The electromagnetically driven magnetised spherical Couette flow is studied experimentally, theoretically and numerically in the laminar regime. The working fluid, Galinstan, is contained in the spherical gap between two concentric spheres at rest. The electromagnetic stirring is primarily generated due to the interaction of a direct current, which is injected through two ring-shaped electrodes located at the equatorial zone of each sphere, and a dipolar magnetic field produced by a permanent magnet located inside the inner sphere. The flows were explored experimentally for a Reynolds number ranging from 450 to 2230 and a Hartmann number of 240. Ultrasound Doppler velocimetry and particle image velocimetry were used to characterise the flow. For low Reynolds numbers, given the symmetry of the problem, a one-dimensional analytic solution is obtained in the equatorial plane from the magnetohydrodynamic equations. The analytical solution reproduces the main characteristics of the flow. In addition, a full three-dimensional numerical model is able to reproduce both the analytical solution and the experimental measurements. To the best knowledge of the authors, this is the first time experimental results of the magnetised spherical Couette flow have been reported with electromagnetic forcing using a liquid metal as the working media.

Los estudios sobre las acciones colectivas de las trabajadoras sexuales se han centrado principalmente en la esfera pública, abordando procesos de organización sindical, movimientos sociales y articulación de redes para la reivindicación de sus derechos. Sin embargo, han prestado escasa atención a las acciones que les permiten sobrellevar los agravios en su contexto laboral. Este estudio tiene como objetivo comprender las acciones colectivas cotidianas de protesta de las trabajadoras sexuales en entornos laborales estigmatizados por la norma de género. Para ello, realizamos una etnografía etnometodológica feminista durante dieciocho meses en el norte de Chile, donde observamos diversos escenarios del trabajo sexual y realizamos dieciocho entrevistas en profundidad. Concluimos que las trabajadoras sexuales producen acciones colectivas de protesta situadas y efímeras, mediante las cuales buscan restituir, aunque precariamente, el equilibrio de poder en sus escenarios laborales, y que relegan la posibilidad de impugnar directamente el orden social debido al costo que significaría en sus vidas.

Common mental disorders (CMDs) are a leading cause of burden and disability globally. Approximately 75% of those living with CMDs reside in low- and middle-income countries (LMICs), and up to 90% of those needing mental health care do not receive it. The Friendship Bench is a task-sharing mental health intervention delivered by lay health workers (LHWs) that utilizes concepts of Problem-Solving Therapy. The aim of this systematic review is to identify and evaluate the barriers and facilitators to the implementation of research outcomes of the Friendship Bench and understand its systematic uptake to narrow the CMD treatment gap. We conducted a systematic review of articles that reported on the Friendship Bench in LMICs, CMDs, implementation research outcomes, and studies that utilized experimental, observational, or qualitative study designs. We identified articles using medical subject headings and keywords from APA PsycINFO, Cochrane, CINAHL, EMBASE, Global Health, OVID, PubMed/Medline, Science Direct, Web of Science, and Google Scholar in February 2023 and again in December 2023 to capture any additional articles. We screened 641 articles, and a total of 7 articles were included in the final analysis. All studies were conducted in Zimbabwe within the past 8 years, and across all the studies, all implementation research outcomes were reported. There is strong evidence that the Friendship Bench is acceptable, appropriate, and feasible to address the CMD treatment gap in Zimbabwe. Facilitators include that the Friendship Bench is culturally adaptable, utilizes trusted LHWs, and has relatively strong community and political buy-in. Conversely, barriers include a lack of a reliable mental health system, limitations in its ability to treat more serious mental conditions, and mental health stigma. There is an opportunity to explore the application of the Friendship Bench for CMDs in other countries and as a basis for novel task-sharing interventions for other health conditions.

Weighted sieves are used to detect numbers with at most S prime factors with $S \in \mathbb{N}$ as small as possible. When one studies problems with two variables in somewhat symmetric roles (such as Chen primes, that is primes p such that $p+2$ has at most two prime factors), one can utilise the switching principle. Here we discuss how different sieve weights work in such a situation, concentrating in particular on detecting a prime along with a product of at most three primes.

As applications, we improve on the works of Yang and Harman concerning Diophantine approximation with a prime and an almost prime, and prove that, in general, one can find a pair $(p, P_3)$ when both the original and the switched problem have level of distribution at least $0.267$.

