Compromised kidney function is associated with an array of environmental contaminants and pathogens that may be considered for regulation. However, there are few valuation estimates for kidney effects for use in benefit–cost analyses, particularly willingness-to-pay estimates. This paper is one of several surveys valuing morbidity developed by the OECD Surveys to elicit Willingness-to-pay to Avoid Chemicals-related negative Health Effects project, which aims to improve the basis for benefit–cost analyses. We report the results of a stated preference survey valuing reduced the risk of symptomatic chronic kidney disease, filling an important gap in the valuation literature and addressing a need for applied benefits analysis of chemical regulation. The survey was administered to representative samples in each of 10 countries: Canada, Chile, China, Denmark, Germany, Italy, Norway, Türkiye, the United Kingdom, and the United States. The mean (median) WTP for an average reduction of 3.5 in 1,000 of the risk of serious kidney disease over 5 years is $2,609 ($764), corresponding to a mean (median) value per statistical case (VSC) of chronic kidney disease of $805,000 ($224,000). The mean VSC varies between $700,000 for Canada and $1,200,000 for Türkiye.

This paper is written at a tipping point in the development of generative AI and related technologies and services, which heralds a new battleground between humans and computers in the shaping of reality. Large language models (LLMs) scrape vast amounts of data from the so called ‘publicly available' internet, enabling new ways for the past to be represented and reimagined at scale, for individuals and societies. Moreover, generative AI changes what memory is and what memory does, pushing it beyond the realm of individual, human influence, and control, yet at the same time offering new modes of expression, conversation, creativity, and ways of overcoming forgetting. I argue here for a ‘third way of memory’, to recognise how the entanglements between humans and machines both enable and endanger human agency in the making and the remixing of individual and collective memory. This includes the growth of AI agents, with increasing autonomy and infinite potential to make, remake, and repurpose individual and collective pasts, beyond human consent and control. This paper outlines two key developments of generative AI-driven services: firstly, they untether the human past from the present, producing a past that was never actually remembered in the first place, and, secondly, they usher in a new ‘conversational’ past through the dialogical construction of memory in the present. Ultimately, developments in generative AI are making it more difficult for us to recognise the human influence on, and pathways from, the past, and that human agency over remembering and forgetting is increasingly challenged.

This paper looks at the progress that the Mosaic database has enabled in the study of family structures in continental Europe in the past. Our main argument is that the combination of comprehensive archival research, digitization and computation, data mining, and open-access dissemination that is at the core of the Mosaic project is bringing about an important shift in the fundamental principles that have driven European family history research to date. These transformative features of Mosaic go beyond mere data infrastructural developments, as scaling up to much larger datasets leads to qualitative differences in measurements, methods, and questions. Integrating these perspectives can lead to an important incremental shift in both the scale and the scope of knowledge about historical European family systems.

Moral naturalists are often said to have trouble making sense of inter-communal moral disagreements. The culprit is typically thought to be the naturalist’s metasemantics and its implications for the sameness of meaning across communities. The most familiar incarnation of this metasemantic challenge is the Moral Twin Earth argument. We address the challenge from the perspective of analytic naturalism and argue that making sense of inter-communal moral disagreement creates no special issues for this view.

A narrowly person-affecting (NPA) axiology is an account of the moral ranking of outcomes such that the comparison of any two outcomes depends on the magnitude and weight of individuals’ well-being gains and losses between the two. This article systematically explores NPA axiology. It argues that NPA axiology yields an outcome ranking that satisfies three fundamental axioms: Pareto, Anonymity and, plausibly, Pigou-Dalton. The axiology is neutral to non-well-being considerations (desert); and (assuming well-being measurability) leads to the Repugnant Conclusion (RC). In short, NPA axiology provides a grounding for Paretian, equity-regarding welfarism, albeit one that includes the RC.

In response to the short-term political cycles that govern law-making, there is growing international attention to the obligations owed to future generations. Within the diverse approaches there is often a single, temporally defined inequality; that is, between now and a depleted future. While inequality is imagined between generations, these generations are often constructed as homogenous. This elides not just contemporary inequalities, but that these injustices are caused by historically rooted inequalities that current planetary threats are likely to deepen. In response, we centre health inequalities which illustrate the complex temporalities and structural causes of inequalities. We argue for a focus on eco-social and embodied generations to better understand – and respond to – inequalities past, present and future. We apply this focus to the Capabilities Approach as an example of the work needed to better articulate what is owed to present and future generations to secure justice and inform future-oriented law-making.

