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Up to 75% of dementia patients will experience behavioural (non-cognitive) symptoms in their lifetime. Therefore, it is important to ensure delivery of high level of quality care to these set of patients.
The NICE guideline recommends that:
1. Non-pharmacological method should be used before pharmacological method in the management of behavioural symptoms.
2. When antipsychotics are used, they should be started at low dose and increased slowly.
3. Those started on antipsychotics should have follow up at least 6 weeks after commencement.
Aim: The audit aims to compare the care we give dementia patients with behavioural symptoms against the NICE guideline.
The objectives are:
1. To assess use of non-pharmacological method before pharmacological method in the management of behavioural symptom in dementia patients.
2. To assess antipsychotic prescriptions in the management of behavioural symptoms in dementia patients.
3. To assess if patients started on antipsychotics were properly followed up.
Methods
Electronic records of 34 patients who met the inclusion criteria were assessed and information related to the objectives were extracted. Data was stored securely in the trust laptop. Analysis of the information was done using Microsoft Excel version 2022. Results were presented in charts.
Results
The result showed that the commonest behavioural symptoms reported was agitation and verbal aggression which accounted for 34% and 29% respectively. About 24% of the patient were commenced on medication for their symptoms without trial of non-pharmacological methods. Out of the patient that were on medications, risperidone was the commonest medication prescribed accounting for 37%. Other medications prescribed included quetiapine, amisulpride and lorazepam. The result also showed that those started on medication were properly followed up according to the NICE guideline.
Conclusion
The audit showed that the NICE guideline is not fully followed, adherence to the guideline is around 75% overall. Efforts should be geared toward enlightening professionals about the need to follow the NICE guideline in managing this condition. It would be worthwhile to re-audit in 12 to 24 months.
To investigate risk assessment and management processes across a health board in the context of the implementation of a new risk screening tool and policy through use of staff focus groups to identify how teams make decisions related to risk and gain an understanding of how the new CRAFT tool is used.
In mental health services, risk assessment and management are key responsibilities for clinical staff. A risk management tool that is structured and evidence-based aims to assist staff in managing risks including violence, self-harm, suicide and self-neglect.
It is not clear whether risk tools have clinical utility in influencing risk-related decision making and previous reviews within the health board indicated that risk policy was not being adhered to, prompting a review of the policy. Furthermore, policy recommends service user and carer collaboration with staff in all areas of mental health in Scotland but despite these recommendations there is little evidence to suggest they are routinely involved in risk assessment and management processes.
The present study is an opportunity to explore how teams think about and discuss risk management.
Methods
A qualitative analysis was carried out of data from two staff focus groups. These groups were identified by contacting interested teams by email. Groups comprised clinical staff from different disciplines within the MDT including medical and nursing staff. Staff were questioned about their understanding of risk, thoughts regarding risk assessment and their experience of being trained in and using the CRAFT tool.
Results
Themes emerging from the data indicate that staff felt the CRAFT had limited clinical utility or impact on their assessment of risk but may prove useful for communicating decisions about risk between staff and services. However, concerns were raised that the format of the tool made it difficult to complete and read, meaning that important information may not be adequately communicated. Staff reported feeling inadequately trained in the use of the CRAFT tool and felt there were inconsistencies in its use across the health board.
Conclusion
Staff focus groups have identified challenges with the completion of the current CRAFT tool and expressed a need for better training in order to improve consistency of use across the health board. An update to the tool is due to be rolled out across the board in an effort to address these issues and improve risk assessment completion on the whole.
Fourth-year medical students from Manchester University undergo a four-week Psychiatry rotation in Stockport as part of their curriculum. Placed in both community and inpatient teams within General Adult and Older Adult Psychiatry services, this placement offers a unique opportunity for students to gain clinical and educational experience in Psychiatry, potentially shaping their perception of the field. This quality improvement project aimed to enhance the overall experience of medical students during their Psychiatry placement in Stockport.
Methods
A retrospective review of quantitative and qualitative feedback from the March to April 2023 cohort (n = 4) involved a 5-point Likert scale and comments covering 10 domains. The feedback focused on aspects such as induction, orientation, learning objectives, patient assessment, procedural skills, supervisor feedback, access to resources, timetables, and the overall experience. An average total score was calculated.
