Ever since the advent of recombinant DNA technology in the early 1970s concerns have been expressed about the misuse potential of this and subsequent biotechnology breakthroughs. This article focuses on the securitization of gain-of-function (GOF) virology research in the United States, utilizing an updated theoretical framework that distinguishes between “riskification” and “threatification.” The paper examines three distinct cases, two historical, one ongoing. It argues that early attempts to govern GOF research primarily employed a riskification approach, characterized by self-governance by the scientific community. However, the controversy over the origins of the COVID-19 pandemic led to a shift toward threatification, bringing in high-level political actors like the U.S. President and Congress, resulting in the adoption of more restrictive, legally-enforced oversight measures. The article concludes that the application of this theoretical distinction provides a better understanding of how the governance of dual-use research has evolved in the United States.

The frequency and severity of disasters are increasing, and promoting the adoption of digital technologies could enhance the agility, reach, and resilience of humanitarian supply chains. Global patterns of digital innovation in humanitarian supply chains are examined through a systematic quantitative literature review and bibliometric analysis of 4,780 Scopus-indexed documents (2015–2025). Combined with targeted qualitative syntheses, co-word analysis, co-citation mapping, and bibliographic coupling, the analysis reveals digitalisation as an expanding technology-led field, dominated by response-phase applications. Dominant clusters centre on: artificial intelligence-driven forecasting, emerging logistics optimisation, last-mile operations, and data analytics platforms. We interpreted these patterns through the Technology–Organisation–Environment model. It is found that digital technologies are necessary and applicable throughout disaster management phases. A conceptual framework reconfigures Technology–Organisation–Environment domains reflecting the context-driven dynamics of humanitarian supply chains, emphasising resilience. Future research should focus on longitudinal, co-designed case and action research into digital adoption, integration challenges, and community-based knowledge in fostering innovation.

The presence of right-to-left shunt has been proposed as a prominent mechanism of paradoxical embolism in patients with active cancer. We conducted a retrospective observational study including patients presenting to the Ottawa Hospital between January 2020 and December 2022 with ischemic stroke with and without active cancer. Among 491 patients (36.9% female, median age 53), 43 (8.8%) had active cancer, with 12 (27.9%, 95% CI 15–44) having a shunt. Of 448 patients without cancer, 133 (29.7%, 95% CI 25–34) had a shunt. Overall, our finding does not support the hypothesis that cancer-associated stroke is related to right-to-left shunting.

En la segunda década del siglo XXI, varios países latinoamericanos vivieron un ciclo de movilizaciones que antecedió a campañas presidenciales marcadas por la disputa entre candidaturas de izquierdas y derechas. En algunos casos, los actores que participaron de los estallidos respaldaron a candidatos de izquierda; en otros, no. Con base en esta variación este artículo analiza los factores que incidieron en ese apoyo en Ecuador, Perú, Chile y Colombia (2021–2022). Se plantea que dicho respaldo depende de la inclusión programática de sus reivindicaciones y de las estrategias de cooperación o conflicto con las candidaturas. El análisis se desarrolla a través de un rastreo de procesos, utilizando una revisión documental de prensa, programas de gobierno y comunicados. Se concluye que los conflictos endógenos y exógenos entre actores movilizados y candidaturas presidenciales son el factor más relevante para explicar el apoyo o rechazo hacia coaliciones de izquierda.

Political science is a field rich in multimodal information sources, from televised debates to parliamentary briefings. This paper bridges a gap between computer and political science in multimodal data analysis using audio. The adoption of multimodal analyses in political science (e.g., video/audio with text-as-data approaches) has been relatively slow due to unequal distribution of computational power and skills needed. We provide solutions to challenges encountered when analyzing audio, advancing the potential for multimodal data analysis in political science. Using a dataset of all televised U.S. presidential debates from 1960 to 2020, we focus on three features encountered when analyzing audio data: low-level descriptors (LLDs), such as pitch or energy; Mel-frequency cepstral coefficients (MFCCs); and audio embeddings/encodings, like Wav2Vec. We showcase four applications: (a) forced alignment of audio text using MFCCs, time-stamping transcripts, and speaker information; (b) speech characterization using LLDs; (c) custom-made classification models with audio embeddings and MFCCs; and (d) emotional recognition models using Wav2Vec for classification of discrete emotions and their valence-arousal dominance. We provide explanations to help understand how these features can be applied for different political research questions and advice on vigilance to naive interpretation, for both experienced researchers and those who want to start working with audio.

