Flow-induced compaction of soft, elastically deformable porous media occurs in numerous industrial processes. A theoretical study of this problem, and its interplay with gravitational and mechanical compaction, is presented here in a one-dimensional configuration. First, it is shown that soft media can be categorised into two ‘types’, based on their compaction behaviour in the limit of large applied fluid pressure drop. This behaviour is controlled by the constitutive laws for effective pressure and permeability, which encode the rheology of the solid matrix, and can be linked to the well-known poroelastic diffusivity. Next, the interaction of gravitational and flow-induced compaction is explored, with the resultant asymmetry between upward and downward flow leading to distinct compaction behaviour. In particular, flow against gravity – upwards – must first relieve gravitational stresses before any bulk compaction of the medium can occur, so upward flow may result in compaction of some regions and decompaction of others, such that the overall depth remains fixed. Finally, the impact of a fixed mechanical load on the sample is considered: again, it is shown that flow must ‘undo’ this external load before any bulk compaction of the whole medium can occur in either flow direction. The interplay of these different compaction mechanisms is explored, and qualitative differences in these behaviours based on the ‘type’ of the medium are identified.

In recent years, scholars argue that, although the principle of fair play is able to establish obligations to reciprocate for benefits received, these do not include political obligations. They contend that recipients themselves should be able to determine the form their recompense takes. I examine different cases of benefit provision and identify instances in which the principle of fair play does not allow such discretion. An important consideration is epistemic difficulties that can be avoided only if citizens accept the judgment of law and follow it. In familiar political obligation cases, disagreements about benefits and burdens should be resolved by democratic procedures. Following decisions arrived at is necessary to avoid problems of two kinds: moral, making sure burdens of cooperation are distributed in ways that are fair to all participants; and empirical/sociological, making sure important benefits are provided.

The years immediately following the issue of Magna Carta and the death of John were of fundamental importance in determining the trajectory of the nascent common law legal system. Although the existence of the Bench had functionally been permanently established under chapter seventeen of Magna Carta, the central royal court faced an uncertain future under conciliar rule and in the aftermath of extensive civil conflict. The extensive extant records of the common law fines made to initiate actions in the Bench as recorded the Fine Rolls offer a window into the roles played by the court in relation to litigants, within the wider structure of royal governance, and in relation to a rapidly evolving legal system. An analysis of these sources can therefore both illuminate the early workings of the common law legal procedures and characterize the demand for royal justice that survived the First Barons’ War before continuing to grow across the thirteenth century. What emerges is a picture of a judicial system at the onset of a period of rapid development and widespread demand that would come to lay the foundation for the massive expansion of royal justice that was to follow throughout the reign of Henry III and beyond.

Biological and physical retrospective dosimetry for ionizing radiation exposure is a rapidly growing field, and several methods for performing biological and physical retrospective dosimetry have been developed to provide absorbed dose estimates for individuals after occupational, accidental, intentional, and incidental exposures to ionizing radiation. In large-scale radiological/nuclear incidents, multiple retrospective dosimetry laboratories from several countries may be involved in providing timely dose estimates for effective medical management of several thousand exposed individuals. In such scenarios, the harmonization of methods among participating laboratories is crucial for consistency in data analysis, dose estimation, and medical decision-making. In this regard, ISO documents ensure that these practices are standardized globally across the laboratories by providing quality assurance and quality control documentation that guide laboratories in maintaining high-quality performance for consistency. With the intent of bringing standardization and harmonization of biological and physical retrospective dosimetry methodologies across national and international laboratories, the ISO working group 18 (WG18) was established under ISO/TC85/SC2 (Technical Committee 85, Subcommittee 2-Radiation Protection) in 1999. This manuscript summarizes some of the past, current, and future activities of WG18 on biological and physical retrospective dosimetry.

In this work, we introduce the type and typeset invariants for equicontinuous group actions on Cantor sets; that is, for generalized odometers. These invariants are collections of equivalence classes of asymptotic Steinitz numbers associated to the action. We show the type is an invariant of the return equivalence class of the action. We introduce the notion of commensurable typesets and show that two actions which are return equivalent have commensurable typesets. Examples are given to illustrate the properties of the type and typeset invariants. The type and typeset invariants are used to define homeomorphism invariants for solenoidal manifolds.

