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The crystal structure of a new form of racemic reboxetine mesylate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Reboxetine mesylate crystallizes in space group P21/c (#14) with a = 14.3054(8), b = 18.0341(4), c = 16.7924(11) Å, β = 113.4470(17)°, V = 3,974.47(19) Å3, and Z = 8 at 298 K. The crystal structure consists of double columns of anions and cations along the a-axis. Strong N–H···O hydrogen bonds link the cations and anions into zig-zag chains along the a-axis. The powder pattern has been submitted to the International Centre for Diffraction Data (ICDD®) for inclusion in the Powder Diffraction File™ (PDF®).
Although fundamental arguments have been presented to support the value-laden nature of all scientific research, they appear to be difficult to apply to basic research in physics. To explain this, I argue that basic research in physics is, in a very specific respect, often value-laden to a lesser degree. To spell this out, I refer to the different signal-to-noise ratios that can be achieved in different fields of research. I also argue that having a very low degree of value-ladenness in the very specific respect that I identify does not mean that the research is not value-laden at all.
The Third Reich established a new financial order in Central Europe. This article examines one aspect of these changes, namely the evolution of banking law. After the seizure of power in 1933, Nazi officials weaponized financial and legal institutions to support the rearmament campaign. They initially worked through the Credit Supervisory Office, a regulatory agency created in 1934, to enforce a standardized model of regulation. Driven by more than a desire for self-sufficiency (autarky) and expropriative control, the authorities devised a system of economic governance that perpetuated the conflict and continually supported German financial interests. The politicization and dismantling of the regulatory office, officially dissolved in 1944, reflected the evolving priorities of the Nazi regime. By reinterpreting existing laws and working with a willing state bureaucracy, officials were able to use regulation as a tool for redesigning the banking systems of Germany and the annexed territories.
Although current prescribing guidelines suggest continuation of psychotropic drugs in pregnant women, population-based evidence supporting their safety is limited.
Aims
This study aims to clarify the plausible causal links between maternal psychotropic drug exposures and obstetric complications.
Method
This cohort study investigated all births by Hong Kong residents ≥18 years of age in public hospitals between 2004 and 2022. Birth episodes were classified according to whether they were unexposed to psychotropic drugs, exposed but discontinued before conception or exposed during pregnancy. Firth’s penalised logistic regression was employed in all analysis, and negative control analysis was conducted to assess causality. False discovery rate correction and sensitivity analyses were performed.
Results
Among 587 419 births, 7182 episodes involved psychotropic prescriptions (antipsychotics, antidepressants, anticonvulsants, benzodiazepines) during pregnancy. In broad drug class analysis, all significant associations observed in the exposed group were also observed in negative control analysis (psychotropics discontinued before conception), suggesting that elevated risks could be attributed to unmeasured confounders. Nevertheless, in subclass analyses, certain psychotropic drugs showed increased risks of obstetric complications, i.e. significant associations between atypical antipsychotics and genito-urinary infection (odds ratio 2.70, 95% CI 1.46–4.83), and between valproate and low birth weight (odds ratio 1.68, 95% CI 1.16–2.37). These associations became non-significant in negative control analysis, and the high E-values (atypical antipsychotics and genito-urinary infection, 4.84; valproate and low birth weight, 2.75) suggested that the results were unlikely to have been driven by unmeasured confounders. Maternal diagnoses of schizophrenia and depression were independently associated with increased risk of obstetric complications, after controlling for the effects of psychotropics.
Conclusions
The population-based data and meticulous analyses did not support any clear causal link between broad-class psychotropic exposure during pregnancy and increased risk of obstetric/neonatal complications. However, some psychotropic subclasses may increase obstetric/neonatal complications. The limited number of episodes involving discontinuation of some psychotropic subclasses may have resulted in false negative findings in the negative control analysis.
We investigate the notion of ideal (equivalently: filter) Schauder basis of a Banach space. We do so by providing bunch of new examples of such bases that are not the standard ones, especially within classical Banach spaces ($\ell _p$, $c_0$, and James’ space). Those examples lead to distinguishing and characterizing ideals (equivalently: filters) in terms of Schauder bases. We investigate the relationship between possibly basic sequences and ideals (equivalently: filters) on the set of natural numbers.
