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In this article, we prove the local-in-time existence of regular solutions to dissipative Aw–Rascle system with the offset equal to gradient of some increasing and regular function of density. It is a mixed degenerate parabolic-hyperbolic hydrodynamic model, and we extend the techniques previously developed for compressible Navier–Stokes equations to show the well-posedness of the system in the $L_2-L_2$ setting. We also discuss relevant existence results for offset involving singular or non-local functions of density.
The Jacobian of a very general complex algebraic curve of genus at least 3 contains an algebraic cycle called the Ceresa cycle that is homologically trivial but algebraically nontrivial. Zharkov defined in analogy the tropical Ceresa cycle of a metric graph and proved a similar result for very general tropical curves overlying the complete graph on four vertices. We extend this result by considering a related, ‘universal’ invariant of the underlying graph called the Ceresa period; we show that having trivial Ceresa period has a forbidden minor characterization that coincides with the graph being of hyperelliptic type.
Early modern urban parliaments suffered an increasing monopolization of political power that hampered urban development. To combat power monopolization, some Swiss city-states reformed their election systems by randomly selecting political representatives from a pre-elected pool of candidates. We implement a difference-in-differences design and find that lottery-based election systems improved the equality of distribution of political seats within parliaments. Lottery-based elections also had positive effects on trade tax revenues, trade volumes, and infrastructure expenditures. We explain this finding by showing that lottery-based election systems fostered the election of merchants to top political positions.
This study reports on a set of experiments designed to clarify the impact of the rotational transform on confinement quality at the TJ-II stellarator. For this purpose, the net plasma current is controlled using external coils, resulting in the modification of the rotational transform profile. Significant and systematic variations of the edge electron density gradients (up to $50\,\%{-}60\,\%$) and the plasma energy content ($20\,\%{-}30\,\%$) are achieved. The explanation of this behaviour relies on the placement of low-order rational surfaces in relation to the edge gradient region, which affect local turbulence fluctuation levels, facilitating the formation of zonal flows and concomitant transport barriers. This hypothesis is confirmed experimentally on the basis of a broad array of diagnostic measurements. Calculations based on a resistive magnetohydrodynamic turbulence model provide qualitative support for this hypothesis, clarifying the impact on confinement of specific rational surfaces and highlighting the complex nature of magnetically confined fusion plasmas.
Chapter 1, Holywell Street Medicine, traces the pornography trade’s birth out of the collapse of revolutionary politics in the 1820s, and shows how early agents in the trade scavenged for content to fill lists of sexual material. This fostered a vibrant mid-century traffic in cheap reprints and reworkings of works on contraception, venereal disease, fertility, and midwifery alongside pornographic novels and prints, bawdy songbooks, and other sexual material, operating out of London’s Holywell Street and other thoroughfares near the Strand. While showing how these agents harnessed the expanding infrastructures of the press and the post to sell their wares works across the nation, this chapter demonstrates that they framed medical works through two different, but compatible, lenses. Following a long line of disreputable publishers, Holywell Street publishers framed medical works as titillating reading material. However, they also adapted earlier radical arguments for sex education and female sexual pleasure, marketing medical works as containers of practical information about the body that readers could apply to support safe, active, and pleasurable sex lives.
Vocal fold vibrations are more difficult to achieve in obstruents than sonorants due to the aerodynamic voicing constraint (AVC), i.e., the fact that a buildup of air pressure in the supraglottal cavity during oral closures reduces the transglottal airflow. The AVC can be circumvented by various voicing adjustment gestures, such as larynx lowering, tongue root advancement and tongue body lowering. The current study employed laryngeal and lingual ultrasound to investigate the use of these strategies in Canadian French. The vertical movement of the larynx was measured using optical flow analysis, while lingual movement was analyzed by tracking X and Y coordinates at distinct fanlines across consecutive images.
Results revealed that there was more pronounced larynx lowering in voiced obstruents and that it tended to be greater in voiced stops than in voiced fricatives. Tongue-related maneuvers displayed more interspeaker variation but tendencies showed that the tongue root was more advanced in voiced stops than in voiced fricatives and slightly more for /d/ than /b/. Significant tongue body lowering was observed for both voiced stops and voiced fricatives only preceding the vowel /a/. Finally, larynx lowering was strongly correlated with voicing duration in voiced obstruents. A similar but weaker correlation was found for tongue root advancement.
