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Narratives and frames have shaped the overdose crisis since its early stages. Efforts to control knowledge about the role of opioids in chronic pain have influenced clinical guidelines and prescribing behaviour. Dominant narratives shape policy by influencing how problems are defined, and which solutions are considered appropriate. A more nuanced understanding of how framing shapes interactions among stakeholders, including patients, clinicians, advocacy groups, industry, educators, and regulators, can clarify these dynamics. Engaging multiple perspectives, rather than relying on a single dominant narrative, offers a more effective path for addressing complex public health emergencies such as the overdose crisis.
Il presente articolo prende in esame tre iscrizioni sepolcrali custodite presso la biblioteca della British School at Rome (BSR) e, fino ad oggi, rimaste inedite. Si propone, pertanto, una trascrizione, accompagnata da un commento e dall’analisi stilistica delle tre lastrine di colombario, nell’attesa che le iscrizioni vengano registrate, fra gli altri, nell’Epigraphic Database Roma. Una delle epigrafi è un componimento metrico che commemora la sepoltura comune di due coniugi, di cui ci perviene solo il nome del marito, Quirino. Il testo metrico articola numerosi topoi della poesia funeraria romana e suggerisce interessanti considerazioni sul processo di componimento e consumo poetico in ambito epigrafico. Le ulteriori tabelle di colombario, che presentano ancora i fori di fissaggio, ricordano la morte prematura di due bambini, Clado e Cyclas. Riportando alla luce questi importanti documenti, l’articolo si propone di fornire utili informazioni relative alla collezione epigrafica della BSR e di contribuire alla conoscenza del materiale epigrafico lato sensu.
Critical interpretive synthesis was introduced in 2006 to address various shortcomings of systematic reviews such as their limitations in synthesizing heterogeneous data, integrating diverse study types, and generating theoretical insights. This review sought to outline the methodological process of conducting critical interpretive syntheses by identifying the methods currently in use, mapping the processes that have been used to date, and highlighting directions for further research. To achieve this, a scoping review of critical interpretive syntheses published between 2006 and 2023 was conducted. Initial searches identified 1628 publications and after removal of duplicates and exclusions, 212 reviews were included in the study. Most reviews focused on health-related subjects. Authors chose to utilize the method due to its iterative, inductive, and recursive nature. Both question-based and topic-based reviews were conducted. Literature searches relied on electronic databases and reference chaining. Mapping to the original six-phase model showed most variability in use of sampling and quality assessment phases, which were each done in 50.7% of reviews. Data extraction utilized a data extraction table. Synthesis involved constant comparison, critique, and consolidation of themes into constructs, and a synthesizing argument. Refining critical interpretive synthesis methodology and its best practices are important for optimizing the utility and impact and ensuring findings are relevant and actionable for informing policy, practice, and future research.
In 1967, Klarner proposed a problem concerning the existence of reflecting n-queens configurations. The problem considers the feasibility of placing n mutually nonattacking queens on the reflecting chessboard, an $n\times n$ chessboard with a $1\times n$ “reflecting strip” of squares added along one side of the board. A queen placed on the reflecting chessboard can attack the squares in the same row, column, and diagonal, with the additional feature that its diagonal path can be reflected via the reflecting strip. Klarner noted the equivalence of this problem to a number theory problem proposed by Slater, which asks: for which n is it possible to pair up the integers 1 through n with the integers $n+1$ through $2n$ such that no two of the sums or differences of the n pairs of integers are the same. We prove the existence of reflecting n-queens configurations for all sufficiently large n, thereby resolving both Slater’s and Klarner’s questions for all but a finite number of integers.
