induced metabolic side effects and treatment resistance; however, adherence to guidelines in these areas was only partial. Despite guideline recommendations, non-pharmacological treatments, including psychotherapy and recovery-oriented care, were generally underutilized, except for psychoeducation and lifestyle recommendations, and cognitive behavioural therapy for treatment of the prodromal phase. Contrary to guidelines, cognitive remediation and physical exercise for cognitive symptoms were significantly neglected.
Conclusions
These discrepancies highlight the need for effective implementation strategies to bridge the gap between research evidence, clinical guidelines/guidance papers, and real-world clinical practice. Clinicians’ unique combination of knowledge and experience positions them to shape future guidelines, especially where real-world practice diverges from recommendations, reinforcing the need to integrate both research evidence and clinical consensus.
Mass street protests and other highly contentious actions often capture headlines and public attention, but what remains after the news cycle moves on? Many times, grassroots initiatives crystallise during or after these intense moments of participation, leaving in their wake effective organisations that continue to make daily life more liveable in contexts of extreme vulnerability. Despite the persistence and impact of these ‘things that work’ – as we call them – they are often less visible and understudied. How do these initiatives emerge and sustain themselves in the communities in which they work? Using ethnographic methods, we investigate the case of a community centre formed in the wake of a land occupation in the urban periphery of Buenos Aires to answer these questions. We argue that grassroots initiatives build local power through everyday care-work: forming relationships, changing identities and providing valuable services and information.
Vagal nerve stimulation (VNS) has recently emerged as a prospective therapeutic approach for addressing trauma- and stressor-related disorders (TSRDs).
Aims
We assessed findings from randomised controlled trials for the safety and efficacy of VNS as a viable treatment for TSRDs.
Method
We systematically searched Medline, Embase, PsycINFO, CINAHL, Web of Science, Cochrane Central databases, trial registries, preprint servers and Google Scholar from inception to December 2023. Rayyan software was used for screening procedures. Two reviewers independently completed data extraction based on the inclusion criteria.
Results
We synthesised data by using a narrative approach. A total of 322 abstracts were identified and assessed, and seven studies were included in the review. Based on evidence synthesis, the present state of VNS as a treatment intervention for TSRDs, namely post-traumatic stress disorder (PTSD), is limited and does not meet clinical expectations. The overall certainty of evidence was very low. However, evidence shows that VNS may alter and reduce specific aspects associated with PTSD phenomenology, including the reduction of anger responses and the attenuation of hyperarousal during psychological interventions.
Conclusions
Although preliminary analyses provide evidence that transcutaneous VNS temporarily increases parasympathetic activity under specific conditions, these effects appear to be short-lasting, and the impact of repeated administration on long-term autonomic function remains unknown. Future randomised control trials should evaluate the therapeutic efficacy of VNS for treating TSRDs.
Tax collection is difficult in low-income countries, and bureaucracies exist alongside non-state actors that extract revenue and provide services informally. Might weak states leverage these actors’ strengths to collect taxes, or should they invest in building fiscal capacity on their own? We conducted a field experiment in Lagos, Nigeria that randomly assigned market vendors to tax appeals delivered by state or non-state agents. Contrary to expectations, non-state actors were not effective messengers. Tax appeals delivered by representatives of marketplace associations, an important social intermediary in this context, were ineffective even at higher levels of trust and message credibility. Messages delivered by state agents, however, were sometimes effective in spurring registration and tax payments, especially among ethnic minorities. This study underlines the importance of social intermediaries in shaping the social contract, and it draws attention to the uneven effects of these kinds of institutions within populations.
We describe a training series using a scaffolded approach informed by Vygotsky’s Learning Theory to advance Hawai‘i -based faculty grant-writing skills. Sponsored by the Professional Development Core of the Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) at the University of Hawai‘i at Mānoa, the initiative includes a 2-week series of 1-hour introductory sessions on aspects of grant writing, a 3-session workshop to develop a specific aims page, and a 5-month training program in grant writing. Over three years, 202 Hawai‘i investigators attended at least one 1-hour introductory session, 62 completed the workshop on preparing specific aims, and 30 completed the 5-month training on grant writing. Participants rated all 3 programs as very useful. Of the 62 unique investigators who completed the Specific Aims Workshop, 21 (33%) submitted PIKO pilot grant applications, 4 (6%) submitted grants elsewhere, and 16 (30%) applied to the 5-month training on grant writing. The 30 GUMSHOE participants reported significant gains in their confidence in accomplishing 21 proposal-writing tasks and, as of May 2025, 26 (87%) submitted grants to the National Institutes of Health or another external funder. This scaffolded training approach is labor- and time-intensive for trainees and faculty mentors, but our outcomes demonstrate its success.