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The associations between circulating PUFA and cardiovascular risk factors and events in healthy Asian populations have been less examined robustly compared with Western populations. This systematic review aimed to summarise current evidence on the associations between n-3 and n-6 PUFA biomarkers and cardiovascular risk factors and events in healthy Asian populations. Four databases were searched for observational studies from 2010 until 2024. Twenty-three studies were eligible, which covered six Asian countries and included events (n 7), traditional risk factors such as blood pressure and lipids (n 4), physical signs such as arterial stiffness (n 4), non-traditional lipid markers (n 1), markers of inflammation (n 4), markers of thrombosis (n 2) and non-invasive imaging-based markers (n 5). Biological sample types included plasma (n 6), serum (n 14) and erythrocyte (n 3). Higher circulating total n-3 PUFA appeared to be associated with lower hypertension risk and specifically EPA and DHA to be associated with lower myocardial infarction risk, reduction in TAG and inflammation. Higher circulating linoleic acid was associated with improved lipid profiles and lower inflammation. Limited evidence led to inconclusive associations between circulating n-6 PUFA biomarkers and CVD events and blood pressure. No consistent associations with arterial stiffness, obesity, thrombosis and imaging-based biomarkers were observed for circulating PUFA biomarkers in Asian populations. Limited studies exist for each outcome; hence, results should be interpreted with caution. More high-quality and prospective studies in Asian populations are warranted. Several recommendations such as sample size justification and reporting of non-respondents rate are proposed for future studies.
Public humanities happens whenever humanities scholarship interacts with public life. Providing a 10-point typology of public humanities, this article explains why we need the humanities – as individuals and as societies – and narrates some moments when the humanities have changed the world. We discuss the rise of “public humanities,” some critiques of the field, and a vision for its future.
Pernicious polarization is an antagonistic Us versus Them division, where the other group is perceived as an existential threat. It is often intertwined with the erosion of democratic norms and institutions. Although studies on polarization abound, there are still some blind spots to be filled. Our contribution is the focus on the mesolevel of civil society and the theoretical development of (de)polarization mechanisms at this level. Empirically, we study think tanks, a special type of civil society organization, in the context of democratic backsliding in Hungary and Poland. The analysis is based on 53 interviews with Hungarian and Polish think tankers conducted between 2020 and 2022. We contend that through a shift in perceptions of Us, Them, and the middle ground, think tanks contribute to both polarization and depolarization. Rather than being passive receptors of polarization dynamics, we showcase think tanks’ agentic roles as they emerge through these three mechanisms and through think tanks resorting to specific patterns of discourse and interactions.
For Peru, the introduction of dispute prevention mechanisms was a consequence of the country's increased openness to foreign investment. Following a severe economic crisis, the government launched several pro-investment reforms in the 1990s. These included signing bilateral investment treaties and free trade agreements with investment protection provisions, as well as investment contracts with foreign investors. The resulting flow of foreign direct investment (FDI) into the country, in turn, increased the likelihood of the state facing investor-state dispute settlement (ISDS) cases. As Peru began to face investment claims in the early 2000s, the Coordination and Response System for International Investment Disputes, also known as “SICRECI” for its acronym in Spanish, was established to manage the practical challenges of coordinating the state's defense. In practice, however, SICRECI's mandate has expanded progressively beyond coordinating ISDS defense, as the institution has undertaken several actions to prevent disputes and otherwise adapted to the specifics of Peru's pro-investment policy. SICRECI became one of the first models of dispute prevention mechanisms, with international organizations showcasing it as an example of how states, in particular developing countries, could address and mitigate a growing number of concerns over the impact of investment arbitration.1
The aim of this study is to understand the path for establishing digital health technologies-health technology assessment (DHT-HTA) in India.
