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Major depressive disorder (MDD) is a heterogeneous with underlying mechanisms that are insufficiently studied. We aimed to identify functional connectivity (FC)-based subtypes of MDD and investigate their biological mechanisms.
Methods
Consensus clustering of FC patterns was applied to a population of 829 MDD patients from the REST-Meta-MDD database, with validity assessed across multiple dimensions, including atlas replication, cross-validated classification, and drug-naïve subgroup analysis. Regression models were used to quantify FC alterations in each MDD subgroup compared with 770 healthy controls, and to analyze spatial associations between FC alterations and publicly available gene transcriptomic and neurotransmitter receptor/transporter density databases.
Results
Two stable MDD subtypes emerged: hypoconnectivity (n = 527) and hyperconnectivity (n = 299), which had both shared and distinct regions with remarkable FC alterations (i.e. epicenters) in the default mode network.
There were several common enriched genes (e.g. axon/brain development, synaptic transmission/organization, etc.) related to FC alterations in both subtypes. However, glial cell and neuronal differentiation genes were specifically enriched in the hypoconnectivity and hyperconnectivity subtypes, respectively.
Both subtypes showed spatial associations between FC alterations and serotonin receptor/transporter density. In the hypoconnectivity subtype, FC alterations correlated with GABA and acetylcholine receptor densities, while norepinephrine transporter and glutamate receptor densities were linked to the hyperconnectivity subtype.
Conclusions
Our findings suggested the presence of two neuroimaging subtypes of MDD characterized by hypoconnectivity or hyperconnectivity, demonstrating robust reproducibility. The two subtypes had both shared and distinct genetic mechanisms and neurotransmitter receptor/transporter profiles, suggesting potential clinical implications for this heterogeneous disorder.
How do succession and the microhabitat interact to shape the mosaic of biocrust types in the Tabernas Desert (semi-arid Southeast Spain)? We hypothesize that succession (in human time scales) occurs only where the habitat allows it and can regress. Reviewing results from an extensive body of research conducted at the Tabernas region, we aimed (i) to show that crust types can be considered successional stages, (ii) to propose a succession model. We used two approaches: (a) direct, in situ monitoring of three sites (13, 17 and 11 years) and examination of unaltered micro-profiles of biocrusted soil; and (b) indirect assessment, by reviewing functional properties (e.g., ecohydrology, soil loss, physical–chemical properties, microbiota and gas exchange) of biocrust types hypothetically considered successional stages. Although differences among communities in these functions do not necessarily imply species replacement, they were consistent with the hypothetical successional order and the evidence of replacement from the direct approaches. Succession occurs at various speeds across space because it is controlled by habitat. Therefore, it is mainly observable in favourable habitats where the biocrust was altered, or in ecotones. We propose a succession model, including microclimatic controls, two early cyanobacterial stages and two later lichen stages, showing the regressive paths.
Being Human in the Digital World is a collection of essays by prominent scholars from various disciplines exploring the impact of digitization on culture, politics, health, work, and relationships. The volume raises important questions about the future of human existence in a world where machine readability and algorithmic prediction are increasingly prevalent and offers new conceptual frameworks and vocabularies to help readers understand and challenge emerging paradigms of what it means to be human. Being Human in the Digital World is an invaluable resource for readers interested in the cultural, economic, political, philosophical, and social conditions that are necessary for a good digital life. This title is also available as Open Access on Cambridge Core.
In this study, we investigate the impact of the age of prime ministers and ministers on the stability of governments across 21 democracies. We examine this issue by using Cox survival analysis, leveraging an original dataset and adopting a comparative perspective. The findings of the study document that younger prime ministers face a lower risk of government discretionary termination compared to their older counterparts. This effect does not appear to be statistically significant for cabinet ministers. By shedding light on this uncharted relationship, we contribute to the flourishing literature on youth representation in politics and the established research agenda on the factors affecting the survival in office of democratic governments. We conclude the study by discussing the implications of the findings for democracy and suggesting avenues for future research.
