We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.
Methods
In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores from the Patient Health Questionnaire-9 (depression symptoms), Generalized Anxiety Disorder-7 (anxiety symptoms), and Work and Social Adjustment Scale (functional impairment). Genome-wide association analyses were performed with REGENIE. Heritability was estimated using GCTA-GREML and genetic correlations with bivariate-GREML.
Results
The phenotypic correlations were moderate across the three measures (Pearson’s r = 0.50–0.69). All three scales were found to be under low but significant genetic influence (single-nucleotide polymorphism-based heritability [h2SNP] = 0.11–0.19) with high genetic correlations between them (rg = 0.79–0.87).
Conclusions
Among individuals with lifetime depression or anxiety from the GLAD Study, the genetic variants that underlie symptom severity largely overlap with those influencing functional impairment. This suggests that self-reported functional impairment, while clinically relevant for diagnosis and treatment outcomes, does not reflect substantial additional genetic liability beyond that captured by symptom-based measures of depression or anxiety.
Developing reduced-order models for the transport of solid particles in turbulence typically requires a statistical description of the particle–turbulence interactions. In this work, we utilize a statistical framework to derive continuum equations for the moments of the slip velocity of inertial, settling Lagrangian particles in a turbulent boundary layer. Using coupled Eulerian–Lagrangian direct numerical simulations, we then identify the dominant mechanisms controlling the slip velocity variance, and find that for a range of Stokes number ${S{\kern-0.5pt}t}^+$, Settling number ${S{\kern-0.5pt}v}^+$ and Reynolds number $\textit{Re}_\tau$ (based on frictional scales),the slip variance is primarily controlled by local differences between the ‘seen’ variance and the particle velocity variance, while terms appearing due to the inhomogeneity of the turbulence are subleading until ${S{\kern-0.5pt}v}^+$ becomes large. We also consider several comparative metrics to assess the relative magnitudes of the fluctuating slip velocity and the mean slip velocity, and we find that the vertical mean slip increases rapidly with ${S{\kern-0.5pt}v}^+$, rendering the variance relatively small – an effect found to be most substantial for ${S{\kern-0.5pt}v}^+\gt 1$. Finally, we compare the results with a model of the acceleration variance (Berk & Coletti 2021 J. Fluid Mech.917, A47) based the concept of a response function described in Csanady (1963 J. Atmos. Sci.20, 201–208), highlighting the role of the crossing trajectories mechanism. We find that while there is good agreement for low ${S{\kern-0.5pt}v}^+$, systematic errors remain, possibly due to implicit non-local effects arising from rapid particle settling and inhomogeneous turbulence. We conclude with a discussion of the implications of this work for modelling the transport of coarse dust grains in the atmospheric surface layer.
The savannah–forest mosaic of the Rupununi region of Guyana is a dispersal corridor between large tracts of intact Guiana Shield forests and a subsistence hunting ground for Indigenous Makushi and Wapichan communities. We conducted a camera-trap survey at 199 sites across four major forested habitat types and used multi-species occupancy modelling to determine regional-scale drivers of mammalian occupancy at both species and community levels, accounting for imperfect detection. We detected 47 savannah- and forest-dwelling mammal species, with the occupancy of medium- and large-bodied terrestrial mammal species (community occupancy) positively related to per cent forest cover and negatively to the presence of gallery forest habitat. The occupancy of 15 of 30 species was positively related to forest cover, suggesting the importance of maintaining forested habitat within the broader mosaic comprising savannahs and intermediate habitats for sustaining maximum mammal diversity. Jaguar Panthera onca occupancy was associated with the presence of livestock, and giant anteater Myrmecophaga tridactyla occupancy was negatively associated with distance to the nearest road, both results of concern in relation to potential human–wildlife conflict. The probability of detecting terrestrial mammal species (community detectability) increased away from villages, as did the detectability of two large-bodied, hunted species, the lowland tapir Tapirus terrestris and collared peccary Pecari tajacu, potentially indicating the negative effects of subsistence and commercial hunting in this savannah mosaic habitat. We use our findings to discuss how management strategies for hunting, fire, timber harvest and agriculture within Indigenous titled lands could help ensure the sustainability of these traditional livelihood activities.