Subsequently, strategies were implemented for the April to May 2023 cohort based on the feedback. Weekly check-ins, updated timetables, team introductions, additional teaching sessions, and opportunities for case presentations were among the interventions.
Quantitative and qualitative feedback from the April to May 2023 cohort (n = 4) were collected and compared with the previous cohort's feedback.
Results
The feedback scores demonstrated improvement, with the average total score increasing from 4.1/5 (82%) in March – April 2023 to 4.7/5 (94%) in April–May 2023. Students praised the helpful staff, opportunities to present cases, and the tailored and useful nature of the placement. Feedback on improvements included addressing vague timetables, unannounced cancellations of teaching sessions, and limited opportunities for case presentations.
Conclusion
This quality improvement project demonstrated that the targeted interventions helped enhance the educational experience of medical students during their psychiatry placement. The increased feedback scores underscore the positive impact of targeted interventions. The findings emphasize the importance of continuous quality improvement in medical education, ensuring a more positive and enriching experience for medical students in Psychiatry rotations.
The skill of critical appraisal is mandatory for evidence-based psychiatric practice although the process of learning can be tough for busy psychiatrist trainees. Ironically, reading alone does not translate into skill acquisition. The accessibility to conventional journal clubs may also be limited for doctors working in busy non-academic training centres. Therefore, attending an intensive workshop on critical appraisal skills can be a viable solution. This study elucidated the experience of using an innovative approach, i.e. Multiple Mini Journal Clubs (MMJC), to improve Malaysian trainee psychiatrists’ critical appraisal skills.
Methods
A one-day workshop was conducted for 19 participants who were preparing for MRCPsych Paper B, using the combination of 1) a pre-recorded video lecture with a two-hour question and answer session; 2) three 45-minute stations in a group of three persons to practice critical appraisal of a cross-sectional, a validation, and a randomised controlled study. A standardised approach, i.e. Critical Appraisal in Five Expressed Steps (CAFES), was used by facilitators. CAFES involved asking and answering the following big heading questions while incorporating other standard critical appraisal techniques under each of the headings: 1) What is the research question; 2) Can the research methodology answer the question; 3) Does the result make sense; 4) Are the findings translatable to my setting; 5) How to improve the study if I were to conduct a similar study. Three formative assessments were carried out using Single Best Answer and Extended Matching Items. Qualitative feedback and informed consent were collected.
Results
Hundred per cent of participants agreed that their objective of attending the workshop had been achieved through the MMJC, i.e. learned both the theory and skill of critical appraisal which allowed immediate translation into practice during the MMJC. Nevertheless, there was no statistical difference in participants’ achievement for pre-, mid- and post-workshop formative assessments, i.e. median of 7/25, 7/28, and 8/27 respectively. Positive responses toward MMJC included less performance anxiety in a small group, active interaction, individualised feedback, and fun. The challenges faced included the need for strict time management and a big group of facilitators. Suggestions for improvement included the extension of the workshop duration and breaking up the lecture into several sessions.
Conclusion
Further improvement and re-evaluation of the effectiveness of MMJC is required to optimise learning outcomes.
Graves’ disease, an autoimmune illness, is one of the most common causes of thyrotoxicosis and often presents with classic symptoms of hyperthyroidism. However, patients can rarely present for the first time with psychiatric symptoms, including psychotic and mood symptoms or a combination of both, and there is limited data on the most effective treatment.
Methods
Here, we report the case of a 24-year-old black British female who had no previous psychiatric or medical history, presenting for the first time with one week history of poor sleep, disordered thought, and bizarre and violent behaviour towards family. Collateral history describes her premorbid personality as “anxious and perfectionist”, with the only recent stressors identified being preparations for her best friend's wedding. Her mental state on presentation was remarkable for tangential and circumstantial speech, incongruent affect, and lack of insight into illness. She was admitted to an acute adult ward under Section 2 of the Mental Health Act (MHA) after being “medically cleared” but before the results of her thyroid function tests were available.