Radiocarbon dating by accelerator mass spectrometry (AMS) requires transforming samples into graphite, a step that typically depends on liquid nitrogen and high-purity carrier gases, increasing both cost and operational complexity. We present μGRAPHILINE, a fully automated, modular combustion–graphitization line that removes these dependencies by combining dual-zone combustion with iron–zinc reduction. Performance was evaluated on more than 180 standards and reference materials targets measured on two independent AMS systems. The μGRAPHILINE consistently achieved >90% graphitization yields, stable backgrounds of ∼0.24 pMC (≈48,500 BP), and sample throughput of ∼3.5 hours per target. Reliable operation was demonstrated for a broad sample-size range, from routine 1 mg C down to ∼0.2 mg C, with ion currents sufficient for precise AMS analysis. The system’s automation, modularity, and low memory effect support improved laboratory throughput and operator efficiency. These results indicate that μGRAPHILINE provides a robust and efficient approach to radiocarbon sample preparation with broad potential applications.

This work demonstrates that magnetohydrodynamic (MHD) stable, quasi-isodynamic (QI) stellarator equilibria with reduced turbulence can be generated with an optimised coilset. We present one such equilibrium which, when being generated by coils, maintains the benefits of its excellent QI quality (low neoclassical transport at small particle collisionality net toroidal current and good fast-particle confinement) while demonstrating ideal-MHD stability and lower ion-temperature-gradient-driven turbulent heat flux than W7-X. As a consequence of its optimised rotational transform profile, this plasma equilibrium has nested flux surfaces and a chain of large islands at the plasma’s edge, for which we present an island divertor design. It additionally features an electron root – a large region in the plasma core in which the radial electric field points outwards, towards the plasma boundary – which provides a potential solution for preventing impurity accumulation in a fusion device.

Can international organizations (IOs) effectively shape attitudes held by individuals? Under what conditions does the public perceive information supplied by IOs as more trustworthy than information provided by other authorities? With the exponential growth of social network platforms, many IOs utilize them to engage individuals directly. Building on the growing literature on IOs’ engagement with the public, we examine if and under what conditions such effort is effective. We adopt insights from the literature on information source effect to theorize that the information disseminated by IOs is more effective than that by domestic health officials in shaping individuals’ attitudes when the IOs are portrayed as impartial and equipped with expertise in the relevant issue area. We test the hypotheses in the context of the World Health Organization (WHO) and the COVID-19-related measures. Our analysis of the survey experiment with a sample of 2865 Americans shows that political independents trust COVID-19-related information provided by the WHO more than information supplied by domestic public health officials, especially when the professional expertise the WHO staff commands is highlighted. In comparison, our analysis indicates that the information source effect is muted when information is delivered to individuals with strongly held existing attitudes, Democrats and Republicans in the case of COVID-19-related information in the United States.

Are nuclear weapons useful for coercion, and, if so, what factors increase the credibility and effectiveness of nuclear threats? While prominent scholars like Thomas Schelling argue that nuclear brinkmanship, or the manipulation of nuclear risk, can effectively coerce adversaries, others contend nuclear weapons are not effective tools of coercion, especially when designed to achieve offensive and revisionist objectives. Simultaneously, there is broad debate about the incorporation of automation via artificial intelligence into military systems, especially nuclear command and control. We develop a theoretical argument that nuclear threats implemented with automated nuclear launch systems are more credible compared to those implemented via non-automated means. By reducing human control over nuclear use, leaders can more effectively tie their hands and thus signal resolve, even if doing so increases the risk of nuclear war and thus is extremely dangerous. Preregistered survey experiments on an elite sample of United Kingdom Members of Parliament and two public samples of UK citizens provide support for these expectations, showing that in a crisis scenario involving a Russian invasion of Estonia, automated nuclear threats can increase credibility and willingness to back down. From a policy perspective, this paper highlights the dangers of countries adopting automated nuclear systems for malign purposes, and contributes to the literatures on coercive bargaining, weapons of mass destruction, and emerging technology.

How does China strategically allocate foreign aid to increase its influence on South China Sea disputes? We posit that China uses foreign aid as a tool of strategic appeasement to manage militarized interstate disputes, particularly targeting claimant states with smaller winning coalitions that are more susceptible to aid influence. The results of our empirical analysis show that China is more likely to allocate aid to the ASEAN SCS claimants with a smaller winning coalition. These findings not only support the notion of foreign aid as a strategic tool employed by China to mitigate tensions in the South China Sea but also highlight the vulnerability of certain recipient states. This article contributes to the foreign assistance and conflict literature by examining the conditionality of claimant donors’ decisions to provide foreign aid to other claimant recipients.