This study examines the political participation of undocumented Mexican immigrants residing in the United States in Mexican external voting. As international mobility of people has increased globally, scholarly attention has grown concerning how overseas citizens engage in electoral processes in their countries of origin. However, previous studies based on traditional survey methods may have yielded biased results due to the underrepresentation of undocumented immigrants, who are less likely to enroll in survey company panels due to concerns about the potential compromise of their identities. To include this hard-to-reach population and conduct representative sampling, our research employs a method called respondent-driven sampling (RDS), which permits the surveying of a population devoid of a sampling frame. Our analysis of the Mexican case demonstrates that a lack of electoral information, lower levels of education, and heightened distrust of the Mexican government are associated with diminished electoral participation.
Cognitive behavioural therapy (CBT) is a frontline treatment for a range of mental health problems and is increasingly offered as the psychological therapy of choice across the globe. Access to or benefit from this psychological therapy relies on proficiency in the dominant language of the area. However, to meet our clients’ needs in an increasingly mobile, multicultural, and diverse society, it may require adaptation through the use of spoken language interpreters. The benefits of interpreter-mediated CBT for mental health problems remains uncertain. The objective of this review is to systematically identify, evaluate, and integrate the existing empirical literature on interpreter-mediated CBT for mental health problems. A comprehensive search was conducted in July 2024 across CINAHL, MEDLINE, PsycINFO and Scopus. Studies meeting the inclusion criteria resulted in a total of eleven articles being included in the review. The included research shows promise in terms of feasibility and efficacy, but not conclusively. The narrative review enabled the synthesis of recommendations, which have been conceptualised as being at individual, service, and organisational levels. There is limited research and a need for further studies into the influence of other factors such as therapist proficiency, interpreter proficiency, complexity/co-morbidity and service context. Further evaluation should consider controlled trials of interpreter-mediated CBT, while also establishing its efficacy more robustly in regular practice. It should also further explore the experiences and perspectives of the client, interpreter, and therapist regarding the suggested recommendations.
Key learning aims
(1) Gain an understanding of the existing evidence on the effectiveness of interpreter-mediated CBT for various mental health problems across diverse populations.
(2) Learn about key recommendations emerging from empirical research on the implementation of interpreter-mediated CBT.
(3) Acquire clear, practical guidance that can inform the work of interpreters, practitioners, services, and healthcare systems to improve the delivery of interpreter-mediated CBT.
In the United Kingdom (UK), approximately one million people cannot speak English well enough to access therapy in English. If there is no shared language used by both the client and therapist, then individuals require access to an interpreter so that they receive an equitable service. Research highlights the anxiety and pressures that working with an interpreter can bring for professionals. In light of the Coronavirus pandemic and increased remote working, this research aimed to explore the experience and perspectives of cognitive behavioural therapists working with language interpreters remotely. Semi-structured interviews were conducted with 18 participants who were asked about their experience of working with interpreters remotely. Data were analysed using Braun and Clarke’s six phases of thematic analysis. The analysis resulted in four main themes being constructed: the system doesn’t make it easier; working in a culturally sensitive way; the powerful role of the interpreter; and remote therapy – different landscape, different journey. Findings offer an understanding of how working with an interpreter impacts ways of working in cognitive behavioural therapy. The findings draw attention to the impact of the organisational context where therapists work.
Key learning aims
After reading this paper, it is hoped that readers will be able to:
(1) Consider cognitive behavioural therapists’ experiences of challenges and barriers when working remotely with interpreters.
(2) Look at the experience and perspectives of cognitive behavioural therapists working with interpreters remotely (in light of the COVID-19 pandemic and increased remote working practices).
(3) Consider the support needed to enable therapists, healthcare services and broader healthcare structures to provide services to clients through working with interpreters and adapting therapy for diverse cultural groups.
