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This study examined how immigrant status and socioeconomic status influence racial self-classification among U.S. Latinx adults aged eighteen and older across multiple nationalities. Using data from the 2010–2018 National Health Interview Survey, we analyzed a nationally representative sample of Mexican, Cuban, Puerto Rican, Dominican, and Central/South American adults (N = 41,133) who identified as White, Black, or Another race. Socioeconomic status was measured using a composite index of income-to-poverty ratio, education, employment status, and homeownership. Multinomial logistic regressions and average marginal effects revealed significant heterogeneity in examined predictors of racial identity. U.S.-born Latinx adults, particularly Puerto Ricans and Central/South Americans, had higher probability of identifying as Black compared to recent immigrants. Latinx adults with low and middle socioeconomic status backgrounds were more likely to identify as Black or Another race across most nationality groups. Findings highlight the complexity of Latinx racial identity, whereby Latinxs may experience racialization differently depending on indicators of acculturation and socioeconomic status. The inclusion of multidimensional measures of race, such as skin color and street race, in future research is needed to better understand Latinx racial identity formation. Findings inform interventions to address race-related stress and anti-Blackness, particularly among AfroLatinx populations, and provide considerations for improving race data collection practices, such as those impacted by recent federal policy changes to the U.S. Census.
Cognitive deficits and immune system dysregulation are core features of psychotic disorders. Among inflammatory markers, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) have been linked to both psychosis pathophysiology and related cognitive impairments.
Methods
We investigated associations among IL-6, TNF-α, and neurocognitive performance in 107 participants: individuals at clinical high risk for psychosis (CHR-P, n = 35), first-episode psychosis (FEP, n = 39), and healthy controls (HC, n = 33). Assessments included memory, processing speed, executive function, and social cognition. Cytokines were measured from fasting serum samples. Analyses included ANOVA, correlations, and multivariate regressions controlling for age, sex, IQ, group, and symptom severity.
Results
TNF-α levels were significantly elevated in FEP compared to CHR-P (p = 0.0251); IL-6 differences were non-significant. FEP showed poorer performance in multiple cognitive domains, especially social cognition. CHR-P individuals exhibited intermediate profiles between FEP and HC in cognition. In adjusted regression models, IL-6 was significantly associated with undermentalization on the MASC task (β = 0.28, p = 0.0337) and showed a trend-level association with slower processing speed (β = 0.98, p = 0.075). TNF-α levels predicted poorer facial emotion recognition (β = −1.37, p = 0.0022). IQ and group were significant covariates in most models.
Conclusions
Our findings suggest that peripheral inflammation, particularly IL-6 and TNF-α, may selectively impact social cognitive functioning in early psychosis. Though modest, these associations highlight potential inflammatory contributions to functional impairment and support further investigation of immunological targets in early intervention.
While it is vital to agree to a set of global objectives and targets to reduce plastic pollution as part of the Global Plastic Treaty, past negotiations have been troubled by differences in regional and national priorities and needs. To take these different priorities and needs into account, this letter proposes the adoption of an interdisciplinary source-to-sea approach. A source-to-sea approach emphasizes the connected nature between land-based sources of marine plastic pollution along the life cycle of plastic products on the one hand, and air, soil, and water cycles that determine marine plastic flows and associated sustainability risks on the other hand. It takes into account how we know more about the way in which production, use and plastic waste contribute to the pollution of rivers and seas in one location (e.g. in Europe), than we do for rivers and seas in other places (e.g. Africa). There are also regional and national differences in how much awareness exist about plastic pollution and how it is governed and regulated. These differences translate in different priorities and needs in terms of how to most efficiently and effectively reduce plastic pollution. The letter argues that these differences should be embraced and that an interdisciplinary source-to-sea approach can help to develop tailor-made regional and national targets and measures that in turn contribute to achieving the global ambitions of the Global Plastic Treaty. A key role is foreseen for existing governance institutions, such as river basin commissions and regional seas conventions (coordinated by UNEP Regional seas Programme), while the Global Plastic Treaty can become a platform for sharing of approaches, lessons and strategies between regions and countries so that over time, plastic pollution will be reduced worldwide.
