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Linear unsteady aerofoil theory, while successfully used for the prediction of unsteady aerofoil lift for many decades, has yet to be proven adequate for predicting the propulsive performance of oscillating aerofoils. In this paper we test the hypothesis that the central shortcoming of linear small-amplitude models, such as the Garrick function, is the failure to account for the flow acceleration caused by aerofoil thrust. A new analytical model is developed by coupling the Garrick function to a cycle-averaged actuator disc model, in a manner analogous to the blade-element momentum theory for wind turbines and propellers. This amounts to assuming the Garrick function to be locally valid and, in combination with a global control volume analysis, enables the prediction of flow acceleration at the aerofoil. The new model is demonstrated to substantially improve the agreement with large-eddy simulations of an aerofoil in combined heave and pitch motion.
This article explores the unmined textual history of one of Tibet's most influential historiographies, the Pillar Testament (bKa’-chems-ka-khol-ma), usually dated to the eleventh or the twelfth century. Drawing on previously known and unknown witnesses, the article compares a variety of narratives across most extant redactions. In doing so, it finds that the redaction chiefly consulted by scholars to date is an expanded and contaminated version that is notably later than previously assumed. Instead, another and heretofore largely neglected witness emerges as the most archaic extant redaction. The textual comparisons spotlight a wide range of alterations in the work's narratives and thus demonstrate how perceptions of early Tibetan historical episodes shifted over time. Such changes affected remembrance of Sino-Tibetan imperial relations, the origins of Buddhism and writing in Tibet and the genealogy of its emperors, among other things. The article concludes by critically discussing the witnesses’ dating and the hope we may place in the hunt for the work's illustrious but elusive original.
5wPatients with end stage kidney disease (ESKD) who receive in-center hemodialysis are disproportionately vulnerable to extreme weather events, including hurricanes and heat waves, that may disrupt access to healthcare providers, and life-sustaining treatments. This current era of climate-driven compounding disasters is progressively elevating the level of threat to the health and well-being of patients with ESKD. This analysis brings together multi-disciplinary expertise to explore the contours of this increasingly complex risk landscape. Despite the challenges, important advances have been made for safeguarding this medically high-risk patient population. Hemodialysis services providers have devised innovative systems for preparing their patients and sustaining, or rapidly reestablishing, hemodialysis services in the aftermath of a disaster, and maintaining open lines of communication with their caseloads of ESKD patients throughout all phases of the event. A description of lessons learned along the path towards improved patient support in disasters, is provided. The article concludes with a detailed case example, describing dialysis providers’ effective response throughout Hurricane Ian’s passage across the State of Florida in 2022. Based on lessons learned, this analysis outlines strategies for protecting patients with ESKD that may be adapted for future climate-potentiated disaster scenarios.
Most clay minerals are characterized by a platy morphology. By contrast, palygorskite has a fibrous morphology and is structurally distinct from the typical 1:1 and 2:1 layer structures. Diverse opinions exist on the origin of palygorskite in soils. Many authors suggest that palygorskite forms after smectite. Others favor its authigenesis during pedogenic processes or its inheritance from the parent material. This review provides a critical synthesis on the origin of palygorskite in the semi-arid-tropical (SAT) Vertisols and arid calcic soils of the Thar Desert of India. It also highlights the specific genetic pathway for the presence of palygorskite in the soils. The ubiquitous association of smectite with palygorskite is inadequate to explain the formation at the expense of smectite, because at pH 8.2 and above the smectite structure is subjected to dissolution to create soluble Si and Al, and the recrystallization of the soluble Si and Al to form palygorskite may not be possible in the Vertisols of the Indian SAT environment. Thus, mildly to moderate alkaline pedochemcial environments of the SAT Vertisols do not favor authigenic precipitation of the palygorskite in such soils. This review shows that the presence of palygorskite in the SAT Vertisols is due to its inheritance from the exhumed inter-trappean beds, infra-trappean beds, and bole beds. This view on the genesis of the palygorskite is also justified by its presence in weakly developed calcic soils of the Thar Desert as detrital flux from the adjoining marine sedimentary rocks.
Haplidus glabricollis Chemsak and Linsley, 1964 is synonymised with Limernaea ochracea (Fisher, 1927) (Coleoptera: Cerambycidae: Cerambycinae: Oemini). Adetus scissicauda (Bates, 1874) (Coleoptera: Cerambycidae: Lamiinae: Apomecynini) is reinstated, and Adetus alboapicalis Breuning, 1943 is proposed as a junior synonym. Adetus salvadorensis Franz, 1954 (Coleoptera: Cerambycidae: Laminae: Apomecynini) is redescribed and recorded from Oaxaca, Mexico. Plistonax antonkozlovi Santos-Silva et al., 2020 (Coleoptera: Cerambycidae: Lamiinae: Acanthoderini) and Hesychotypa danilevskyi Nearns and Nascimento, 2019 (Coleoptera: Cerambycidae: Lamiinae: Onciderini) are recorded for the first time for the province of Bocas del Toro, Panama. Dorcasta borealis Breuning, 1940 (Coleoptera: Cerambycidae: Lamiinae: Apomecynini) is newly recorded from Mexico (Yucatán). The type locality of Eupogonius longipilis Bates, 1880 (Coleoptera: Cerambycidae: Lamiinae: Desmiphorini) is corroborated and new state record from Chiapas, Mexico, is reported. Eupogonius vittipennis Bates, 1885 is recorded for Campeche, Mexico. Trichastylopsis skillmaninew species (Coleoptera: Cerambycidae: Laminae: Acanthocinini) is described from Jalisco and Michoacán, Mexico.
