To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
New challenges and opportunities are emerging to support young people to learn about socio-ecological risk. While experiences with risk are a daily occurrence, a new phase of history defined by global environmental change will transform lives in complex ways. All young people need to be provided with the knowledge and skills to critique the failings of modernity and learn to manage risk. For that reason, environmental pedagogies need to be balanced with critical understandings of risk across different societies. Forest research in Australia, Nepal and Switzerland highlights that understanding local perceptions of value and risk generates vital knowledge to inform conceptions of sustainable forest management, while providing critical knowledge and processes to support active learning. There are opportunities to guide education systems to help people develop understandings of how beautiful, biodiverse, forested landscapes can be managed sustainably within local socio-cultural contexts. Educators can utilise constructivist pedagogies to identify the values and risks of forests with walks, rides, explorations, monitoring, and analysis of different conceptions of sustainable management. In such a manner, learning about socio-ecological risk develops knowledge and skills, but also supports young people to become advocates and actors for positive change in the forest and beyond.
Erroneously labeled penicillin allergies can lead to prolonged hospitalization, increased adverse effects and infection rates with alternative antibiotics. Although elderly patients are more vulnerable to these negative outcomes, penicillin allergy assessments and de-labeling remain underutilized in this population.
Objective:
To assess the efficacy and challenges of implementing penicillin allergy de-labeling in hospitalized elderly patients.
Methods:
Between March 2024 and April 2025, we conducted a quality improvement study on patients who were 65 years and older, had a penicillin allergy, and were admitted to Burnaby Hospital Acute Care for Elderly (ACE) Unit. Patients were proactively screened, interviewed, and assessed for eligibility in allergy de-labeling based on PEN-FAST score ≤1, predefined criteria, clinical judgment, and patient consent. If penicillin challenge was given, patients received pharmacist follow-up and 4-week outcomes were documented. A post-implementation survey was distributed to ward healthcare staff to identify barriers to implementation.
Results:
Out of 105 patients screened, 87 patients met study inclusion criteria. Among 34 patients deemed eligible for de-labeling, 24 patients (71%) were de-labeled from either oral amoxicillin challenge or information gathering alone. Within four weeks after de-labeling, 10 patients (42%) received beta-lactam antibiotics, and no patients received guideline-discordant broad-spectrum antibiotics. Only 1 patient experienced a delayed reaction to amoxicillin-clavulanate. From surveying ACE unit nursing, physician, and pharmacy staff, frequently reported barriers to allergy assessment and de-labeling included time and staffing constraints, and patient complexity.
Conclusions:
Our pharmacy-driven interdisciplinary penicillin allergy de-labeling initiative is effective and safe for eligible hospitalized older adults with low PEN-FAST scores (≤1).
Sexual-identity disparities in substance use among U.S. veterans, and whether mental-health treatment mitigates risk for those with depression, remain under-examined. Using data on veterans from the 2021–2023 National Survey on Drug Use and Health (NSDUH; N = 7,212), disparities were estimated in past-30-day nicotine, marijuana, binge drinking, and polysubstance use, as well as severe psychological distress (K6≥13) and past-year suicidal ideation. Guided by a biosocial/minority-stress framework, multiple imputation was applied (m = 20) and survey-weighted logistic regression adjusting for age, year, race/ethnicity, sex, education, metro status, insurance, marital status, employment, and income; among veterans with a past-year major depressive episode (MDE), interactions were tested between sexual identity and (a) depression-related clinical contact (DRC) and (b) prescription medication for depressive feelings. Bisexual veterans showed the highest prevalence of marijuana (33.5%) and polysubstance use (30.6%), exceeding that of heterosexual (11.8%, 14.9%) and gay/lesbian veterans (24.0%, 18.8%). Models restricted to veterans with MDE, past-year DRC (DRC defined as any visit or conversation with a health professional about depressive feelings) moderated risk for gay/lesbian veterans, with DRC associated with lower odds of binge drinking and polysubstance use; prescription medication showed a similar moderating pattern for nicotine and polysubstance outcomes. Findings for severe psychological distress and suicidal ideation were mixed and consistent with confounding by indication. Results should be interpreted cautiously given the cross-sectional data, self-report, small sexual-minority subgroups, and non-aligned recall windows (past-year mental health/treatment vs past-30-day substance use). Overall, sexual-identity disparities in substance use are evident, with bisexual veterans bearing the greatest burden, and engagement in DRC and medication among veterans with MDE, particularly gay/lesbian veterans, showing associations consistent with a buffering effect of affirming care. Longitudinal and qualitative studies are needed to test causal pathways and to illuminate lived experiences, and policy/clinical efforts should expand culturally competent, integrated services and routine SOGI data collection to monitor and reduce inequities.