It has been argued that under certain conditions bilingualism can confer adaptations to the human mind and brain. Among the possible moderators of such adaptations, language distance occupies a distinctly ambiguous role. Equally unclear is the directionality of the effect, as juggling different languages may become more or less cognitively costly depending on how (dis)similar competing alternatives are. If different language pairings entail that a different degree of cognitive effort is needed to manage bilingualism, language distance asymmetries are predicted to differentially contribute to the robustness of bilingual adaptations. In this systematic review and Bayesian analysis, we find strong evidence for a distance effect in bilingualism, but mixed evidence concerning its directionality in terms of being more pronounced in similar versus distant languages. We chart the extreme variability that exists across studies, highlighting the need for developing ecologically accepted metrics of what counts as similar in language processing.
Violence in early dating relationships can continue into adulthood. The literature usually focuses on the negative effects of violent relationships, but rarely includes the reasons for or antecedents of such behavior. The main objectives of this study were to identify different psychosocial profiles in terms of frustration tolerance and partner dependency and how they are correlated with psychological partner violence, as well as to analyze the justifications for such violence in adolescents and young adults. A total of 69.9% of the final 1044 participants (62.1% girls; age range = 15–22) were involved in a relationship at the time of the evaluation. From a person-centered approach, latent profile analyses yielded three profiles (anxious dependent, low anxious and exclusive dependency, and low exclusive dependency). Significant differences were found between groups, except for the scores between Profiles 2 and 3 in exclusive dependency and anxious attachment between Profiles 3 and 1, with Profile 3 having the highest correlation with violence despite scoring lower in emotional dependency and exclusive dependency than Profile 1. Moreover, significant differences were found among the three groups in terms of violence in the relationship, but all three groups experienced bidirectional violence. The justifications were similar in all three groups, with the concern response being the most reported, together with jealousy in many cases. This research increases knowledge about the psychosocial factors associated with offline and online psychological violence in young couples and allows us to deeply examine the motives that young people express to justify violence in their relationships.
This article studies the making of return predictability among economically linked firms. I characterize an asymmetric cross-firm tug-of-war: i) High peer overnight returns are followed by elevated overnight returns for focal stocks, which fully reverse during intraday, and ii) high peer intraday returns are followed by high intraday returns but minor overnight price reactions. This pattern aligns with the story that individuals’ persistent trading on salient information distorts opening prices, while slow-moving arbitrage by professional investors gradually corrects mispricing. Mutual fund and hedge fund flows exhibit distinct associations with the tug-of-war, supporting the hypothesis that heterogeneous demand drives the return predictability.
David Armitage’s idea of reading The Marriage of Figaro in the context of international law and diplomacy is extremely fruitful for understanding this opera in its original historical context and in our present world. Opera, especially this one, is still part of our culture, as it is performed every year, and as such, it is a trans-historical and trans-national work-event, occupying a liminal zone between a text produced in a specific historical context and event reoccurring time and again in ever-changing performance practice. There is no shortage of great operas composed in the eighteenth century, including some by Mozart, which have entirely or nearly disappeared from the active repertory. The Marriage of Figaro is still present not only because of the undisputable beauty of its music but also because it continues to appeal to our sensibility by dramatizing interpersonal tensions and resolutions that persist today.
This is a fascinating project, and I have learned a great deal about Mozart from Armitage’s Lecture I and about recent operas in Lecture III’s general introduction and the detailed discussion of The Consul. I make two minor criticisms and then broaden the topic by thinking of what I shall term “internal exile”—deprivation of rights and full citizenship that happens to some groups of people within the borders of a state, although nominally they are citizens thereof. This is a rich theme for operas, past and present. And at least some of these exiles triumph over rules.
