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This fourth edition of what is now Kleinman's Diagnostic Imaging of Child Abuse remains the premier source of comprehensive information on all aspects of medical imaging related to child abuse and its differential diagnosis. Chapters cover all aspects of imaging of the abused child – musculoskeletal, spine, visceral and abusive head trauma. Thoroughly updated and revised, there are new chapters on imaging of abusive orbital and facial trauma, post-mortem imaging and on the differential diagnosis of abusive head and spine trauma. A section of the book addresses differential diagnoses for child abuse in the musculoskeletal system. The text is richly illustrated with over 1500 high-quality imaging examples by radiography, computed tomography (CT), magnetic resonance imaging (MRI), nuclear scintigraphy and ultrasound, supplemented with select correlative pathology images. With contributions from experts of multiple disciplines, this book is the sought-after source for reputable information on diagnostic imaging of the suspected victim of child abuse.
Step into this authoritative clinical guide designed to transform how you interpret semen tests and approach male fertility assessment. Specifically crafted for urologists, andrologists, reproductive endocrinologists, infertility specialists, fertility nurses, laboratory professionals, and researchers, this indispensable resource uniquely bridges laboratory findings with clinical decision-making. Drawing on the sixth edition of the WHO Laboratory Manual, the book offers a comprehensive exploration of basic, extended, and advanced semen tests – highlighting their diagnostic value and clinical implications. As the latest WHO guidelines move away from fixed reference ranges, clinicians are now challenged to make nuanced, patient-specific decisions. This guide meets that challenge head-on with expert insights, real-world context, and practical strategies for interpreting semen reports and translating them into next steps in patient care. Whether you're new to the field or an experienced practitioner, this essential reference empowers you to harness the full potential of semen analysis in diagnosing and managing male infertility. Elevate your expertise – improve outcomes.
Genomic epidemiology was essential for characterizing SARS-CoV-2 transmission during the early COVID-19 pandemic. This systematic review examined how whole-genome sequencing was used in local outbreak investigations published between March 2020 and March 2021. Searches of PubMed, Scopus, and Web of Science identified 32 studies from 18 countries that integrated genomic and epidemiological data for local outbreak investigations. Most studies were conducted in healthcare settings or in high-income countries. A limited number of studies were conducted in low- and middle-income countries, except for China and Vietnam. Illumina or Oxford Nanopore platforms and tiled-amplicon protocols were the most common sequencing methods. Phylogenetic trees were the most common genomic epidemiology analytical approach. Genomic data enabled confirmation of suspected transmission links, detection of multiple introductions, and identification of asymptomatic or presymptomatic transmission. Important enablers of early implementation included open-access genomics databases, standardized protocols (e.g. ARTIC), open-source tools (e.g. Nextstrain), and cross-sector partnerships and funding. Study quality and adherence to common observational study reporting guidelines varied widely. Familiarity with the STROME-ID guidelines for molecular epidemiology studies would have improved overall quality. These findings highlight the utility of genomic epidemiology in outbreak response and support its continued integration into public health surveillance systems.
Children with CHD have demonstrated a rise in obesity, and have unique risks related to comorbidities of obesity, including feeding dysfunction and exercise limitations. The incidence and cause of obesity among patients with surgically corrected CHD are not fully understood. This single-centre, longitudinal, retrospective cohort study identified patients between 2004 and 2020 with surgical correction. Diagnoses were restricted to d-transposition of the great arteries, coarctation of the aorta, or tetralogy of Fallot with surgical repair by 6 months of life without long-term post-operative complications or chromosomal abnormalities. Evaluation of Body Mass Index by survival curve for endpoints of overweight and obesity, as well as descriptive analysis of the population, was performed compared to the expected prevalence in the state of Oregon (13.7%). Cohorts were divided into eras in 5-year increments. Of 240 patients identified, 87 (36.2%) were overweight and 50 (20.8%) obese, findings significantly higher than expected prevalence (p = <0.01) for the same time period in the state of Oregon. Patients with coarctation of the aorta had a higher prevalence than other diagnoses (p = <0.01). Patients in the 2004–2008 cohort had the highest rates of obesity compared to other cohorts (p = <0.01 and p = <0.01, respectively), likely due to a longer observational period. However, the 2014–17 cohort had the highest rate of increase in hazard ratio. Children with surgically corrected CHD demonstrate higher prevalences of obesity compared to the general population. There is variation by diagnosis, with coarctation of the aorta having comparatively higher prevalences of obesity. Several factors may impact this discrepancy, including sports participation restrictions and initial emphasis on weight gain.
