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To explore nurses’ perceptions regarding their knowledge, degree of autonomy, and the difficulties encountered in managing diabetic foot in Primary Care.
Background:
Diabetes mellitus is a chronic condition with a high prevalence in Spain, predominantly type 2. One of its most serious complications is diabetic foot disease, affecting between 19% and 34% of patients and associated with considerable morbidity and amputation risk. Primary Care, particularly nursing professionals, plays a pivotal role in the prevention, assessment, and management of diabetic foot. However, institutional, methodological, and personal barriers continue to affect care quality.
Methods:
A descriptive, cross-sectional observational study was conducted using quantitative and qualitative methods. A validated ad hoc questionnaire was administered to 176 nurses from the Murcian Health Service participating in a blended learning course on diabetic foot. Variables assessed included professional autonomy, knowledge, dressings use, clinical documentation, training, and perceived challenges. Qualitative analysis was based on open-ended responses using content analysis.
Findings:
A total of 88.1% of nurses reported autonomy in performing foot examinations; however, only 45.5% managed wound care independently. Just 19.9% considered themselves sufficiently trained, while 42.6% felt confident in selecting dressings appropriate to the healing phase. Although 56.8% regularly completed specific clinical documentation forms, many still expressed uncertainty about dressing use. Qualitative analysis identified five key barriers: lack of knowledge, patient complexity, institutional constraints, issues of authority and communication, and professional insecurity. These findings provide a current picture of persistent barriers in diabetic foot care and reinforce the need for targeted training and institutional support.
In Brazil, decisions regarding the incorporation of health technologies, guided by health technology assessment (HTA), are made independently within the public and private health systems. There is ongoing discussion about establishing a unified HTA agency to address incorporation across both sectors. This study sought to compare the decision-making criteria for technology incorporation in Brazil’s public and private health systems.
Methods
A dataset of new medicines registered in Brazil between 2010 and 2020, along with their corresponding indications, was compiled to identify and assess medication-indication pairs. Case studies were developed for pairs that underwent coverage evaluations in both the public and private health systems. These HTA coverage decisions were systematically analyzed and compared using a published evidence-based methodological framework. This methodology requires that research questions from different HTA agencies be sufficiently alike to enable a meaningful comparison of decision-making criteria.
Results
Twenty medicines across 10 indications were analyzed. Oncology related pairs (10 medicines, five indications) could not be compared due to differing research focuses: public evaluations covered entire treatment lines, whereas private assessments focused on specific medicine-indication pairs. Non-oncology cases (10 medicines, five indications) targeted eosinophilic asthma, ulcerative colitis, psoriasis, multiple sclerosis, and neuronal ceroid lipofuscinosis type 2. Public sector decisions prioritized unmet needs, disease impact, clinical benefits, and negotiated prices. In contrast, the private sector focused on expanding therapeutic options, with clinical uncertainties having limited influence. The private sector did not consider costs in decision-making, even when medicines lacked clinical superiority over comparators.
Conclusions
Decision-making in the public sector relies on HTA principles, while the private sector focuses on therapeutic expansion, ignoring efficiency and clinical uncertainties. A unified HTA agency in Brazil could negatively affect the public sector if private sector priorities dominate. Moreover, such an agency is unlikely to reduce the workload, as research questions differ significantly across sectors.
The world is facing an urgent environmental emergency that calls for ambitious, coordinated action by governments to improve humankind’s relationship with nature. Mitigation (reducing pollution) and adaptation (adjusting to pollution) are both necessary, and “NextGen” health technology assessment can play a key role in helping to guide health system decision-makers to achieve environmental sustainability.
Methods
In 2022, the International Network of Agencies for Health Technology Assessment (INAHTA) identified environmental impact assessment (EIA) as an important and urgent topic for a white paper. An international author group (n=10), formed of staff from INAHTA member agencies, wrote the paper. The author group met seven times over 2022 to 2024 to develop the paper, which is based on a literature review and expert opinion of INAHTA members. A second group of members formed an international advisory group (n=11), which reviewed the draft twice. The paper was approved by the INAHTA Board before release on the INAHTA website.
Results
EIA can be useful to help achieve the “green” policy goals of health systems by identifying technologies that are comparatively harmful to the environment. However, health technology assessment (HTA) agencies are subject to the institutional structures and regulations of their local health system that can constrain their ability to independently adapt to incorporate EIA. Nevertheless, HTA agencies are starting to do this with some success, but difficult challenges remain, particularly around lack of data and methods. Looking ahead, raising awareness and working together across the HTA ecosystem will be key to achieving the shared goal of environmental sustainability.