Although much has been written on legislative reciprocity, rarely have scholars had an opportunity to leverage a randomly assigned asset to assess whether and how legislators reciprocate when their colleagues assist them. Using the lottery that allows Canadian Members of Parliament (MPs) to propose bills or motions, we examine whether MPs’ priority numbers affect their proclivity to second motions made by other MPs, which would be expected if MPs sought to build support for their own proposals by supporting proposals by others. Although MPs almost always make a proposal if their priority number allows them to do so, we find a weak relationship between MPs’ priority numbers and their probability of seconding others’ proposals. Moreover, when we look at successive parliaments, we see only faint indications that those who, by chance, won the right to propose in the previous session (and who therefore were eligible to attract seconds) are more likely to second others’ proposals in the current session. Although subject to a fair amount of statistical uncertainty that will gradually dissipate as future parliaments are examined, this pattern of evidence currently suggests that correlated seconding behavior among legislators is more the product of homophily than reciprocity.
Chapter 7, Be Careful about the Publisher, examines how the diverse sources, distribution networks, and audiences associated with sexology undermined Havelock Ellis’s attempts to frame his book on homosexuality with John Addington Symonds, Sexual Inversion (1897), as a serious medical work, and led to its appearance in the obscenity trial R. v. Bedborough (1898). Authorities charged Bedborough aiming to break up a radical group, but sexologists and their allies framed the trial as an ignorant attack on scientific progress. Elaborating on strategies pioneered by birth-controllers, they argued that the censorship of “naturalistic” sexual expression had mired society in sexual ignorance, fostering “abnormal” sexual behaviour and an appetite for pornography, the rightful target of obscenity laws. In positioning their own work as vital to society and pornography as a product of sexual science’s suppression, they obfuscated ways in which early sexologists relied on pornographers and their products. By examining sexologists’ attempts to navigate these issues, this chapter further demonstrates how arguments about obscenity were used tactically to sanitize sexual knowledge and its producers.
Does the presence of two or more transborder minorities alter the logic of nation-building and affect minority securitization? This article goes beyond the triadic nexus framework commonly applied to minorities caught between their home- and kin-states, proposing a complex lens for analyzing states with multiple ethnic minorities. Titular political elites dealing with multiple minorities assign them to contradictory frames to manage the challenging reality of ethnic demography and regional security. By framing one minority as a “model minority” — trustworthy and law-abiding — and another as a “fifth column” — threatening and disruptive – they accomplish two aims: (1) maintain the dominant status of the titular nation by discrediting minority claims for institutional changes, and (2) legitimize the differential treatment of minorities. Ethnic minorities’ responses to these frames vary from relative acquiescence to violent conflict. I explore why the initially excluded Poles have been recently accommodated in Lithuania, why the marginalized Uzbeks became targets of repression in the Kyrgyz Republic, and why the relatively accommodated Russian speakers, former colonizers, became framed as a security threat in Lithuania but not in the Kyrgyz Republic after the Russian invasion of Ukraine. Understanding how strategic framing advances nation-building offers generalizable insights on (de)securitization of ethnicity.
Reparations for African Americans reflect both material concerns aimed at eliminating the Black–White racial wealth gap and symbolic political aspirations, including the end of structural racism. But do material or symbolic considerations drive policy evaluations across racial and partisan divides? What knowledge and experiences undergird processes through which individuals weigh the symbolic importance of a policy against its actual benefits? Leveraging a set of forty-one in-depth interviews with Black and White residents of Evanston, Illinois—the first municipality in the United States to approve a publicly-funded reparations-related ordinance—we highlight a mechanism through which individuals develop their opinions about reparations: political socialization. Black interviewees linked their understanding of reparations to robust financial compensation while White Democrats viewed their support for Evanston’s policy as symbolic of their longstanding, affective commitments to racial equality. Drawing from these observations, we present a framework highlighting policy attributes that frame how different constituencies respond to reparations-related policies. We test this framework using a conjoint experiment about reparations policies fielded in the 2022 Cooperative Election Study. We find Americans—especially White Republicans—possess less familiarity about reparations and remain strongly opposed to these policies, regardless of the form they take. While White Democrats are more familiar with reparations and more supportive of policies mirroring Evanston’s, Black Americans—those who are most familiar with reparations—support direct cash payments regardless of their political identification.