This article explores the concept of transfer as it emerges in German-speaking academic discourse and considers its broader implications for the Global Public Literary Humanities. While transfer has become an established term in university policy, especially in Germany, its potential for literary studies remains under-examined. Building on both German and Francophone models, this article offers a nuanced framework that distinguishes between transfer and its synonyms—such as application, practice, communication, cooperation, and mediation—and proposes the concept of transferability as a means to sharpen theoretical and practical awareness regarding the conditions for successful transfer. This article presents a model that identifies both enabling conditions (such as relevance and resonance) and practical forms of transfer, arguing that transferability is shaped by ethical, esthetic, and anthropological considerations. Drawing on examples from current German debates (e.g., #RelevanteLiteraturwissenschaft, collaborative literary festivals, and citizen science projects), the analysis demonstrates that successful literary transfer is always co-creative and dialogical. Ultimately, this article calls for more institutional and structural efforts to enable transferability within literary studies and suggests that increased awareness of its prerequisites and possibilities for implementation can make academic work more responsive, inclusive, and socially engaged. This essay also advocates for extending the debate by incorporating concepts and practices from other linguistic and cultural traditions, thereby advancing the vision of Global Public Literary Humanities as a truly interconnected, dynamic, and transformative field. In doing so, this article hopes to encourage further critical reflection, experimentation, and the opening of new perspectives in research, teaching, and public engagement.
We prove that for every relatively prime pair of integers $(d,r)$ with $r>0$, there exists an exceptional pair $({\mathcal {O}},V)$ on any del Pezzo surface of degree $4$, such that V is a bundle of rank r and degree d. As an application, we prove that every Feigin-Odesskii Poisson bracket on a projective space can be included into a $5$-dimensional linear space of compatible Poisson brackets. We also construct new examples of linear spaces of compatible Feigin-Odesskii Poisson brackets of dimension $>5$, coming from del Pezzo surfaces of degree $>4$.
This essay argues that the women, life, freedom movement should be understood as crucial site for the study of revolutionary praxis and feminist theory from which scholars and activists around the world can learn. While much attention has been given to efforts to co-opt the movement by monarchist and other “regime change” factions in diaspora, a lesser-known diasporic consequence has been the creation of Iranian feminist collectives oriented around intersectional and anti-colonial forms of transnational solidarity. By analyzing three such collectives that aimed to uplift critical feminist orientations emerging from the uprising in Iran, I chart shifts in ideas about organization, the meaning of revolution, and the contours of a “decolonial” feminist analysis in the Iranian context. I argue that these Iranian feminist collectives have built on the transnational feminist practice of making connections across differences, placing their critique of the Iranian state in relation to other iterations of patriarchal and militarized authoritarianism globally, including in the west.
We consider the Schrödinger equation on the one dimensional torus with a general odd-power nonlinearity $p \geq 5$, which is known to be globally well-posed in the Sobolev space $H^\sigma(\mathbb{T})$, for every $\sigma \geq 1$, thanks to the conservation and finiteness of the energy. For regularities σ < 1, where this energy is infinite, we explore a globalization argument adapted to random initial data distributed according to the Gaussian measures µs, with covariance operator $(1-\Delta)^s$, for s in a range $(s_p,\frac{3}{2}]$. We combine a deterministic local Cauchy theory with the quasi-invariance of Gaussian measures µs, with additional Lq-bounds on the Radon-Nikodym derivatives, to prove that the Gaussian initial data generate almost surely global solutions. These Lq-bounds are obtained with respect to Gaussian measures accompanied by a cutoff on a renormalization of the energy; the main tools to prove them are the Boué-Dupuis variational formula and a Poincaré-Dulac normal form reduction. This approach is similar in spirit to Bourgain’s invariant argument [7] and to arecent work by Forlano-Tolomeo in [18].
This article explores biophilic (nature-centred) instrument design and its intersection with architecture and music. While the connection between these disciplines is often discussed figuratively, they are less often combined in practice. The Biophilic Instrument Pavilion (BIP), a site-responsive sound and light installation, serves as a model for such a collaboration using biophilic design as a unifying principle. This multidisciplinary project demonstrates spatialisation in ecological, sonic, visual and social contexts, offering insights into environmental instrument practices and collaborative creative processes.