Methods
A rapid review of HTA and DHT frameworks on PubMed (MEDLINE) and Google Scholar was conducted to identify DHT-HTA guidelines, and HTA processes in India. MS-Excel template was created with key domains for assessing DHT in resource-constrained settings based on studies and reports identified. Responses received from seventeen experts with varying expertise in DHT, HTA, clinical, and research were contacted using an online form. Following the principles of qualitative research rooted on grounded theory approach, themes and domains were derived for a framework which was again circulated through participants. Weightage for each theme was assigned based on the frequency of responses and qualifiers were used to interpret results. Inductively derived themes from these responses were clubbed together to identify macro-level systems requirements, and finally pre-requisites for setting up DHT-HTA framework was synthesized.
Results
HT are commonly perceived by experts (64.7 percent participants) as a technology strictly connected to health information. Real-world data (i.e., electronic health data) are recognized as a relevant tool in support of decision-making for clinical and managerial levels. Experts identified some pre-requisites for the establishment of DHT-HTA in the country in terms of infrastructure, contextual factors, training, finance, data security, and scale-up.
Conclusion
Our research not only identified the pre-requisites for the adoption of a DHT-HTA framework for India, but confirmed the need to address DHT-HTA’s acceptability among. Hospitals and health insurance providers.
Post-racing thoroughbreds (TBs) are increasingly being considered for Equine Assisted Services (EAS), but their use has not yet been widely characterised. This study aimed to generate detailed data on TBs and other breeds (OBs) of horses in EAS via an online survey. The survey was completed by 129 EAS practitioners from 15 countries and reported detailed data on 427 EAS equids, including 57 TBs. Most of the EAS horses were housed collectively, had access to free exercise over 12 h per day and had unrestricted access to forage. The most commonly recorded selection criteria for EAS horses consisted of: demonstrating a good personality; enjoying the work; absence of propensity to kick/bite. Detailed data gathered on individual horses showed that in comparison to OBs, TBs were younger, more likely to be a gelding, less likely to be used in ridden programmes, and tended to present more behavioural issues than OBs. The majority of the participants agreed that TBs have specific assets of particular interest to EAS programmes, such as sensitivity, body/movement characteristics or responsiveness/flight response. Finally, a large majority of participants reported that they believe TBs to be suitable for EAS programmes and some would consider working with them. These results showed TBs to already be in use in various EAS programmes and more could be incorporated in the future. In terms of animal welfare and beneficiaries’ safety, a selection process could therefore be designed and implemented to choose the most adapted horses for each EAS centre, according to living conditions and EAS activities practised (ridden or not ridden).
Theories of learning and attention predict a positive relationship between reading times on unfamiliar words and their learning; however, empirical findings of contextual learning studies range from a strong positive relationship to no relationship. To test the conjecture that longer reading times may reflect different cognitive and metacognitive processes, the need to infer novel word meanings from context was deliberately manipulated. One hundred and two adult first– and second–language English language speakers read sixty passages containing pseudowords while their eye movements were recorded. The passages were either preceded or followed by pseudoword definitions. After reading, participants completed posttests of cued meaning recall and form recognition. Meaning recall was positively associated with (i) individual cumulative reading times and (ii) participants’ general vocabulary knowledge, but not when definitions were provided before reading. Form recognition was unaffected by cumulative reading times. Our findings call for a cautious approach in making causative links between eye–movement measures and vocabulary learning from reading.
Dominant debates about China’s growing presence in the Pacific Islands – through infrastructure, aid, trade, and investment – suggest that Chinese material power directly translates to influence and effective interference in Pacific states’ domestic and foreign affairs. These perspectives fail to clarify the causal link between Chinese economic statecraft and Pacific governments’ alignment with Beijing’s interests. They also deny Pacific people agency, overlooking how power relations are mediated by Pacific state and non-state actors operating across complex political and socio-economic structures. We challenge such rationalist conceptualisations of Chinese power by developing a constructivist taxonomy of power as presence (dormant capability), influence (socialisation), and interference (incentives), and applying it to the Melanesian subregion. We argue that Chinese power is not merely material, causal, and unidirectional. Chinese power can also (re)shape the identities and interests of Pacific elites and publics in a constitutive manner, potentially aligning their ideas about substantive norms, rules, and practices guiding their foreign relations with Chinese ‘core interests’ and perspectives on regional and global politics.