Immune dysregulation contributes to the pathophysiology of depression and is a potential link between depression and comorbid medical conditions. DNA methylation is a dynamic transcriptional regulator of the immune system.
Aims
To study changes in DNA methylation of disease- and comorbidity-associated immune genes in patients with and without depression diagnoses from the German BiDirect Study.
Method
We performed a cross-sectional (baseline, y0) and longitudinal (consecutive assessments at 3-year intervals, y0, y3, y6) differential methylation analyses of 382 immune-related genes associated with depression, obesity, diabetes and/or gout in 276 patients with depression and in 207 individuals without a lifetime depression diagnosis from the BiDirect Study. In addition, we applied unsupervised clustering to identify subgroups of individuals with depression based on longitudinal methylation patterns.
Results
There were no significant methylation changes between individuals with depression and controls at baseline. Follow-up analyses used to assess the top (P < 0.05) 151 methylation probes longitudinally identified 42 CpG sites that showed time-dependent changes associated with depression, and defined 3 depression clusters with differential profiles of serum inflammation markers at baseline. The implicated genes corresponded in the majority to those associated with diabetes risk, and were enriched in processes relevant for haematopoiesis.
Conclusions
Our results suggest that immune dysregulation associated with DNA methylation profiles contributes to the pathophysiology of depression and is a plausible link to chronic medical conditions such as diabetes.
A dimer model is a quiver with faces embedded in a surface. We define and investigate notions of consistency for dimer models on general surfaces with boundary which restrict to well-studied consistency conditions in the disk and torus case. We define weak consistency in terms of the associated dimer algebra and show that it is equivalent to the absence of bad configurations on the strand diagram. In the disk and torus case, weakly consistent models are nondegenerate, meaning that every arrow is contained in a perfect matching; this is not true for general surfaces. Strong consistency is defined to require weak consistency as well as nondegeneracy. We prove that the completed as well as the noncompleted dimer algebra of a strongly consistent dimer model are bimodule internally 3-Calabi-Yau with respect to their boundary idempotents. As a consequence, the Gorenstein-projective module category of the completed boundary algebra of suitable dimer models categorifies the cluster algebra given by their underlying quiver. We provide additional consequences of weak and strong consistency, including that one may reduce a strongly consistent dimer model by removing digons and that consistency behaves well under taking dimer submodels.
Impaired glycaemic control is a major risk factor for developing type 2 diabetes (T2D), a worldwide health epidemic intrinsically linked to diet and obesity. Whey proteins (WP) are increasingly popular supplements that are a rich source of branched-chain amino acids (BCAA), essential for muscle protein synthesis and metabolic regulation. In humans, fasting plasma concentrations of BCAA are maintained around 350 µM but become chronically elevated by 10–25% in persons with T2D. Little is known about whether BCAA from WP impacts circulating BCAA concentrations and contributes to this phenomenon. This narrative review used a systematic search approach with relevant keywords to identify evidence from randomised controlled trials in normoglycaemic humans and those with insulin resistance or T2D, on the effects of WP intake on plasma BCAA and glycaemic control. This review is, to the authors’ knowledge, the first to specifically examine the effects of WP intake on plasma BCAA concentrations in relation to glycaemic control. Whilst the majority of acute studies identified (n = 6) reported that WP consumption between 10 and 50 g significantly elevates postprandial BCAA and insulin responses (as evidenced by peak concentration and/or area under the curve), evidence from chronic studies (n = 3) report inconsistent findings on the impact of 9–51 g of WP/d on fasting BCAA and glycaemic control (for example, fasting glucose and insulin, insulin clearance). Findings from this literature review highlight the need for further studies that investigate the relationship between WP consumption with BCAA and glycaemic control, and to determine underlying mechanisms of action.