During a period of universal admission respiratory virus testing, many events (5%–14%) that might have been classified as healthcare-associated respiratory viral infections (HARVI) during routine operations were found to be community-acquired. These findings emphasize unique challenges for HARVI surveillance and the impact that testing strategies have on reported rates.
The response to disasters or mass casualty incidents requires a multi-hazard approach and a rapid, comprehensive response. Community Emergency Response Teams have been formed around the world, where civilians, often laypersons, are integrated into local disaster response. Professionals have been organized into Disaster Medical Assistance Teams, where they are deployed to respond to a distant site. During the October 7, 2023, large-scale attacks in southern Israel, the country found itself in a new and unfamiliar reality. Initiatives began to prepare the population for possible future MCIs. The objective of this article is to describe initiatives that have developed throughout Israel to train medical professionals, including physicians, nurses, and paramedical personnel in local disaster response. These became known as Professional Community Emergency Response Teams. This includes those trained through Magen David Adom, Israel’s National Emergency Medical Service, and those through a Frontline Emergency Medicine model.
To assess the purchases and prices of unprocessed or minimally processed foods according to the type of food outlet and household income.
Design:
Cross-sectional study conducted with data from the 2017–2018 Brazilian Household Budget Survey. Food acquisition and income were the variables of interest. Unprocessed or minimally processed foods were identified according to the NOVA classification, and the shares of energy (kcal) and quantity (grams), as well as prices paid, were analysed. Food outlets were grouped into nine types. Household income per person was assessed in quintiles (Q). Descriptive analyses were conducted.
Setting:
Brazil.
Participants:
A nationally representative sample of 57 920 households.
Results:
The amount of unprocessed or minimally processed foods acquired varied from 320 g (Q1 of income) to 493 g (Q5). The increase in income had a positive effect on the share of foods purchased in supermarkets (Q1: 27·6 % v. Q5: 63·8 %) and fruit and vegetable retailers (Q1: 1·5 % v. Q4: 4·6 %). In contrast, an inverse relation was observed for Mini-markets (Q1: 34·9 % v. Q5: 16·2 %), butchers (Q1: 6·8 % v. Q5: 2·3 %), street markets (Q1: 13·3 % v. Q5: 3·8 %) and street food vendors (Q1: 5·3 % v. Q5: 1·0 %). The price paid for unprocessed or minimally processed foods in supermarkets, mini-markets, butchers and street markets was positively associated with income, which means that a higher mean price was observed in the highest income quintile.
Conclusions:
The availability and affordability of unprocessed or minimally processed foods differed according to food outlets and were influenced by income level.
This study aimed to develop and validate a questionnaire assessing the nutrition knowledge (NK) of Italian adult women regarding the relationship between diet, lifestyle and bone health.
Design:
A thirty-item questionnaire in Italian was developed by experts based on a literature review. Participants completed the questionnaire twice, with a 2–4 week gap between the two administrations. During the initial administration, weight and height were recorded using a mechanical scale and a stadiometer, while bone mineral density (BMD) of the lumbar spine (L1-L4), femoral neck and total femur were assessed via dual-energy X-ray absorptiometry (DXA).
Setting:
Centre for Metabolic Bone Diseases at the Parma University Hospital, from January 2022 to June 2024.
Participants:
Women aged 45–75 years old, native Italian speakers, undergoing DXA at the Centre participated.
Results:
The sample included 295 women with a median age of 63 years (interquartile range 11·5). The questionnaire demonstrated good internal consistency (Cronbach’s alpha = 0·698) and high temporal stability (R = 0·810, P = 0·002), effectively differentiating between individuals with and without a nutritional background. Regression analysis indicated negative associations between NK score and age (β1 = –0·130, P < 0·001) and BMI (β1 = –0·193, P < 0·001).
Conclusions:
The NutriBone questionnaire is a valid and reliable tool for evaluating NK related to bone health in Italian adult women undergoing DXA, with potential for future research applications.
To define the incidence of donor-derived infection (DDI) in recipients of solid organ transplant (SOT) from donors with positive blood cultures and to assess the impact of shorter versus longer duration of targeted preemptive antibiotic therapy (PAT).