Thomas Kaufmann's The saved and the damned was first published in Germany in 2017. It was therefore one of many publications that year offered to mark the fifth centennial of Martin Luther nailing up his Ninety-Five Theses (quite possibly a legendary event, as the author notes). Kaufmann's work, now available in English translation, is an unapologetically blunt assertion that ‘In the beginning was Luther’ (p. 6). In this it is much the same as some other English-language scholarship from 2017, such as the monumental Oxford handbook of the Protestant Reformations, which also began with Luther. Although a comparatively recent entry in English-language Reformation scholarship, The saved and the damned has already generated academic discussion and was the focus of a panel at the Sixteenth Century Society Conference in 2023.
The widely used model predictive control of discrete-time control barrier functions (MPC-CBF) has difficulties in obstacle avoidance for unmanned ground vehicles (UGVs) in complex terrain. To address this problem, we propose adaptive dynamic control barrier functions (AD-CBF). AD-CBF is able to adaptively select an extended class of functions of CBF to optimize the feasibility and flexibility of obstacle avoidance behaviors based on the relative positions of the UGV and the obstacle, which in turn improves the obstacle avoidance speed and safety of the MPC algorithm when integrated with MPC. The algorithmic constraints of the CBF employ hierarchical density-based spatial clustering of applications with noise (HDBSCAN) for parameterization of dynamic obstacle information and unscaled Kalman filter (UKF) for trajectory prediction. Through simulations and practical experiments, we demonstrate the effectiveness of the AD-CBF-MPC algorithm in planning optimal obstacle avoidance paths in dynamic environments, overcoming the limitations of the point-by-point feasibility of MPC-CBF.
Understanding the propulsion of a swimmer in a large group of individuals holds the key to unravelling the intriguing dynamics of active matter collective motion. Here, we develop a two-dimensional (2-D) self-assembled rotor, powered by bacterial flagella. At a water–air interface, the average direction of rotation of a rotor is fixed. When the chiral rotor is put into a 2-D bacterial suspension, we examine the average and fluctuation of the angular velocity of the rotor. Remarkably, the average angular velocity of a rotor is found to increase up to 3 times when the density of surrounding bacterial suspension increases and the increase is nonlinear. In a dense suspension of bacteria, the existence of a rotor disrupts vortices in the surrounding active turbulence, and the acceleration of the rotor is independent of the activity level of the surrounding free bacteria. The nonlinear acceleration thus results from hydrodynamic interaction with surrounding crowdedness that can be quantitatively explained by hydrodynamic simulation. The simultaneity between the acceleration of rotor and free bacteria in active turbulence suggests that crowding-induced acceleration may promote the onset of instability. The result will inspire new active-matter-based microfluidic devices with improved transport properties.
A new vacuum line to extract CO2 from carbonate and dissolved inorganic carbon (DIC) in water was established at Guangxi Normal University. The vacuum line consisted of two main components: a CO2 bubble circulation region and a CO2 purification collection region, both of which were made of quartz glass and metal pipelines. To validate its reliability, a series of carbonate samples were prepared using this system. The total recovery rate of CO2 extraction and graphitization exceeded 80%. Furthermore, the carbon content in calcium carbonate exhibited a linear relationship with the CO2 pressure within the system, demonstrating its stability and reliability. The system was also employed to prepare and analyze various samples, including calcium carbonate blanks, foraminiferal, shell, groundwater, and subsurface oil-water samples. The accelerator mass spectrometry (AMS) results indicated that the average beam current for 12C- in the samples exceeded 40 μA. Additionally, the contamination introduced during the liquid sample preparation process was approximately (1.77 ± 0.57) × 10−14. Overall, the graphitized preparation system for carbonate and DIC in water exhibited high efficiency and recovery, meeting the requirements for samples dating back to approximately 30,000 years.
Evidence-based conservation can be hindered by limited field data, but historical archives have the potential to provide unique insights into conservation-relevant parameters, such as identification of suitable habitat for threatened species. The Manumea or Tooth-billed Pigeon Didunculus strigirostris has declined on Samoa and only a tiny remnant population still persists, and a key first step for conservation is to locate surviving birds. Numerous Manumea records are available from the nineteenth century onwards, and we used historical and modern records to generate a series of species distribution models to predict the distribution of suitable habitat across Samoa to guide new field searches. Manumea distribution is closely associated with forest cover or its proxies. Preferred Manumea food plants are suggested to be low-elevation trees, but elevation provides relatively low percentage contribution in most models, thus not excluding the possibility that Manumea might occur at high elevations. There is also little evidence for elevational change in records over the past century. Models based on visual versus acoustic records exhibit differences in predicted habitat suitability, suggesting that some purported acoustic records might not actually represent Manumea calls. Field searches should target areas representing high habitat suitability across all models, notably the forested central axis of Upolu.