This study aimed to investigate leptin (LEP) (G-2548A) and leptin receptor (LEPR) (668A>G) gene polymorphisms in schizophrenia patients with and without suicide attempts, compared to controls.
Methods:
The study included 120 patients with schizophrenia and 130 healthy volunteers. Sociodemographic characteristics, suicidal behavior, and symptom severity were assessed using data collection forms. Gene polymorphisms were analyzed from DNA samples using the polymerase chain reaction–restriction fragment length polymorphism.
Results:
The LEP genotype distribution in schizophrenia patients differed significantly from controls, with the heterozygous GA genotype more frequent in controls (p = 0.026). Within schizophrenia, LEPR genotype distribution differed by suicide attempt history; the heterozygous AG genotype was more frequent in non-attempters (p = 0.048). Logistic regression showed that the LEPR polymorphism (p = 0.023), number of hospitalizations (p = 0.036), and Positive and Negative Syndrome Scale-psychopathology score (p = 0.023) predict suicide attempt history in schizophrenia.
Conclusion:
Our findings suggest that LEP polymorphism may contribute to schizophrenia susceptibility, while LEPR polymorphism may be linked to suicide attempts in schizophrenia.
Climate hazards impact pastoral communities due to their dependency on nature for their primary livelihoods. This study analyzes climate risk in ten pastoral livestock farming communities in Patagonia drylands of Argentina. A participatory impact chains (PICs) approach was used as a qualitative and participatory bottom-up methodology allowing for the identification and contextualization of climate hazards, exposure, intermediate impacts and vulnerability dimensions through knowledge co-production with local stakeholders. Results show that, although drought is the predominant climate hazard across the region, its impacts are heterogeneous and mediated by local socio-environmental conditions. The analysis underlines that vulnerability is not evenly distributed but is shaped by specific historical, political and environmental pathways. These findings challenge standardized top-down risk assessments, and highlight the need for adaptation strategies that are context-sensitive, territorially differentiated and that integrate local knowledge. The study also contributes to advancing qualitative participatory methodologies for climate risk assessment in pastoral systems in arid areas of Latin America, showing the regional heterogeneity and social inequalities.
At the low-coherence Kunwu laser facility with a 0.6% bandwidth, we experimentally studied the laser absorption efficiency of laser–target coupling at intensities of (3–5) × 1014 W cm–2. To characterize side scattering across a wide angular range, we developed a novel radiochromic film-based diagnostic system, which enables continuous spatial mapping over approximately π steradians for the first time. The results indicate a substantial reduction in total loss rate (by more than three times) when compared to a monochromatic laser. We focused on analyzing the influence of laser bandwidth on stimulated Brillouin scattering and stimulated Raman scattering (SRS). Notably, we found that the broadband laser enhances SRS at high intensities, which is contrary to the results obtained at low intensities. These results highlight the role of bandwidth as a quantitative control parameter for improving laser–plasma coupling, which is of particular significance for advancing direct-drive inertial confinement fusion.
This study proposes a new qualitative method in historical pragmatics to extract politeness formulae for master-servant directives from nineteenth-century French advice literature. Whereas traditional politeness models study strategic face-saving, this study investigates non-strategic, routinized or conventionalized politeness by mapping explicit linguistic instructions in historical prescriptive metasources. Because etiquette and conduct books targeted middle-class households – typically defined as having at least one live-in servant – they routinely discussed interactions with servants. The self-built corpus comprises 43 sources: etiquette and conduct manuals, alongside servant manuals. Through close reading I manually extract politeness formulae, which are compiled into a formulary. Historians underline servants’ harsh conditions and social erasure, typically mirrored by bare imperatives. Advice on a kind prosody is widespread, but politeness formulae (e.g. voulez-vous? – je vous prie) only emerge in the 1870s, when the crisis of domestic service begins. This shift suggests that domestic service was increasingly viewed in transactional rather than purely hierarchical terms. Despite these changes, master-servant, servant-master and peer directives remain rigidly compartmentalized. The article addresses a notable gap in French historical im/politeness studies by showing how politeness formulae in prescriptive discourse reveal the persistence of caste-like social structures in nineteenth-century French domestic service.