Several scholars noted that the pronunciations of 天 “sky” tiān and 風 “wind” fēng in Bai appear to be akin to the western variants of the words attested in the paronomastic gloss dictionary Shìmíng 釋名. I will demonstrate in the current study that there are additional commonalities shared by both Bai and the ancient western dialect, termed Old Western Chinese (OWC) in this study. In both languages, one can identify words with zy- in Middle Chinese (MC) that are pronounced j-. Bai and Old Western Chinese use the same word (椹 shèn) for “fungus”. Furthermore, Old Chinese (OC) cluster *-p/t-s yields -t in both languages in lieu of yielding -j as observed in Middle Chinese. Last but not least, it appears that in both languages, words with *lˤ- (whence MC d-) and -ʔ (whence MC rising tone) are distinct from other words with d- in Middle Chinese. Hence, this paper puts the claim that Bai is akin to Old Western Chinese on a stronger footing. As a side note, judging from the fact that 四 “four” sì contains -t in Old Western Chinese and early Bai, its Old Chinese form most likely ends in *-[t]-s.

The rumen microbiome has attracted tremendous interest among microbiologists and ruminant nutritionists because of its crucial role in mediating feed digestion and fermentation and supplying most of the energy, nutrients, and precursors for producing ruminant products. The application of various omics technologies, including metataxonomics, metagenomics, metatranscriptomics, metaproteomics, and metabolomics, have enabled unprecedented investigations into this ecosystem, shedding new light on its interactions with diet and animals and its relationships with key production traits. Despite the valuable insights these omics technologies provide, each has its unique utility and inherent limitations. Achieving a holistic characterization of the rumen microbiome and deciphering its causal relationship with diet and key animal production traits remain an ongoing endeavor. In this perspective review paper, we highlight the limitations of individual technologies and advocate for an integrated multi-omics approach and data analyses in studying the intricate relationships between diet, rumen microbes, and ruminant nutrition. This approach, termed “rumen microbiome nutriomics,” aims to comprehensively understand the rumen microbiome in the context of diets and animal productivity. Our emphasis lies in recognizing the necessity of integrated analysis across multiple data layers, encompassing data of diet, rumen microbiome features, animal genotypes, and production traits and identifying the causal relationship among them. We also call for collaborative efforts to develop a comprehensive rumen microbiome genome database, including prokaryotes, protozoa, fungi, and viruses. Furthermore, standardization of processes and analyses is crucial to address the variability observed in the literature, facilitating comparison of results among future studies and enabling robust data reanalysis through advanced data analytics.

Research on the relationship between performance and trust is commonplace in social sciences, yet trust in child protection systems (CPS) remains an emerging area of study. This research delves into how three dimensions of performance – distributive justice, procedural fairness, and functional effectiveness – affect trust in CPS in England and Norway, drawing insights from organisational and social psychology literature. A cross-sectional survey collected data from 981 individuals in England and 1,140 in Norway. Results suggest that procedural fairness and the competences indicator of functional effectiveness significantly and positively impact trust in CPS in both countries. Resources significantly influence trust in Norway’s CPS, while distributive justice has no impact on trust in either country’s CPS. These findings hold theoretical and practical implications for trust in CPS.

Phishing emails cost companies millions. In the absence of technology to perfectly block phishing emails, the responsibility falls on employees to identify and appropriately respond to phishing attempts and on employers to train them to do so. We report results from an experiment with around 11,000 employees of a large U.S. corporation, testing the efficacy of just-in-time feedback delivered at a teachable moment – immediately after succumbing to a phishing email – to reduce susceptibility to phishing emails. Employees in the study were sent an initial pseudo-phishing email, and those who either ignored or fell victim to the phishing email were randomized to receive or not receive feedback about their response. Just-in-time feedback for employees who fell victim to or ignored the initial pseudo-phishing email reduced susceptibility to a second pseudo-phishing email sent by the research team. Additionally, for employees who ignored the initial email, feedback also increased reporting rates.