She was transferred back to the acute medical ward a day into psychiatric admission, where she was treated medically for thyrotoxicosis and discharged with the support of the Home Treatment Team after an almost complete recovery in her mental state. Initial symptoms recurred two weeks after discharge, culminating in another admission cycle initially to a psychiatric unit under the MHA, where she was treated with oral risperidone and a medical ward for further medical investigations. Her mental state improved significantly again, and she was discharged home to the concerted care of both a community mental health team and follow-up with the endocrinology team. On outpatient psychiatric review a year following discharge, the patient remains stable in her mental state and has achieved a euthyroid state with plans to taper off and withdraw risperidone gradually.
Results
This case shows the importance of a thorough physical health assessment and investigation before making psychiatric management decisions. It also points out the drawback of the divide between physical and mental health services, the impact this has on patient care and experience within the National Health Service, and the mixed success of medical management in controlling psychiatric symptoms.
Conclusion
This case describes the rare presentation and successful management of psychosis induced by thyrotoxicosis in a female patient with Graves’ disease. It highlights the need for prompt, interdisciplinary care to diagnose and safely manage such patients correctly.
Looting and plough damage to the eighth–fifth centuries BC tumulus of Creney-le-Paradis, France, hinders interpretation of this potentially significant site. Nevertheless, application of novel microtomographic techniques in combination with optical and scanning electron microscopy allows the first detailed examination of 99 textile fragments recovered from the central pit. The authors argue that the diversity of textiles revealed—at least 16 different items—and the quality of weaving involved confirm earlier interpretations of the high status of this burial, which is comparable, at least in terms of textiles and metal urns, with other ‘aristocratic’ tombs of the European Iron Age.
The Maghreb (north-west Africa) played an important role during the Palaeolithic and later in connecting the western Mediterranean from the Phoenician to Islamic periods. Yet, knowledge of its later prehistory is limited, particularly between c. 4000 and 1000 BC. Here, the authors present the first results of investigations at Oued Beht, Morocco, revealing a hitherto unknown farming society dated to c. 3400–2900 BC. This is currently the earliest and largest agricultural complex in Africa beyond the Nile corridor. Pottery and lithics, together with numerous pits, point to a community that brings the Maghreb into dialogue with contemporaneous wider western Mediterranean developments.
Governments across the Global South have decentralized a degree of power to municipal authorities. Are local officials sufficiently knowledgeable about how to execute their expanded portfolio of responsibilities? Past studies have focused on whether citizens lack the requisite information to hold local officials accountable. We instead draw on extensive fieldwork and a novel survey of small-town politicians in India to show that local officials themselves have distressingly low levels of procedural knowledge on how to govern. We further show that procedural knowledge shapes the capabilities of officials to represent their constituents and that asymmetries in knowledge may blunt the representative potential of these bodies. Finally, we show that winning office does not provide an institutionalized pathway to knowledge acquisition, highlighting the need for policy-based solutions. Our findings demonstrate the importance of assessing knowledge deficits among politicians, and not only citizens, to make local governance work.
Applications of moral foundations theory in political science have revealed differences in the degree to which liberals and conservatives explicitly endorse five core moral foundations of care, fairness, authority, loyalty, and sanctity. We argue that differences between liberals and conservatives in their explicit ratings of abstract and generalized moral principles do not imply that citizens with different political orientations have fundamentally different moral intuitions. We introduce a new approach for measuring the importance of the five moral foundations by asking U.K. and U.S. survey respondents to compare pairs of vignettes describing violations relevant to each foundation. We analyze responses to these comparisons using a hierarchical Bradley–Terry model which allows us to evaluate the relative importance of each foundation to individuals with different political perspectives. Our results suggest that, despite prominent claims to the contrary, voters on the left and the right of politics share broadly similar moral intuitions.
Recent research suggests that a strong identity attachment to leisure activity affects the hobbyists’ political preferences and behavior. This paper further evaluates the claim that hobbyists – in this case, gamers – react differently to political stimuli that directly involve their hobby of choice. Using original survey experiment data, this paper shows that gamers become more interested in foreign trade policy when presented in the context of video games. This finding indicates that even seemingly apolitical identities matter in framing political behavior. Aspects of hobbyist identities seep into political attitudes, even if preferences in the strictest meaning of the word may take longer to form.
