This research paper addresses the hypothesis that the in vivo criterion of bovine somatic cell count (SCC) < 200,000 cells/ml milk as a diagnostic marker for healthy mammary tissue is not suitable to be adopted to milk samples taken post slaughter. To study immune mechanisms associated with intramammary infections, we developed a mammary explant model. As SCC is routinely applied to differentiate between healthy and inflamed mammary tissue, donor cows were selected based on their milk SCC obtained in vivo. Furthermore, milk cell differentiation for early mastitis detection via flow cytometry allows identification of leucocyte subpopulations and complements SCC. To replace in vivo examination and allow for post mortem selection of donor cows, this explorative study aimed to investigate how slaughter influences the reliability of SCC and differential milk cell count (DMCC) and to assess their validity as diagnostic markers for udder health in bovine milk samples obtained post slaughter. Therefore, quarter milk samples from cows were obtained in vivo and post mortem and analysed to determine SCC and DMCC and identify major mastitis pathogens. The logarithmized numbers of SCC, non-viable cells, viable cells, lymphoid cells, polymorphonuclear (PMN) and large cells per ml milk were compared using linear mixed-effects models in milk samples obtained from cows in vivo and post mortem. The number of lymphoid cells, PMN and large cells was significantly higher in milk samples obtained post mortem than in vivo, with PMN being the most prominent cell population. Higher milk SCC values measured post mortem might be explained by migration of leucocytes into the periphery during slaughter. This should be considered when modelling intramammary infection in vitro using udder tissue. Reflecting these findings, it is not feasible to endorse SCC as a reliable marker for post mortem selection of donor cows with healthy mammary tissue for in vitro models.

Sonic agencies of climate change refers to the relational fluxes of human and nonhuman agencies sounding and musicking the climate crisis. This article discusses what understandings of Indigenous onto-epistemologies of the nonhuman in commercial music can contribute to the notion and vice-versa. In Greenland, site of the rapidly melting North Polar Ice Cap, popular song lyrics in Inuit Greenlandic or Kalallissut as well as their music videos and album cover art engage nonhuman aspects of human internal experiences and societal coming-to-terms around global heating. Sonic agencies of climate change is used here to investigate how emotion, affect, protest, and debate through musicking—which music scholarship tends to approach anthropocentrically—navigate the nonhuman as well as human-nonhuman relationalities. Relevant Greenlandic musical contents pose alternatives to an epistemology behind climate change, while their commercialization relies on environmentally destructive industries. Sonic agencies of climate change may be politically, ideologically and otherwise complex and contradictory.

The Inter-American Commission on Human Rights (IACHR) issued a landmark merits decision in 2025 holding the United States internationally responsible for the torture and death of Mexican national Anastasio Hernández Rojas, and for denying his family justice. The Commission found violations of the protections of life, humane treatment during arrest, health, and access to justice in the American Declaration of the Rights and Duties of Man (American Declaration) and ordered the United States to reopen the criminal investigation, impose sanctions, provide legal remedies and adopt non-repetition measures, including aligning use-of-force standards with international law, such as banning electric shock weapons, after specific legal findings of torture by the European Court of Human Rights and the UN Rapporteur, which both regarded its use as disproportionate, unnecessary, and inhumane.1

This presidential address discusses the developing body of research on the quality and idiosyncrasies of historical data, focusing in particular on historical census microdata. I argue that greater attention to source criticism as a genuine subfield of social science history is essential for four reasons: to fully benefit from the expansion of big historical data, to imagine new ways to analyze historical data beyond the intentions of creators, to share insights with a wider range of scholars, and to contribute nuanced perspectives on historical data to public debates surrounding the use of these sources. I contend that historians outside social science history are vastly underestimating the creativity that is happening in our field. I also argue that social science historians are underestimating how important our work is to informing public discourse.

While physical and mental health are widely recognized dimensions of human well-being, this article introduces philosophical health as a crucial third dimension that addresses our fundamental orientation in life and our deeper sense of purpose. As we face unprecedented global challenges, from environmental and political crises to technological disruption, philosophical health offers practical wisdom for creating what Leibniz called ‘the best of all possible worlds’: one where individual fulfilment and collective flourishing become complementary, offering ‘compossible’ rather than competing goals. The article concludes by suggesting how philosophical health can be cultivated through regular practice, suggesting that this development is essential for addressing our most pressing contemporary challenges.

Electronic dance music is usually produced and played at fixed tempi. However, tempo modulation occasionally appears within a recorded track or DJ performance. This article explores tempo modulation in electronic dance music production and performance, maps out how the technique operates, and explores the technique’s wider potential. Pivot mixing, where a tempo shift is created by reinterpreting a pivot loop as different note values, can be particularly effective in an electronic dance music context when the pivot is expressed as repetitive material carried across the tempo shift. Many modulations between familiar dance music tempi are possible with conventional note values and can serve as DJ tools yet are largely underutilized. Tempo modulation is not a prevalent characteristic in electronic dance music but when it does occur the technique is highly effective and temporally engaging. Pivot mixing expands the temporal vocabulary of electronic dance music from beatmatching in temporal unisons to temporal intervals.