Conclusions
The successful inclusion of EIA in priority setting, assessment, and appraisal, as well as knowledge sharing and dissemination activities of HTA, is a challenge since the operating principles, methods, and data in this area are not yet mature. The successful inclusion of environmental impacts in HTA will require some reconsideration of existing value frameworks and methods.
The aim of this paper is to review the latest evidence on food reformulation as a public health policy to improve our understanding of how different policy designs can drive reformulation and influence food system change. The focus is on three key nutrients of concern – trans fatty acids, salt and sugar. In recent times, food reformulation has been categorised as either mandatory or voluntary, a distinction that can help assess policy effectiveness. However, this binary classification oversimplifies a far more complex policy landscape. Some policies, whether mandated by government or voluntarily suggested to industry, are explicitly intended to trigger reformulation. In contrast, others, may have never been designed with the intention to encourage reformulation but have nonetheless prompted significant changes in product composition, intake and potential health outcomes. Within what is commonly described as mandatory reformulation, for example, we find a broad mix of policy tools that operate very differently. Some, such as the UK’s Soft Drinks Industry Levy, were deliberately created to incentivise reformulation by applying financial pressure. Others, including front of pack nutrition labelling systems (particularly warning labels) and school food standards have encouraged reformulation only as a positive unintended consequence. These indirect drivers are not always evaluated for their impact on reformulation, which may lead to an incomplete understanding of their contribution to reducing intake of nutrients of concern and improving health outcomes. Nevertheless, emerging evidence suggests no single policy encourages reformulation alone, instead a combination of approaches are likely to drive it and contribute to meaningful and sustained food system change.
To evaluate eligibility and participation in nutrition assistance programmes (Supplemental Nutrition Assistance Program (SNAP) and Women, Infants and Children (WIC)) among transgender and gender diverse (TGD) adults in the USA and to capture their experiences when accessing food benefits.
Design:
This was a cross-sectional analysis of the US Transgender Survey (USTS) dataset – the largest survey of TGD adults in the US SNAP and WIC participation and experiences when visiting the public assistance office were reported using descriptive statistics; stratified analyses were conducted based on race using multivariate logistic regression modelling.
Setting:
The USTS was completed electronically in the USA.
Participants:
27 715 TGD adults.
Results:
Approximately 40·9 % of the full sample were SNAP eligible, yet only 30·6 % of those eligible were receiving the benefit; 0·45 % of the sample reported receiving WIC. TGD adults avoided the public assistance office because they feared being mistreated (3·2 %), were identified as transgender (46·2 %), were denied equal treatment (6·5 %) or were verbally harassed (5·2 %). People of colour were more likely to be denied equal treatment and verbally harassed at the public benefits office than their white peers. The impact of age, education level, employment status, relationship status and census region varied within each racial group.
Conclusions:
Far more TGD adults need food assistance compared with the general population, yet fewer are receiving the benefit. Culturally informed interventions are urgently needed to resolve the root causes of food insecurity, increase SNAP participation and address the negative experiences of TGD adults when accessing food benefits.
Aspects of the school food environment can influence food purchasing and consumption among adolescents, particularly those without access to a school meal programme. Our objective was to describe and compare food vendors of junior high schools (JHS) in Ghana.
Design:
We conducted structured observations of food vendors within a 0·25-km radius of eight JHSs. We compared foods sold and hygiene practices by vendor and community characteristics, such as on- v. off-campus location, urban v. rural, and predominant income-generating activity of the community. We also assessed the relationship between adolescent diet quality (food group diversity, all-5, NCD-protect and NCD-risk scores) and procurement method for foods consumed during the school day.
Setting:
Cape Coast and Elmina, Ghana.
Participants:
200 randomly selected students.
Results:
Of 265 identified vendors, 25·3 % sold foods on-campus. On-campus vendors were less likely to sell branded snacks (19·4 % v. 33·8 %, P = 0·001) and beverages (17·9 % v. 35·4 %, P = 0·008) and more likely to sell prepared dishes (53·7 % v. 31·8 %, P = 0·001) than off-campus vendors. Vendors practised an average of 38·8 % of applicable food hygiene practices, which did not differ by on- or off-campus location. In the previous month, 59·4 % of students most often purchased food on campus. There were no significant relationships between method of food procurement and diet quality.
Conclusion:
Many adolescents purchased food at school, and there were differences in foods sold by on- and off-campus vendors. School policies may be a promising avenue to alter food environments for adolescents.