Measurement is the weak link between theory and empirical test. Complex concepts such as ideology, identity, and legitimacy are difficult to measure; yet, without measurement that matches theoretical constructs, careful empirical studies may not be testing that which they had intended. Item response theory (IRT) models offer promise by producing transparent and improvable measures of latent factors thought to underlie behavior. Unfortunately, those factors have no intrinsic substantive interpretations. Prior solutions to the substantive interpretation problem require exogenous information about the units, such as legislators or survey respondents, which make up the data; limit analysis to one latent factor; and/or are difficult to generalize. We propose and validate a solution, IRT-M, that produces multiple, potentially correlated, generalizable, latent dimensions, each with substantive meaning that the analyst specifies before analysis to match theoretical concepts. We offer an R package and step-by-step instructions in its use, via an application to survey data.
Patients prescribed clozapine are increasingly living into old age. However, there is a lack of studies to guide prescribing in this age group. We sought to identify all clozapine patients in Hertfordshire Partnership NHS Foundation Trust over a 5-year period and review side-effect burden and co-prescribing in all patients aged over 65 years.
Results
We identified 69 patients. The majority (61%) were stable in terms of mental state; 94% of cases had experienced a side-effect within the past year, with constipation occurring most commonly (65% of cases).
Clinical implications
Our findings reveal a significant side-effect burden, particularly in relation to constipation. Clozapine-induced gastrointestinal hypomotility (CIGH) can be fatal; however, increasing age has not been a recognised risk factor for constipation in clozapine patients to date. This raises questions about increasing risk to physical health as patients age and adds to concerns about the lack of monitoring for CIGH.
Education is widely believed to predict attitudes toward immigration, but what causal relationship underlies this descriptive pattern? This research employs three distinct natural experiments and considers genetic factors to triangulate this relationship: Study 1 analyses discordant monozygotic twins; Study 2 assesses the impact of a Swedish education reform; and Study 3 analyses dizygotic twins with the use of a polygenic index for education, a DNA-based measure for genetic predispositions toward education. The results indicate that education does modestly promote open views toward immigration (Study 1), yet the reform’s effect remains uncertain (Study 2). Study 3 offers direct evidence of the effects of genetic predispositions and suggests that genetics related to education may influence attitudes beyond achieved educational attainment. These findings confirm the positive impact of education while pointing to the combined influence of genetic and social pathways in shaping immigration attitudes.
In this paper, we explore the applications of Tail Variance (TV) as a measure of tail riskiness and the confidence level of using Tail Conditional Expectation (TCE)-based risk capital. While TCE measures the expected loss of a risk that exceeds a certain threshold, TV measures the variability of risk along its tails. We first derive analytical formulas of TV and TCE for a large variety of probability distributions. These formulas are useful instruments for relevant research works on tail risk measures. We then propose a distribution-free approach utilizing TV to estimate the lower bounds of the confidence level of using TCE-based risk capital. In doing so, we introduce sharpened conditional probability inequalities, which halve the bounds of conventional Markov and Cantelli inequalities. Such an approach is easy to implement. We further investigate the characterization of tail risks by TV through an exploration of TV’s asymptotics. A distribution-free limit formula is derived for the asymptotics of TV. To further investigate the asymptotic properties, we consider two broad distribution families defined on tails, namely, the polynomial-tailed distributions and the exponential-tailed distributions. The two distribution families are found to exhibit an asymptotic equivalence between TV and the reciprocal square of the hazard rate. We also establish asymptotic relationships between TCE and VaR for the two families. Our asymptotic analysis contributes to the existing research by unifying the asymptotic expressions and the convergence rate of TV for Student-t distributions, exponential distributions, and normal distributions, which complements the discussion on the convergence rate of univariate cases in [28]. To show the usefulness of our results, we present two case studies based on real data from the industry. We first show how to use conditional inequalities to assess the confidence of using TCE-based risk capital for different types of insurance businesses. Then, for financial data, we provide alternative evidence for the relationship between the data frequency and the tail categorization by the asymptotics of TV.
What shapes voter perceptions of election outcomes? Recent disputes in Malawi and Kenya highlight the vulnerability of local vote counts to accusations of malfeasance, which often generate negative public perceptions of vote reliability. Election monitoring in these countries is thought to crucially affect both the quality of the election and voters’ perceptions of the same. To date, most research on this topic has focused on the effect of non-partisan electoral observers. However, in many countries, two other interest groups also monitor the vote-counting process: political party agents and government election officials. Does the presence of these actors also affect voter perceptions of election integrity? To answer this question, I conducted a conjoint experiment in Malawi and Kenya in which voters evaluate the reliability of vote counts from hypothetical polling stations where the presence of party agents, non-partisan observers, and election officials is varied. I find that the presence of each of these groups does indeed shape voter perceptions: voters are more likely to view vote counts as reliable when they are co-signed by a party agent, election official, or non-partisan observer. Further, these preferences persist regardless of the voters’ own party affiliation or trust in electoral institutions.