We give a categorical formulation of the p-adic local Langlands correspondence for ${\mathrm{GL}}_2({{{\mathbb{Q}_{p}}}})$ as an embedding of the derived category of locally admissible representations into the category of Ind-coherent sheaves on the moduli stack of two-dimensional representations of$\mathrm{Gal}(\overline{{\mathbb{Q}}}_p/{{{\mathbb{Q}_{p}}}})$. The Montréal functor appears as the‘Whittaker coefficient’ for the universal Galois representation, in the sense of the geometric Langlands program. Moreover, we relate our version of the p-adic local Langlands correspondence for ${\mathrm{GL}}_2({{{\mathbb{Q}_{p}}}})$ to the cohomology of modular curves through a local–global compatibility formula.

This study investigated the independent and interactive effects of dietary behaviors and physical activity on poor sleep quality among 15,059 Chinese adolescents. Using a cross-sectional design, we assessed sleep quality (Pittsburgh Sleep Quality Index, PSQI), dietary habits, and physical activity. Logistic regression and interaction analysis were performed to examine associations, adjusting for covariates. The prevalence of poor sleep quality (PSQI score ≥ 7) was 9.72%. Seven healthy dietary behaviors were identified as protective (e.g., regular diet, abstaining from alcohol; ORs=0.49–0.56). While physical activity showed no independent association, limiting screen-based sedentary screen time(≤2h/day) reduced poor sleep odds by 31% (OR = 0.69). Two significant interactions emerged: abstaining from alcohol combined with limiting sugary beverages synergistically reduced the odds of poor sleep quality by 42% (OR = 0.58), whereas the combination of healthy dining out and high physical activity was associated with a 181% increased odds of poor sleep quality (OR = 2.81). While healthy dietary patterns are strongly associated with better sleep quality, the interplay between behaviors is complex, demonstrating both synergistic protective association and antagonistic outcomes. Findings highlight the need for integrated lifestyle interventions that account for behavioral interactions in promoting adolescent sleep quality.

Cogongrass [Imperata cylindrica (L.) P. Beauv.] is a recalcitrant invasive grass widespread in the southeastern United States. In non-crop systems, management relies on foliar applications of glyphosate and imazapyr; multiple applications over several years are often required, increasing labor, logistical, and chemical costs. Although numerous herbicide alternatives have been evaluated, few match the efficacy of glyphosate or imazapyr. Glufosinate is a broad-spectrum herbicide, and demand for glyphosate alternatives has generated interest in its potential for invasive grass management, but long-term evaluations of glufosinate and tank mixes for I. cylindrica are limited. This study evaluated single foliar spot applications of glufosinate (2.0 kg ae ha−1) alone and in tank mixtures with glyphosate (3.4 kg ae ha−1) or imazapyr (1.1 kg ae ha−1) at three Florida field sites heavily invaded (88% to 92% cover) by I. cylindrica using percent cover and belowground biomass. All treatments containing glufosinate produced rapid foliar necrosis, reducing cover to 15% to 21% within 14 days after treatment (DAT). By 270 DAT, cover increased in the glufosinate-alone (43%) and glufosinate + glyphosate (42%) treatments but remained approximately 25 to 30 percentage points lower than the control. At 540 DAT, cover in these treatments did not differ from that in the control. Across all sites, I. cylindrica cover at 540 DAT was reduced relative to the control by glyphosate (37%), imazapyr (9%), imazapyr + glufosinate (7%), and imazapyr + glyphosate (11%). Notably, the imazapyr + glufosinate mixture produced both rapid and sustained reductions in I. cylindrica cover. These results suggest glufosinate alone provides short-term suppression of aboveground tissue but can be enhanced through tank mixing with soil-active herbicides such as imazapyr to improve long-term suppression of belowground meristems.

Large-language models (LLMs) have transformed natural language processing and opened new possibilities for the computational social sciences and digital humanities. Yet translating historical sources remains difficult because early modern varieties are scarcely represented in contemporary training corpora and because standard tokenizers fragment their non-standard orthography. This article tackles these gaps by adapting open LLMs to early modern Dutch-to-English translation and advances two concrete contributions: (i) a memory-efficient fine-tuning workflow that runs on a single consumer GPU, comparing order-reward policy optimization with the Unsloth supervised fine-tuning approach and (ii) a verifiable evaluation protocol that combines embedding-based metrics with systematic expert review. Experiments on testimonial texts (1680–1792) show that fine-tuning choice decisively shapes quality: the Unsloth-tuned Mistral model attains the highest BERTScore and METEOR values and most faithfully preserves historical nuance. The framework supports a collaborative workflow where machine-generated drafts accelerate expert translation, making archival texts more accessible while maintaining scholarly oversight through domain-expert validation.

