The purpose of this review is to examine the effects of hesperidin and hesperetin on liver disorders. Metabolic dysfunction-associated steatotic liver disease is a complicated disorder influenced by many factors, including inflammation, diabetes and obesity. Currently, the most prominent treatment method is lifestyle changes. If left untreated, it can progress to cirrhosis, liver fibrosis and liver cancer. Hesperidin, which is a flavanone glycoside polyphenolic plant compound, belongs to the flavanone class and was first isolated from citrus peel. Hesperidin includes aglycone hesperetin and rutinoside sugar. It is the most dominant form of flavonoid in citrus fruits. In our review, we discuss the effects of these phytochemicals on liver diseases, focusing on their relationship with inflammation, blood sugar regulation and blood lipids. Hesperidin and hesperetin are seen as promising agents for many diseases. Their antioxidant and anti-inflammatory properties support this view. Although their low water solubility limits their potential effects, many studies have demonstrated their benefits. They are thought to play an effective role in inflammatory processes, particularly in liver diseases. More studies are required to find the optimum dosage and to use them as a therapeutic agent for the liver.

In this paper, we define and study an equivariant analogue of Cohen, Farber and Weinberger’s parametrized topological complexity. We show that several results in the non-equivariant case can be extended to the equivariant case. For example, we establish the fibrewise equivariant homotopy invariance of the sequential equivariant parametrized topological complexity. We obtain several bounds on sequential equivariant topological complexity involving the equivariant category. We also obtain the cohomological lower bound and the dimension-connectivity upper bound on the sequential equivariant parametrized topological complexity. In the end, we use these results to compute the sequential equivariant parametrized topological complexity of equivariant Fadell–Neuwirth fibrations and some equivariant fibrations involving generalized projective product spaces.

Vernacular discourse about science reveals theorizations of it as a power-laden, morally charged experimentation with the world guided by (often implicit) ethical orientations. Applying these vernacular theorizations to interpret professional class science on the continent, the author argues that this science has been shaped most profoundly by the politics of independence. While indigenous projects, European imperialism, and neoliberalism shape scientific institutions, African independence continues to inform the moral and political ends toward which science is thought to work. Understanding the alignment of professional class science with nation-building can help guide the recalibration of science toward the goal of substantive independence.

Cadra cautella is a serious insect pest of stored figs and dates. The irradiation sensitivity of different development stages of C. cautella and large-scale testing of the proposed irradiation quarantine doses (50–500 Gy), were investigated. The impact of a PI dose of 400 Gy on the physiochemical and microbiological quality of dry dates (Bartamoda cv.) stored at room temperature was also investigated. An irradiation dose of 100 Gy prevented egg hatching in the F1 generation when 1–3 days old eggs were irradiated. Irradiation doses of 200 and 300 Gy prevented adult emergence when 2nd and 4th instar larvae were irradiated. When the pupae stage was irradiated, an irradiation dose of 400 Gy prevented the hatchability of F1 generation, indicating that this stage was the most radio-tolerant. The results of large-scale testing of the proposed phytosanitary irradiation dose (400 Gy) applied to 18, 0000 pupae resulted in no reproduction (zero hatching of F1 generation). There were no significant differences in the physiochemical properties of stored dates during the storage period at room temperature. Stable ESR signal intensity was recorded for 6 months in all parts of the irradiated fruits, and the intensity was highest in the kernel. The PI dose of 400 Gy also slightly reduced all microorganisms' counts. In conclusion, the dose level of 400 Gy stopped the reproduction potential of C. cautella. and they maintained the quality characteristics of dry date Bartamoda fruits during storage at room temperature for 6 months in tightly closed packages.