Anxiety disorders are a major public health burden with limited treatment options.
Aims
We investigated the long-term safety and efficacy of lysergic acid diethylamide (LSD)-assisted therapy in patients with anxiety with or without life-threatening illness.
Method
This study was an a priori-planned long-term follow-up of an investigator-initiated, two-centre trial that used a double-blind, placebo-controlled, two-period, random-order, crossover design with two sessions with either oral LSD (200 μg) or placebo per period. Participants (n = 39) were followed up 1 year after the end-of-study visit to assess symptoms of anxiety, depression and long-term effects of psychedelics using Spielberger's State-Trait Anxiety Inventory–Global (STAI-G), the Beck Depression Inventory (BDI), the Persisting Effects Questionnaire and measures of personality traits using the NEO-Five-Factor Inventory.
Results
Participants reported a sustained reduction of STAI-G scores compared with baseline (least square means (95% CI) = −21.6 (−32.7, −10.4), d = 1.04, P < 0.001, for those who received LSD in the first period (94 weeks after the last LSD treatment) and −16.5 (−26.2, −6.8), d = 1.02, P < 0.05, for those who received LSD in the second period (68 weeks after the last LSD treatment)). Similar effects were observed for comorbid depression with change from baseline BDI scores of −8.1 (−13.2, −3.1), d = 0.71, P < 0.01, and −8.9 (−12.9, −4.9), d = 1.21, P < 0.01, for the LSD-first and placebo-first groups, respectively. Personality trait neuroticism decreased (P < 0.0001) and trait extraversion increased (P < 0.01) compared with study inclusion. Individuals attributed positive long-term effects to the psychedelic experience.
Conclusions
Patients reported sustained long-term effects of LSD-assisted therapy for anxiety.
Cocoa-derived flavanols (CDF) may act as prebiotics. However, evidence is inconsistent, and the duration and dose of CDF intake needed to elicit any prebiotic effect are undefined. This randomized, double-blind, crossover study determined the effects of short-term, high-dose dietary supplementation with CDF versus matched placebo on gut microbiota composition in 8 healthy adults. A single faecal sample was collected 8 d after supplementation with 900 mg/d CDF or placebo. Gut microbiota composition and Bifidobacterium spp. and Lactobacillus spp. abundance were measured as secondary outcomes by 16S ribosomal ribonucleic acid (rRNA) amplicon sequencing and quantitative polymerase chain reaction, respectively. No between-treatment differences in the relative or absolute abundance of Bifidobacterium spp. (Cohen’s d = 0.89, P = 0.22) or Lactobacillus spp. (Cohen’s d = 0.42, P = 0.65) were detected. Shannon diversity (Cohen’s d = 0.38, P = 0.04) and overall community richness (Cohen’s d = 0.34, P = 0.06) were lower following CDF supplementation versus placebo, but no between-treatment differences in β-diversity or taxa relative abundances were observed. Findings are not consistent with a clear prebiotic effect of this short-term, high-dose CDF supplementation strategy relative to placebo.
Community treatment orders (CTOs) have been introduced in many jurisdictions with evidence of increasing use over time as well as a disproportionate use in marginalised populations. Rates of CTOs also vary widely, both internationally and within the same country, for reasons that are poorly understood. This is despite evidence for effectiveness being mixed and, as a result, there have been calls for a reappraisal of this type of legislation. In the UK, a parliamentary committee on reforming the existing Mental Health Act recommended abolishing CTOs other than for people in the criminal justice system. Two recent Australian papers based on large state-wide administrative data-sets give conflicting results and came to markedly different conclusions regarding the desirability of reducing CTO rates. The debate about the effectiveness of CTOs therefore remains unresolved. This is of concern beyond Australia, as other jurisdictions such as England, Scotland and Canada have similar clinician-initiated orders.