Tropical cyclones (TC) can produce waves and water levels that markedly reshape sand cay shorelines. TC Jasper (December 2023) passed near Low Island (Low Isles, Northern Great Barrier Reef [GBF]) as a category 2 storm. Using a combination of remote sensing and ground surveys, we compare detailed, high-resolution digital terrain models created before and after TC Jasper to quantify sediment redistribution around the cay during and after the event. During TC Jasper, net transport of 8,870 m3 occurred to elongate the spits at the eastern and western ends of the cay, but the sediment volume of the cay did not significantly change. Following TC Jasper, the shoreline at Low Island returned to its modal seasonal state within six months. This accords with historical accounts of seasonal shifts in shoreline configuration driven by prevailing wind and wave regimes, as well as the relatively rapid readjustment to a modal form following episodic extreme events. Overall, the documented changes to Low Island following cyclonic events highlight the complex interplay between episodic disturbances and longer-term geomorphic stability, emphasising the importance of ongoing research into these interactions as higher-intensity cyclones increase in frequency due to climate change.
Understanding the spatiotemporal variability of global summer monsoons and the factors controlling them is essential for testing and predicting their future changes under the anticipated global warming. Here, we reconstructed a series of East Asian summer monsoon (EASM) patterns over South Korea. Based on radiocarbon dates, grain size, carbon/sulfur (C/S) ratios, and high-resolution X-ray fluorescence core scanning (XRF-CS) data (e.g., Ti/Al and Zr/Al ratios) from a paleo-bay site in Hadong area, southern Korea, we investigated the multi-decadal- to centennial-scale variation in the terrestrial element inputs as a proxy for the EASM rainfall during the period from 8600 to 7800 cal yr BP and compared previous results from the Buan area, western coast of Korea, to test possible synchronous local-scale hydroclimate change. We also explored global teleconnections among EASM over Korea, the Indian summer monsoon (ISM), and the movement of the Intertropical Convergence Zone (ITCZ). We found that the EASM variability was positively correlated with that of the ISM through latitudinal shifts of the ITCZ. High-latitude cooling climates, including the 8.2 ka cooling event, were also directly connected to the weakened EASM via the intensified winter monsoon and southward shift of the westerly jet position over the Tibetan Plateau. To predict future changes in summer rainfall, synchronized changes in the global summer precipitation should be considered in terms of ITCZ and high-latitude climate change, including westerly jet shifts over Asian regions.
Drawing on two decades of collaborative legal ethnographic research with Indigenous communities, this article weaves personal narrative and lived experience to highlight working-class scholar-activism and embodied spiritual rituality as an act of resistance within academia. It critically challenges Western research ethics paradigms by emphasising ethics as a lived, relational practice grounded in rituality and interconnectedness rather than mere compliance. Through an audiovisual lens, it demonstrates how visual storytelling can embody and amplify more-than-human voices, fostering relationality and responsibility. The paper offers two key contributions: recentring the positionality of working-class scholars and recentring the agency of the more-than-human int he field of law as vital in knowledge production. While decolonial and Indigenous scholarship advocate for diverse epistemologies, they often overlook working-class perspectives rooted in societal justice. I argue that a heart-based resistance grounded in critical care, relationality, Indigenous ontologies and spirituality can foster transformative academic knowledge.
Image reconstruction in very-long baseline interferometry operates under severely sparse aperture coverage with calibration challenges from both the participating instruments and propagation medium, which introduce the risk of biases and artefacts. Interferometric closure invariants offer calibration-independent information on the true source morphology, but the inverse transformation from closure invariants to the source intensity distribution is an ill-posed problem. In this work, we present a generative deep learning approach to tackle the inverse problem of directly reconstructing images from their observed closure invariants. Trained in a supervised manner with simple shapes and the CIFAR-10 dataset, the resulting trained model achieves reduced chi-square data adherence scores of $\chi^2_{\mathrm{CI}} \lesssim 1$ and maximum normalised cross-correlation image fidelity scores of $\rho_{\mathrm{NX}} \gt 0.9$ on tests of both trained and untrained morphologies, where $\rho_{\mathrm{NX}}=1$ denotes a perfect reconstruction. We also adapt our model for the Next Generation Event Horizon Telescope total intensity analysis challenge. Our results on quantitative metrics are competitive to other state-of-the-art image reconstruction algorithms. As an algorithm that does not require finely hand-tuned hyperparameters, this method offers a relatively simple and reproducible calibration-independent imaging solution for very-long baseline interferometry, which ultimately enhances the reliability of sparse very-long baseline radio interferometry imaging results.
