The EU’s policies in the field of technology broadly defined are increasingly marked by a concern over strategic autonomy, and Europe’s place in the world. Regulatory interventions are framed in terms of “digital sovereignty,” with the Commission seeking to ensure that external dependencies are reduced with the aim of increasing the EU’s resilience to geopolitical instability and external shocks. Using the case study of semiconductors, the chips that power modern electronic devices, this article explores how technology policy in the EU sits at the economy–security nexus, in which economic goals and security goals are interdependent and inseparable. Focusing on the life cycle of the semiconductor supply chain from the control over natural resources through to the cybersecurity requirements placed on the finished products, this article demonstrates the increasing security logic embedded within a burgeoning industrial technology policy.

Ice shelves regulate the flow of the Antarctic ice sheet toward the ocean and its contribution to sea-level rise. Accurately monitoring the basal and surface melting of ice shelves is therefore essential for predicting the ice sheet's response to climatic warming. In this study, we utilize Sentinel-1A synthetic aperture radar satellite imagery combined with shipboard measurements of water temperature and salinity to investigate the presence of surficial meltwater plumes along the Antarctic coastline. Our approach reveals a strong correlation between areas of pronounced low radar backscatter extending from ice shelves and significant decreases in water temperature and salinity, suggesting meltwater-enriched ocean waters. We propose that the low radar backscatter signature of meltwater outflows is caused by stable stratification of the upper water column, driven by density contrasts from buoyant, low-salinity meltwater and surface current shear that reduce Bragg scattering waves. The resulting smooth water surfaces were observed adjacent to the surface expression of deep basal channels, documented in a helicopter survey along part of the Bellingshausen Sea ice edge. We present high-temporal resolution satellite radar as a tool for identifying meltwater release from beneath ice shelves, capable of all-weather, day-and-night imaging.

Work-related stress is a major occupational health and safety (OHS) issue that has industrial relations origins. Aside from the moral and human rights imperatives to improve the corporate climate for worker psychological health (as per psychosocial safety climate, PSC), there are strong economic costs for not doing so. PSC refers to worker perceptions of the corporate safety system to protect and promote workers’ psychological health and wellbeing. It is a leading indicator of working conditions, which in turn affect workers’ health and work engagement. In this study, we estimate the attributable economic cost of low PSC due to sickness absence and turnover. Data were collected from a multinational company using survey at Time 1 (T1) and objective company data (i.e., sickness absence and turnover) after one year (T2). Using regression analysis and a matched sample of 617 responses, PSC was negatively related to future sickness absence. A binomial logistic regression with 1268 respondents (i.e., all responses at T1) showed that PSC was negatively related to future voluntary turnover. An economic analysis suggests that improving OHS via PSC could save an organisation with 5000 employees USD 0.6–2.7 million per year. Building PSC to protect and promote workers’ psychological health is a likely economic saving on organisational productivity.

This paper describes the content and evolution of a fourth-year course for medical students on teaching pathographies of mental illness. (It is a follow-up to Nathan Carlin’s Pathographies of Mental Illness that appeared as an Element in the Bioethics and Neuroethics series published by Cambridge University Press.) The course originally centered on classic (and some contemporary) memoirs; however, responding to student evaluations, newer material now ensures more diversity, with material written by women and people of color, and describes the difference that can make.

Six-month-olds infer object size based on pitch: they map high-pitched vowels onto smaller objects and low-pitched vowels onto larger objects (Peña et al., 2011). The ‘sound symbolism bootstrapping hypothesis’ (Imai & Kita, 2014) proposes that this may support understanding of word-meaning correspondences; by drawing on iconic pairings between linguistic cues and corresponding referents (e.g., higher pitch for smaller objects), infants develop understanding of word-referent associations. Here we analyse mother-child interactions, testing whether sound-symbolic pitch-size correspondences occur in infant-directed speech. 40 dyads engaged in (semi-)naturalistic interaction around picture books containing images of toys of varying sizes. We compare mothers’ pitch when referring to small versus large toys, analysing i) actual size (bigger vs. smaller toys); ii) relative toy size congruence (i.e., congruent vs. incongruent with real-world expectation); and iii) transparency of the test paradigm as regards its focus on size contrastiveness (non-transparent, moderately transparent, highly transparent) to observe the nuances of size sound symbolism in infant-directed speech.