CD33 has been implicated in the pathogenesis of Alzheimer’s disease primarily through its role in inhibiting the clearance of beta-amyloid (Aβ). However, genetic studies yield mixed results and it is unclear whether the impact of CD33 is specific to Alzheimer’s disease or related to broader neurodegenerative processes. Interestingly, CD33 has also been shown to interact with the hepatitis B (HBV) and C viruses (HCV).
Aims
This study aims to investigate the effects of CD33 single-nucleotide polymorphisms (SNPs) on cognitive functions across diverse populations, including healthy controls, individuals with chronic HBV or HCV and those diagnosed with Parkinson’s disease.
Method
We genotyped CD33 SNPs in 563 participants using the Affymetrix platform. Participants’ cognitive functions were cross-sectionally assessed using a neuropsychological test battery spanning six domains.
Results
Our analysis revealed that CD33 SNP variations had no significant cognitive impact on healthy individuals or Parkinson’s disease patients. However, chronic HBV and HCV patients exhibited significant cognitive differences, particularly in memory, related to CD33 SNP genotypes. Moderation analysis indicated a heightened influence of CD33 SNPs on cognitive functions in chronic HBV and HCV individuals. Our data also suggest that inflammation severity may modulate the cognitive effects in hepatitis patients with specific CD33 SNPs.
Conclusions
This study highlights the importance of CD33 SNPs in cognitive outcomes, emphasising their role in the context of chronic viral hepatitis. It contributes to understanding the cognitive profiles influenced by CD33 SNPs and posits CD33’s potential contribution to neurodegenerative disease progression, potentially intensified by HBV/HCV-induced inflammation.
n-3 PUFA, including ALA, EPA and DHA, are widely found in plant oils and marine organisms. These fatty acids demonstrate significant biological effects, and their adequate intake is essential for maintaining health. However, modern diets often lack sufficient n-3 PUFA, especially among populations that consume little fish or seafood, leading to a growing interest in n-3 PUFA supplementation in nutrition and health research. In recent decades, the role of n-3 PUFA in preventing and treating various diseases has gained increasing attention, particularly in cardiovascular, neurological, ophthalmic, allergic, hepatic and oncological fields. In orthopaedics, n-3 PUFA exert beneficial effects through several mechanisms, including modulation of inflammatory responses, enhancement of cartilage repair and regulation of bone metabolism. These effects demonstrate potential for the treatment of conditions such as osteoarthritis, rheumatoid arthritis, gout, osteoporosis, fractures, sarcopenia and spinal degenerative diseases. This review summarises the clinical applications of n-3 PUFA, with a focus on their research progress in the field of orthopaedics, and explores their potential in the treatment of orthopaedic diseases.
International human rights law (IHRL) provides extensive protections for the living, but little in the way of direct protections for the dead. International humanitarian law (IHL) has more detailed protections for the dead, but is only triggered during armed conflicts. At first glance, this seems to create a protection gap for the dead during peacetime. This article explores how the Convention on the Rights of Persons with Disabilities (CRPD) creates a connection between IHL, IHRL and transitional justice to fill in this perceived gap in protections for the dead. While the CRPD does not explicitly address the dead, IHL contains several specific rules to guide how dead bodies are to be handled. When read together with the CRPD framework, these rules provide ample guidance on the treatment of individuals with disabilities after death. Some IHL protections of the dead extend temporally beyond the conflict, when transitional justice mechanisms should be in play, although neither the CRPD nor IHL address with any specificity how the five pillars of transitional justice – truth, justice, reparation, memorialization and guarantees of non-recurrence – might apply in relation to IHL rules regarding dead bodies. Nonetheless, Article 11 of the CRPD forges a bidirectional link to IHL protections and obligations supporting transitional justice. Accordingly, there is a legal framework for examining the interrelationships between rules in the CRPD, IHL and human rights law writ large, and for how we think about dead bodies under the various regimes of international law. Each ought to inform the others if the implications of CRPD Article 11 are to be fully realized and the siloing and fragmentation of international law avoided.