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Cattle (Bos spp.) grazing on weed–mixed forage biomass may potentially spread weed seeds, leading to plant invasions across pasturelands. Understanding the possibility and intensity of this spread is crucial for developing effective weed control methods in grazed areas. This research undertook an in vitro experiment to evaluate the germination and survival of five dominant weed species in the southern United States [Palmer amaranth (Amaranthus palmeri S. Watson), yellow foxtail [Setaria pumila (Poir.) Roem. & Schult.], johnsongrass [Sorghum halepense (L.) Pers.], field bindweed (Convolvulus arvensis L.) and pitted morningglory (Ipomoea lacunosa L.)] upon incubation in rumen fluid for eight time periods (0, 4, 8, 12, 24, 24, 48, 72, and 96 h). For the 96-h treatment, a full Tilley and Terry procedure was applied after 48 h for stopping fermentation, followed by incubation for another 48 h simulating abomasum digestion. Seed germination, upon incubation, varied significantly among weed species, with I. lacunosa reaching zero germination after only 24 h of incubation, whereas A. palmeri and S. halepense retained up to 3% germination even after 96 h of incubation. The hard seed coats of A. palmeri and S. halepense likely made them highly resistant, whereas the I. lacunosa seed coat became easily permeable and ruptured under rumen fluid incubation. This suggests that cattle grazing can selectively affect seed distribution and invasiveness of weeds in grazed grasslands and rangelands, including the designated invasive and noxious weed species. As grazing is a significant component in animal husbandry, a major economic sector in the U.S. South, our research provides important insights into the potential role of grazing as a dispersal mechanism for some of the troublesome arable weeds in the United States. The results offer opportunities for devising customized feeding and grazing practices combined with timely removal of weeds in grazeable lands at the pre-flowering stage for effective containment of weeds.
Children born very preterm (VPT; ≤32 weeks’ gestation) are at higher risk of developing behavioural problems, encompassing socio-emotional processing and attention, compared to term-born children. This study aimed to examine multi-dimensional predictors of late childhood behavioural and psychiatric outcomes in very preterm children, using longitudinal clinical, environmental, and cognitive measures.
Methods
Participants were 153 VPT children previously enrolled in the Evaluation of Preterm Imaging study who underwent neuropsychological assessments at 18–24 months, 4–7 years and 8–11 years as part of the Brain Immunity and Psychopathology following very Preterm birth (BIPP) study. Predictors of late childhood behavioural and psychiatric outcomes were investigated, including clinical, environmental, cognitive, and behavioural measures in toddlerhood and early childhood. Parallel analysis and exploratory factor analysis were conducted to define outcome variables. A prediction model using elastic-net regularisation and repeated nested cross-validation was applied to evaluate the predictive strength of these variables.
Results
Factor analysis revealed two key outcome factors in late childhood: externalising and internalising-socio-emotional problems. The strongest predictors of externalising problems were response inhibition, effortful control and internalising symptoms in early childhood (cross-validated R2=.256). The strongest predictors of internalising problems were autism traits and poor cognitive flexibility in early childhood (cross-validated R2=.123). Cross-validation demonstrated robust prediction models, with higher accuracy for externalising symptoms.
Conclusions
Early childhood cognitive and behavioural outcomes predicted late childhood behavioural and psychiatric outcomes in very preterm children. These findings underscore the importance of early interventions targeting cognitive development and behavioural regulation to mitigate long-term psychiatric risks in very preterm children.
Shenoute of Atripe (348–465) was the most important Egyptian monastic leader in late antiquity. He developed a formalized discipline with which he governed three monasteries (two for men, one for women) located in the village of Atripe, across the Nile River from the city Panopolis (modern Akhmim). Thanks to Shenoute’s leadership, these monastic complexes, collectively known as the White Monastery Federation, played a major role in the social, political, economic, and religious lives of people in the region (Christians and non-Christians alike) and would become the hub of Christian literary culture in Egypt well into the Arab period. Shenoute himself occasionally preached public sermons in his native Coptic tongue to large crowds consisting of monastics, clergy members, lay people, government officials, military professionals, and other local luminaries. In those moments, Shenoute repeatedly defined the moral contours of the Christian community by stridently and repeatedly lambasting any zdepravity he believed present among his hearers, such as exploitation of the poor by rich landowners, adultery, violation of monastic vows, theft, cultic veneration of pagan gods, and Origenist and eventually Chalcedonian heresy.
Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
Edited by
David Mabey, London School of Hygiene and Tropical Medicine,Martin W. Weber, World Health Organization,Moffat Nyirenda, London School of Hygiene and Tropical Medicine,Dorothy Yeboah-Manu, Noguchi Memorial Institute for Medical Research, University of Ghana,Jackson Orem, Uganda Cancer Institute, Kampala,Laura Benjamin, University College London,Michael Marks, London School of Hygiene and Tropical Medicine,Nicholas A. Feasey, Liverpool School of Tropical Medicine
Chronic and non-communicable disease encompasses conditions that are not caused by transmissible infections, have long-term health consequences and often create a need for continuing treatment and care. It is an imprecise term as many non-communicable diseases have an infectious cause, for example, rheumatic heart disease following Strep. pyogenes infection or the many cancers initiated by viral infections. Although covering a vast area of medical practice ranging from neurological conditions and mental illness to musculoskeletal disease and disability, four main groups account for 70% of deaths worldwide: cardiovascular disease, chronic respiratory disease, diabetes and cancer. Personal injuries – mainly due to road accidents, are usually included as an expanded definition, non-communicable disease and injuries (NCDI).
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
We measured the harmonic-space power spectrum of Galaxy clustering auto-correlation from the Evolutionary Map of the Universe Pilot Survey 1 data (EMU PS1) and its cross-correlation with the lensing convergence map of cosmic microwave background (CMB) from Planck Public Release 4 at the linear scale range from $\ell=2$ to 500. We applied two flux density cuts at $0.18$ and $0.4$ mJy on the radio galaxies observed at 944MHz and considered two source detection algorithms. We found the auto-correlation measurements from the two algorithms at the 0.18 mJy cut to deviate for $\ell\gtrsim250$ due to the different criteria assumed on the source detection and decided to ignore data above this scale. We report a cross-correlation detection of EMU PS1 with CMB lensing at $\sim$5.5$\sigma$, irrespective of flux density cut. In our theoretical modelling we considered the SKADS and T-RECS redshift distribution simulation models that yield consistent results, a linear and a non-linear matter power spectrum, and two linear galaxy bias models. That is a constant redshift-independent galaxy bias $b(z)=b_g$ and a constant amplitude galaxy bias $b(z)=b_g/D(z)$. By fixing a cosmology model and considering a non-linear matter power spectrum with SKADS, we measured a constant galaxy bias at $0.18$ mJy ($0.4$ mJy) with $b_g=2.32^{+0.41}_{-0.33}$ ($2.18^{+0.17}_{-0.25}$) and a constant amplitude bias with $b_g=1.72^{+0.31}_{-0.21}$ ($1.78^{+0.22}_{-0.15}$). When $\sigma_8$ is a free parameter for the same models at $0.18$ mJy ($0.4$ mJy) with the constant model we found $\sigma_8=0.68^{+0.16}_{-0.14}$ ($0.82\pm0.10$), while with the constant amplitude model we measured $\sigma_8=0.61^{+0.18}_{-0.20}$ ($0.78^{+0.11}_{-0.09}$), respectively. Our results agree at $1\sigma$ with the measurements from Planck CMB and the weak lensing surveys and also show the potential of cosmology studies with future radio continuum survey data.
Advances in medicine have led to an improvement in life expectancy, thus increasing the population of older individuals within the criminal justice system. This study investigates the determinants of risk formulation, care plan, and disposition among older adult forensic patients (OAFP) in Ontario, Canada.
Methods
This retrospective analysis utilized the Ontario Review Board database, focusing on 161 OAFP, aged 55 years and older. Hierarchical regression was used to analyze the relationship between changes in risk and six blocks of variables: sociodemographic characteristics (Block 1), circumstances during the index offense (Block 2), current clinical profile (Block 3), past psychiatric history and behavioral patterns (Block 4), criminal history and legal status (Block 5), and recent violent events (Block 6).