This article maps out the challenges of public global health communication in the context of the COVID-19 pandemic by providing an overview of the shifting media of health communication from the post-Second World War era to the present. The article explores the communication of science in real-time or live media of film, television, video and digital social media during three emerging infectious-disease (EID) outbreaks to place COVID-19 health communication in historical perspective. Examination of the transition from centralized, top-down communications to distributed, many-to-many, mobile communication illuminates challenges to expertise, authority and control of health narratives and imagery. Through theories of intermediality, the article explores the central function of gaps in communication networks. The article considers three cases of crisis communications amid EIDs: the influenza outbreak of 1957, HIV/AIDS around 1990 and COVID-19 in the early 2020s, and the challenges posed by scientific uncertainty under these circumstances of live, intermedial health communication. The article concludes that ‘liveness’ in intermedial health communications may have an inherently destabilizing effect on scientific authority.
Temporal bone computed tomography delivers a relatively high radiation dose. Cone beam computed tomography could be a promising alternative, offering good performance with reduced radiation exposure. This study aimed to compare the irradiation during temporal bone imaging using computed tomography versus cone beam computed tomography.
Materials and methods
We conducted a single-centre prospective study evaluating dosimetric data collected from patients undergoing temporal bone imaging via computed tomography or cone beam computed tomography. Absorbed doses (milligrays) were measured using mini-dosimeters placed on key anatomical sites: eyes, ears, lower neck and pubic region, and compared between the two imaging modalities.
Results
CBCT significantly reduced radiation, with absorbed doses being two to six times lower than those observed with conventional computed tomography, depending on the measured sites.
Conclusion
Our findings align with existing literature, confirming the reduced irradiation with cone beam computed tomography in ear imaging. Further studies are warranted to evaluate image quality relative to radiation dose between the two techniques.
In 2022, an anti-vaccine mandate protest in Canada received millions of dollars in support through online crowdfunding. This event catalyzed political crowdfunding in Canada by demonstrating its ability to disseminate ideological discourse and mobilize collective action. Given its newfound visibility and impact, this study examines the landscape of political crowdfunding in Canada. We examined 60 campaigns from the legal, current events and political categories on the crowdfunding platform GiveSendGo and classified campaigns into: COVID-19-related topics, alternative media and free speech, climate change skepticism, and other political campaigns. Thematic analysis of the interactive discourse between campaign hosts and donors revealed that many campaigns were motivated by defending individual rights and freedoms amidst perceived government overreach, which fuels a distrust towards authority, including the government and mainstream media. Our study suggests that political crowdfunding empowers individuals to symbolically reflect their political and ideological beliefs through financial donations.
True bugs (Hemiptera: Acanthosomatidae, Coreidae, and Pentatomidae) include harmful crop pests affecting global agriculture, with different species displaying distinct optimal conditions for development and using different habitats. Over a 2-year period, this research investigates how habitat variation and altitude can influence the species composition of true bugs and their egg parasitoids in South Tyrol (North Italy), unveiling different trends in their population and diversity across habitats: apple orchards, urban areas, and forests. A total of 25 true bug species were sampled. Urban environments hosted the highest bug abundance, predominantly driven by the invasive Halyomorpha halys, while forests showed a higher prevalence of native species such as Pentatoma rufipes and Palomena prasina. Altitude significantly influenced species composition, with H. halys and P. rufipes abundance negatively and positively correlated with altitude, respectively. A total of 12 parasitoid species (Hymenoptera: Eupelmidae, and Scelionidae) emerged from the field-collected bug eggs, including the exotic Trissolcus japonicus, predominantly associated with H. halys in urban areas. Native parasitoids exhibited higher parasitism rates on native bug species, indicating co-evolutionary relationships. The results give an insight into the ecological dynamics of local true bug species and their egg parasitoids, and highlight the value of natural and urban areas for conserving both hemipteran and parasitoid species richness and abundance.
Physiologic data streaming and aggregation platforms such as Sickbay® and Etiometry are becoming increasingly used in the paediatric acute care setting. As these platforms gain popularity in clinical settings, there has been a parallel growth in scholarly interest. The primary aim of this study is to characterise research productivity utilising high-fidelity physiologic streaming data with Sickbay® or Etiometry in the acute care paediatric setting.
Methods:
A systematic review of the literature was conducted to identify paediatric publications using data from Sickbay® or Etiometry. The resulting publications were reviewed to characterise them and identify trends in these publications.