To maximize its value, the design, development and implementation of structural health monitoring (SHM) should focus on its role in facilitating decision support. In this position paper, we offer perspectives on the synergy between SHM and decision-making. We propose a classification of SHM use cases aligning with various dimensions that are closely linked to the respective decision contexts. The types of decisions that have to be supported by the SHM system within these settings are discussed along with the corresponding challenges. We provide an overview of different classes of models that are required for integrating SHM in the decision-making process to support the operation and maintenance of structures and infrastructure systems. Fundamental decision-theoretic principles and state-of-the-art methods for optimizing maintenance and operational decision-making under uncertainty are briefly discussed. Finally, we offer a viewpoint on the appropriate course of action for quantifying, validating, and maximizing the added value generated by SHM. This work aspires to synthesize the different perspectives of the SHM, Prognostic Health Management, and reliability communities, and provide directions to researchers and practitioners working towards more pervasive monitoring-based decision-support.
It made for a great photograph. Icons of the feminist movement, stars of women's sport, and amateur athletes joined in a show of solidarity, rallied around the torch that would inaugurate the 1977 National Women's Conference in Houston, Texas (Figure 1). It was the first federally funded meeting of its kind, and 20,000 people cheered the arrival of the flame and the illustrious if motley crew that bore it aloft. The moment was, according to the official proceedings, “one of the most dramatic features of the Conference.”
Shock refraction in a gas–liquid interface is ubiquitous in nature and engineering. This study investigates the shock refraction phenomena in air–water interfaces for various inclination angles. The interface inclination angles are achieved using a tiltable vertical shock tube. The time-resolved schlieren images are compared with numerical simulations performed using the BlastFoam solver in the OpenFOAM software. The stiffened gas equation of state is used to model water in the simulations. The shock polar analysis using modified shock relations for a stiffened gas is used to elucidate the refraction patterns. A regular refraction pattern with a reflected shock wave and a bound precursor refraction with a regular reflection are observed experimentally for the first time in an air–water system. Further, a new free precursor refraction pattern with a Mach reflection is observed. The transition criteria and the corresponding boundaries for each refraction pattern are demarcated in the ($M_S, \theta _w^c$)-plane. The refraction sequence and the range for various incident shock strength regimes are also identified.
In the social, historical, and political context of Xi Jinping’s China, particular forms of racialization and racial capitalism have emerged in Altay Prefecture, the homeland of ethnic Kazakhs on China’s northwest border. This study examines the husbandry industry in Altay Prefecture to elucidate how Xi’s China has built a mode of racial capitalism through the management of Kazakh land, ethnicity, and culture. Within the framework of a case study, I employ document collection and participant observation methods to gather data that are then interpreted through critical policy analysis. The research shows that Kazakhs have been racialized based on their mobile pastoral traditions, enslaved in the “debt economy,” and exploited through husbandry policies and programs. The particular ways in which husbandry has been restructured and assimilated into Chinese industrial production chains exploit and reproduce the Kazakh-Han hierarchy and segregation. This close look at racial capitalism in Altay sheds light on the operations of Xi’s ecological civilization and war on poverty policies in an ethnic minority border region and discusses how they align with the broader geopolitics of the Belt and Road Initiative in Central Asia and Eastern Europe.