The Indian Pulsar Timing Array (InPTA) employs unique features of the upgraded Giant Metrewave Radio Telescope (uGMRT) to monitor dozens of the International Pulsar Timing Array (IPTA) millisecond pulsars (MSPs), simultaneously in the 300–500 MHz and the 1260–1460 MHz bands. This dual-band approach ensures that any frequency-dependent delays are accurately characterised, significantly improving the timing precision for pulsar observations, which is crucial for pulsar timing arrays. We present details of InPTA’s second data release that involves 7 yr of data on 27 IPTA MSPs. This includes sub-banded times of arrival (ToAs), dispersion measures (DM), and initial timing ephemerides for our MSPs. A part of this dataset, originally released in InPTA’s first data release, is being incorporated into IPTA’s third data release, which is expected to detect and characterise nanohertz gravitational waves (GWs) in the coming years. The entire dataset is reprocessed in this second data release providing some of the highest precision DM estimates so far and interesting solar wind-related DM variations in some pulsars. This is likely to characterise the noise introduced by the dynamic inter-stellar ionised medium much better than the previous release thereby increasing sensitivity to any future GW search.
The current study characterized voice onset time (VOT) and vowel onset fundamental frequency (F0) in the production of three Vietnamese alveolar stops (i.e. /t̪ʰ/, /t/, and /d/) by monolingual Vietnamese children and adults. Eighty Vietnamese children aged 3–7 years and 16 adults aged 22–44 years participated in this study. Unlike speakers of other languages with a three-way voicing contrast, Vietnamese children were able to produce distinct categories for the three Vietnamese stop categories by 3 years of age. However, differences in vowel onset F0 among the three voicing categories were not significant in any age group. These findings enhance our understanding of how Vietnamese children acquire three-way voicing contrast in stop production and offer broader insights into stop consonant acquisition across languages.
In March 1645, a large number of Potiguara people from various regions of north-eastern Brazil gathered in the aldeamento (Indigenous settlements under colonial control or supervision) of Tapesserica on Itamaracá. The primary objectives of the assembly included the establishment of Indigenous câmaras (municipal councils) and deliberations on the law of native freedom. Notably, in this period, some Indigenous people in Brazil were still held as slaves in territories under Dutch jurisdiction. The Tapesserica Assembly produced a remonstrance (‘remonstrantie’), which was delivered to the Dutch government in Recife by the Potiguara. This article scrutinises the Potiguara Assembly, the earliest recorded Indigenous assembly in Brazil, and reconstructs its connections to Indigenous political culture predating the European arrival in Brazil. It explores the Indigenous perspective on the Dutch–Portuguese wars and demonstrates the role of the Potiguara as historical agents, navigating the complexities of conflict and decision-making processes that ultimately shaped their destiny.
A new species of Loimos MacCallum, 1917 is described more than half a century after the last species was described in 1972. The new species was collected from the gills of Rhizoprionodon taylori (Ogilby, 1915) off the Central Queensland coast, Australia, and is the first Loimos species and the first representative of the Loimoinae Price, 1936 known from Oceania. A detailed morphological description and 28S rDNA molecular sequences are provided for the new species. In the molecular phylogeny based on available 28S rDNA sequences for relevant Monocotylidae, the new species grouped together with the only other Loimos sequence available in GenBank, that of the nonugen Loimos sp. from China (OM060238), sister to Loimosina wilsoni Manter, 1944. The estimated genetic divergence between the new species and the nonugen Loimos sp. sequence is low, between 0.0452 and 0.0737, suggesting that the nonugen sequence may represent the new species, or a very closely related congener. Host identity was confirmed by comparing COI sequences with those of known sharks in GenBank. We also provide the first 12S and 16S molecular sequences for this shark species.
In this article, I argue for a “multifunctional account” of political feasibility and against recent attempts by several theorists to defend accounts of political feasibility that reduce feasibility judgments to a single function. According to the view I defend, political feasibility can (and should) serve multiple useful functions in our political deliberative practices. This pluralist and context-dependent approach allows us to retain the insights provided by various monofunctional accounts, while avoiding the limitations of each.