Ruminants can recycle nitrogen (N) and phosphorus (P), which are essential for vital body processes. Reduced N- and P-intake in ruminants is desirable for economic and ecologic reasons. Simultaneous modulation of mineral homoeostasis and bone metabolism occurs in young goats. This study aimed to investigate potential effects of dietary N- and/or P-restriction on molecular changes in bone metabolism. The twenty-eight young male goats were fed a control diet, an N-reduced diet, a P-reduced diet or a combined N- and P-reduced diet for 6–8 weeks. The N-restricted goats had lower plasma Ca concentration and higher plasma osteocalcin (OC) and CrossLaps concentrations. The P-restricted goats had reduced plasma inorganic phosphate (Pi) concentrations and increased plasma Ca concentrations. Due to the initiation of a signalling pathway that inhibits the fibroblast growth factor 23 (FGF23) expression, this was lower with P-restriction. Consequently, lower Pi concentrations were the main factor influencing the reduction in FGF23. The changes in mineral homoeostasis associated with P-restriction led to a reduction in OC, bone mineral content and mineral density. Simultaneously, bone resorption potentially increased with P-restriction as indicated by an increased receptor activator of NF-κB ligand/osteoprotegerin (OPG) ratio and an increase in OPG mRNA expression. Additionally, the increased mRNA expression of the calcitonin receptor during P-restriction points to a higher number of osteoclasts. This study demonstrates an impairment of bone remodelling processes in young goats by N- or P-restriction. With P-restriction, bone mineralisation rate was potentially reduced and bone quality impaired, while with N-restriction, bone remodelling increased.

Impulsivity is elevated in psychosis and during mania in bipolar disorder. Studies in unaffected relatives may help establish whether impulsivity is a heritable, state independent endophenotype. The aim of this systematic review and meta-analysis was to examine whether impulsivity is elevated in unaffected relatives of those with bipolar disorder, schizophrenia, and schizoaffective disorder, compared to controls. Databases were systematically searched up until March 2023 for articles reporting data on a behavioral or self-report measure of impulsivity in first-degree relatives and controls. Nineteen studies were included. Behavioral (10 studies, d = 0.35, p < 0.001) and self-reported impulsivity was significantly elevated in bipolar disorder relatives compared to controls (5 studies, d = 0.46, p < 0.001), with small effect sizes. Relatives of those with schizophrenia did not show significantly elevated impulsivity compared to controls on behavioral measures (6 studies, d = 0.42, p = 0.102). There were not enough studies to conduct a meta-analysis on self-report data in schizophrenia relatives or schizoaffective disorder relatives (self-report or behavioral). Study quality was good, however there was moderate to high heterogeneity in behavioral meta-analyses. Results suggest elevated impulsivity may be an endophenotype for bipolar disorder, present in an attenuated state before and after the illness and in at-risk individuals. This trait, amongst other behavioral and psychological indices, could be used to identify those who are at risk of developing bipolar disorder. Future research should refine measurement across studies and establish which components of impulsivity are affected in those at risk of psychotic and bipolar disorders.

This paper explores the development of the Dissemination and Implementation Science Collaborative (DISC) at the Medical University of South Carolina, established through the Clinical and Translational Science Award program. DISC aims to accelerate clinical and translational science by providing training, mentorship, and collaboration opportunities in dissemination and implementation (D&I) science. Through DISC, investigators, trainees, and community partners are equipped with the knowledge and skills to conduct D&I research and translate findings into practice, particularly in South Carolina’s public health and healthcare landscape. We describe efforts to achieve the major overarching aims of DISC, which include conducting scientific workforce training, providing mentorship and consultation, and advancing methods and processes for D&I research. By sharing DISC experiences, successes, and challenges, this paper aims to support the growth of D&I research and capacity-building programs, fostering collaboration and shared resources in the field.

Infant sleep quality is increasingly regarded as an important factor for children long-term functioning and adaptation. The early roots of sleep disturbances are still poorly understood and likely involve a complex interplay between prenatal and postnatal factors. This study investigated whether exclusive breastfeeding during the first 6 months moderated the association between maternal prenatal pandemic-related stress (PRS) and sleep problems in 24-months children born during the COVID-19 pandemic. We also explored the potential contribution of maternal postnatal anxiety in these relations. Seventy-eight infants (50% males) and their mothers provided complete data from birth to 24 months. Between 12 and 48 h from birth, maternal PRS during pregnancy was retrospectively reported as well as maternal anxiety and exclusive breastfeeding. Maternal anxiety and exclusive breastfeeding were also reported at 3 and 6 months after childbirth. Children sleep disturbances were reported at 24 months. Bayesian analyses revealed that maternal PRS was positively associated with sleep problems in children who were not exclusively breastfed from birth to 6 months. Findings add to the growing literature on the lasting impact of early pre- and postnatal experiences on child well-being and development.

