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The frequency responses of circulation control and separation control using mini-spoilers for loads attenuation on plunging swept and unswept wings were compared in a water tunnel study. At the pre-stall angle-of-attack, the effectiveness of the spoilers significantly diminishes with increasing reduced frequency of the plunging motion. For the leading-edge spoiler, this happens because the roll-up of the vorticity promotes flow reattachment and reduces the effectiveness of loads attenuation. For the trailing-edge spoiler, the effectiveness of lift attenuation also decreases with increasing reduced frequency, due to the shedding of leading-edge vortices and immersion of the trailing-edge spoiler in the separated flow. The decay of the frequency response for both types of spoilers is similar, implying that it is dictated by the flow separation near the leading edge of the wing in both cases. With increasing sweep angle of the wings, the spoilers’ effectiveness decreases significantly in comparison to the unswept wing. Strong spanwise flow develops for the leading-edge spoiler, which sheds a streamwise vortex, with the same direction of rotation as the wing-tip trailing vortex. This causes partial reattachment of the flow and reduction of the separation area behind the spoiler. With increasing reduced frequency, strong leading-edge vortices dominate the flow over the wing. The leading-edge vortices generate additional vortex lift and also cause the trailing-edge spoiler to be immersed in the massively separated flows. Both factors reduce the effectiveness of the spoilers.
Bipolar depression remains difficult to treat, and people often experience ongoing residual symptoms, decreased functioning and impaired quality of life. Adjunctive therapies targeting novel pathways can provide wider treatment options and improve clinical outcomes. Garcinia mangostana Linn. (mangosteen) pericarp has serotonogenic, antioxidant anti-inflammatory and neurogenic properties of relevance to the mechanisms of bipolar depression.
Aims
The current 28-week randomised, multisite, double-blind, placebo-controlled trial investigated mangosteen pericarp extract as an adjunct to treatment-as-usual for treatment of bipolar depression.
Method
This trial was prospectively registered on the Australia New Zealand Clinical Trials Registry (no. ACTRN12616000028404). Participants aged 18 years and older with a diagnosis of bipolar I or II and with at least moderate depressive symptoms were eligible for the study. A total of 1016 participants were initially approached or volunteered for the study, of whom 712 did not progress to screening, with an additional 152 screened out. Seventy participants were randomly allocated to mangosteen and 82 to a placebo control. Fifty participants in the mangosteen and 64 participants in the placebo condition completed the treatment period and were analysed.
Results
Results indicated limited support for the primary hypothesis of superior depression symptom reduction following 24 weeks of treatment. Although overall changes in depressive symptoms did not substantially differ between conditions over the course of the trial, we observed significantly greater improvements for the mangosteen condition at 24 weeks, compared with baseline, for mood symptoms, clinical impressions of bipolar severity and social functioning compared with controls. These differences were attenuated at week 28 post-discontinuation assessment.
Conclusions
Adjunctive mangosteen pericarp treatment appeared to have limited efficacy in mood and functional symptoms associated with bipolar disorder, but not with manic symptoms or quality of life, suggesting a novel therapeutic approach that should be verified by replication.
Preserving or improving biodiversity outcomes requires a coordinated approach across policy levels and land managers. Agri-environmental collectives in the Netherlands adapt environmental policies to local conditions and coordinate the conservation efforts of their members. This paper describes the functions performed by the Dutch collectives through a meso-institutional lens and assesses whether the effectiveness of agri-environmental schemes has improved since the introduction of the collective approach. To this end, we use a case study of one of the Dutch collectives, and a mixed-methods approach including interviews and quantitative assessments of changes in the spatial coordination of the agri-environmental scheme for meadow bird conservation since the introduction of the collective scheme. The analysis shows an increase in contracted farmland area and spatial coordination of the contracted measures on these farmlands. The results highlight the potential value of the collective approach for the implementation of environmental policies for biodiversity.
This article is an introduction and guide to investigating past relationships between climate and human behavior. Improving understanding of these relationships is essential as humanity confronts the challenges of our warming world. However, how to investigate potential climatic influences on human behavior in the past is rarely presented or discussed as a distinct mode of inquiry. This article aims to fill this gap by providing a practical tool kit for students, archaeologists, anthropologists, and other historically focused social scientists. It is structured as a series of seven key steps to creating a research design for a climate and human behavior study, from identifying research questions to presenting results. Most of the conceptual models, methods, data, and examples provided have worldwide relevance and are informed by the long history of climate and human behavior studies in the North American Southwest. By expanding competence in this domain, we can enrich documentation and interpretations of the past and insights will emerge that will contribute to preparing for and responding to our warming world.
