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By associating cunnilingus with a Tootsie commercial aimed at children, Lil' Kim's 'How Many Licks' mischievously risks broaching one of the biggest taboos in the American culture. Childhood, as a sacred place of uncorrupted innocence, is largely an invention of romanticism, popularly resonant in the writings of Jean-Jacques Rousseau and in William Blake's 'Songs of Innocence' for example. In the generic mom and pop rage that characterises many lyrics in nu metal, Korn's in particular, the father tends to vacillate between the imaginary and the real registers. The chapter looks at another symptom of adolescent rage that seems to be more radical than the therapised mom and pop rage. Apparently indifferent to mom, pop and their surrogates at school, the target of this destructive rage is American adolescence itself, as a symbol of the American way of life.
Mental stress-induced myocardial ischemia (MSIMI) is common in women with angina with no obstructive coronary artery disease (ANOCA) and is associated with adverse cardiovascular outcomes. Interleukin-6 (IL-6), a central mediator of chronic inflammation, predicts future cardiovascular risk, but its relationship with MSIMI remains unclear.
Methods
Eighty women with ANOCA underwent 13N-ammonia positron emission tomography/computed tomography to assess myocardial perfusion and myocardial blood flow (MBF) at rest, during mental stress, and during adenosine-induced stress. Resting inflammatory biomarkers were measured, and multivariable logistic and linear regression models were used to evaluate associations with mental stress-induced perfusion defects. Proteomic profiling was performed in a selected subset to explore potential underlying mechanisms.
Results
Mental stress induced significantly greater myocardial perfusion defects in MSIMI+ patients. Resting IL-6 levels were significantly higher in MSIMI+ patients (3.20 versus 1.80 pg/mL, p = 0.024). Although baseline CRP, hsCRP, and complement C3 levels were also higher in MSIMI+ patients, only resting IL-6 remained independently associated with both the presence of MSIMI and the severity of mental stress-induced myocardial perfusion defects after adjustment for demographic, clinical, and psychosocial factors, and resting MBF. Proteomic analyses demonstrated enrichment of innate immune–hemostatic pathways and mitochondrial oxidative phosphorylation in MSIMI+ patients with high IL-6 levels.
Conclusions
Elevated resting IL-6 is independently associated with the presence and severity of MSIMI in women with ANOCA. These findings suggest that IL-6 may serve as a biomarker of MSIMI and support IL-6-related inflammation as a key pathophysiological pathway underlying MSIMI, with potential implications for targeted therapeutic strategies.
This chapter considers the role of British naval suppression in the production of the image of West Africa. The transformation of the slave trade from something that was central to Britain's relationship with Africa and from which it profited, into something that it was seeking to end, was central to this process. According to Forbes, the British had signed an anti-slave trade treaty with King Fano-Toro in 1846. Among all the anecdotes and general observations about Africa, some suppressionist writers did seek to probe deeper into the societies they encountered to provide more detailed understanding of historical events, political structures and economic systems. Following the publicity elicited by an intense pamphlet war, a Royal Commission was sent to investigate the healthness of Britain's West African settlements, including Sierra Leone and the Gambia.
This chapter outlines the key themes of the book: the importance of Africa, decolonisation and the legacies of empire in shaping the fortunes of the small and middling powers in the Cold War; and the special role Africa played in defining Ireland's identity. It argues for a more nuanced reading of the Cold War narrative, to take account of the close inter-relationship between national histories, cultures, social structures and foreign policy. It introduces the ‘fire brigade’ states – Canada, Denmark, Finland, Ireland, Norway and Sweden, a group of small and middling powers valued by the international community for their support of collective security and the primacy of international law – and their contribution (collectively and individually) to a changing international system. It explores the manner in which Africa defined the parameters in which they operated. And it examines the special place of Africa in the Irish consciousness.