Overall, this study suggests that larynx lowering is an efficient strategy to circumvent the AVC in Canadian French but that some speakers may also resort to lingual adjustments. Additional strategies that are known to play a role, such as nasal or oral leakage, were not considered.
Involving knowledge users (KUs) such as patients, clinicians, or health policymakers is particularly relevant when conducting rapid reviews (RRs), as they should be tailored to decision-makers’ needs. However, little is known about how common KU involvement currently is in RRs.
Objectives
We wanted to assess the proportion of KU involvement reported in recently published RRs (2021 onwards), which groups of KUs were involved in each phase of the RR process, to what extent, and which factors were associated with KU involvement in RRs.
Methods
We conducted a meta-research cross-sectional study. A systematic literature search in Ovid MEDLINE and Epistemonikos in January 2024 identified 2,493 unique records. We dually screened the identified records (partly with assistance from an artificial intelligence (AI)-based application) until we reached the a priori calculated sample size of 104 RRs. We dually extracted data and analyzed it descriptively.
Results
The proportion of RRs that reported KU involvement was 19% (95% confidence interval [CI]: 12%–28%). Most often, KUs were involved during the initial preparation of the RR, the systematic searches, and the interpretation and dissemination of results. Researchers/content experts and public/patient partners were the KU groups most often involved. KU involvement was more common in RRs focusing on patient involvement/shared decision-making, having a published protocol, and being commissioned.
Conclusions
Reporting KU involvement in published RRs is uncommon and often vague. Future research should explore barriers and facilitators for KU involvement and its reporting in RRs. Guidance regarding reporting on KU involvement in RRs is needed.
Predicting calving in glacier models is challenging, as observations of diverse calving styles appear to contradict a universal calving law. Here, we generalize and apply the analytical Horizontal Force-Balance fracture model from ice shelves to land- and marine-terminating glaciers. We consider different combinations of “crack configurations” including surface crevasses with or without meltwater above saltwater- or meltwater-filled basal crevasses. Our generalized crevasse-depth model analytically reveals that, in the absence of meltwater, the calving criterion depends on two dimensionless variables: buttressing B and dimensionless water level λ. Using a calving regime diagram, we quantitatively demonstrate that glaciers are generally more prone to calving with reduced buttressing B and lower water level λ. For a specified set of $B, \lambda$ and crack configuration, an analytical calving law can be derived. For example, the calving law for an ice shelf, land-, or marine-terminating glacier with a dry surface crevasse above a saltwater basal crevasse reduces to a state with no buttressing (B = 0). With climate warming, glaciers are expected to become more vulnerable to calving due to meltwater-driven surface and basal crevassing. Our findings provide a framework for understanding diverse calving styles.
Understanding the relative costs and effectiveness of all competing interventions is crucial to informing health resource allocations. However, to receive regulatory approval for efficacy, novel pharmaceuticals are typically only compared against placebo or standard of care. The relative efficacy against the best alternative intervention relies on indirect comparisons of different interventions. When treatment effect modifiers are distributed differently across trials, population adjustment is necessary to ensure a fair comparison. Matching-Adjusted Indirect Comparisons (MAIC) is the most widely adopted weighting-based method for this purpose. Nevertheless, MAIC can exhibit instability under poor population overlap. Regression-based approaches to overcome this issue are heavily dependent on parametric assumptions.
Methods
We introduce a novel method, ‘G-MAIC,’ which combines outcome regression and weighting-adjustment to address these limitations. Inspired by Bayesian survey inference, G-MAIC employs Bayesian bootstrap to propagate the uncertainty of population-adjusted estimates. We evaluate the performance of G-MAIC against standard non-adjusted methods, MAIC and Parametric G-computation, in a simulation study encompassing 18 scenarios with varying trial sample sizes, population overlaps, and covariate structures.
Results
Under poor overlap and small sample sizes, MAIC can produce non-sensible variance estimations or increased bias compared to non-adjusted methods, depending on covariate structures in the two trials compared. G-MAIC mitigates this issue, achieving comparable performance to parametric G-computation with reduced reliance on parametric assumptions.
Conclusion
G-MAIC presents a robust alternative to the widely adopted MAIC for population-adjusted indirect comparisons. The underlying framework is flexible such that it can accommodate advanced nonparametric outcome models and alternative weighting schemes.