Results
The median age of patients was 61 years (IQR 58–67), with 83.4% being male. Schizophrenia was the most common diagnosis (68.3%), and 9.3% had neurocognitive disorders. The model with six blocks of factors explained 92% of the variability in risk change. Models 2 (blocks 1 and 2) and 4 (blocks 1–4) were statistically significant, explaining 34% (p = 0.010) and 22% (p = 0.018) of the variance in the change in risk of threat to public safety, respectively. OAFP with a significant risk to public safety were more likely to be inpatients and less likely intoxicated during their index offense.
Conclusion
Resources, policies, and a supervised model of care to curtail behavioral risks are relevant to the care of OAFP. Innovative risk management models for OAFP are indicated.
The shallow-water equations are widely used to model interactions between horizontal shear flows and (rotating) gravity waves in thin planetary atmospheres. Their extension to allow for interactions with magnetic fields – the equations of shallow-water magnetohydrodynamics (SWMHD) – is often used to model waves and instabilities in thin stratified layers in stellar and planetary atmospheres, in the perfectly conducting limit. Here we consider how magnetic diffusion should be added to the equations of SWMHD. This is crucial for an accurate balance between advection and diffusion in the induction equation, and hence for modelling instabilities and turbulence. For the straightforward choice of Laplacian diffusion, we explain how fundamental mathematical and physical inconsistencies arise in the equations of SWMHD, and show that unphysical dynamo action can result. We then derive a physically consistent magnetic diffusion term by performing an asymptotic analysis of the three-dimensional equations of magnetohydrodynamics in the thin-layer limit, giving the resulting diffusion term explicitly in both planar and spherical coordinates. We show how this magnetic diffusion term, which allows for a horizontally varying diffusivity, is consistent with the standard shallow-water solenoidal constraint, and leads to negative semidefinite Ohmic dissipation. We also establish a basic type of antidynamo theorem.
When turbulent convection interacts with a turbulent shear flow, the cores of convective cells become aligned with the mean current, and these cells (which span the height of the domain) may interact with motions closer to the solid boundary. In this work, we use coupled Eulerian–Lagrangian direct numerical simulations of a turbulent channel flow to demonstrate that, under conditions of turbulent mixed convection, interactions between motions associated with ejections and low-speed streaks near the solid boundary and coherent superstructures in the interior of the flow interact and lead to significant vertical transport of strongly settling Lagrangian particles. We show that the primary suspension mechanism is associated with strong ejection events (canonical low-speed streaks and hairpin vortices characterised by $u'\lt 0$ and $w'\gt 0$, where $u'$ and $w'$ are the streamwise and vertical turbulent velocity fluctuations), whereas secondary suspension is strongly associated with large-scale plume structures aligned with the mean shear (characterised by $w'\gt 0$ and $\theta '\gt 0$, where $\theta$ represents temperature fluctuations). This coupling, which is absent in the limiting cases (pure channel flow or free convection) is shown to lead to a sudden increase in the interior concentration profiles as ${Ri}_\tau$, the friction Richardson number, increases, resulting in concentrations that are larger by roughly an order of magnitude at the channel midplane.
The nature and extent of interactions between the distant regions and cultures of Mesoamerica remain open to much debate. Close economic and political ties developed between Teotihuacan and the lowland Maya during the Early Classic period (AD 250–550), yet the relationship between these cultures continues to perplex scholars. This article presents an elaborately painted altar from an elite residential group at the lowland Maya centre of Tikal, Guatemala. Dating to the fifth century AD, the altar is unique in its display of Teotihuacan architectural and artistic forms, adding to evidence not only for cultural influence during this period, but also for an active Teotihuacan presence at Tikal.
This is the first history to grapple with the vast project of British imperial investigation in the years between the Battle of Waterloo in 1815 and the Great Reform Act. Beginning in 1819, commissions of inquiry were sent to examine law, governance, and economy from New South Wales and the Caribbean to Malta and West Africa. They left behind a matchless record of colonial life in the form of papers, reports and more than 200 volumes of testimonies and correspondence. Inquiring into Empire taps this under-used archive to develop a new understanding of imperial reform. The authors argue that, far from being a first step in the march towards liberalism, the commissions represented a deeply pragmatic, messy but concerted effort to chart a middle way between reaction and revolution which was constantly buffeted by the politics of colonial encounter.