Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders.

The authors’ primary goal in this paper is to enhance the study of $T_0$ topological spaces by using the order of specialization of a $T_0$-space to introduce the lower topology (with a subbasis of closed sets $\mathord{\uparrow } x$) and studying the interaction of the original topology and the lower topology. Using the lower topology, one can define and study new properties of the original space that provide deeper insight into its structure. One focus of study is the property R, which asserts that if the intersection of a family of finitely generated sets $\mathord{\uparrow } F$, $F$ finite, is contained in an open set $U$, then the same is true for finitely many of the family. We first show that property R is equivalent to several other interesting properties, for example, the property that all closed subsets of the original space are compact in the lower topology. We then find conditions under which these spaces are compact, well-filtered, and coherent, a weaker variant of stably compact spaces. We also investigate what have been called strong $d$-spaces, develop some of their basic properties, and make connections with the earlier considerations involving spaces satisfying property R. Two key results we obtain are that if a dcpo $P$ with the Scott topology is a strong $d$-space, then it is well-filtered, and if additionally the Scott topology of the product $P\times P$ is the product of the Scott topologies of the factors, then the Scott space of $P$ is sober. We also exhibit connections of this work with de Groot duality.

The concept of heightened human rights due diligence (hHRDD) is often used to address corporate responsibilities in situations of armed conflict. For companies in these contexts, the first step is to assess whether their activities impact the conflict and its dynamics, and, as a result, whether they are involved in conflict-related human rights abuses. However, companies often find that they have no impact on the conflict. Should companies in these scenarios just focus on regular human rights due diligence (HRDD)? This piece aims to illustrate, based on the example of Ukraine, the human rights challenges that emerge during a war which companies with no influence on the conflict still face and to respond to the question of whether in such situations companies should still engage in hHRDD or continue to conduct HRDD as usual.

We construct a new stochastic interest rate model with two stochastic factors, by introducing a stochastic long-run equilibrium level into the Vasicek interest rate model which follows another Ornstein–Uhlenbeck process. With the interest rate under the Black–Scholes model being assumed to follow the newly proposed model, a closed-form representation of European option prices is successfully presented, when the analytical characteristic function of the underlying log-price under a forward measure is derived. To assess the model performance, a preliminary empirical study is conducted using S&P 500 index and its options, with the Vasicek model and an alternative two-factor Vasicek model taken as benchmarks.

Let G be a connected semisimple real algebraic group. For a Zariski dense Anosov subgroup $\Gamma <G$ with respect to a parabolic subgroup $P_\theta $, we prove that any $\Gamma $-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $. More generally, we prove that for a Zariski dense $\theta $-transverse subgroup $\Gamma <G$, any $(\Gamma , \psi )$-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $, provided the $\psi $-Poincaré series of $\Gamma $ diverges at its abscissa of convergence. In particular, our result also applies to relatively Anosov subgroups.

Amputation as a life-saving measure for earthquake-trapped patients is supported by WHO and INSARAG guidelines. However, implementing these guidelines in highly stressful contexts can complicate decision-making. This report presents a case of life-saving amputation during the 2023 Turkey earthquake, adhering to recommended guidelines. The 16-year-old patient was trapped for 55 hours in a narrow corridor. Extensive interdisciplinary discussions led to the decision for a field amputation after alternative rescue attempts failed. Consent was obtained from the family, given the patient’s delirium. Meticulous planning and anesthesia using midazolam and ketamine ensured successful amputation with minimal blood loss. Challenges encountered during the disaster response were discussed. Delays in administering antibiotics, a lack of cervical protection, ethical dilemmas, psychological concerns, and legal implications were highlighted. Continued improvement and addressing ethical, legal, and psychological aspects are essential for optimal disaster response outcomes.

Rapid technological development means that the ground on which recent academic studies and public debates about the future of work organisation are based is shifting too rapidly for predictions to be credible. Organisational studies scholars have provided a counterpoint to this futuristic, speculative debate about the world of tomorrow with studies that contextualise seemingly new trends within a longer history of industrial capitalism. In this article, using Moritz Altenried's The Digital Factory (2022) as a starting point, I further explore the historical contextualisation of two aspects of platform capitalism: its de-spatialisation and its use of “autonomy”.

More than two-thirds of women during childbearing years (20–39 years old) are overweight or obese in the United States, with protein intake among 20–49-year-old women being 1.6 times higher than recommended (75.4 g/day versus 46 g/day) that can be considered as a relatively high-protein diet (HPD). Both gestational obesity and HPDs during gestation adversely affect offspring health. This study investigates the impact of HPDs fed during gestation and lactation on obese mothers and their offspring in Wistar rats. Dams randomized to either a normal-protein diet (NPD) or HPD (n = 12/group). Pups from each maternal group were weaned to either NPD or HPD for 17 weeks (n = 12/group). No effect of maternal or weaning diet on food intake, body weight, or body fat/weight ratio was observed. However, NPD dams exhibited higher glucose area under the curve compared with HPD dams (p < 0.03). At weaning, offspring born to NPD dams showed higher fasting plasma glucose (P < 0.03) and insulin/glucose ratio (P = 0.05) than those born to HPD dams. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index was higher in offspring born to NPD dams (P < 0.04) and weaned to NPD (P < 0.05) at week 17. These findings underscore the role of high-protein maternal and weaning diets in pregnancy outcomes for obese mothers, particularly in glucose homeostasis, although gestational obesity may overshadow other parameters. Further research is needed to fully understand the impact on both maternal and offspring health and their underlying mechanisms in this context.

This study describes the presence of the royal cucumber Parastichopus regalis (Cuvier, 1817) in The Natural Park of Ria Formosa (NPRF), Portugal. A single individual was observed during a monitoring scuba dive at a depth of 3 m inside this shallow mesotidal lagoon. The most plausible explanation for this occurrence is attributed to the rejection by trawlers when returning to their home port from their fishing grounds. This marine species has a deeper distribution outside the lagoon and is commonly captured as by-catch and subsequently discarded. This study also alerts us to the growing presence of non-indigenous species and the emergent threat of new invasions, highlighting the need to adopt biosecurity measures, like good practices for fishers when dealing with discards to avoid new species introductions in this fragile coastal marine habitat.

To capture prey more efficiently, cetaceans can display a wide range of foraging tactics to separate individual prey. Barrier feeding tactics are performed to restrict prey movements, using natural and non-natural barriers and some species can even create barriers with their own bodies. Mud ring feeding has been observed in bottlenose dolphins in Florida Bay and in Chetumal-Corozal Bay, where ring-maker dolphins create ring-shaped mud plumes to encircle fish schools. Here, we document for the first time Guiana dolphins performing the mud ring feeding behaviour in the Cananéia estuarine system, in the southern portion of the state of São Paulo, Brazil. A total of 11 dolphins were recorded in four expeditions through aerial footage engaging in the behaviour. These findings expand our knowledge about the behavioural plasticity of the species and builds upon existing records of mud ring feeding behaviour in cetaceans.