Medicinal cannabis has been trialled for Tourette syndrome in adults, but it has not been studied in adolescents. This open-label, single-arm trial study evaluated the feasibility, acceptability and signal of efficacy of medicinal cannabis in adolescents (12–18 years), using a Δ9-tetrahydrocannabinol:cannabidiol ratio of 10:15, with dose varying from 5 to 20 mg/day based on body weight and response. The study demonstrated feasibility of recruitment, acceptability of study procedures, potential benefits and a favourable safety profile, with no serious adverse events. Commonly reported adverse events were tiredness and drowsiness, followed by dry mouth. Statistically significant improvement was observed in parent and clinician reports on tics (paired t-test P = 0.003), and behavioural and emotional issues (paired t-test P = 0.048) and quality of life as reported by the parent and young person (paired t-test P = 0.027 and 0.032, respectively). A larger-scale, randomised controlled trial is needed to validate these findings.
The family of relevant logics can be faceted by a hierarchy of increasingly fine-grained variable sharing properties—requiring that in valid entailments $A\to B$, some atom must appear in both A and B with some additional condition (e.g., with the same sign or nested within the same number of conditionals). In this paper, we consider an incredibly strong variable sharing property of lericone relevance that takes into account the path of negations and conditionals in which an atom appears in the parse trees of the antecedent and consequent. We show that this property of lericone relevance holds of the relevant logic $\mathbf {BM}$ (and that a related property of faithful lericone relevance holds of $\mathbf {B}$) and characterize the largest fragments of classical logic with these properties. Along the way, we consider the consequences for lericone relevance for the theory of subject-matter, for Logan’s notion of hyperformalism, and for the very definition of a relevant logic itself.
The conclusion, Victorian Ignorance, places the history that Selling Sexual Knowledge has traced into conversation with the emergence of a new history of sexual knowledge at the dawn of the twentieth century. While considering how well publishing activities that the book explores would have served Victorian readers, it argues that the ways Victorians discussed their reading experiences evince what the historian Kate Fisher has called an “epistemology of sexual ignorance,” in which sexual knowledge is thought of as a set of facts that must be learned through interaction with an expert. It further argues that commercial and rhetorical practices explored in the book not only encouraged this way of conceptualizing sexual knowledge, but helped foster the emergence of a historical narrative about Victorian censorship that would serve as a powerful justification for sexual-scientific research and sex reform movements in the twentieth century. At the same time, this narrative would obfuscate the extent to which Victorians enjoyed access to sexual information in the new age of mass print.
In previous publications, it was shown that finite non-deterministic matrices are quite powerful in providing semantics for a large class of normal and non-normal modal logics. However, some modal logics, such as those whose axiom systems contained the Löb axiom or the McKinsey formula, were not analyzed via non-deterministic semantics. Furthermore, other modal rules than the rule of necessitation were not yet characterized in the framework.
In this paper, we will overcome this shortcoming and present a novel approach for constructing semantics for normal and non-normal modal logics that is based on restricted non-deterministic matrices. This approach not only offers a uniform semantical framework for modal logics, while keeping the interpretation of the involved modal operators the same, and thus making different systems of modal logic comparable. It might also lead to a new understanding of the concept of modality.
Antarctica, which has always been of great interest to researchers worldwide, is currently attracting considerable attention owing to climate change and other topics. In this context, bibliometric analysis allows the identification of hot topics, scientific productivity, cooperation, research gaps and strategic areas of potential interest. We conducted a bibliometric study to evaluate the global production of Antarctic research between 1980 and 2023 and analysed Spanish National Antarctic Programme (NAP) production as a case study. Scientific publications were reviewed and classified based on their main themes, key word co-occurrence and international collaborations. We found that scientific production worldwide and in the Spanish NAP has progressively increased since 1980. Globally, the main areas of research are the geosciences, oceanography and atmospheric sciences. However, the Spanish NAP, which reported 2287 publications, has focused more on the geosciences and ecology. Spanish Antarctic researchers have mainly collaborated with researchers from the USA, the UK, Germany and Italy. Our research highlights the importance of strengthening research plans to diversify and facilitate international collaboration, promoting a more interdisciplinary approach to address the current and future challenges identified by the scientific community. In this context, specific opportunities for developing a Spanish NAP strategic plan are discussed.
Chapter 4, Obscene… in a Certain Sense, shows how charges of obscenity were used against pornographers and irregulars during the 1850s and 1860s, amid landmark changes to obscenity law. In doing so, it introduces one of the book’s major arguments: that allegations of medical obscenity were usually tactical, and became increasingly imbricated in projects aimed at contesting medical authority. The most influential anti-vice group of the period, the Society for the Suppression of Vice, led a crackdown on the pornography trade during this period, which brought medical works into the courtroom, and some were destroyed on the grounds that they were obscene. The chapter parallels arguments that medical works could be obscene in court with tactics in the medical press. With mixed success, campaigns against “obscene quackery” attacked irregular practitioners who treated sexual issues by arguing that their manuals’ low prices and wide circulation made them a threat to public morals. The chapter ends with the 1868 formulation of the Hicklin test, a legal test of obscenity that affirmed that arguments examined in this chapter could justify the destruction of medical works.