The superior sinus venosus defect is an uncommon CHD, typically associated with partial anomalous pulmonary venous drainage. While surgical correction is the traditional treatment, transcatheter techniques have emerged as a promising alternative. This analysis assesses the evolution of transcatheter correction for superior sinus venosus defect over the past decade, analysing trends on technique, procedural outcomes, and safety.
Methods:
Systematic research identified 23 studies involving approximately 676 patients from 2014 to 2024. Data on demographics, procedural details, and outcomes were extracted, and study quality was assessed using established checklists. Descriptive analyses and trend evaluations were conducted.
Results:
Initially, transcatheter procedures were reserved for high surgical-risk cases, but recent studies emphasise selecting patients with favourable anatomy for interventional closure. Improved screening and patient referral have reduced exclusion rates. While earlier studies utilised 3D printing for planning, later studies increasingly employed periinterventional imaging, particularly CT-fluoroscopy fusion. Balloon-expandable long covered stents, especially custom-made designs, became predominant, with median stent length increasing from 55 mm to 75 mm. Complication rates, including stent embolisation and pulmonary vein obstruction, declined over time.
Conclusions:
Advancements in patient selection, imaging modalities, and procedural techniques have improved the safety and efficacy of transcatheter superior sinus venosus defect correction, reducing reliance on surgical interventions. Custom stents and advanced imaging have played key roles in achieving better outcomes. However, larger studies are required to confirm these findings and evaluate long-term outcomes.
Religious language plays a pivotal role in shaping political behavior and attitudes. This study investigates how representatives utilize religious rhetoric when addressing the House floor and their constituents, and how this language is influenced by congressional leadership. The inauguration of openly religious Mike Johnson as House Speaker in 2023 provides a unique case to explore these dynamics. Using difference-in-differences and triple difference models, we analyze House speeches and newsletters from before and after Johnson became House Speaker to assess changes in religious speech between Republican and Democratic representatives. Our findings reveal a significant increase in newsletters using religious language sent out by Republicans after Johnson became Speaker, while religious speech on the House floor remains unchanged. Overall, our findings contribute to the literature on the relationship between religion, partisanship, and Congressional leadership, highlighting the potential influence of the Speaker of the House on religious communication to constituents.
We show that the cohomological Brauer groups of the moduli stacks of stable genus g curves over the integers and an algebraic closure of the rational numbers vanish for any $g\geq 2$. For the n marked version, we show the same vanishing result in the range $(g,n)=(1,n)$ with $1\leq n \leq 6$ and all $(g,n)$ with $g\geq 4.$ We also discuss several finiteness results on cohomological Brauer groups of proper and smooth Deligne-Mumford stacks over the integers.
This article studies the aftermath of the Second World and decolonization (1945–1960) in the Indo-Burmese highlands, challenging predominant notions of state-building. Using the ‘Zomia’ heuristic, it argues how trans-border Naga tribal communities residing in so-called ‘No-Man’s-Lands’ between British India’s Assam province and Burma neither entirely resisted states, nor attracted uniform state interest. This dual refusal of states and social actors reveals negotiated sovereignty practices, using violence. The article illustrates the Naga tribes’ agency in negotiating with colonial and post-colonial states by using mimetic discourses of primitive violence, represented by headhunting. Violence served as a significant means of communication between communities and state agents, amounting to shifting cultural and territorial boundaries. Such practices selectively securitized colonial frontiers that became international borders post-decolonization. Gradually, violence and the desire for development invited state extension here. The article reveals that uneven state-building and developmental exclusions by bordering created conditions for violence to emerge. It engages scholarship on ‘Blank Spaces’ to analyse the varying sovereignty arrangements that produced ‘checkered’ zones. It highlights the relationship between spatial history and violence to explain the persistence of coercive development and demands for more borders and states today across highland Asia. It uncovers the embeddedness of violence in creating and challenging developmental and democratic exclusions in post-colonial nation-building projects. The analysis complicates imperial legacies of producing territorial enclosures within democracies, allowing exceptional violence to occur. More broadly, it complicates contemporary geopolitical cartographic contests and stakes of state-possession, using historical methods with approaches from anthropology and political geography.