To enhance the aerodynamic performance of hypersonic nozzles, a three-dimensional method of characteristics (3D MOC) is proposed for designing single expansion ramp nozzles (SERN). The flowfield structures and aerodynamic performances of nozzles designed using the 3D and conventional two-dimensional (2D) MOC approaches are compared through three-dimensional numerical simulations. Results indicate that the major geometric differences occur along the circumferential wall. Under typical flight conditions, the nozzle designed by 3D MOC achieves over 0.45% higher axial thrust coefficient and more than 8% higher lift coefficient than the 2D MOC design. Furthermore, based on the 3D MOC, both rectangular nozzle (RN) and circular nozzle (CN) configurations are designed and analysed. The CN exhibits slightly superior aerodynamic performance compared with the RN. By further modifying the upper and lower wall infill surfaces of the RN, three new nozzle variants are obtained. Comparative results show that these geometric infills have a pronounced influence on lift and pitching moment, while the axial thrust coefficient remains nearly constant. Finally, the effect of the tracing radius on the RN and CN configurations is examined. Increasing the tracing radius notably reduces the lift coefficient but has minimal impact on the thrust and pitching moment. These findings highlight the potential of the 3D MOC-based design method to flexibly balance aerodynamic moment and lift in hypersonic nozzle optimisation.
In many areas in linguistic study it is difficult to decide where the study of language ends and the study of other aspects of human cognition begins. In this article, we discuss a particularly striking case of this, the use of the signing space (loci) for marking linguistic relations. The use of loci in the nominal and verbal domains has received a wide range of analyses, from those considering loci to be abstract linguistic mechanisms such as semantic indices and syntactic agreement to those considering them to be making use of nonlinguistic mechanisms such as spatial cognition. We defend the view that the use of loci is both fundamentally linguistic (they are modifiers) and fundamentally spatial (they express an association with space), providing possible descriptive content in both the verbal and the nominal domain. This analysis allows for a uniform account of loci use in the two linguistic domains and accounts for an important, yet less noticed, property of loci, which is that their distribution is pragmatically conditioned for the purpose of disambiguation.
From the creation of Châlons Camp to military environmentalist policies in the twenty-first century, the French and other militaries have mobilized nature within France to prepare for and wage war. Although war and militarization are profoundly human activities, they can only take place through the active and at times difficult mobilization of nature. Dead animals, flattened forests, ruined fields, polluted sites, and lost homelands need to be added to war and militarization's impact on France. At Suippes Camp, the civilian presence within the militarized environment is hidden but largely consensual. Beyond military-civilian cooperation over hunting and the management of the Natura 2000 site, Suippes Camp is a site of memorialization. In the 1970s and 1980s Abbé Kuhn, priest of Sommepy-Tahure, produced a number of publications on the ruined villages, outlining their 'calm and peaceful' pre-1914 history and subsequent destruction during the war.
This chapter discusses the influence of Freethought in the development of first-wave feminism, focusing on debates over marriage, birth control and sexual morality. It examines the tensions between feminism, Free Love and Freethought while showing that, despite these tensions, Freethought provided an intellectual framework in which it was possible to envisage a more radical transformation of heterosexual relations than the rest of the women's movement was willing to imagine. The Freethought renunciation of Christianity necessarily entailed a rejection of the moral authority of the Church, particularly its role in legitimising sexual relations. Secularists were therefore required to find a new basis for morality.
We perform analytical and numerical analyses of the propulsion of a rigid body in a viscous fluid subjected to a periodic force with zero average over a period. This general formulation specifically addresses the significant case where propulsion is generated by the oscillation of a mass located in an internal cavity of the body. We provide a rigorous proof of the necessary and sufficient conditions for propulsion at the second order of magnitude of the force. These conditions are implemented and confirmed by numerical tests for bodies without fore-and-aft symmetry, while they are silent for bodies with such symmetry, like round ellipsoids. Consequently, in this case, propulsion can only occur at an order higher than the second. This problem is investigated by numerically integrating the entire set of equations, and the result shows that, in fact, propulsion does occur, thus opening new avenues for further analytical studies.
The paradox of the wigga, the white suburban teenager who mimics black speech and style, is that he or she cannot help drawing attention to an incongruous whiteness. The wigga's mimicry circulates G thang, the ambivalent nature of which is nicely encapsulated by the term 'nigga' itself. Expropriated from the term 'nigger', that signifier obscenely loaded with hatred and suffering, nigga is an ambivalent signifier of affirmative negativity. The nigga has no essence even though he resides as the x-essence of the white neoliberal supercapitalism. While the x-essence of gangsta is traceable in the marketing strategies of companies like Nike, the heterogeneity of the figure cannot be utilised or controlled in any unproblematic way. The 'sovereignty' that is attributed to African-American culture should not be understood in the sense of that term when it refers to the sovereignty of states as defined by the international law.