In the mid-20th century, The Cold War structured possibilities for politics across the Global South. These strategies were articulated through three competing means to realize the justice and equality promised by newly won independence from colonialism. Global South states could choose from among the following three options, which had many overlaps and intersections: alignment with the United States, alignment with the Soviet Union, and non-alignment. By the 1970s and into the 1980s, left- and right-wing alternatives developed to oppose the limitations of these three perspectives. On the left, Maoism inspired anti-imperialists of the Global South and also sympathizers in the North who stood in solidarity with anti-imperialist struggles. On the right, newly oil-wealthy Saudi Arabia developed a puritanical Islamic alternative to Maoist anti-imperialism and promoted these ideas across Africa and Asia. These ideas did not fall from public consciousness with the formal collapse of the Soviet Union and live on today. My article assesses the different templates for political and economic development that the Cold War engendered, focusing on the legacy of left and right alternatives developed in reaction to their failures. I conclude that these ideological contestations from the Global South reveal that the Cold War was not a mere rivalry between the United States and Soviet Union, it was a global ideological contestation over liberalism; the constituting ideology of capitalism.

This experiment aimed to investigate the impacts of tributyrin (TB) dietary supplementation on serum biochemical indices and meat quality characteristics of longissimus thoracis et lumborum (LTL) muscle of lambs after weaning. Thirty healthy Small-Tailed Han female lambs (27.5 ± 4.1 kg; mean ± standard deviation) were randomly assigned to five treatments: basal diet (1) without TB, (2) with 0.5 g/kg TB, (3) with 1.0 g/kg TB, (4) with 2.0 g/kg TB or (5) with 4.0 g/kg TB. Each treatment consisted of six lambs, and the lambs were weaned on d 90 and were raised until d 165. Results showed that supplementing TB significantly promoted serum immunoglobulin concentrations of lambs such as immunoglobulins G, A and M. Besides, TB significantly increased muscle ether extract content, intermuscular fat length, pH value and redness but decreased lightness, drip loss and shear force. In addition, TB significantly elevated inosine-5ʹ-phosphate content and upregulated the relative expressions of genes related to lipid metabolism such as SREBP-1C, SCD, PPARγ, FAS and LPL. The mostly important, TB significantly enhanced essential amino acids (EAAs) and conjugated linoleic acids contents of the LTL muscle, despite it decreased total unsaturated fatty acids level. In conclusion, supplementing TB not only could promote the healthy status of weaned lambs via promoting serum immunity but also may improve nutritional quality of LTL muscle by improving EAA and conjugated linoleic acid contents.

Here we investigate present tense verbal -s/zero variability in a dialect of Eastern England in which -s marking can only appear in third-person singular contexts. Our objective is to explore constraints on -s/zero marking, and to consider the grammatical function of -s in such a variety. In order to investigate this, we reanalyzed verbal -s/zero marking in 63 sociolinguistic interviews found in Peter Trudgill’s (1974) corpus from Norwich. The results show not only a significant role for subject animacy (animate subjects mark -s less than inanimates) and lexical (punctual verbs mark -s less than duratives) and structural aspect (punctual and habitual events mark less -s than durative ones), but also an interaction between animacy and aspect. To account for the findings, we draw upon the notion of differential subject marking (e.g., Aissen, 2003), which considers the role of the canonicity of arguments in accounting for morphological marking.

The global challenge of methane emissions from enteric fermentation is critical, as it contributes significantly to atmospheric greenhouse gases and represents a loss of energy that could otherwise be utilized by ruminants. With the increasing demand for dairy and meat products, finding effective methods to reduce methane production is essential. This review explores the use of advanced meta-omics techniques – including metagenomics, metatranscriptomics, metaproteomics, and metabolomics – to deepen our understanding of ruminal methane production and identify potential strategies for its mitigation. These high-throughput technologies provide comprehensive insights into the rumen microbial communities and their metabolic functions by analyzing DNA, RNA, proteins, and metabolites directly from environmental samples. Metagenomics and metatranscriptomics offer a detailed view of microbial diversity and gene expression, while metaproteomics can identify specific enzymes and proteins directly involved in methane production pathways, revealing potential targets for mitigation strategies. Integrating these meta-omics approaches allows for a holistic understanding of the microbial processes that drive methane emissions, enabling the development of more precise interventions, such as tailored dietary modifications and the use of specific inhibitors. This review underscores the importance of a multi-omics strategy in characterizing microbial roles and interactions within the rumen, which is crucial for devising effective and sustainable methods to reduce methane emissions without compromising livestock productivity.

A too rarely emphasized feature of modern deontological ethics is the structure of its directives. Faced with alternatives, the question for the moral agent is “which, if either, must I perform (or avoid)?” Getting it right, one is, morally speaking, done…until the next set of freighted options presents. We should wonder whether this makes sense: whether there is not a more complex structure to deontological requirements that resists the “one and done” idea. Rehabilitating the Kantian idea of duty as a value-based deliberative principle, I argue for a more plausible deontology whose requirements are often temporally extended and interpersonally complex.