Women tend to be underconfident about their financial knowledge. In this longitudinal study, we tested two interventions intended to raise financial confidence and engagement in positive financial management behaviors among young Canadian women (N = 1119). One intervention included a brief educational task, teaching participants definitions of financial terms. Another intervention challenged social beliefs about financial competence by prompting participants to describe and browse other women’s stories about financial competence experiences on a website. Directly after the interventions, financial confidence ratings from women assigned to either or both of the intervention conditions were about 6% higher than ratings in a control condition. This effect persisted one week later, though a month later the size of the effect had dropped to non-significance. Confidence was linked to better financial management behaviors and more savings. Results also showed that participants in all conditions reported higher financial confidence and better financial management behaviors at later vs. earlier surveys. We conclude that simply reporting on financial attitudes and behaviors over time can increase women’s financial confidence and recommend fostering discourse about finances to close the gender gap in financial confidence.

Based on the High Magnetic field Helicon eXperiment (HMHX), considering parabolic distribution and Gaussian distribution of radial plasma density, the HELIC code was used to study the parameter optimisation design of a helicon wave plasma (HWP) source. Some parameters (antenna type, radio frequency, discharge gas, plasma radius, magnetic field) were selected. The results show that a half-helix antenna is the excitation antenna and a frequency of 13.56 MHz is the most commonly used power source for HMHX. Argon and nitrogen are selected as discharge gases to achieve the best effect of power deposition. In order to realise hydrogen–HWP discharge, a new antenna with plasma radius of 10.5 mm and antenna radius of 13.5 mm can be designed. For the new antenna, when the magnetic field intensity is 1000 Gs, the best discharge effect can be achieved. The results of this paper can provide guidance for the design of a plasma source for HWP discharge under different conditions in the future.

We develop a methodology for conducting inference on extreme quantiles of unobserved individual heterogeneity (e.g., heterogeneous coefficients and treatment effects) in panel data and meta-analysis settings. Inference is challenging in such settings: only noisy estimates of heterogeneity are available, and central limit approximations perform poorly in the tails. We derive a necessary and sufficient condition under which noisy estimates are informative about extreme quantiles, along with sufficient rate and moment conditions. Under these conditions, we establish an extreme value theorem and an intermediate order theorem for noisy estimates. These results yield simple optimization-free confidence intervals (CIs) for extreme quantiles. Simulations show that our CIs have favorable coverage and that the rate conditions matter for the validity of inference. We illustrate the method with an application to firm productivity differences across areas of varying population density. By analyzing the left tails of the productivity distributions, we find no evidence of stronger firm selection in more densely populated areas.

Welwitschia mirabilis, a unique gymnosperm native to Namibia and Angola, is a keystone plant species in the Namib Desert. It represents the only extremely long-lived non-clonal plant species occurring under hyperarid desert conditions, yet limited attempts have been made to accurately determine its age. Here, we present radiocarbon dates from a dead, sectioned Welwitschia of moderate size. We find the outer caudex tissue growth to progressively increase in age from the leaf base towards the ground level in this dwarf tree, while the inner cortex tissue becomes younger. Our sampling strategy revealed that the oldest tissue from this Welwitschia, found at the base of the caudex in the middle of the lobe, was dated to 531 ± 20 14C years, suggesting a vertical growth rate of approximately 0.47 to 0.67 mm/year. These findings can serve as a basis for future dating of larger, living individuals.

This article examines the adoption of voting methods designed to support individuals with intellectual disabilities in elections. It focuses on two widely used approaches, frequently explored in scholarly discourse: assisted voting and proxy voting. Both of these voting methods rely on third-party involvement and therefore require the consideration of the prohibition of plural voting in the Australian Constitution. The article concludes that while assisted voting and a limited form of proxy voting-where the proxy must strictly follow the elector’s explicit instructions-are constitutional, proxy voting becomes unconstitutional if the elector is unable to communicate their electoral judgment. Assisted voting therefore emerges as the most practical and constitutionally compliant option.

Given a number field F with ring of integers $\mathcal {O}_{F}$, one can associate to any torsion free subgroup of $\operatorname {SL}(2,\mathcal {O}_{F})$ of finite index a complete Riemannian manifold of finite volume with fibered cusp ends. For natural choices of flat vector bundles on such a manifold, we show that analytic torsion is identified with the Reidemeister torsion of the Borel-Serre compactification. This is used to obtain exponential growth of torsion in the cohomology for sequences of congruence subgroups.