Design:
Retrospective, single-center, cohort study.
Setting:
Mayo Clinic Arizona.
Patients:
Recipients transplanted between 1/1/2019 and 7/1/2024 who received an organ from a donor with positive blood cultures.
Methods:
The primary outcome was incidence of DDI. Secondary outcomes included duration of PAT and incidence of donor blood culture contamination.
Results:
Among 199 SOT recipients from 167 unique donors with positive blood cultures, two recipients developed confirmed DDI within 30 days of SOT. Both cases were gram negative bacillary bacteremia not treated in donors and occurred immediately posttransplant prior to adequate recipient PAT. Six-month graft survival and recipient survival were 96.5% and 97.5% respectively. 139 recipients (69.8%) received PAT for a median duration of 7 days. There was no difference in rate of infections between recipients provided with ≤7 days versus 8–14 days of PAT for donor blood cultures; however, recipients who received 8–14 days had more Clostridioides difficile infections (CDIs) within 60 days of SOT (7.7% vs 1.5% ≤ 7 days, P = .040) and were more often discharged on intravenous antibiotics (32.3% vs 11.3%, P < .001).
Conclusion:
We observed a low rate of DDI following receipt of organs from donors with positive blood cultures. DDI occurred in cases without adequate donor/recipient treatment. Longer durations of targeted PAT resulted in more CDI and intravenous antibiotics on discharge.
This study explores associations between clusters characterising urban Canadians’ retail food environments and their acceptability levels of three policies aimed at promoting healthier restaurant food environments (RFE).
Design:
The three examined policies related to (1) proposing healthier menu default options, (2) restricting the establishment of fast-food restaurants near schools and (3) eliminating unhealthy foods from municipal buildings’ food outlets. Retail food environment clusters were available for 1- and 3-km buffer zones from the centroid of participants’ residential dissemination area. Retail food environment data were extracted from Can-FED, whereas acceptability data were provided by the THEPA dataset.
Setting:
Retail food environments present across Canada’s seventeen most populated census metropolitan areas.
Participants:
Urban-dwelling Canadians (n 27 162).
Results:
Results from multivariate multilevel logistic regression analyses showed that those who were surrounded by the greatest relative density of both healthy food outlets (HFO) and fast-food outlets (FFO) within a 3-km buffer zone were less likely to be in complete agreement with the fast-food zoning policy than the reference category. Findings also indicated that, within a 1-km buffer zone, those whose retail food environment was categorised as being the least healthy (no HFO and highest relative density of FFO) were less likely to be in complete agreement with the unhealthy food elimination policy than the reference category.
Conclusions:
This study provides new evidence of associations between retail food environments and RFE policy acceptability, which may help orient the implementation of these policies.
Individuals with type 2 diabetes are at increased risk for developing CVD. We assessed how dietary counselling on a high-quality, fibre-rich diet influenced cardiometabolic health of patients with type 2 diabetes. In this 6-month trial, 121 patients with type 2 diabetes (67 (sd 8·7) years, 68 % men, BMI 27·8 kg/m2) were assigned to dietary counselling (n 61) or standard care (n 60). Counselling included 4–7 individual sessions with a dietitian, aimed at increasing fibre intake to improve diet quality. The primary outcome was a composite risk score estimating 10-year CVD risk. Secondary outcomes included diet quality, assessed by the Dutch Healthy Eating Index-2015 (DHD15-index), HbA1c, LDL-cholesterol, blood pressure, body weight and medication use. Diet quality score at baseline was 115 (sd 26) and similar across groups. Over 6 months, DHD15-index scores improved by 4·5 points (95 % CI: −0·2, 9·1) in the intervention group v. control, but not significant. The change in 10-year CVD risk across the 6 months of the trial (primary outcome) did not differ between groups −0·1 %, 95 % CI: −0·2, 0·1. Changes over time in HbA1c (–1·1 mmol/mol, 95 % CI: −4·4, 2·3), LDL-cholesterol (0·0 mmol/l, 95 % CI: −0·2, 0·3), blood pressure (–1 mmHg, 95 % CI: −6, 4), body weight (–0·1 kg, 95 % CI: −1·2, 1·1) or medication use did not differ between groups. Dietary counselling for 6 months slightly improved adherence to a high-quality, fibre-rich diet in patients with type 2 diabetes but did not significantly impact cardiometabolic health or medication use.