Debates on the connection between human trafficking and war have been discussed in wars and conflicts across the globe. Russia’s war on Ukraine has brought this relationship to the forefront again, questioning whether trafficking flows have increased, examining the types of trafficking in war, and determining the conditions (if any) that make it flourish. This article examines human trafficking in Ukraine before the war and during limited and total war to determine how governments with robust anti-trafficking institutions negotiate anti-trafficking responses over different stages of war. The main research question of this study aims to determine how different stages of the war in Ukraine have changed human trafficking dynamics and responses over time. Using data from interviews and participant observations from Ukraine, I analyze the different types of human trafficking characteristics and flows, conditions that create vulnerabilities, and prevention tools that have been used in different periods. I theorize that war fundamentally alters human trafficking prevention but a foundation of prevention tools before war means that governments are better able to respond to human trafficking dynamics and flows when war occurs. Ukraine offers a unique and important perspective from which to examine human trafficking dynamics and the consequences of war due to a stable government, external aggressor, and clear path for those fleeing the violence to the European Union. The results show that Ukraine’s strong prevention efforts before the war helped shape responses after the war and full-scale invasion began. The data revealed that human trafficking is a longer-term form of gender-based violence in war because the exploitation is prolonged and there is a delay in identifying victims.

This commentary article explores some of the problems encountered by independent scholars seeking to get their work published in peer-reviewed journals and in particular the difficulties they face in accessing online resources. Though often hidden, these issues are nevertheless very real for aspiring historians and those who have returned late to the historical fold. The article acknowledges the efforts of a number of journals to encourage different voices, but highlights how the limitations of current licensing and Open Access arrangements hinders this ambition.

Ecological inference is a statistical technique used to infer individual behavior from aggregate data. A particularly relevant instance of ecological inference involves the estimation of the inner cells of a set of R × C related contingency tables when only their aggregate margins are known. This problem spans multiple disciplines, including quantitative history, epidemiology, political science, marketing, and sociology. This paper proposes new models for solving the problem using the latent structure theory, and presents the ecolRxC package, an R implementation of this methodology. This article exemplifies, explains, and statistically documents the new extensions and, using real inner cell election data, shows how the new models in ecolRxC lead to significantly more accurate solutions than ecol and VTR, two Stata routines suggested within this framework. ecolRxC also holds its own against ei.MD.bayes and nslphom, the two algorithms currently identified in the literature as the most accurate to solve this problem. ecolRxC records accuracies as good as those reported for ei.MD.bayes and nslphom. Besides, from a theoretical perspective, ecolRxC stands up for modeling a causal theory of political behavior to build its algorithm. This distinguishes it from other procedures proposed from different frameworks (such as ei.MD.bayes and nslphom) which model expected behaviors, instead of modeling how voters make choices based on their underlying preferences as ecolRxC does.

The practice of antenatal colostrum expression (ACE), or the extraction of colostrum from the breasts during pregnancy, has an interesting history and continues to evolve. This narrative review aims to describe how perception and practices of ACE have changed over time, summarise the evidence on ACE in maternal and infant care, and highlight areas for future research. The literature demonstrates that ACE is safe for low-risk women when done from around 36 weeks’ gestation. Women should be reassured that the skill of hand expressing is a valuable tool post-birth, regardless of whether they are able to collect colostrum antenatally or not. The collection and storage of colostrum in pregnancy can help avoid formula use in hospital, which may have follow on effects immune function and other areas. Ideally, colostrum collected during pregnancy would be kept safely frozen during the hospital stay and only defrosted and used during the stay if medically indicated, with parents supported through that process. Although ACE does not appear to improve long-term breastfeeding rates at present, it can increase confidence around breastfeeding. Further research in more diverse population groups, long-term breastfeeding and long-term health outcomes of using frozen antenatally expressed colostrum for babies (as compared to formula or fresh colostrum) would be valuable to gain a better understanding of the importance of ACE in maternity care.

Although transboundary crises have gained relevance in an increasingly interdependent world, our understanding of the relational dynamics governing these phenomena remains limited. This paper addresses this knowledge gap by identifying common characteristics across interorganizational transboundary crisis networks and drivers of tie formation in successful structures. For this purpose, it applies descriptive Social Network Analysis and Exponential Random Graph Models to an original dataset of three networks. Results show that these structures combine elements of issue networks and policy communities. Common features include moderately high centralization, reciprocated ties, core-periphery structures, and the popularity of international organizations. Additionally, successful networks display smooth communication between NGOs and international organizations, whereas unsuccessful networks have fewer heterophilous interactions. Transitivity seems to play a role in network success too. These findings suggest that crisis networks are robust structures that reconcile bridging and bonding dynamics, thereby highlighting how evidence from relational studies could guide transboundary crisis management.

Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced to a new level of rapid development in tumour treatment, their limited therapeutic effectiveness and unexpected side effects prevent them from becoming the first option in clinical treatment. With rapid advancement in nanotechnology, the utilization of nanomaterials in therapeutics offers the potential to address the shortcomings in cancer treatment. Notably, multifunctional metal-organic framework (MOF) has been widely employed in cancer therapy due to their customizable shape, adjustable diameter, high porosity, diverse compositions, large specific surface area, high degree of functionalization and strong biocompatibility. This paper reviews the current progress and success of MOF-based multifunctional nanoplatforms for cancer starvation therapy, as well as the prospects and potential barriers for the application of MOF nanoplatforms in cancer starvation therapy.