This article examines women’s work in rural areas of the Republic of Venice between the seventeenth and eighteenth centuries, with a focus on the district of Padua. By applying the verb-oriented method to judicial sources, it reconstructs a detailed and nuanced picture of female labour, highlighting the extent and continuity of women’s economic activities. The findings show that women were engaged across all sectors of the economy, including sectors far beyond care and housework. They played an active role in agriculture, trade, and manufacturing. Moreover, their work was fully integrated into the household economy, structured around seasonal labour demands, and performed throughout the year. A comparison with previous studies suggests that women’s work in the Venetian countryside aligned closely with broader European patterns. These findings underscore the fundamental contribution of female labour to household survival, challenging long-standing assumptions about women’s economic roles in Italy and the Mediterranean.
We prove that every irreducible component of the coarse Kollár-Shepherd-Barron and Alexeev (KSBA) moduli space of stable log Calabi–Yau surfaces admits a finite cover by a projective toric variety. This verifies a conjecture of Hacking–Keel–Yu. The proof combines tools from log smooth deformation theory, the minimal model program, punctured log Gromov–Witten theory, and mirror symmetry.
Clozapine remains underused despite its unparalleled efficacy in treatment-refractory schizophrenia. One of the reasons for its underuse is the fear of severe neutropenia and its consequences.
Aims
To scrutinise the association between severe neutropenia and clozapine in a cohort of patients clinically diagnosed with clozapine-induced severe neutropenia.
Method
We used data from the South London and Maudsley National Health Service Foundation Trust’s anonymised case register, known as the Clinical Record Interactive Search. We extracted details of cases where clozapine use was associated with two consecutive neutrophil counts below 1.5 × 109/L. A panel of clinicians independently assessed each case. Agreement was reached on which cases clozapine was the likely or definite cause of the severe neutropenia, the risk to life and whether or not rechallenge with clozapine could be attempted.
Results
There were 96 cases where two consecutive neutrophil counts below 1.5 × 109/L were registered. The panel judged that 9 (9.4%) were definitely caused by clozapine and a further 11 (11.5%) were probably caused by clozapine. Overall, 18 (18.8%) patients should be precluded from ever receiving clozapine again according to the panel (all from the 20 cases where clozapine was the definite or probable cause). Of the remaining 76 cases of severe neutropenia the cause could not be determined in 60 cases, but in 11 cases the cause was benign ethnic neutropenia, in 2 others the cause was cancer chemotherapy, in 2 it was infections and in 1 it was laboratory error. In almost 80% of cases, clozapine was not the clear cause of the neutropenia observed.
Conclusions
The large majority of severe neutropenia episodes mandating cessation of clozapine may not be caused by clozapine. Threshold-based monitoring systems cause unnecessary stopping of clozapine because they lack the necessary specificity for clozapine-related blood disorders.
This guide provides a philosophical framework and practical advice for gathering, analyzing, and reporting a particular type of qualitative data. These data are obtained from including an open-text box following the key quantitative question in survey-style studies with the request to ‘Please explain your response’. While many studies currently collect such data, they often either fail to report or analyze it, or they conduct unstructured analyses with limited detail, often mistakenly referring to it as ‘thematic analysis’. Content analysis provides a well-established framework for analyzing such data, and the simplicity of the data form allows for a highly pragmatic and flexible approach. The guide integrates the concept of reflexivity from qualitative research to navigate the large number of researcher degrees of freedom involved in the process, particularly in working with the second coder. It begins by arguing for the value of this data, before outlining the guide’s philosophy, offering advice on maximizing the validity of your data, and addressing the common concern of confabulation. It then provides advice on developing a coding scheme, recruiting and collaborating with a second coder, and writing your report, considering the potential role of large language models at these various stages. Additionally, it provides a checklist for reviewers to evaluate the quality of a given analysis. Throughout the guide, a running example is used to demonstrate the implementation of the provided advice, accompanied by extensive example materials in the online repository, which can be used to practice the method.