To investigate food consumption behaviour and self-perceived nutrition knowledge among university students, and to draw implications for nutrition education in contexts where formal nutrition education before university is limited.
Design:
A mixed-methods approach was adopted. A survey was first conducted to examine participants’ food consumption behaviour and self-perceived nutrition knowledge. Thirty-four participants were then invited to take part in semi-structured interviews to gain more in-depth insights into their self-declared knowledge and related behaviours.
Setting:
Universities in China, representing a context of limited formal nutrition education in pre-university schooling.
Participants:
190 university students.
Analysis:
Interview transcripts were reviewed to verify participants’ self-declared nutrition knowledge and identify misconceptions or gaps in understanding. Questionnaire data were analysed using descriptive statistics.
Results:
Students with higher education levels reported paying more attention to nutrition labels and selecting healthier snacks. However, interviews revealed that students who claimed to read nutritional claims during food purchases often misunderstood the meaning of sugar and fat content information. A significant ‘illusion of knowing’ was observed, and participants generally lacked awareness of authoritative food standards.
Conclusion and implications:
Illusion of knowing is common among students who have not received formal systematic nutrition education. Nutrition education programmes should prioritise raising students’ understanding of basic food concepts and improving their ability to interpret nutrition information accurately, as part of broader health promotion efforts.
Episodic memory decline is among the earliest and most prominent cognitive changes observed in both normal aging and Alzheimer’s disease. The Free and Cued Selective Reminding Test (FCSRT) enhances differentiation of memory deficits through controlled semantic encoding and cue-based retrieval. However, culturally appropriate normative data for Mandarin-speaking adult populations have been lacking. This study aimed to establish normative data for the Taiwan version of the FCSRT (T-FCSRT), examine demographic effects on test performance, and evaluate its psychometric properties and clinical applicability.
Method:
A total of 372 cognitively healthy adults aged 45–86 years were recruited using stratified sampling to reflect the Taiwanese population across sex, age, and education levels. Participants completed the T-FCSRT, and regression-based analyses were used to adjust for demographic effects. Reliability and validity were assessed using test–retest data and correlations with established neuropsychological measures.
Results:
All T-FCSRT core indices were significantly influenced by age and education level, whereas sex effects were confined to immediate and delayed free-recall measures. The T-FCSRT demonstrated good test–retest reliability, criterion-related and construct validity, and regression-based percentile norms that provide population-representative benchmarks.
Conclusion:
The T-FCSRT demonstrates strong psychometric properties and provides culturally appropriate normative data for Mandarin-speaking adults in Taiwan. These findings support its utility for clinical assessment and research on episodic memory, enabling more accurate differentiation between normal and pathological aging.
Emotion regulation, while closely linked to depressive symptoms, has seldom been examined together with them in studies of the relationship between chronotype and suicidality. We therefore examined whether chronotype predicts suicidality through the sequential mediation of poor emotion regulation and depressive symptoms. In addition, we examined whether these mediation pathways differ between morning-type and evening-type groups.
Methods:
This study included 3109 Korean adults from the general population. Chronotype, depressive symptoms, emotion regulation, and suicidality were assessed using the Composite Scale of Morningness, Self-Rating Depression Scale, Emotion Regulation Skills Questionnaire, and the Suicidality module of the Mini International Neuropsychiatric Interview, respectively.
Results:
Chronotype did not have a direct effect on suicidality. Instead, eveningness was indirectly linked to higher suicidality. Specifically, individuals with stronger eveningness tendencies reported poorer emotion regulation, which increased depressive symptoms; depressive symptoms, in turn, predicted suicidal ideation, which emerged as a significant predictor of suicide attempts. Subgroup analyses revealed that the same sequential pathway was significant only among evening-types, but not among morning-types.
Conclusions:
Chronotype appears to play a role in suicide risk in the general population. Screening for chronotype and focusing on emotion regulation and depressive symptoms may enhance prevention efforts tailored to chronotype, especially for evening-type individuals.
The dual burden of tuberculosis (TB) and diabetes mellitus (DM) presents a growing challenge for health systems in low- and middle-income countries (LMICs), including Pakistan. Despite global and national policies advocating for integrated care, evidence on health facility readiness to operationalize integration remains scarce. This study assessed the readiness of TB basic management units (BMUs) to deliver integrated TB-DM care and explored implementation barriers using the Consolidated Framework for Implementation Research (CFIR).