This study examined the temporal and seasonal distribution of sudden sensorineural hearing loss admissions and audiogram types from 2015 to 2024 using seasonal-trend decomposition with locally estimated scatterplot smoothing.
Methods
A retrospective analysis included sudden sensorineural hearing loss patients admitted to a tertiary otorhinolaryngology clinic between January 2015 and December 2024. Demographics, admission dates and audiogram types were evaluated.
Results
Among 738 patients (mean age 45.7 ± 15.6 years; 58.4% male), admissions varied significantly across years, months and seasons, peaking from November to March. Winter admissions were highest, while autumn had the lowest. Seasonal-trend decomposition with locally estimated scatterplot smoothing confirmed recurring seasonal patterns. Although audiogram types showed no seasonal or pandemic association, their distribution differed significantly by month.
Conclusion
Sudden sensorineural hearing loss admissions demonstrate clear temporal and seasonal clustering, aligning with influenza-like illness peaks and suggesting a viral contribution. Monthly audiogram variations imply possible environmental influences.
The present study examined the association of body mass index (BMI), screen and sleep time, physical fitness and eating behaviour with Mediterranean diet (MD) adherence in a sample of pre-schoolers from Granada, Spain.
Design:
A cross-sectional, non-randomised design was employed. A multilinear regression model with backward elimination was used for analysis.
Setting:
Variables included age, BMI, screen time, hours of nightly sleep, physical fitness, food approach and food avoidance. The developed model met assumptions of multiple regression in terms of linearity, homoscedasticity, normality, independence and non-multicollinearity.
Participants:
Data were collected from 653 of the 2250 three-to-six-year-old children attending the 18 schools invited to take part in the present study.
Results:
Better sleep time and lower screen time and food avoidance were found to be predictive of MD adherence. These variables explained 15% of the variance in pre-schoolers MD adherence.
Conclusions:
The present study suggests that sleep and screen time and food avoidance are important components to consider when targeting improvements in MD adherence in pre-schoolers. Future research should explore the way in which parental health behaviours influence their children’s health habits in order to better understand outcomes.
The role of healthcare provider ownership in shaping health system performance remains contested. An umbrella review was conducted to synthesise evidence on the relationship between healthcare provider ownership and performance in high-income countries. Systematic reviews were included that examined performance of healthcare providers based on ownership status. Searches yielded 1,862 results, with 31 systematic reviews meeting the inclusion criteria, and one further systematic review identified through grey literature searches. Following the exclusion of 10 reviews classified as low-quality and two previous umbrella reviews both published in 2014, 20 reviews were eligible for data extraction and synthesis. Inconsistent evidence was found across reviews between healthcare provider ownership and several performance indicators including health outcomes, technical efficiency, and patient satisfaction. Private hospitals tend to serve wealthier patients, select less complex or costly patients, and charge higher payments for care than public comparators. Private for-profit (FP) providers of hospital and long-term care generally had poorer workforce outcomes than private not-for-profit or public providers, including reduced staffing levels, higher workloads, and lower job satisfaction. Private PF hospitals and nursing homes had improved financial performance based on revenues or profit margins. Our findings underscore the need for nuanced regulatory responses to the expansion of private FP provision within publicly funded systems.
This study aims to examine the awareness, attitudes, and acceptability of medical aid in dying (MAiD) among healthcare professionals in Pakistan, a predominantly Muslim country where cultural and religious values heavily influence medical ethics and end-of-life decisions.
Methods
A cross-sectional survey was conducted online among 70 healthcare professionals, including physicians, nurses, and allied health workers in Pakistan. Data were collected via a structured, self-administered online questionnaire assessing knowledge, attitudes, and willingness to participate in MAiD-related actions. Descriptive and correlational analyses were conducted to identify patterns and associations.
Results
Participants demonstrated moderate knowledge about MAiD (M = 17.13, SD = 3.42) and moderate support for its legalization (M = 18.89, SD = 4.99). However, levels of negative attitudes (M = 32.21, SD = 6.11) and legal and ethical concerns (M = 24.73, SD = 3.66) were high. Behavioral willingness to engage in MAiD-related actions remained low (M = 2.42, SD = 3.38), with limited intent to assist (M = 0.39), refer (M = 0.64), or approve physician-assisted MAID (M = 0.81). A significant negative correlation emerged between knowledge and support for legalization (r = − .25, p = .037), while no significant associations were observed between knowledge and willingness to participate in MAiD. Gender and profession did not significantly influence attitudes or willingness.