The paper presents a Wittgensteinian account of the concept woman, in terms of family resemblance. This approach is deemed superior to the Carnapian account, championed by Sally Haslanger, in that it allows for more inclusivity and to locate the source of sexism not so much in the very concept of woman but in the beliefs sexist people have about women. The compatibility of this account with semantic externalism is explored, as well as its relationship with stereotypes and paradigmatic examples of women. It is further shown how present-day attempts to extend the application of the concept of woman beyond human females may be made sense in terms of a change of hinges—that is, of the rules of evidential significance, which a community of speakers brings to bear on the determination of whether a person is a woman. Finally, it is argued that, despite Wittgenstein's metaphilosophical quietism, such an account is politically significant. This in turn shows that in fact Wittgenstein's metaphilosophical pronouncements far from being inimical to political and societal change may in fact be conducive to it.
Studies with multiple radiocarbon dates often contain useful information on the relative locations of the dated levels. Such information can be used to obtain robust, integrated site chronologies, with at times more precise ages than those of the individual dates, where outliers can be identified and downweighted, and where the ages of any undated levels can also be estimated. Examples include trees with radiocarbon dates separated by exactly known amounts of yearly tree-rings, or sedimentary sites where ages further down the stratigraphy can be assumed to be older than ages further up. Here we present coffee, an R package for Bayesian models that apply chronological ordering for fossils and environmental events. Coffee runs natively within the popular and versatile R environment, with no need for importing or exporting data or code from other programs, and works with plain-text input files that are relatively easy to read and write. It thus provides a new, transparent and adaptable educational and research platform designed to make chronology building more accessible.
Clozapine is the most effective medication for treatment-resistant psychoses, but the balance of benefits and risks is understudied in real-world settings.
Aims
To examine the relative re-hospitalisation rates for mental health relapse and adverse events associated with clozapine and other antipsychotics in adult and child/youth cohorts.
Method
Data were obtained from the Canadian Institute of Health Information for adults (n = 45 616) and children/youth (n = 1476) initially hospitalised for mental health conditions in British Columbia, Manitoba and Saskatchewan from 2008 to 2018. Patient demographics and hospitalisations were linked with antipsychotic prescriptions dispensed following the initial visit. Recurrent events survival analysis for relapse and adverse events were created and compared between clozapine and other antipsychotics.
Results
In adults, clozapine was associated with a 14% lower relapse rate versus other drugs (adjusted hazard ratio: 0.86, 95% CI: 0.83–0.90) over the 10-year follow-up. In the first 21 months, the relapse rate was higher for clozapine but then reversed. Over 1000 person-months, clozapine-treated adults could be expected to have 38 relapse hospitalisations compared with 45 for other drugs. In children/youth, clozapine had a 38% lower relapse rate compared with other antipsychotic medications (adjusted hazard ratio: 0.62, 95% CI: 0.49–0.78) over the follow-up period. This equates to 29 hospitalisations for clozapine and 48 for other drugs over 1000 person-months. In adults, clozapine had a higher risk for adverse events (hazard ratio: 1.34, 95% CI: 1.18–1.54) over the entire follow-up compared with other antipsychotics. This equates to 1.77 and 1.30 hospitalisations over 1000 person-months for clozapine and other drugs, respectively.
Conclusions
Clozapine was associated with lower relapse overall, but this was accompanied by higher adverse events for adults. For children/youth, clozapine was associated with lower relapse all throughout and had no difference in adverse events compared with other antipsychotics.
Eve Caroline Southward (1930–2023) was a multi-talented scientist, motivated by her curiosity and love of nature. Since she was never paid as a scientist, Eve was an amateur, in the best sense of the word. She was highly proficient at transmission electron microscopy and made lasting contributions to polychaete taxonomy, morphology and ecology. Eve was internationally respected, especially for her studies on the Siboglinidae, mouthless and gutless tubeworms (formerly called Pogonophora) that are found worldwide in the deep-sea. She described how the siboglinids obtained nutrition from symbiotic, sulphur-oxidising bacteria and described similar symbiotic relationships in several bivalve species. Eve wrote over 140 scientific publications and described 56 new benthic species, 47 being mouthless and gutless ‘pogonophores’. Eve assisted her husband Alan Southward in starting broad-scale intertidal surveys around the British Isles and Northwest Europe. These surveys formed the foundation for the time-series, later continued by others, that allowed assessments of the influence of climatic fluctuations, using intertidal rocky shore biota as indicators. Eve contributed, with Alan, to what became a 50-year study describing the long-term effects on intertidal communities of the oil pollution and excessive dispersant use resulting from the Torrey Canyon oil spill in 1967. Eve also co-wrote the Linnaean Society Synopsis on Echinoderms of the British Isles and helped complete unpublished work by Alan Southward and others on barnacle taxonomy.