Recent debates over how to address racial injustice in the United States often center on two types of policies: redistributive measures that redress material inequities between groups and symbolic reforms that challenge dominant racial narratives. How do citizens evaluate these differing approaches to advancing racial justice? How do recent removals of Confederate symbols shape support for each of these policy types? In a survey of American adults, we find that support for redistributive and symbolic policies is positively correlated across partisan, racial, and regional lines. However, when pressed, respondents express a stronger preference for redistributive measures, often viewing symbolic reforms as insufficient or distracting. In an experimental framework, we find that informing respondents about recent Confederate statue removals does not significantly alter support for either policy type. Looking at qualitative reactions to the treatment, we identify a plausible explanation for this null finding: most respondents see the removals as a fight over history and less directly relevant to a broader racial justice policy agenda.
While almost all charities rely on a set of donor appreciation strategies, their effectiveness for the success of fundraising campaigns is underresearched. Through two preregistered field studies conducted in collaboration with a leading German opera house (N = 10,000), we explore the significance of expressing gratitude and examine two different approaches to doing so. Our first study investigates the impact of a ‘thank you in advance’ statement in fundraising letters, a common strategy among fundraisers. In the second study, we explore the effectiveness of handwritten thankyou postcards versus printed postcards, shedding light on the roles of personalization and handwriting in donor appeals. Our findings challenge conventional wisdom, revealing that neither ‘thank you in advance’ nor handwritten thank you notes significantly affect donor contributions.
An effective communication seemed to be crucial in all the cancer care phases, like diagnosis, prognosis, and treatment options.
Objectives
To analyze and interpret structured and open-ended questionnaire responses, focusing on the communication of bad news in onco-hematology: health care professionals’ attitudes, communication methods, and perceived stress levels.
Methods
By employing a free Large Language Model, we identified and summarized the main emotions and perspectives shared by professionals.
Results
A total of 221 Italian nurses and physicians employed in onco-hematology field were enrolled. The analysis revealed key emotional themes, offering insights into the professionals’ emotional states and coping mechanisms when delivering difficult news.
Significance of results
Data highlighted the duality of emotions experienced by nurses when delivering bad news – balancing professional composure with emotional distress, underscoring the critical role of empathy, team support, and adequate preparation in helping nurses navigate these challenging conversations.
Is the formation of venture capital (VC) markets a national phenomenon? Against the common view that VC emerged in the US in the post-WWII period and later (yet independently) in Europe, we argue that the uneven relation between US and UK VC markets was crucial for British VC formation since the 1980s. Based on an empirical analysis of secondary literature and financial data, the article demonstrates that this relation is better understood through the lens of international financial subordination and identifies three types of dependencies to qualify this relation: the dependencies of UK VC on US start-up investments, US growth capital, and US exit deals. This type of financial subordination is specific to ‘alternative finance’, because highly profitable VC exits kick-started a flywheel effect in UK VC in the 2000s, and the subsequent expansion of British VC went hand in hand with a concentration of capital because UK VC followed a ‘winners-take-all’ logic that is characteristic of alt-finance in general. This suggests, counterintuitively, that after UK VC formed, the US economy benefitted more in financial, economic, and technological terms from the growing British VC market than its UK counterpart mainly because most large exit deals took place in the US.
Central to the UK’s Referendum on EU membership, immigration concerns underpinned support for Leave. This article examines ethnic minority support for Brexit, comparing their immigration attitudes with white British voters. Why immigrants and ethnic minorities would support immigration controls through voting Leave presents a theoretical puzzle with existing research finding they generally hold positive attitudes to immigration. Drawing on focus groups and interviews, I find opposition to Eastern European immigration motivated ethnic minority Leave support, who bolstered their own position as “good” immigrants while denigrating Eastern Europeans as “bad” immigrants. This echoes emerging trends of minoritized groups opposing newer migrants, including increased Latino/x support for Trump in 2024. White British Leave voters, however, rarely distinguished between EU and non-EU migrants, often including British ethnic minorities in their “mental image” of immigrants. Thus, tighter borders may do little to quell qualms over immigration which (partly) reflect concerns over rising racial diversity.