Oropharyngeal squamous cell carcinoma (SCC) is a common type of head and neck cancer often linked to tobacco, alcohol use, and, in youngers, HPV infection. Standard care for locally advanced SCC involves radiotherapy (RT) and cisplatin, (total doses of 66–70Gy in 30–35fractions). However, some patients with significant comorbidities cannot tolerate chemotherapy, requiring alternative approaches. We present a case of a 66-year-old male with p16-negative oropharyngeal SCC and bulky cervical nodal metastasis, ineligible for chemotherapy.
Materials & Methods:
The patient was treated using adaptive volumetric modulated arc therapy (VMAT) with simultaneous integrated boost (SIB) and central gross tumor volume (GTV) dose escalation. This approach delivered up to 72Gy to the central GTV in 30 fractions; 66 Gy in 30 fractions to the high-risk area; 60Gy in 30 fractions to the intermediate-risk area; 54 Gy in 30 fractions to the low-risk area.
Results:
An epithelolysis (grade 3) led to a four-day treatment pause. A mid-treatment CT showed tumor shrinkage, reducing the nodal GTV volume from 107to 33cc, prompting adaptive planning to optimize dose distribution and reduce toxicity. The patient completed RT without further interruptions. At six months post-treatment, no recurrence or severe toxicities were detected and four years post-treatment, the patient remains in complete remission without significant late toxicity.
Conclusions:
This case demonstrates the effectiveness of VMAT with SIB in delivering accelerated radiotherapy to a bulky nodal lesion in a patient with p16-negative oropharyngeal SCC unfit for chemotherapy; This allowed for tumor control while minimizing exposure to critical structure.
Weed seeds are potential contaminants of composts derived from biowastes. We assessed the effect of steam treatment alone and in combination with composting on the mortality of barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.] seeds in a biowaste substrate consisting of a mixture of onion (Allium spp.) waste (60%), horse (Equus spp.) manure (20%), and wood shavings (20%). In the first study, seeds of six populations of E. crus-galli exposed to temperatures ranging from ca. 60 to 99 C followed by a 3-min residence time exhibited a decline in seed germination from approximately 25% to 0%. The E. crus-galli populations varied greatly in germinability and responded differently to high temperatures. Samples with lower germinability as assessed in controls were killed at lower temperatures than samples with higher initial germinability. However, to ensure an almost 100% kill of all seeds in the populations, a mean temperature of 100 C was necessary. In another study, seed germination was assessed after steaming the biowaste mixture to a mean temperature of about 60 C and subsequently composting. A short steaming period of the biowaste mixture at approximately 60 C before composting was unnecessary, as all composted seed samples, including the non-steamed control seeds, died during the composting process.
Adolescents are at a heightened risk of suicide reattempts following hospital discharge, but few evidence-based interventions exist. This study evaluated the efficacy of the self-awareness of mental health (SAM) program combined with treatment as usual (TAU) versus TAU alone in reducing reattempts among high-risk adolescents.
Methods
A randomized clinical trial was conducted across nine Spanish hospitals (January 2021–March 2024) with 261 adolescents (12–17 years) who had attempted suicide within the last 15 days. Participants were assigned to SAM + TAU (n=128) or TAU (n=133), with 12-month follow-up. The primary outcome was suicide reattempts within 12 months; secondary analyses examined time to reattempt and associated risk factors.
Results
After 12-months, no significant differences were found in reattempt rates [22.6% (SAM) versus 27.8% (TAU); OR=0.610, 95%CI (0.321–1.151), p=0.127] or time to reattempt [HR=0.606, 95%CI (0.390–1.021), p=0.060]. In SAM, attentional impulsivity emerged as a significant risk factor [HR=1.126, 95% CI (1.004–1.263), p=0.043], while nonplanning impulsivity was protective [HR=0.878, 95%CI (0.814–0.948), p<0.001]. In TAU, increased suicide risk was linked to suicidal intentionality [HR=1.341, 95%CI (1.009–1.782), p=0.044] and more prior attempts [HR=1.230, 95%CI (1.039–1.457), p=0.016]. Conversely, fewer psychiatric diagnoses emerged as a protective factor [HR=0.821, 95%CI (0.677–0.996), p=0.045].
Conclusions
While no significant differences were found between groups, SAM identified important psychological factors influencing suicide risk. These findings provide a foundation for targeted interventions to prevent reattempts in adolescents.