The paper discusses the stochastic dynamics of the vortex shedding process in the presence of external harmonic excitation and coloured multiplicative noise. The situation is encountered in a turbulent practical combustor experiencing combustion instability. Acoustic feedback and turbulent flow are imitated by the harmonic and stochastic excitations, respectively. The Ornstein–Uhlenbeck process is used to generate the noise. A low-order model for vortex shedding is used. The Fokker–Planck framework is used to obtain the evolution of the probability density function of the shedding time period. Stochastic lock-in and resonance characteristics are studied for various parameters associated with the harmonic (amplitude, frequency) and noise (amplitude, correlation time, multiplicative noise factor) excitations. We observed that: (i) the stochastic lock-in (s-lock-in) boundary strongly depends on the noise correlation time; (ii) the parameter sites for s-lock-in can be approximately identified from the noise-induced shedding statistics; and (iii) stochastic resonance is significant for some intermediate correlation times. The effects of the above-mentioned observations are discussed in the context of combustion instability.
It has often been considered that the representations of the gods in Ancient Central Mexico were purely symbolic and that we should not look for the presence of glottograms, i.e. signs that encode linguistic units pronounced in the Nahuatl language. This article intends to demonstrate that we should reject the image/writing dichotomy in this context. In order to understand the identity of the Nahua gods, it is necessary to combine symbolic deciphering with a reading of the names embedded in their bodies and ornaments. This article takes the example of several representations of gods in codices of the Aztec tradition. It shows that this embedded script used the main scriptural techniques known in Nahuatl writing: logograms, phonograms, and indicators. In this way, the identity of the god, and therefore its ritual effectiveness, was expressed simultaneously visually and phonically.
A deep-learning-based closure model to address energy loss in low-dimensional surrogate models based on proper-orthogonal-decomposition (POD) modes is introduced. Using a transformer-encoder block with an easy-attention mechanism, the model predicts the spatial probability density function of fluctuations not captured by the truncated POD modes. The methodology is demonstrated on the wake of the Windsor body at yaw angles of $\delta = [2.5^\circ ,5^\circ ,7.5^\circ ,10^\circ ,12.5^\circ ]$, with $\delta = 7.5^\circ$ as a test case, and in a realistic urban environment at wind directions of $\delta = [-45^\circ ,-22.5^\circ ,0^\circ ,22.5^\circ ,45^\circ ]$, with $\delta = 0^\circ$ as a test case. Key coherent modes are identified by clustering them based on dominant frequency dynamics using Hotelling’s $T^2$ on the spectral properties of temporal coefficients. These coherent modes account for nearly $60 \,\%$ and $75 \,\%$ of the total energy for the Windsor body and the urban environment, respectively. For each case, a common POD basis is created by concatenating coherent modes from training angles and orthonormalising the set without losing information. Transformers with different size on the attention layer, (64, 128 and 256), are trained to model the missing fluctuations in the Windsor body case. Larger attention sizes always improve predictions for the training set, but the transformer with an attention layer of size 256 slightly overshoots the fluctuation predictions in the Windsor body test set because they have lower intensity than in the training cases. A single transformer with an attention size of 256 is trained for the urban flow. In both cases, adding the predicted fluctuations close the energy gap between the reconstruction and the original flow field, improving predictions for energy, root-mean-square velocity fluctuations and instantaneous flow fields. For instance, in the Windsor body case, the deepest architecture reduces the mean energy error from $37 \,\%$ to $12 \,\%$ and decreases the Kullback–Leibler divergence of velocity distributions from ${\mathcal{D}}_{\mathcal{KL}}=0.2$ to below ${\mathcal{D}}_{\mathcal{KL}}=0.026$.