In the post-World War II period, as they faced a spate of prison riots and rising concerns about juvenile delinquency, many states set up penal forestry camps. Portrayed as a progressive step that would make incarcerated people fit for freedom through healthy work in natural settings, forestry camps also promised to contribute to the public good by fulfilling the forests’ manpower needs. At a moment when outdoor leisure was increasingly popular, the work of incarcerated workers helped create infrastructures that would make forests accessible to visitors. Using primarily the case of Washington state, this article shows how and why incarcerated people became a material and ideological resource for the state. It also shows how official discourse about forestry camps clashed with material and human realities on the ground.
This introduction outlines how studying the book trade can help us better understand the circulation of medical knowledge about sex and reproduction during the Victorian period, and the development of busineses, institutions, and narratives that claimed authority over it. Weaving a historiographic overview with an overview of the book’s approach and argument, it turns readers’ attention to medical works’ status as more than texts, highlighting the fact that they are material objects that must be made, promoted, and distributed, and that these actions accrue meanings of their own. It then articulates the book’s focus on the activities of four differently identified groups of players – pornographers, radicals, regular practitioners, and irregular practitioners – who brought sexual knowledge into non-expert readers’ hands and, in various ways, became embroiled in debates about medical obscenity. The introduction then outlines how the book tracks these agents’ intersecting activities to open up an argument about how and why allegations of obscenity became a means of selling books, contesting authority, and consolidating emergent collective identities.
How should epistemologists respond to skepticism about knowledge of the external world? Michael Bergmann advocates noninferential antiskepticism. The thought is that, to reply to a skeptical argument, we should start with premises that do not require inference. I argue that Bergmann’s reasoning runs into the problem of easy knowledge and propose an alternative inferential antiskepticism. This view faces the problem of vicious circularity. I agree that, if we go down the inferential path, a certain type of circularity is unavoidable. I deny, however, that this type of circularity is vicious.
Chapter 5, Dull Instead of Light, examines regular practitioners’ increasing efforts to disambiguate “medicine” and “quackery” in the wake of the 1868 formulation of the Hicklin test of obscenity. The first section explores how medical groups experimented with using obscenity laws as alternatives to the Medical Act (1858) to regulate medical practice. These actions’ impact on the book trade is debatable, but regular practitioners’ tireless efforts to collapse quackery and obscenity influenced new legislation governing medical advertising. The rest of the chapter examines parallel efforts to professionalize medical publishing. In advocating for limitations on medical book advertising, the use of dry, technical language in medical writing, and other changes to medical print culture, regular practitioners further sought to disambiguate “medicine” from “quackery.” The lines between popular and professional medical works had previously been blurry. The changes examined in this chapter helped cleave a growing chasm between the kinds of sexual knowledge accessible to medical and non-medical audiences.
In this paper, we aim to investigate the fluid model associated with an open large-scale storage network of non-reliable file servers with finite capacity, where new files can be added, and a file with only one copy can be lost or duplicated. The Skorokhod problem with oblique reflection in a bounded convex domain is used to identify the fluid limits. This analysis involves three regimes: the under-loaded, the critically loaded, and the overloaded regimes. The overloaded regime is of particular importance. To identify the fluid limits, new martingales are derived, and an averaging principle is established. This paper extends the results of El Kharroubi and El Masmari [7].
Ostracoderms, Paleozoic jawless stem-gnathostomes, are characterized by distinctive bony shields covering the front of their bodies. These headshields exhibit significant variations in morphology across species, boasting frontal, lateral, and dorsal processes. Ostracoderms represent pivotal intermediaries between modern jawless and jawed vertebrates, so understanding their biology and ecology is crucial for unraveling the selective pressures that shaped the early evolution and diversification of jawed vertebrates, which now dominate vertebrate diversity. This study employs virtual paleontology techniques and phylogenetic comparative methods to explore the hydrodynamic and ecological implications of these processes, focusing on pteraspidomorphs, the most diverse ostracoderm group. The analysis reveals widespread convergence in the arrangement and development of headshield processes. Lateral processes enhance hydrodynamic efficiency and generate lift, while combined lateral and dorsal processes provide stability in rolling, yawing, and pitching. Frontal processes reduce drag in many cases. These findings illuminate the enigmatic roles of ostracoderm headshields, showing how the dimensions and arrangement of their processes are biomechanically linked to a range of functions and ecological roles. Collectively, this highlights the intricate evolutionary pathways of lifestyles and ecologies within stem-gnathostomes, challenging the idea of a unidirectional trend toward more active lifestyles in vertebrate evolution and suggesting diverse ecological roles for ostracoderms.
We propose a novel pricing factor for currency returns motivated by the market microstructure literature. Our factor aggregates order flow data to provide a measure of buying and selling pressure related to conventional currency trading strategies. It successfully prices the cross-section of currency returns sorted on the basis of forward discount and momentum. The association between our factor and currency returns differs according to the customer segment of the foreign exchange market. In particular, it appears that financial customers are risk-takers in the market, while nonfinancial customers serve as liquidity providers.