The transition from conventional cage systems to cage-free egg production in China remains limited despite apparently increasing consumer demand for cage-free eggs. This study interviewed 15 large-scale Chinese egg producers using cages and/or cage-free systems (i.e. single-, multi-tier and free-range) to investigate the perceived challenges and opportunities during the transition. The cage farms’ scales range from 110,000 to 30 million, while the cage-free farms keep between 12,000 and 300,000 laying hens. Drawing upon the COM-B model of the Behaviour Change Wheel, this study explored how producers’ Capabilities, Opportunities, and Motivations impact decision-making processes. Key findings reveal that cage and cage-free producers considered consumer demand and profitability as primary drivers for adopting cage-free systems. While free-range producers were more confident in the market, barn system producers faced greater uncertainty due to limited engagement from corporate buyers. Moreover, these cage-free producers believed reliable certification and labelling schemes to be critical for building consumer trust and ensuring the success of cage-free operations. All the participants perceived access to sufficient land and financial resources to be essential for a successful transition. While most studies propose education as a long-term strategy to promote the growth of the cage-free egg sector, our findings are the first to highlight that engaging corporate buyers and establishing trustworthy certification schemes are the most crucial short-term interventions required to drive the development of large-scale cage-free farms and support sustained improvements in animal welfare in China.
Over the years, cultural and linguistic diversity in schools across Europe has significantly increased due to migration and refugee flows. In response, international organizations, such as the Council of Europe and the European Commission, advocate intercultural education as both an educational strategy and a social policy tool to foster inclusion, address inequality, and build cohesive societies. This study contributes to the intercultural education literature by addressing an underexplored area: the process of translating intercultural policies into school practices. Using Street-Level Bureaucracy theory and qualitative research in Trento, Italy, it highlights the mechanisms and challenges shaping teachers’ practices and the extent of the policy–practice gap. Furthermore, the research also contributes to the Street-Level Bureaucracy theory. It shows that teachers can act as innovators in the policy implementation process. By engaging civil society members, notably students and members of migrant communities, as co-implementers, teachers reshape policy ecosystems through participatory and bottom-up approaches.
Five species of monorchiids are known from fishes of the family Gerreidae, of which one is from Australian waters. Here, we report it and two new monorchiids from three species of Gerres Quoy & Gaimard, 1824 from off Lizard Island, northern Great Barrier Reef, and Moreton Bay in south-eastern Queensland: Gerres oyena (Forsskål), Gerres oblongus Cuvier and Gerres subfasciatus Cuvier. One of the new species, found only in G. oblongus at Lizard Island, conforms most closely to the concept of Proctotrema Odhner, 1911. However, it differs from species of Proctotrema in oral sucker shape and location of intestinal bifurcation and termination. It is phylogenetically distinct from two sequenced species of Proctotrema; thus, we propose Obscuromonorchis ranae n. g., n. sp. The second new species infects all three gerreids, occurs at both Lizard Island and Moreton Bay, and is morphologically most similar to the concept of Monorchicestrahelmins Yamaguti, 1971. However, the combination of the length of the caeca, size of the testis and post-testicular region, and the form of spination in the genital atrium presents a clear genus-level distinction that warrants proposal of a new genus. There are no molecular data for the three recognised species of Monorchicestrahelmins. We propose Argenticola shuyinae n. g., n. sp. for this species. New specimens of Gerricola queenslandensis Wee, Cutmore & Cribb, 2021 were collected from off Lizard Island and Moreton Bay. The three species form a well-supported clade but with internal branch lengths and topology consistent with genus-level differentiation.
The Intergovernmental Negotiating Committee (INC) on plastic pollution are United Nations member states who will convene for the second part of the fifth session of the Intergovernmental Negotiating Committee in Geneva (INC5.2) 5-14 August, 2025 to negotiate a global plastics treaty. The Scientists’ Coalition for an Effective Plastics Treaty (‘The Scientists’ Coalition’) is an international network of independent scientific and technical experts who have been contributing robust science to treaty negotiators since INC1 in 2022. The Scientists’ Coalition established a series of working groups following INC5.1 in Busan, Korea 25 November – 1 December 2024. Each working group has produced science-based responses to the selected articles of ‘the Chair’s text’ (the latest version of the draft global plastics treaty text). This Letter to the Editor summarises those responses.