Significance of results
While Pakistani healthcare professionals display a conceptual understanding of MAiD, their readiness to participate remains low, primarily due to ethical, legal, and religious concerns. These findings highlight the need for creating awareness regarding MAiD and for providing culturally sensitive education, structured training in palliative care, and the development of clear legal frameworks to guide end-of-life decision-making in Muslim-majority contexts.
To explore the experiences of military medical first responders managing mass casualty incidents (MCIs) during the ongoing conflict in Ukraine to identify key challenges and insights.
Methods
This qualitative study employed in-depth, semi-structured interviews with medical first responders who managed MCIs in Ukraine. Thematic analysis was leveraged by our research team to identify recurring themes and patterns within the interview data.
Results
Our results revealed crucial takeaways related to the (1) need for preparedness and training, (2) variability of triage, (3) importance of communication and teamwork, and (4) the resulting psychological strain.
Conclusions
These firsthand accounts offer valuable lessons for identifying challenges of first responders, developing areas of future research for MCI response strategies, and enhancing the readiness and well-being of medical first responders in current and future conflicts.
This study assessed iron-rich food consumption and its associated factors among children aged 6–23 months in South and Southeast Asia.
Design:
A cross-sectional study from the Standard Demographic and Health Survey (2015–2022).
Setting:
South and Southeast Asian countries.
Participants:
Data collected from 95 515 children aged 6–23 months, including information from their parents or caregivers.
Results:
The overall proportion of children, aged 6–23 months, consuming iron-rich foods in the region was 29·87 % (95 % CI: 29·58, 30·16). Higher odds of iron-rich food consumption were observed among children aged 12–23 months (adjusted OR (AOR) = 3·59; 95 % CI: 3·45, 3·76), had history of exclusive breast-feeding (AOR = 1·17; 95 % CI: 1·12, 1·23), born to teenage motherhood (AOR = 1·09; 95 % CI: 1·02, 1·17), born in health institution (AOR = 1·10; 95 % CI: 1·02, 1·19) and had pregnant mother at the time of the survey (AOR = 1·60; 95 % CI: 1·50, 1·72). Children of birth order 2–4 (AOR = 1·26; 95 % CI: 1·20, 1·32) and 5+ (AOR = 1·29; 95 % CI: 1·18, 1·43), from female-headed households (AOR = 1·06; 95 % CI: 1·01, 1·12) and those with household mass media exposure (AOR = 1·27; 95 % CI: 1·19, 1·36) also had significantly higher odds of iron-rich food consumption. Additionally, higher odds ratio (OR) (AOR > 1) of iron-rich food consumption were observed in Cambodia, Bangladesh, Indonesia, Myanmar, Maldives, Philippines, Pakistan and Timor-Leste.
Conclusion:
Across countries, only about 30 % of children consumed iron-rich foods, with significant variation. Targeted public health efforts are essential to address maternal, child and household factors that influence intake.
Patients with chronic liver disease (CLD) often experience hypozincemia. The clinical factors associated with hypozincemia have not been established. We investigated clinical factors that may be useful to predict hypozincemia in patients with CLD. The serum zinc levels CLD patients were measured; Study 1 investigated the predictive factors of hypozincemia, and Study 2 was performed to validate the factors identified in Study 1. Study 1 included 197 participants, of whom 28 and 106 had serum zinc levels <60 µg/dL and <80 µg/dL, respectively. A multivariate analysis revealed that serum zinc levels <60 µg/dL or <80 µg/dL were associated with the albumin–bilirubin (ALBI) score and serum albumin level. A receiver operating characteristic curve analysis revealed that the ALBI score ≥ −1.83 and the serum albumin level ≤3.3 g/dL were the cut-off values for a serum zinc level <60 µg/dL, whereas the ALBI score ≥ −2.44 and the serum albumin level ≤3.6 g/dL were the cut-off values for a serum zinc level <80 µg/dL. In Study 2 (n = 177), the diagnostic accuracy rates for serum zinc <60 µg/dL were 81.9% for the ALBI score and 75.1% for the serum albumin level, and those for serum zinc <80 µg/dL were 70.1% for both parameters. Together these findings indicate that the ALBI score may serve as a predictive factor of hypozincemia in CLD patients.
This study aimed to evaluate adult women’s cooking (CS) and food preparation skills (FPS) and their nutrition literacy (NL) levels and to examine the relationship between these two concepts.
Design:
Data were collected via face-to-face interviews using a personal information form, the Cooking and Food Preparation Skills scale, and the Evaluation Instrument of Nutrition Literacy on Adults. Data were analysed with SPSS, with P < 0·05 considered significant.