Results:
A total of 41 papers have been published over 9 years using either platform. This involved 179 authors across 21 institutions. Most studies utilised Sickbay®, involved cardiac patients, were single-centre, and did not utilise machine learning or artificial intelligence methods. The number of publications has been significantly increasing over the past 9 years, and the average number of citations for each publication was 7.9.
Conclusion:
A total of 41 papers have been published over 9 years using Sickbay® or Etiometry data in the paediatric setting. Although the majority of these are single-centre and pertain to cardiac patients, growth in publication volume suggests growing utilisation of high-fidelity physiologic data beyond clinical applications. Multicentre efforts may help increase the number of centres that can do such work and help drive improvements in clinical care.
Healthy diets are unaffordable for billions of people worldwide, with food prices rising in high-, middle- and low-income nations in recent times. Despite widespread attention to this issue, recent actions taken to inform policy prioritisation and government responses to high food inflation have not been comprehensively synthesised. Our review summarises (i) innovative efforts to monitor national food and healthy diet price, ii) new policy responses adopted by governments to address food inflation and (iii) future research directions to inform new evidence. Evidence synthesis. Global. None. We describe how timely food and beverage pricing data can provide transparency in the food industry and identify key areas for intervention. However, government policies that improve food affordability are often short-lived and lack sustained commitment. Achieving meaningful impact will require long-term, cross-sectoral actions that are led by governments to support food security, healthy diets and resilient sustainable food systems. This will necessitate a better understanding of how the political economy enables (or hinders) policy implementation, including through coherent problem framing, mitigating conflicts of interest in policymaking, working together as coalitions and developing and utilising evidence on the food security and related impacts of food pricing and affordability policies. Diverse actors must be better equipped with robust data platforms and actionable policy solutions that improve the affordability of healthy and sustainable diets, including by lowering food prices and addressing the broader socio-political determinants of food insecurity.
Two Xiphinema species, one new and one known, were found from Bushehr province, southern Iran, and are herein described based on morphological and molecular data. These include Xiphinema pedrami sp. nov. and X. basiri, both belonging to the ‘Xiphinema non-americanum group’. The new dagger nematode is characterised by a body length of 3.54–5.00 mm, a lip region separated from the rest of body by a depression, odontostyle 128–148 μm long, 60–89 μm long odontophore, guiding ring at 107–138 μm from anterior end, female tail rounded to dorsally more convex with small bulge and four juvenile stages. Males have one pair of cloacal and three to five ventromedian single supplements. The new species belongs to morphospecies Xiphinema non-americanum group 5, characterised by having two equally developed female genital branches with uterine differentiation in the form of pseudo-Z-organ along with the rhomboid-shaped crystalloid bodies, and a short, rounded tail ending in a peg. The polytomous identification codes of the new species are A4, B2, C5a5b, D6, E56, F4(5), G23, H2, I34, J5a5b, K3, L2. Morphologically, the new species comes close to several known species (namely, X. andalusiense, X. artemisiae, X. baetica, X. hyrcaniense, X. ingens, X. macroacanthum and X. pseudocoxi) belonging to morphospecies group 5. The morphological differences of the new species and the aforementioned species are discussed. The second recovered species, Xiphinema basiri, belongs to the same group and has a pseudo-Z-organ in the shape of globular bodies close to pars dilatata uterus and short, conical, distinctly digitate tail. Integrative diagnosis was completed using molecular data obtained from partial sequences of the D2-D3 region of 28S rDNA, ITS1 rDNA, 18S rDNA, and COI mtDNA genes.
Agencies, boards, and commissions (ABCs) in Canada have a distinct character and set of governance dynamics compared with the conventional public service. ABCs are often conceived to deliver a particular service or regulate or adjudicate matters with some distance from the government of the day, yet (perhaps counter-intuitively) are among the few remaining sites of patronage-like appointments in Canada. This article compiles ABC appointment data (N = 2,248) from the Province of Alberta over two distinct periods—the Notley government (2015–2019) and the Kenney/Smith governments (2019–2024)—to explore the character and patterns of appointments. We find mixed evidence that appointments to ABCs with more formal autonomy are more likely to be politicized. Some metrics also suggest that the conservative party appointees are slightly more often politically connected, particularly in ABCs that reside in high priority policy areas for the appointing government, and in particular in crown corporations and regulatory agencies.