Let $[a_1(x),a_2(x),\ldots ,a_n(x),\ldots ]$ be the continued fraction expansion of $x\in [0,1)$ and $q_n(x)$ be the denominator of its nth convergent. The irrationality exponent and Khintchine exponent of x are respectively defined by

$$ \begin{align*} \overline{v}(x)=2+\limsup_{n\to\infty}\frac{\log a_{n+1}(x)}{\log q_n(x)} \quad \text{and}\quad \gamma(x)=\lim_{n\to\infty}\frac{1}{n}\sum_{i=1}^{n}\log a_i(x). \end{align*} $$

We study the multifractal spectrum of the irrationality exponent and the Khintchine exponent for continued fractions with nondecreasing partial quotients. For any $v>2$, we completely determine the Hausdorff dimensions of the sets $\{x\in [0,1): a_1(x)\leq a_2(x)\leq \cdots , \overline {v}(x)=v\}$ and

$$ \begin{align*}\bigg\{x\in[0,1): a_1(x)\leq a_2(x)\leq\cdots, \lim\limits_{n\to\infty}\frac{\log a_1(x)+\log a_2(x)+\cdots+\log a_n(x)}{\psi(n)}=1\bigg\},\end{align*} $$

where $\psi :\mathbb {N}\rightarrow \mathbb {R}^+$ is a function satisfying $\psi (n)\to \infty $ as $n\to \infty $.

Court restructuring has become a salient national political issue, with proposals to increase the number of justices on the US Supreme Court gaining traction in response to various Court controversies. However, relatively little attention has been paid to state-level efforts, some successful, to increase the number of justices on state supreme courts. Although the number of justices on the US Supreme Court has not been changed since 1869, the size of most state supreme courts has been less stable. To place recent state supreme court expansions into context, this article analyzes the historical dynamics of state supreme court expansion. Analyzing an original dataset that includes every change made to the size of a state supreme court since 1789, it finds that court expansion has been more likely when the political competitiveness of a state is low and when state judicial selection and retention systems provide for lower levels of judicial independence.

We evaluate three measures of state legislative professionalism: Squire’s (1992) index that measures professionalism relative to the US House, Bowen and Greene’s (2014b) two-dimensional scaling, and legislative operating expenditures per member, an older measure that remains in occasional use. Replications of 18 recent articles show that these three measures regularly produce significantly different estimates of the effect of professionalism, particularly in longitudinal analysis; when they do, the choice of measure often affects whether other central variables retain a significant relationship with the dependent variable. These divergent results appear to reflect differences among these measures in terms of missingness, vulnerability to outliers, measurement of session length, and whether to benchmark to the US House. Researchers seeking a general indicator of professionalism should consider these differences when choosing an appropriate measure.

In the context of climate change, the impacts of extreme weather events are increasingly recognised as a significant threat to mental health in the UK. As clinicians and researchers with an interest in mental health, we have a collective responsibility to help understand and mitigate these impacts. To achieve this, however, it is vital to have an appreciation of the relevant policy and regulatory frameworks. In this feature article, a collaboration amongst mental health and policy experts, we provide an overview of the integration of mental health within current climate policies and regulations in the UK, including gaps and opportunities. We argue that current policy and regulatory frameworks are lacking in coverage, ambition, detail and implementation, as increases in weather extremes and their negative impacts on mental health outpace action. For example, across current national and local climate policies, there is almost no reference to the impacts of extreme weather events on mental health. Whilst alarming, this provides scope for future research to fill evidence gaps and inform policy and regulatory change. We call for mental health and policy experts to work together to improve our understanding of underlying mechanisms and develop practical interventions, helping to bring mental health within climate policy and regulatory frameworks.

Latin America historically has had some of the strictest abortion laws in the world, making unsafe procedures a main cause of mortality among women and girls. However, in the context of the Green Wave, three countries recently have amply decriminalized access to abortion: Mexico (2021, 2023), Colombia (2022), and Argentina (2020) (Uruguay did so in 2012). The recent wave of decriminalization is the culmination of larger, historical processes that involved the gradual judicialization of reproductive rights in the region. Courts have been a central part of the story. In these three cases, arguments advanced by state and nonstate actors in favor of decriminalization significantly built on jurisprudence developed over many years. The process of abortion decriminalization has been partly a tale of gradual judicialization.