Effective conservation management of threatened species with transboundary distributions is a challenge, requiring international coordination to ensure that country-specific actions align with regional imperatives. Many international conservation efforts overlook species needing attention and fail to incorporate the field expertise of local researchers in regional-level assessments. Here we focus on the taruka Hippocamelus antisensis, a threatened and little-studied deer of the Central Andes Ecoregion in South America. Since 2016, experts, managers and governmental authorities from all countries encompassing the species’ range have gathered to collate information about its presence and coordinate efforts to conserve it. We constructed taruka distribution models using historical records and more recent sightings reported during the last 50 years. Our findings revealed several critical insights: slope, normalized difference vegetation index (NDVI) during the dry season, and daily and seasonal temperature variability are primary predictors of taruka distribution, and the largest part of its range is in Peru (54%), followed by Bolivia (30%), Argentina (10%) and Chile (6%). The species’ core distribution is confined to the western and eastern limits of the Central Andes Ecoregion, bordered by the Sechura and Atacama Desert to the west and the Yungas Forest to the east. Protection is limited, with only 12 and 8% of the core and non-core areas, respectively, of the species’ range under formal protection. We recommend safeguarding connectivity of the core distribution by establishing transboundary protected areas, improving taruka coexistence with local communities, strengthening and formalizing international collaboration amongst taruka experts and raising the species’ appeal amongst policymakers and the public. In particular, we hope to encourage international collaboration between Southern Hemisphere specialists. This is important because these researchers have extensive field knowledge that could improve global conservation efforts, especially in regions that lack adequate conservation funding.

Late talkers (LTs) exhibit delayed vocabulary development, which might stem from a lack of a typical word learning strategy to generalise object labels by shape, called the ‘shape bias’. We investigated whether LTs can acquire a shape bias and whether this accelerates vocabulary learning. Fourteen LTs were randomly allocated to either a shape training group (Mage = 2.76 years, 6 males), which was taught that objects similar in shape have the same name, or a control group (Mage = 2.61 years, 4 males), which was taught real words without any focus on object shape. After seven training sessions, children in the shape training group generalised trained labels by shape (d = 1.28), but not unfamiliar labels. Children in the control group extended all labels randomly. Training did not affect expressive vocabulary.

We applied a Density-Based Clustering algorithm on samples of galaxies and galaxy systems belonging to 53 rich superclusters from the Main SuperCluster Catalogue to identify the presence of “central regions’’, or cores, in these large-scale structures. Cores are defined here as large gravitationally bound galaxy structures, comprised of two or more clusters and groups, with sufficient matter density to survive cosmic expansion and virialize in the future. We identified a total of 105 galaxy structures classified as cores, which exhibit a high density contrast of mass and galaxies. The Density-based Core Catalogue, presented here, includes cores that were previously reported in well-known superclusters of the Local Universe, and also several newly identified ones. We found that 83% of the rich superclusters in our sample have at least one core. While more than three cores with different dynamical state are possible, the presence of a single core in the superclusters is more common. Our work confirms the existence of nucleation regions in the internal structure of most rich superclusters and points to the fact that these cores are the densest and most massive features that can be identified in the cosmic web with high probability for future virialization.

Body composition and phase angle (PhA) have been used to predict mortality in multiple diseases. However, little has been studied regarding segmental measurements, which could potentially help assess subtle changes in specific tissue segments. This study aimed to identify the total PhA cut-off point associated with mortality risk and changes in body composition within a week of hospitalisation in non-critical hospitalised patients with COVID-19. A cohort study was conducted where patients underwent to a complete nutritional assessment upon admission and after seven days, and followed up until hospital discharge or death. A receiver operating characteristic curve was constructed to determine the PhA cut-off point, and the Kaplan–Meier estimator was used to determine survival analysis. Segmental and complete body compositions on admission and after 7 d were compared. We included 110 patients (60 men) with a mean age of 50·5 ± 15·0 years and a median BMI of 28·5 (IQR, 25·6–33·5) kg/m2. The median length of hospital stay was 6 (IQR, 4–9) d, and the mortality rate was 13·6 %. The PhA cut-off point obtained was 4°, with significant differences in the survival rate (P < 0·001) and mortality (HR = 5·81, 95 % CI: 1·80, 18·67, P = 0·003). Segmental and whole-body compositions were negatively affected within one week of hospitalisation, with changes in the approach by the graphical method in both sexes. Nutritional status deteriorates within a week of hospitalisation. PhA < 4° is strongly associated with increased mortality in non-critical hospitalised patients with COVID-19.

The present study aimed to determine the prevalence of adiposity-based chronic disease (ABCD) and its association with anthropometric indices in the Mexican population. A cross-sectional study was conducted in 514 adults seen at a clinical research unit. The American Association of Clinical Endocrinology/AACE/ACE criteria were used to diagnose ABCD by first identifying subjects with BMI ≥ 25 kg/m2 and those with BMI of 23–24·9 kg/m2 and waist circumference ≥ 80 cm in women or ≥ 90 cm in men. The presence of metabolic and clinical complications associated with adiposity, such as factors related to metabolic syndrome, prediabetes, type 2 diabetes, dyslipidaemia and arterial hypertension, were subsequently evaluated. Anthropometric indices related to cardiometabolic risk factors were then determined. The results showed the prevalence of ABCD was 87·4 % in total, 91·5 % in men and 86 % in women. The prevalence of ABCD stage 0 was 2·4 %, stage 1 was 33·7 % and stage 2 was 51·3 %. The prevalence of obesity according to BMI was 57·6 %. The waist/hip circumference index (prevalence ratio (PR) = 7·57; 95 % CI 1·52, 37·5) and the conicity index (PR = 3·46; 95 % CI 1·34, 8·93) were better predictors of ABCD, while appendicular skeletal mass % and skeletal muscle mass % decreased the risk of developing ABCD (PR = 0·93; 95 % CI 0·90, 0·96; and PR = 0·95; 95 % CI 0·93, 0·98). In conclusion, the prevalence of ABCD in our study was 87·4 %. This prevalence increased with age. It is important to emphasise that one out of two subjects had severe obesity-related complications (ABCD stage 2).