Aneuploidy in oocytes is a leading cause of implantation failure, miscarriage and congenital disorders. During meiosis, proper timing of chromosome segregation is regulated by the spindle assembly checkpoint (SAC) and the anaphase-promoting complex/cyclosome (APC/C). However, how pharmacological manipulation of these regulatory pathways affects aneuploidy remains incompletely understood. In this study, we investigated whether SAC inhibition by reversine induces aneuploidy in mouse oocytes and whether partial inhibition of APC/C by proTAME can alleviate these errors. Germinal vesicle (GV) oocytes were matured in vitro in the presence of various concentrations of reversine. To optimize the timing of treatment, oocytes were exposed to reversine for 0, 3, 5 or 7 h, followed by culture with or without proTAME. A proTAME-only group (2.5 nM) was also included. Chromosome spreads were analyzed at the metaphase II (MII) stage to determine aneuploidy rates. Reversine (5 nM) yielded an MII maturation rate of 80.5% but induced a high aneuploidy rate of 77.0%. Sequential treatment with 2.5 nM proTAME significantly reduced aneuploidy to 33.3%. In contrast, proTAME alone led to 79.0% aneuploidy, suggesting its effect is contingent upon prior SAC disruption. These results indicate that reversine compromises chromosomal integrity, while appropriately timed, low-dose proTAME can partially rescue segregation errors. Our findings underscore the potential of pharmacologically regulating APC/C activity to reduce aneuploidy and enhance oocyte quality, offering new avenues for improving outcomes in assisted reproductive technologies.

The term “embodied knowledge” is often used as if its meaning is evident, and as if there is clarity about the relations it brings into view. The bodies in motion of the kumina festival Tambufest tell us about the forms of collective world-building that exist outside of but in relation to the juridical structures of sovereignty that govern modern Western political and social life.

Autism Spectrum Disorder (ASD) is defined as a unidimensional condition, and autism traits are measured on a continuum where the high end of the spectrum represents individuals likely to have an ASD diagnosis. However, the large heterogeneity of ASD has thrown this unidimensional conceptualization into question. With the exact underlying cause(s) of autism yet to be identified, there is a pressing need to establish core, underlying dimensions of ASD that can capture heterogeneity within the autism spectrum, thereby better specifying both autistic traits and ASD symptoms. Here we describe one important transdiagnostic dimension, the cognitive rigidity-flexibility dimension, that may impact autistic traits and symptoms across symptom-relevant cognitive domains. We first discuss how diminished cognitive flexibility manifests in core autistic traits and autism symptoms in perception, attention, learning, social cognition, and communication. We then propose to supplement assessments of autistic traits in the general population and autism symptoms in individuals with an ASD diagnosis with a comprehensive batter of cognitive flexibility measures in these symptom-relevant domains. We conjecture that systematic differences in domain-general versus domain-specific cognitive flexibility can distill subgroups within the autism phenotype. While we focus on the cognitive flexibility dimension here, we believe that it is important to extend this framework to other higher order dimensions that can capture core autism symptoms and transdiagnostic symptom severity. This approach can characterize the latent, multi-faceted structure of autism, thereby yielding greater precision in diagnostic classification and the creation of more targeted interventions.

Alcohol use disorders (AUDs) often coexist with psychotic disorders. Both are common and each can cause or perpetuate the other. Comorbid diagnoses are multifactorial in origin, and both diagnostically and therapeutically challenging. This article is a narrative review of the epidemiology, diagnosis and management of comorbid AUDs and psychotic disorders. Although there is a lack of robust evidence on many aspects of this association, AUDs have been repeatedly shown to worsen outcomes in individuals with schizophrenia. The importance of a rigorous approach to diagnosis is emphasised. Three main treatment strategies emerge: considering particular antipsychotic drugs, relapse-prevention medication and engagement with a number of psychosocial interventions.

This article examines the connections between existing democratic deficits in law and contemporary democratic backsliding processes. To undermine the democratic process, present-day autocrats employ various legal strategies, including enacting new legal institutions (such as constitutional amendments or key statutory reforms) or manipulating existing ones. Focusing on a legal legacy of military rule in Turkey, the Specially Authorized Courts, this study argues that in consolidating power, autocrats also capitalize on pre-existing authoritarian zones within legal systems. In Turkey’s case, the AKP government has leveraged the exceptional procedures of Specially Authorized Courts to silence adversaries while simultaneously framing its reforms to the structure of these courts and the trials held at these courts as efforts to democratize the country and eradicate authoritarian legacies. As a result, the AKP masked its repressive actions behind a narrative of democratization in the early stages of Turkey’s democratic regression. Overall, the article presents both the coercive and legitimating uses of pre-existing “zones of authoritarianism” in law in contemporary processes of democratic backsliding. In doing this, it highlights how aspiring autocrats exploit the histories embedded in legal institutions to obscure their repressive actions.