Studying social behaviour of mobile and cryptic marine mammals is challenging, particularly for small species like harbour porpoises whom in many areas tend to be challenging to initially spot and then gain repeated observations. Recently, there has been a rise in the number of observations of harbour porpoises occurring in atypical group sizes that are larger than the typical size of two to three individuals. This behaviour, in conjunction with the evolving availability and usability of Unmanned Aerial Vehicle (UAV) technology, is supporting and improving the capture of information on social behaviours. Around Shetland, Scotland, harbour porpoises are sighted from land via opportunistic and systematic surveys year-round with atypical group sizes also observed. To capture information on group size, opportunistic and systematically collected UAV footage were collated and analysed. This revealed sexual approach behaviours in typical group sizes of small groups (two to four individuals), as well as atypical group sizes of medium groups (five to nine individuals), large groups (10 to 19 individuals), and aggregations (≥20 individuals) occur in multiple bays around Shetland. This is the first insight into group sizes and behaviours for the region which was recently designated as an Important Marine Mammal Area (IMMA). Further insight into these social behaviours and group size (e.g. seasonality, site fidelity) could aid harbour porpoise conservation and management within the IMMA and elsewhere.

We investigate whether judges’ political ideology affects corporate tax behaviors. We find that firms engaging in less aggressive tax planning when Circuit Court judges are more liberal. Cross-sectionally, the deterrent effect of liberal judge ideology is more pronounced for firms that engage in judiciary-sensitive tax strategies, face higher enforcement risk from the Internal Revenue Service (IRS), or have larger reputational costs from tax disputes. Our findings further suggest that liberal judge ideology reduces firms’ R&D investments and market value by constraining tax planning. Overall, our evidence highlights the importance of judge ideology for firm behavior in the context of corporate tax planning.

The suitability of marine limpet shells for radiocarbon dating may depend on potential offsets due to diet and habitat, especially with regard to grazing mollusks on carbonate substrates (Dye 1994; England et al. 2013). A previous study on one grazing limpet species on the coast of Ireland found no offsets from carbonate substrates (Allen et al. 2019), but a similar study from mediterranean coasts found significant offsets on carbonate substrates (Ferguson et al. 2011). We carried out a new study of radiocarbon and stable carbon isotopes, using multiple species of mollusks collected live from the coasts of Gibraltar and Sardinia, from both carbonate and non-carbonate substrates. The 14C results indicate that one species, inhabiting the upper shore, has a significant offset at the carbonate locations. This species, Patella rustica, has adapted to tolerate desiccation and may have biological traits that result in higher metabolic-derived carbon incorporated in its shell. The results of this preliminary study imply that selected species of grazing mollusks are suitable for radiocarbon dating, even in areas of carbonate geology.

This article explores the evolving Chinese representations of Queen Victoria from the First Opium War (1839) to her Diamond Jubilee (1897), beginning with early Qing official histories that deliberately omitted or delegitimized her presence, portraying her implicitly as a female usurper whose rule violated Confucian gender norms and dynastic orthodoxy. Such initial silencing is later juxtaposed with increasingly complex portrayals across a broad spectrum of textual and visual sources, including painting captions, diplomatic travelogues, private poems, newspaper reports, and illustrations. Focusing on envoys like Binchun, whose cautious official diary contrasts with his more admiring private poetry, and Zhang Zuyi, whose pseudonymous writings convey ambivalence and critique, the essay examines how rhetorical strategies were shaped by genre, anonymity, and audience. The analysis also extends to popular and elite print culture, particularly Dianshizhai Pictorial and Shenbao, to trace how Queen Victoria’s image circulated among both literate and semiliterate readers. Throughout, the article argues that acts of translation and mediation—visual, linguistic, and ideological—shaped not only perceptions of the British monarch but also reflected the fractured modernity of the Qing empire. The study contributes to global Victorian studies by foregrounding non-Western receptions and complicating imperial iconography through a Sinocentric lens.

Food systems sustainability has interested researchers for decades; one area of interest is developing methods to measure it in various contexts. Our review of the literature finds many studies that have posited metrics and indicators for measuring sustainability in the food system, with most of them relying on secondary data rather than direct inquiry of stakeholders like farmers. This Preliminary Report presents results of farmer perceptions of sustainability, focusing on consumer-facing agriculture (direct market and agritourism) farms in Vermont, as part of the first phase of research in one of a set of projects aimed at developing sustainability metrics. We emphasize metrics that can be used for farm management, marketing, and policy advocacy, and add two dimensions (human and production) to the more common three (ecological, economic, and social). Using interviews from six case studies, we posit indicators across five dimensions of sustainability and identify tradeoffs in achieving them, emphasizing the farmers’ experiences. Our discussion compares and contrasts our results with the literature. Results will form the basis of a statewide farmer survey, which will be conducted in the next year.