Setting:
Female adults aged 20–64 years who participated in family support courses in Tepebaşı, Eskişehir, Turkey.
Participants:
The study sample consisted of 330 female individuals between the ages of 20 and 64 years who agreed to participate in the survey.
Results:
NL was generally adequate (91·8 %), though gaps were identified in portion knowledge (54·2 %) and food label reading (44·2 %, borderline). Higher literacy levels were associated with being younger, more educated and employed (P < 0·05). CS and FPS were higher among married women and those with children. Cooking frequency and enjoyment significantly influenced these skills (P < 0·05). Those who cooked more often had higher scores in food label reading and basic math (P < 0·001) and higher total scores (P = 0·049). Participants who enjoyed cooking had better reading comprehension (P = 0·030). A weak but significant correlation was found between FPS and general nutrition knowledge, but no strong relationship was observed between overall cooking skills (CS) and total NL.
Conclusion:
Although no strong link was found between NL and CS, these skills appear to support healthier eating behaviours. Promoting cooking and food preparation through nutrition education may help improve public health.
Both host identity and environmental factors are known to influence parasite species richness. Here, we analysed selected host traits and environmental variables associated with 3 aspects of helminth diversity in African ruminants. Based on the helminth faunas of 35 species of antelope and 1 species of giraffe, we studied drivers of species richness as well as taxonomic and functional diversity, combined for all helminths and separately for nematodes, cestodes and trematodes. A larger geographic host range and/or multiple habitats were associated with higher species richness in all helminths and each group individually as well as with functional diversity in all helminths, trematodes and cestodes. A wider host distribution range and larger relative brain size were both linked to higher taxonomic diversity in all helminths, and an increase in host longevity was linked to higher taxonomic diversity in nematodes. A higher level of climate moisture, relative humidity and primary production had a positive effect on trematode species richness and taxonomic diversity in all helminths, while trematode taxonomic diversity decreased in hosts from drier areas but increased in cestodes harboured by hosts from warmer areas. Our results highlight that patterns in parasite species richness and diversity emerge from an interplay of numerous factors, including host biology, environmental conditions and ecological traits of the parasites themselves. This points to the importance of carefully choosing the range of hosts considered for large-scale parasite diversity studies and underscores the need to avoid grouping too many types of parasites when looking for ecological patterns.
In team science, invitation to writing groups can be subjective and secretive. Confronted with this challenge in the ISCHEMIA trial, with 320 participating sites, 4 coordinating centers, 6 core laboratories, and numerous committees, we adapted an existing model to develop a transparent, objective, and equitable method for determining authorship eligibility.
Methods:
We developed a scoring system based on site performance of tasks critical to trial success that meet the ICJME criteria for authorship. Sites were ranked according to points earned, and points required for potential authorship were communicated to all sites. Site investigators were surveyed for their manuscript topic preferences for writing groups. Beyond the point-based system, authorship positions were also reserved for trial contributors who were not site investigators.
Results:
To date, 50 original, peer-reviewed ISCHEMIA trial manuscripts have been published. In total, 208 authors from 33 countries participated in at least one publication. Of the 87 sites that randomized at least 15 participants over a mean of 5 years, 72% had authorship positions across published manuscripts. Surveys were sent to 334 site investigators and 27% responded. Among respondents, 61% indicated that ISCHEMIA was the first trial they had worked on with performance-based criteria for authorship invitation. Respondents agreed the system was transparent (81%), objective (83%), and equitable for early career researchers (70%) and underrepresented minorities in research (57%).
Conclusions:
ISCHEMIA employed a point-based authorship eligibility system that most authors found objective, merit-based, transparent, and equitable. Implementation of such a system should be considered for team science publications.
This study describes the management and outcomes of temporal bone fractures resulting from falls.
Methods
We retrospectively reviewed patients with traumatic temporal bone fractures from 2018 through 2022.
Results
We analysed 171 patients with temporal bone fractures, 62 (36.3 per cent) of which occurred secondary to falls. Fall patients were significantly older than non-fall patients (mean age 46 vs. 38 years; p = 0.0079) and had higher Modified Frailty Index-5 scores (0.63 vs. 0.20; p = 0.0003). Fall patients had shorter hospital stays (10.1 vs. 15.8 days; p = 0.015), were more frequently discharged home (66.1 vs. 44.0 per cent; p = 0.007) and were less likely to experience non-resolving facial nerve weakness (6.5 vs. 21.1 per cent; p = 0.030).
Conclusion
Patients with temporal bone fractures from falls are older and frailer than non-fall patients and have unique preventative and rehabilitation needs.