In this article, we analyze the influence of the colonial policy of the Russian Empire and the Soviet Union on Ukrainian art-historical writing. As we shall reveal, the mechanisms of knowledge production created during that period continued to operate after the Declaration of Independence of Ukraine in 1991. The limitations that were imposed on the art-historical community, which can be regarded as colonial, shaped the crucial narratives (of the “triune nation”) and dictated the thematic scope of Ukrainian scholarship. The new notion of “mysteztvoznavstvo,” introduced in 1937 instead of the previously established Theory and History of Art, eventually led to a profound rift between Soviet Russian and Ukrainian scholarship and the Western world more generally. “Mysteztvoznavstvo” was supposed to be an umbrella term for art history, theory, and art criticism but ended up doing a disservice to each domain. Art theory in Ukraine was virtually nonexistent, whereas art history was mixed with art criticism, resulting in writing that did not meet widely accepted academic standards. This led to the isolation of Ukrainian scholars, who were confined to the Russian-speaking community and had very limited access to foreign scholarship. We also analyze the decolonization processes in the history of Ukrainian art prompted by the invasion of the Russian Federation into Ukraine after 2013, such as The Revolution of Dignity and “decommunization.” We argue that horizontal art history and decolonial approaches cannot adequately be applied if colonial tools are still used by the discipline. Epistemic decolonization can only be achieved after challenging the standards of “mysteztvoznavstvo” and, thus, by dividing art studies into three separate domains: art history, art theory, and art criticism, as each discipline has its own goals and methods.
When do political transitions lead to greater inclusion for groups historically excluded from power? Scholars and policymakers often assume the answer is simple: a transition will result in more inclusion when it ends in democracy. Yet this answer is incomplete at best, since many democracies systematically exclude women, particular ethnic groups, or lower economic classes from power. Using data on political transitions around the world from 1945 to 2014, this study shows that a political transition’s initiating force critically shapes post-transition political inclusion. When transitions are initiated through unarmed civil resistance campaigns they achieve greater advances in inclusion relative to other types of transition. We propose three mechanisms to explain this effect: civil resistance leads to greater continued mobilization and civic activism among the historically excluded, provides greater opportunities for elites from historically excluded groups to rise to positions of leadership in new regimes, and forges more pluralistic norms of political behavior.
We compared Ed Diener’s Satisfaction With Life Scale (SWLS), which was designed as a purely cognitive measure of global life satisfaction, with the Affective Neuroscience Personality Scales 3.1, which provides self-report measures of Panksepp’s six primary emotions (excluding LUST), in two English-speaking samples: a main sample and a hold-out validation sample. Our data showed robust negative correlations between higher satisfaction with life and lower FEAR, lower SADNESS/Separation Distress, and positive associations (albeit less strong) between higher satisfaction with life and higher PLAY and SEEKING in both samples. The relationships between the SWLS and at least four of Panksepp’s primary emotions suggest Diener’s SWLS is not purely cognitive and includes a strong affective component. In addition, detailed analysis of the negative correlation between the SWLS and the ANPS 3.1 SADNESS scale provides insight into the importance of the low arousal end of the SADNESS/Separation Distress brain system and supports the idea of a continuum of psychological states from high SADNESS including loneliness and depression to low SADNESS psychological states characterized by social comfort, self-confidence, and social strength.
Migraine can affect adults during their most productive years, yet few studies in Canada have examined the relationship between migraine-related disability and productivity loss. In particular, the impact of migraine on unpaid productivity loss has not been quantified.
Methods:
In this cross-sectional study, employed adults living with migraine were recruited from across Canada to complete a web-based questionnaire. Migraine-related disability was assessed using the Migraine Disability Assessment questionnaire, and productivity loss was evaluated using the Valuation of Lost Productivity questionnaire. Multiple regression models were used to quantify the association between migraine-related disability level and productivity loss after adjusting for relevant clinical, occupational and sociodemographic covariates.
Results:
There were 441 participants, of which 60.1% were female, and the mean (SD) age was 37.7 (10.9). Compared to participants with little to no migraine-related disability, hours of total productivity loss were higher among those with moderate disability (54.1 [95% CI: 10.2–98.1] adjusted hours per 3 months) and severe disability (110.5 [95% CI: 65.5–155.6] adjusted hours per 3 months); paid productivity loss was higher among participants with moderate disability (32.4 [95% CI: 3.1–61.8] adjusted hours per 3 months) and severe disability (61.6 [95% CI: 31.5–91.7] adjusted hours per 3 months); and unpaid productivity loss was greater in those with severe disability (43.5 [95% CI: 12.7–74.3] adjusted hours per 3 months).