Methods:
We conducted an explanatory sequential mixed-methods study from September 2024 to February 2025 across 13 TB BMUs in five districts of Pakistan. Quantitative readiness data were collected using a structured tool adapted from the WHO Service Availability and Readiness Assessment (SARA), generating a composite score across four domains. Subsequently, qualitative data were gathered through multi-stakeholder focus group discussions with healthcare providers, facility managers, patients, caregivers, and policymakers. Reflexive thematic analysis was conducted and mapped to CFIR Inner Setting constructs to contextualize quantitative findings.
Results:
Only one facility demonstrated high readiness, while 12 showed low readiness. Facilities lacked routine comorbidity screening, trained staff, diagnostic capacity, and essential medicines. Key barriers included inadequate infrastructure, workforce shortages, fragmented information systems, and low prioritisation of integrated care. Financial constraints and limited coordination further hindered implementation.
Conclusion:
This study highlights critically low readiness among TB facilities in different districts of Pakistan to deliver integrated TB-DM care, reflecting systemic weaknesses across core domains. Strengthening systems, building capacity, and improving integration strategies are essential to bridge gaps between policy and practice.
This research was conducted to determine if and how Australian and Canadian dietetic regulatory bodies incorporate social justice into regulatory documents and how this compares between two otherwise demographically and politically similar countries.
Design:
Quantitative and qualitative content analysis of Australian and Canadian dietetic regulatory documents was performed to determine how often and in what context social justice terms were incorporated into dietetics regulation.
Setting:
Australia and Canada
Participants:
Regulatory documents in Australia and Canada
Results:
Findings reveal that social justice is framed differently between the two countries, particularly related to working with people who experience marginalisation. Regulatory documents seldom addressed issues of systemic injustice, focusing instead on self-awareness and individualistic approaches to care.
Conclusions:
Social justice is currently framed in nutrition and dietetics regulatory documents in ways that do not align with core principles of social justice. Social justice should be reframed in regulatory documents to shift attention away from awareness, towards action, and should be done in a way that addresses systemic injustices in healthcare. Developing a clear and consistent definition of what social justice is is a critical first step in achieving this goal to overcome the challenges identified in this research study.
To optimise school food baskets in Ghana to meet newly proposed food and nutrition targets while considering cultural acceptability and cost.
Design:
This was a modelling study. Data on existing school meal menus were collected from various regions to provide baseline inputs. Linear programming (LP) was used to model school meal baskets that satisfied minimum nutrient and food targets for school meals while meeting cost and acceptability constraints. Five LP models were tested, each varying in budget constraints and acceptability/food-based parameters.
Setting:
Ghana.
Participants:
NA.
Results:
Baseline school food baskets were significantly deficient in energy, protein, Fe, Zn, vitamin A, folate, vitamin B12 and vitamin C compared to food and nutrient standards for school meals in Ghana. Optimisation resulted in school food baskets that met cost, nutrient and food-based/acceptability targets but with substantial deviations from baseline. Achieving nutritional adequacy within cost limits increased reliance on animal-source foods and led to higher environmental impacts, indicating trade-offs between nutrition, affordability and environmental sustainability.
Conclusion:
The study underscores LP’s potential for enhancing school meals in Ghana but highlights the need for increased financial investment for reaching dietary goals. Addressing local realities and cultural preferences is essential for implementing effective, sustainable school meal strategies and improving child health.
In 2020, the American Academy of Clinical Neuropsychology (AACN) published consensus labels for the uniform description of normally distributed test results in the field of clinical neuropsychology. These consensus labels were developed in a North American context, but other countries have also struggled with the challenges of harmonizing verbal descriptive labels in neuropsychological reports. A recent effort in Norway has demonstrated that literal translations of the AACN labels do not always work in a different language and culture. Also, verbal labels may not be unequivocally understandable for patients, their significant others, and other healthcare professionals who refer patients for neuropsychological services. In this Commentary, we illustrate the process of coming to uniform descriptions for normally distributed test results for the Dutch language, spoken primarily in the Netherlands, the Flanders part of Belgium, the Dutch Caribbean, and Suriname. We also highlight the hurdles that need to be overcome to establish a global consensus.