The decline of native plant species associated with alien plant invasion is often assumed to be driven by competitive exclusion. However, invasive alien plant species could also directly or indirectly impact native plants by limiting reproductive success. Here, we tested whether invasive alien plants influence seed production, viability, and germination using the Benjoin [Terminalia bentzoe (L.) L.f. subsp. bentzoe], a critically endangered tree endemic to the Mascarene Islands (southwest Indian Ocean), as a model species. Seed production was estimated from seed densities under the canopy of adult individuals from one of the largest remaining subpopulations of the species (in Cirque de Mafate, Reunion Island). Seed viability was determined using a tetrazolium test on the different sets of seeds collected in the field. Densities of seeds and viable seeds were then tested for correlation with the percentage cover of invasive alien plant species in the liana, tree, shrub, and herbaceous forest layers. Seed germination was studied by sowing seeds in soils where three alien invasive plants, three endemics, and T. bentzoe subsp. bentzoe had previously been grown. Seed production and viability decreased with increasing abundance in invasive alien plants in the liana and tree strata but not in the lower vegetation strata. Mechanisms specific to tall-statured invasive alien plants could include competition for resources, interference with pollinator behavior and mechanical constraints. Seed germination was inhibited by the invasive alien succulent Mauritius hemp [Furcraea foetida (L.) Haw.] and T. bentzoe subsp. bentzoe itself, but enhanced by the endemic tree species Poupartia borbonica J.F.Gmel. These species may differ in their resource use intensity, associated microbial communities, and allelopathic effects. Our findings therefore suggest that plant invasions can significantly contribute to the decline of native plants through reduced reproductive ability and induce an extinction debt due to a lack of regeneration.
This paper explores the enduring tension between rational technique (technē) and creative intuition in art, tracing its origins from Plato’s Ion through Kant’s notion of genius as nature’s unteachable rule-giving via the productive imagination. It then examines Jacques Maritain’s and Étienne Gilson’s complementary Thomistic aesthetics as a unified resolution. Maritain locates creative intuition in the soul’s spiritual unconscious, a pre-conceptual grasp of Being (esse) uniting intellect, imagination, and senses in a metaphysical act mirroring divine creation, where poetry reveals beauty as transcendent radiance. Gilson, conversely, emphasizes art as cognitio factiva: the craftsman’s imposition of intelligible form on matter, producing an ontological entity that manifests Being’s splendor objectively, independent of subjectivity. Addressing modern unbelief, the analysis affirms that beauty depends on Being, not belief; even non-theistic artists intuitively participate in esse through form, yielding works that testify to divine reality despite denial.
Parental adverse childhood experiences have been associated with poorer health outcomes for children in the general population. This single-centre study examined the prevalence of parental adverse childhood experiences in a sample of young children with single ventricle CHD, the associations between parental adverse childhood experiences and child health outcomes, and the moderating effects of parental stress and social support on the relationship between parental adverse childhood experiences and child health outcomes.
Method:
Parents (N = 72) responded to questionnaires assessing demographic characteristics, parental adverse childhood experiences, social support, and stress. Child health outcomes (hospital admissions, length of stay, missed appointments) were assessed via parent-report and medical record review.
Results:
Half of parents (52.8%) endorsed exposure to at least one adverse childhood experience. In univariate analyses, children whose parents had a history of adverse childhood experiences were 1.78 times as likely to have more parent-reported hospital admissions (p = 0.002) and 2.22 times as likely to have more missed visits (p = 0.03) compared to children of parents without a history of adverse childhood experiences. Parental social support significantly moderated the relationship between parental adverse childhood experiences and total hospital length of stay (p = 0.03). Specifically, for each unit increase in parents’ social support total score, parents with a history of adverse childhood experiences were likely to have an 83% reduction in their child’s length of stay.
Conclusions:
Parental adverse childhood experiences may be associated with poorer single ventricle CHD outcomes. Strengthening parental social support may improve health outcomes for children with single ventricle CHD in the setting of pre-existing psychosocial risk.
While climate adaptation has been widely viewed as a local problem, more national government strategies are also needed to achieve more favorable policies. We seek to direct attention to the impacts of national government adaptation policies on attitudes of vulnerable citizens. Specifically, we argue that responses to different forms of climate disaster, such as flooding (as opposed to drought), can more readily reduce citizens’ trust in government. Examining extreme weather victim views in Guatemala, one of the world’s most vulnerable nations, we consider differences in the impacts of flood-related extreme weather and drought-related extreme weather. Using a 2023 national survey with flood and drought over-samples, we show that flood zone respondents, especially those reporting firsthand climate impacts, have a more negative view of government adaptation performance than those suffering “slow harms” droughts which respondents did not as readily attribute to climate change.
This work explores the travels of Ugandan Enoch Olinga, as an example of a person who enjoyed connections with global minorities across national boundaries and as a unique lens into the Black international experience in the mid-twentieth century. I examine his internationalist experiences through the lens of emotions to emphasize different dynamics of global racial identities and transnational diasporic connections during the 1950s–1970s, an era of decolonization and civil rights movements. I argue that Olinga, a prominent Baha’i who traveled worldwide during this era, advocated for unification among global minorities by emphasizing common racial and cultural heritages and expansive concepts of a politicized kinship. Through the Baha’i Cause, he articulated his own ideas about striving for global harmony and racial unity, with a connection to Africa serving as the linchpin. Emotional analysis provides insights into how Olinga invoked diverse notions of family and kin to arouse particular emotions amongst people of color both within and beyond the unity offered by the Baha’i Faith.