Conclusions:
Greater migraine-related disability was associated with more total, paid and unpaid productivity loss among employed adults. These data will be valuable when evaluating the cost-effectiveness of emerging migraine therapies.
At the beginning of the 1970s, college sports were on turbulent ground. “Colleges prepare for the impact of rising costs and more campus unrest,” warned the New York Times. The Los Angeles Times was a bit blunter in its prognosis, reporting that “like housewives everywhere, athletic directors of the nation's colleges [were] having budget trouble.” National Collegiate Athletics Association (NCAA) Executive Director, Walter Byers, warned of “cadres of disgruntled athletes,” demanding rights, money, and control. Byers was also troubled by Title IX, the new educational amendment mandating gender equity in federally funded schools, including in athletic departments. “The possible doom of our collegiate sports is near,” Byers proclaimed. “There is not an athletic department in the country where officials are optimistic,” University of Michigan's Athletic Director (AD), Don Canham, lamented. Norv Richey, University of Oregon's AD concurred, declaring, “The future of intercollegiate athletics are in peril.”
Many Royal College of Physicians and Surgeons of Canada (RCPSC) graduates in neurosurgery face significant challenges in finding full-time employment. The current study describes the career outcomes of neurosurgery residents from Canadian programs.
Methods:
All RCPSC neurosurgery graduates (n = 106) who completed their residency between 2015 and 2020 were included in this study. Baseline characteristics were determined for the entire cohort and then stratified by employment status. Several logistic regression models were used to identify predictors of full-time employment after residency.
Results:
Overall, 26.4% of neurosurgery graduates from 2015 to 2020 have been underemployed, defined as locum and clinical associate positions (6.6%), the pursuit of multiple fellowships (16%) and career change/nonsurgical career (3.8%). Only 52.0% of graduates were fully employed in Canada, with 30.2% appointed at academic institutions. Skull-base/open vascular (OR: 0.055, 95%CI [<0.01, 0.74]) and general neurosurgery (OR: 0.027, 95% CI [<0.01, 0.61]) fellowships were associated with underemployment. Advanced research degrees (master’s or Ph.D.) and sex were not associated with full-time employment.
Conclusions:
Over one-quarter of recent Canadian neurosurgery graduates were underemployed, and nearly half do not find employment in Canada. These results reflect a concerning reality for current and prospective neurosurgery graduates in Canada and will hopefully serve as a call to action for the Canadian neurosurgery community.
The gut microbiome is impacted by certain types of dietary fibre. However, the type, duration and dose needed to elicit gut microbial changes and whether these changes also influence microbial metabolites remain unclear. This study investigated the effects of supplementing healthy participants with two types of non-digestible carbohydrates (resistant starch (RS) and polydextrose (PD)) on the stool microbiota and microbial metabolite concentrations in plasma, stool and urine, as secondary outcomes in the Dietary Intervention Stem Cells and Colorectal Cancer (DISC) Study. The DISC study was a double-blind, randomised controlled trial that supplemented healthy participants with RS and/or PD or placebo for 50 d in a 2 × 2 factorial design. DNA was extracted from stool samples collected pre- and post-intervention, and V4 16S rRNA gene sequencing was used to profile the gut microbiota. Metabolite concentrations were measured in stool, plasma and urine by high-performance liquid chromatography. A total of fifty-eight participants with paired samples available were included. After 50 d, no effects of RS or PD were detected on composition of the gut microbiota diversity (alpha- and beta-diversity), on genus relative abundance or on metabolite concentrations. However, Drichlet’s multinomial mixture clustering-based approach suggests that some participants changed microbial enterotype post-intervention. The gut microbiota and fecal, plasma and urinary microbial metabolites were stable in response to a 50-d fibre intervention in middle-aged adults. Larger and longer studies, including those which explore the effects of specific fibre sub-types, may be required to determine the relationships between fibre intake, the gut microbiome and host health.