OBJECTIVES/GOALS: Pancreatic ductal adenocarcinoma (PDAC) is a relatively radioresistant disease, and inhibition of DNA homologous recombination (HR) repair in combination with radiation therapy (RT) is a potentially attractive strategy to overcome radioresistance. We have found that the expression of the HR protein RAD18 is upregulated in PDAC cells. METHODS/STUDY POPULATION: Standard clonogenic assays, γH2aX foci staining, HR-GFP reporter assay, and western blot analysis of DNA damage response proteins were performed in MIA-PaCa2 (MP2) and PANC-1 cells following knockdown of RAD18 in cells via short hairpin RNA (shRNA). Drug targeting of RAD18 was achieved through the use of a USP-7 inhibitor, P5091. Cells with or without stable knockdown of RAD18 were implanted orthotopically in the pancreas of athymic nude mice and treated with sham radiation or radiation to a dose of 20 Gy in 5 daily fractions once tumors reached 100-150 mm3. RESULTS/ANTICIPATED RESULTS: Stable knockdown of RAD18 in MP2 and PANC-1 resulted in decreased radiation clonogenic survival in vitro (dose enhancement factor (DEF)=1.52 and 1.51, respectively), decreased DNA repair after radiation as measured by the increased number of γH2aX nuclear foci assay at 6, 12, and 24 hours (all p<0.05), decreased HR activation following DNA damage via an HR-GFP reporter assay (p=0.039), and increased tumor growth delay following radiation in vivo (p<0.001). P5091 treatment of both MP2 and PANC-1 resulted in efficient knockdown of RAD18, which was confirmed through western blotting, qRT-PCR, and luciferase reporter assays. P5091 increased radiosensitization, yH2aX nuclear foci remained elevated at 12 and 24 hours (p<0.05), and HR repair was also reduced (p=0.014). DISCUSSION/SIGNIFICANCE: Herein, we show the HR repair protein RAD18, and that modulation of RAD18 expression correlates with in vitro and in vivo radiosensitization through altered HR-mediated DNA repair. USP7 inhibition successfully reduced RAD18 expression and resulted in enhanced radiosensitization.

Social influence among people is widely understood to be a universal component of the human experience. However, studies of political behavior have generally approached social influence as specific to a type of behavior, such as voting, in a particular national context. There are good reasons to expect that social influence is observable across diverse behaviors and national contexts. In this study, we test this expectation using a two-wave panel survey of national samples in 19 countries. We employ autoregressive models that address some of the endogeneity challenges associated with attempts to measure social influence with survey designs. Our measure of social influence is predictive of diverse political behaviors in many countries with average effects comparable in size to important standard predictors of behavior.

Results from seven direct and large-eddy simulations of gravity currents on slopes ranging from 0.14$^{\circ }$ to 2.86$^{\circ }$ that span from the subcritical to the supercritical regime are studied. By considering a long domain, attention is focused on the near-self-similar state approached by these currents far downstream. In the self-similar limit, the various shape factors, local Richardson number, entrainment coefficient, velocity scale and basal drag coefficient reach a constant value, while the current height, volume and momentum fluxes continue to increase linearly. Their dependence on slope is presented.

Although it has been demonstrated that environmental changes within a year can affect the reproduction, survival, and growth of invasive species, these factors have rarely been incorporated into demographic analyses. Therefore, we applied multistate demographic models (based on capture–recapture animal methods accounting for imperfect detectability of individuals in natural conditions) to evaluate the effects of reproductive phenology and rainy season on the survival and transition/retrogression rates among stage categories of black elderberry (Sambucus nigra L.)—an invasive tree species widely distributed in temperate forests of Europe and America. In the Abies religiosa temperate forest, Mexico City, a multistate demographic model of S. nigra was built using bimonthly censuses during a year. We selected the best-fitting model according to Akaike’s information criterion adjusted for small sample sizes (AICc). We determined the response of reproductive phenology of S. nigra to the rainy season for 2 yr through repeatability and phenotypic plasticity indexes. Our results showed that the reproductive phenology of S. nigra has a low repeatability index and a high phenotypic plasticity index. We demonstrated that additive and interactive effects of reproductive phenology and rainy season promote changes in survival and transition/retrogression rates among stage categories. During the rainy season, the survival probability of seedlings and transition probability toward the adult category increased. Therefore, our study represents a significant contribution to the knowledge of the demographic dynamics of invasive species on an intra-annual scale.