There has been growing public interest in traditional cheese production and consumption over the past decade, in contrast to the 1990s and 2000s, when food safety regulations excluded traditional cheesemakers from Turkey’s dairy commodity chains. This article focuses on two cheeses, Kars Kaşarı and Boğatepe Gravyeri, designated in 2015 with national Geographical Indication and international Slow Food Presidium labels. Drawing on archival and long-term ethnographic research, we trace the historical trajectory of commercial dairying in Kars and its articulation and disarticulation within national and international commodity chains. Against the backdrop of twentieth-century transformations, we investigate how place-based labels have contested neoliberal agricultural policies that imposed industrialization and standardization on the dairy sector. We argue that the re-articulation of Kars in the 2010s relied on community development and collective action, and practices negotiating between tradition and standardization to establish new conventions of quality. This article conceptualizes re-articulation as a transformative socio-ecological process rather than a simple reversal of disarticulation. It demonstrates how peripheral regions re-enter markets through locally negotiated strategies balancing standardization, authenticity, and solidarity. It also foregrounds material and ecological relations, recognizing the agency of non-human elements – such as pastures and artisanal tools – in shaping value and quality.
This project investigates archaeological material collected from north-west China in the 1920s and housed at the Museum of Far Eastern Antiquities, Stockholm. Finds and archival materials are examined and catalogued to learn about prehistoric cultural interactions and to reconnect discoveries with the original excavation contexts and excavators.
This article examines the EU’s Corporate Sustainability Due Diligence Directive (Directive) and its proposed amendment, especially from a Third World view. It establishes that, practically, the Directive has a limited value for Africans because it cannot stop corporate human rights abuses and economic exploitation in Africa. In contrast, the Directive entrenches neocolonial norms in the Business and Human Rights (BHR) field. This article also argues that it is futile for Third World Peoples to look to international law, given its capitalist history and the growing EU dominance in the BHR treaty discussions. Instead of looking to Europe or international law to save Africans from corporate abuses and economic exploitation, African states must look inward to create subsidiary norms that challenge and resist neocolonialism in the BHR field. To achieve this, it discusses the normative agency of the African Union in leading an Africanization agenda.
An oscillating body floating at the water surface produces a field of self-generated waves. When the oscillation induces a difference in fore–aft wave amplitude squared, these self-generated waves can be used as a mechanism to propel the body horizontally across the surface (Longuet-Higgins 1977 Proc. R. Soc. Lond. A, vol. 352, no. 1671, pp. 463–480). The optimisation of this wave-driven propulsion is the interest of this work. To study the conditions necessary to produce optimal thrust we will consider a shallow water set-up where a periodically oscillating pressure source acts as the body. In this framework, an expression for the thrust is derived by relation to the difference in fore–aft amplitude squared. The conditions on the source for maximal thrust are explored both analytically and numerically in two optimal control problems. The first case is where a bound is imposed on the norm of the control function to regularise it. Secondly, a more physically motivated case is studied where the power injected by the source is bounded. The body is permitted to have a drift velocity $U$. When scaled with the wave speed $c$, the dimensionless velocity $v=U/c$ divides the study into subcritical, critical and supercritical regimes and the optimal conditions are presented for each. The result in the bounded power case is then used to demonstrate how the modulation of power injected can slowly change the cruising velocity from rest to supercritical velocities.
In the third chapter of his book, Reciprocal Freedom, Ernest Weinrib lucidly lays out a Kantian conception of ownership, and deftly lays to rest a series of questions to which that conception might be thought to give rise. Here I explore two issues lying at the root of the Kantian account of ownership as elaborated by Weinrib: The first is how it is that acquired rights to external things are possible in the first place; the second is why, once the possibility of acquired rights is established, the form that they take should be that of a traditional right of ownership, rather than, for instance, a more limited right to use. Ultimately, Weinrib’s discussion leaves me more favorably disposed toward the Kantian view of the possibility of acquired rights, but it seems to leave some important questions about the form of those rights unanswered.
Can we rationally double-check something we already know? Those who say “no” endorse the Ignorance Norm, which states that we should not ask a question whose answer we already know, thereby classifying double-checking as improper. Those who say “yes” reject the Ignorance Norm, instead proposing a broader norm that accommodates double-checking. I argue that both positions are unsatisfactory. Instead, I propose a novel solution that offers two key advantages over existing accounts. First, it preserves the Ignorance Norm. Second, it treats double-checking as a proper form of asking questions. The proposed solution draws on insights from speech act theory, arguing for a distinction between the default way of asking questions – governed by the Ignorance Norm – and the practice of double-checking which is subject to a stronger norm. While in default contexts we ask questions to acquire knowledge, in cases of double-checking we seek further epistemic goods, such as certainty or second-order knowledge.